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    nmo nemo [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 38890, updated on 18-Sep-2024

    Summary

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    Official Symbol
    nmoprovided by FlyBase
    Official Full Name
    nemoprovided by FlyBase
    Primary source
    FLYBASE:FBgn0011817
    Locus tag
    Dmel_CG7892
    See related
    AllianceGenome:FB:FBgn0011817
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    adk; adk1; anon-EST:Gibbs3; anon-EST:Liang-2.43; anon-WO0118547.332; anon-WO0140519.256; anon-WO0172774.138; CG7892; clone 2.43; Dmel\CG7892; Nemo; NEMO; NEMO/NLK; Nlk; NLK; Nmo; ORE-6
    Summary
    Enables protein serine/threonine kinase activity. Involved in several processes, including ommatidial rotation; positive regulation of synaptic assembly at neuromuscular junction; and wing disc development. Predicted to be active in cytoplasm and nucleus. Is expressed in several structures, including embryonic optic lobe primordium; embryonic/larval digestive system; eye-antennal disc; nervous system; and presumptive embryonic/larval system. Orthologous to human NLK (nemo like kinase). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    See nmo in Genome Data Viewer
    Location:
    66A22-66B3; 3-22 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (7979046..8054147)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (7972146..8047247)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Heterochromatin protein 4 Neighboring gene POP4 ribonuclease P/MRP subunit Neighboring gene transfer RNA:Alanine-AGC 2-1 Neighboring gene antisense RNA:CR45867 Neighboring gene antisense RNA:CR45868 Neighboring gene bip1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Nemo-like kinase is a novel regulator of spinal and bulbar muscular atrophy. Todd TW, et al. Elife, 2015 Aug 26. PMID 26308581, Free PMC Article
    2. Characterization and isolation of novel microsatellites from the Drosophila dunni subgroup. Wilder JA, et al. Genet Res, 2002 Dec. PMID 12688656
    3. Phosphorylation of the transcription activator CLOCK regulates progression through a ∼ 24-h feedback loop to influence the circadian period in Drosophila. Mahesh G, et al. J Biol Chem, 2014 Jul 11. PMID 24872414, Free PMC Article
    4. Polyglutamine disease toxicity is regulated by Nemo-like kinase in spinocerebellar ataxia type 1. Ju H, et al. J Neurosci, 2013 May 29. PMID 23719801, Free PMC Article
    5. Genome-Wide Analysis in Drosophila Reveals the Genetic Basis of Variation in Age-Specific Physical Performance and Response to ACE Inhibition. Gabrawy MM, et al. Genes (Basel), 2022 Jan 14. PMID 35052483, Free PMC Article

    See all (179) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Data indicate Prickle protein as a mitogen-activated protein kinase Nemo substrate.
      Title: Prickle is phosphorylated by Nemo and targeted for degradation to maintain Prickle/Spiny-legs isoform balance during planar cell polarity establishment.
    2. nmo promotes Notch-mediated lateral inhibition downstream of proneural factors during neurogenesis.
      Title: Nemo promotes Notch-mediated lateral inhibition downstream of proneural factors.
    3. One of the roles of Nmo during ommatial rotation is to repress miple expression, which may in turn affect the dynamics in E-cadherin-beta-catenin complexes.
      Title: Nemo regulates cell dynamics and represses the expression of miple, a midkine/pleiotrophin cytokine, during ommatidial rotation.
    4. NEMO kinase contributes to core period determination by slowing the pace of the Drosophila circadian oscillator.
      Title: NEMO kinase contributes to core period determination by slowing the pace of the Drosophila circadian oscillator.
    5. Findings identify NEMO as a clock kinase and demonstrate that long-range interactions between functionally distinct phospho-clusters collaborate to set circadian clock speed.
      Title: NEMO/NLK phosphorylates PERIOD to initiate a time-delay phosphorylation circuit that sets circadian clock speed.
    6. These data suggest that Nemo serves as a conserved molecular link between strabismus and prickle proteins and E-cadherin-beta-catenin complexes, promoting cell motility.
      Title: Nemo kinase phosphorylates β-catenin to promote ommatidial rotation and connects core PCP factors to E-cadherin-β-catenin.
    7. These studies reveal a novel role for the Nmo kinase in embryonic pattern formation through its regulation of the homeodomain-containing transcription factor Eve.
      Title: Nemo phosphorylates Even-skipped and promotes Eve-mediated repression of odd-skipped in even parasegments during Drosophila embryogenesis.
    8. phosphorylation of Mad by Nmo ensures normal accumulation and distribution of Mad and thereby fine tunes BMP signaling in motor neurons
      Title: Nemo kinase interacts with Mad to coordinate synaptic growth at the Drosophila neuromuscular junction.
    9. nmo promotes normal and ectopic eye development directed by the retinal determination gene network
      Title: Drosophila nemo promotes eye specification directed by the retinal determination gene network.
    10. Drosophila Nemo antagonizes BMP signaling by phosphorylation of Mad and inhibition of its nuclear accumulation.
      Title: Drosophila Nemo antagonizes BMP signaling by phosphorylation of Mad and inhibition of its nuclear accumulation.
    Submit: New GeneRIF Correction See all GeneRIFs (13)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables MAP kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables MAP kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in compound eye development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in gravitaxis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in imaginal disc-derived wing morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in imaginal disc-derived wing vein specification IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in intracellular signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of BMP signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of canonical Wnt signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in ommatidial rotation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of synaptic assembly at neuromuscular junction IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of establishment of planar polarity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in wing disc dorsal/ventral pattern formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    nemo
    Names
    CG7892-PA
    CG7892-PB
    CG7892-PC
    CG7892-PE
    CG7892-PF
    CG7892-PG
    CG7892-PH
    CG7892-PI
    NEMO
    Nemo-like kinase
    adirondack
    dNEMO
    nmo-PA
    nmo-PB
    nmo-PC
    nmo-PE
    nmo-PF
    nmo-PG
    nmo-PH
    nmo-PI
    NP_001261555.1
    NP_001356976.1
    NP_523967.2
    NP_729316.1
    NP_729317.1
    NP_729318.1
    NP_729319.1
    NP_729320.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      7979046..8054147
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001274626.1 → NP_001261555.1  nemo, isoform H [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261555.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q23994, Q8IQ91
      Conserved Domains (1) summary
      cd07853
      Location:39 → 411
      STKc_NLK; Catalytic domain of the Serine/Threonine Kinase, Nemo-Like Kinase

    2. NM_168251.3 → NP_729319.1  nemo, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_729319.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q23994, Q8T030, Q9VSC7
      Related
      FBpp0076471
      Conserved Domains (1) summary
      cd07853
      Location:39 → 411
      STKc_NLK; Catalytic domain of the Serine/Threonine Kinase, Nemo-Like Kinase

    3. NM_168252.3 → NP_729320.1  nemo, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_729320.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q23994, Q8T030, Q9VSC7
      Related
      FBpp0076472
      Conserved Domains (1) summary
      cd07853
      Location:39 → 411
      STKc_NLK; Catalytic domain of the Serine/Threonine Kinase, Nemo-Like Kinase

    4. NM_168249.3 → NP_729317.1  nemo, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_729317.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q23994, Q8IQ91
      Related
      FBpp0076475
      Conserved Domains (1) summary
      cd07853
      Location:39 → 411
      STKc_NLK; Catalytic domain of the Serine/Threonine Kinase, Nemo-Like Kinase

    5. NM_168248.3 → NP_729316.1  nemo, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_729316.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q23994, Q8IQ91
      Related
      FBpp0076473
      Conserved Domains (1) summary
      cd07853
      Location:39 → 411
      STKc_NLK; Catalytic domain of the Serine/Threonine Kinase, Nemo-Like Kinase

    6. NM_079243.4 → NP_523967.2  nemo, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_523967.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q23994, Q8T030, Q9VSC7
      Related
      FBpp0076474
      Conserved Domains (1) summary
      cd07853
      Location:39 → 411
      STKc_NLK; Catalytic domain of the Serine/Threonine Kinase, Nemo-Like Kinase

    7. NM_001370048.1 → NP_001356976.1  nemo, isoform I [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A4D6K823, Q23994
      Conserved Domains (1) summary
      cd07853
      Location:39 → 411
      STKc_NLK; Catalytic domain of the Serine/Threonine Kinase, Nemo-Like Kinase

    8. NM_168250.3 → NP_729318.1  nemo, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_729318.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q23994, Q8IQ91
      Related
      FBpp0076476
      Conserved Domains (1) summary
      cd07853
      Location:39 → 411
      STKc_NLK; Catalytic domain of the Serine/Threonine Kinase, Nemo-Like Kinase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A4D6K823 A0A4D6K823
    Q23993 Q23993
    Q23994 Q23994
    Q8IQ91 Q8IQ91
    Q8T030 Q8T030

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