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    CG7059 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 42626, updated on 19-Jun-2024

    Summary

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    Official Symbol
    CG7059provided by FlyBase
    Primary source
    FLYBASE:FBgn0038957
    Locus tag
    Dmel_CG7059
    See related
    AllianceGenome:FB:FBgn0038957
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Dmel\CG7059
    Summary
    Predicted to enable phosphoglycerate mutase activity. Predicted to be involved in glycolytic process. Is expressed in eye. Human ortholog(s) of this gene implicated in familial erythrocytosis 8 and myoglobinuria. Orthologous to several human genes including PGAM1 (phosphoglycerate mutase 1); PGAM2 (phosphoglycerate mutase 2); and PGAM4 (phosphoglycerate mutase family member 4). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    See CG7059 in Genome Data Viewer
    Location:
    94A11-94A11; 3-74 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (22389780..22392349)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (18215502..18218071)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Glycerol-3-phosphate dehydrogenase 3 Neighboring gene Carbonic anhydrase 8 Neighboring gene uncharacterized protein Neighboring gene transfer RNA:Serine-GCT 2-3 Neighboring gene transfer RNA:Serine-GCT 2-4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Mechanisms underlying the cooperation between loss of epithelial polarity and Notch signaling during neoplastic growth in Drosophila. Logeay R, et al. Development, 2022 Feb 1. PMID 35005772
    2. dTcf/Pangolin suppresses growth and tumor formation in Drosophila. Song S, et al. Proc Natl Acad Sci U S A, 2019 Jul 9. PMID 31235567, Free PMC Article
    3. Quantitative trait loci for response to ethanol in an intercontinental set of recombinant inbred lines of Drosophila melanogaster. Defays R, et al. Alcohol, 2012 Dec. PMID 22925826
    4. Drosophila PDGF/VEGF signaling from muscles to hepatocyte-like cells protects against obesity. Ghosh AC, et al. Elife, 2020 Oct 27. PMID 33107824, Free PMC Article
    5. Probing the canonicity of the Wnt/Wingless signaling pathway. Franz A, et al. PLoS Genet, 2017 Apr. PMID 28369070, Free PMC Article

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables bisphosphoglycerate mutase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables intramolecular phosphotransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in canonical glycolysis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in gluconeogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in glycolytic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG7059-PA
    CG7059-PC
    CG7059-PD
    NP_651034.2
    NP_732730.1
    NP_788713.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      22389780..22392349
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_142777.2 → NP_651034.2  uncharacterized protein Dmel_CG7059, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_651034.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8T8W6, Q9VD18
      Related
      FBpp0083616
      Conserved Domains (1) summary
      cl11399
      Location:19 → 266
      HP; Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction

    2. NM_176536.2 → NP_788713.1  uncharacterized protein Dmel_CG7059, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_788713.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q86BN6
      Related
      FBpp0083618
      Conserved Domains (1) summary
      cl11399
      Location:14 → 261
      HP; Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction

    3. NM_170008.2 → NP_732730.1  uncharacterized protein Dmel_CG7059, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_732730.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q86BN5
      Related
      FBpp0083617
      Conserved Domains (1) summary
      cl11399
      Location:5 → 252
      HP; Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q86BN5 Q86BN5
    Q86BN6 Q86BN6
    Q8T8W6 Q8T8W6

    Gene LinkOut

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