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    ifc infertile crescent [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 33836, updated on 2-Nov-2024

    Summary

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    Official Symbol
    ifcprovided by FlyBase
    Official Full Name
    infertile crescentprovided by FlyBase
    Primary source
    FLYBASE:FBgn0001941
    Locus tag
    Dmel_CG9078
    See related
    AllianceGenome:FB:FBgn0001941
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG9078; des; des-1; Des-1; DES-1; des1; Des1; Dmel\CG9078; Ifc; l(2)26Ab; l(2)gdh-2; ms(2)04875
    Summary
    Enables sphingolipid delta-4 desaturase activity. Involved in negative regulation of lipophagy. Located in endoplasmic reticulum and late endosome. Is expressed in several structures, including Malpighian tubule primordium; circulatory system primordium; embryonic/larval midgut primordium; germline cell; and gut section. Used to study neurodegenerative disease and obesity. Human ortholog(s) of this gene implicated in hypomyelinating leukodystrophy 18. Orthologous to human DEGS1 (delta 4-desaturase, sphingolipid 1) and DEGS2 (delta 4-desaturase, sphingolipid 2). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    all
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    Genomic context

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    See ifc in Genome Data Viewer
    Location:
    26B2-26B2; 2-18 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (5986348..5988854)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (5986348..5988854)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene chickadee Neighboring gene eukaryotic translation initiation factor 4A Neighboring gene Lysine demethylase 5 Neighboring gene Tetraspanin 26A Neighboring gene beta galactosidase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Degenerative spermatocyte, a novel gene encoding a transmembrane protein required for the initiation of meiosis in Drosophila spermatogenesis. Endo K, et al. Mol Gen Genet, 1996 Nov 27. PMID 9003299
    2. A new retroposed gene in Drosophila heterochromatin detected by microarray-based comparative genomic hybridization. Fan C, et al. J Mol Evol, 2007 Feb. PMID 17177089
    3. Endosymbiotic origins of sex. Bazinet C. Bioessays, 2004 May. PMID 15112236
    4. Lipophagy prevents activity-dependent neurodegeneration due to dihydroceramide accumulation in vivo. Jung WH, et al. EMBO Rep, 2017 Jul. PMID 28507162, Free PMC Article
    5. The Des-1 protein, required for central spindle assembly and cytokinesis, is associated with mitochondria along the meiotic spindle apparatus and with the contractile ring during male meiosis in Drosophila melanogaster. Basu J, et al. Mol Gen Genet, 1998 Oct. PMID 9819060

    See all (57) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Dihydroceramide desaturase regulates the compartmentalization of Rac1 for neuronal oxidative stress.
      Title: Dihydroceramide desaturase regulates the compartmentalization of Rac1 for neuronal oxidative stress.
    2. Systemic and heart autonomous effects of sphingosine Delta4 desaturase deficiency in lipotoxic cardiac pathophysiology.
      Title: Systemic and heart autonomous effects of sphingosine Δ4 desaturase deficiency in lipotoxic cardiac pathophysiology.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables sphingolipid delta-4 desaturase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables sphingolipid delta-4 desaturase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables sphingolipid delta-4 desaturase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in ceramide biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of lipophagy IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in sphingolipid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in late endosome IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    infertile crescent
    Names
    CG9078-PA
    CG9078-PB
    degenerating spermatocyte
    degenerative spermatocyte
    ifc-PA
    ifc-PB
    sphingolipid delta 4 desaturase
    sphingosine Delta-4 desaturase
    NP_001260118.1
    NP_476594.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      5986348..5988854
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_057246.5 → NP_476594.1  infertile crescent, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_476594.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q94515
      Related
      FBpp0078810
      Conserved Domains (2) summary
      cd03508
      Location:26 → 315
      Delta4-sphingolipid-FADS-like; The Delta4-sphingolipid Fatty Acid Desaturase (Delta4-sphingolipid-FADS)-like CD includes the integral-membrane enzymes, dihydroceramide Delta-4 desaturase, involved in the synthesis of sphingosine; and the human membrane fatty acid (lipid) desaturase ...
      pfam08557
      Location:6 → 42
      Lipid_DES; Sphingolipid Delta4-desaturase (DES)

    2. NM_001273189.1 → NP_001260118.1  infertile crescent, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260118.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PC47
      Conserved Domains (1) summary
      cl00615
      Location:1 → 96
      Membrane-FADS-like; The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M9PC47 M9PC47
    Q94515.1 Q94515

    Gene LinkOut

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