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    Tep3 Thioester-containing protein 3 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 34045, updated on 18-Sep-2024

    Summary

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    Official Symbol
    Tep3provided by FlyBase
    Official Full Name
    Thioester-containing protein 3provided by FlyBase
    Primary source
    FLYBASE:FBgn0041181
    Locus tag
    Dmel_CG7068
    See related
    AllianceGenome:FB:FBgn0041181
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG7068; Dmel\CG7068; dTEPIII; TEP3; TEP3mel; TepIII; TEPIII
    Summary
    Predicted to enable endopeptidase inhibitor activity. Involved in defense response to Gram-positive bacterium and innate immune response. Predicted to be located in extracellular space. Is expressed in anterior-posterior subdivision of organism; embryonic/larval plasmatocyte; and foregut. Human ortholog(s) of this gene implicated in several diseases, including complement deficiency (multiple); macular degeneration (multiple); paroxysmal nocturnal hemoglobinuria; sickle cell anemia; and silicosis. Orthologous to several human genes including CD109 (CD109 molecule). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    See Tep3 in Genome Data Viewer
    Location:
    28C1-28C1; 2-28 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (7702805..7710690)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (7702805..7710690)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Thioester-containing protein 2 Neighboring gene antisense RNA:CR44990 Neighboring gene transfer RNA:Tyrosine-GTA 1-9 Neighboring gene Neurotransmitter transporter-like Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Quorum-sensing regulator RhlR but not its autoinducer RhlI enables Pseudomonas to evade opsonization. Haller S, et al. EMBO Rep, 2018 May. PMID 29523648, Free PMC Article
    2. Evolution and Function of Thioester-Containing Proteins and the Complement System in the Innate Immune Response. Shokal U, et al. Front Immunol, 2017. PMID 28706521, Free PMC Article
    3. Thioester-containing Proteins in the Drosophila melanogaster Immune Response against the Pathogen Photorhabdus. Eleftherianos I, et al. Insects, 2020 Jan 28. PMID 32013030, Free PMC Article
    4. Contrasting evolutionary patterns in Drosophila immune receptors. Jiggins FM, et al. J Mol Evol, 2006 Dec. PMID 17103056, Free PMC Article
    5. Constitutive expression of a complement-like protein in toll and JAK gain-of-function mutants of Drosophila. Lagueux M, et al. Proc Natl Acad Sci U S A, 2000 Oct 10. PMID 11027343, Free PMC Article

    See all (53) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables endopeptidase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in defense response to Gram-positive bacterium IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in defense response to other organism IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in innate immune response IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Thioester-containing protein 3
    Names
    CG7068-PA
    TEP
    Tep3-PA
    thiolester containing protein III

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      7702805..7710690
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_078783.3 → NP_523507.2  Thioester-containing protein 3 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_523507.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8T0U4, Q9NFV6, Q9VLY7
      Related
      FBpp0079101
      Conserved Domains (6) summary
      cd02897
      Location:918 → 1203
      A2M_2; Proteins similar to alpha2-macroglobulin (alpha (2)-M). This group also contains the pregnancy zone protein (PZP). Alpha(2)-M and PZP are broadly specific proteinase inhibitors. Alpha (2)-M is a major carrier protein in serum. The structural thioester ...
      pfam00207
      Location:697 → 787
      A2M; Alpha-2-macroglobulin family
      pfam01835
      Location:124 → 215
      A2M_N; MG2 domain
      pfam07677
      Location:1313 → 1402
      A2M_recep; A-macroglobulin receptor
      pfam07678
      Location:967 → 1200
      A2M_comp; A-macroglobulin complement component
      pfam07703
      Location:448 → 573
      A2M_N_2; Alpha-2-macroglobulin family N-terminal region
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9NFV6 Q9NFV6
    Q9VLY7 Q9VLY7

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