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    CG3355 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 33667, updated on 4-Jul-2024

    Summary

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    Official Symbol
    CG3355provided by FlyBase
    Primary source
    FLYBASE:FBgn0031619
    Locus tag
    Dmel_CG3355
    See related
    AllianceGenome:FB:FBgn0031619
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Dmel\CG3355; SP21
    Summary
    Enables serine hydrolase activity. Predicted to be involved in proteolysis. Predicted to be active in extracellular space. Is expressed in ventral sensory complex primordium. Human ortholog(s) of this gene implicated in microcytic anemia. Orthologous to human HPN (hepsin) and TMPRSS6 (transmembrane serine protease 6). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    See CG3355 in Genome Data Viewer
    Location:
    25A2-25A2; 2-13 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (4651403..4652892)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (4651403..4652892)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene long noncoding RNA: testis-specific 6 Neighboring gene uncharacterized protein Neighboring gene Early boundary activity 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Broad Transcription Factor Links Hormonal Signaling, Gene Expression, and Cellular Morphogenesis Events During Drosophila Imaginal Disc Development. Rice C, et al. Genetics, 2020 Dec. PMID 33115752, Free PMC Article
    2. The female-specific doublesex isoform regulates pleiotropic transcription factors to pattern genital development in Drosophila. Chatterjee SS, et al. Development, 2011 Mar. PMID 21343364
    3. Transcriptome Analysis of Drosophila melanogaster Third Instar Larval Ring Glands Points to Novel Functions and Uncovers a Cytochrome p450 Required for Development. Christesen D, et al. G3 (Bethesda), 2017 Feb 9. PMID 27974438, Free PMC Article
    4. Nutrient control of gene expression in Drosophila: microarray analysis of starvation and sugar-dependent response. Zinke I, et al. EMBO J, 2002 Nov 15. PMID 12426388, Free PMC Article
    5. Enhanced function annotations for Drosophila serine proteases: a case study for systematic annotation of multi-member gene families. Shah PK, et al. Gene, 2008 Jan 15. PMID 17996400

    See all (32) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables serine hydrolase activity HDA PubMed 
    enables serine-type endopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables serine-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables serine-type endopeptidase activity ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in proteolysis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in proteolysis ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG3355-PA
    CG3355-PB
    NP_608848.1
    NP_723001.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      4651403..4652892
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_164594.1 → NP_723001.1  uncharacterized protein Dmel_CG3355, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_723001.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q2PDW5, Q8MT30
      Conserved Domains (2) summary
      smart00020
      Location:75 → 201
      Tryp_SPc; Trypsin-like serine protease
      cd00190
      Location:76 → 201
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

    2. NM_135004.2 → NP_608848.1  uncharacterized protein Dmel_CG3355, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_608848.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      E6PBX7, Q9VR15
      Related
      FBpp0077068
      Conserved Domains (2) summary
      smart00020
      Location:75 → 302
      Tryp_SPc; Trypsin-like serine protease
      cd00190
      Location:76 → 305
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q2PDW5 Q2PDW5
    Q8MT30 Q8MT30
    Q9VR15 Q9VR15

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