Unr Upstream of N-ras [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Unrprovided by FlyBase
Official Full Name: Upstream of N-rasprovided by FlyBase
Primary source: FLYBASE:FBgn0263352
Locus tag: Dmel_CG7015
See related: AllianceGenome:FB:FBgn0263352
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: BcDNA:LD13080; CG7015; CR32028; Dmel\CG7015; dunr; dUnr; dUNR; MRE30; unr; UNR
Old locus tag: Dmel_CR32028
Summary: Enables long noncoding RNA binding activity; mRNA 3'-UTR binding activity; and translation repressor activity, mRNA regulatory element binding. Involved in dosage compensation complex assembly and negative regulation of translational initiation. Part of messenger ribonucleoprotein complex. Is active in cytosol. Is expressed in central brain primordium; embryonic brain; larval ventral nerve cord; organism; and ventral nerve cord primordium. Used to study autism spectrum disorder. Orthologous to human CSDE1 (cold shock domain containing E1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Genomic context

Location:: 66C12-66C13; 3-24 cM

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3L	NT_037436.4 (8432322..8442381, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3L	NT_037436.3 (8425422..8435481, complement)

Chromosome 3L - NT_037436.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Upstream of N-Ras C-terminal cold shock domains mediate poly(A) specificity in a novel RNA recognition mode and bind poly(A) binding protein.
Title: Upstream of N-Ras C-terminal cold shock domains mediate poly(A) specificity in a novel RNA recognition mode and bind poly(A) binding protein.
Pseudo-RNA-Binding Domains Mediate RNA Structure Specificity in Upstream of N-Ras.
Title: Pseudo-RNA-Binding Domains Mediate RNA Structure Specificity in Upstream of N-Ras.
UNR promotes the targeting of the activating male-specific-lethal complex to the X-chromosome by facilitating the interaction of two crucial subunits: the RNA helicase MLE and the long non-coding RNA roX2.
Title: UNR facilitates the interaction of MLE with the lncRNA roX2 during Drosophila dosage compensation.
2.8 A crystal structure, NMR and small-angle X-ray and neutron scattering data of the ternary Sxl-Unr-msl2 ribonucleoprotein complex featuring unprecedented intertwined interactions of two Sxl RNA recognition motifs, a Unr cold-shock domain and RNA
Title: Structural basis for the assembly of the Sxl-Unr translation regulatory complex.
These results suggest that UNR exploits the transcript diversity generated by alternative processing and alternative promoter usage to bind and regulate target genes in a sex-specific manner.
Title: Widespread generation of alternative UTRs contributes to sex-specific RNA binding by UNR.
Efficient msl-2 mRNA silencing via the 3' UTR requires both a poly(A) tail and PABP function, indicating that UNR directly interacts with PABP.
Title: The SXL-UNR corepressor complex uses a PABP-mediated mechanism to inhibit ribosome recruitment to msl-2 mRNA.
These results uncover dual sex-specific functions of UNR in dosage compensation.
Title: Dual sex-specific functions of Drosophila Upstream of N-ras in the control of X chromosome dosage compensation.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables RISC complex binding	IPI Inferred from Physical Interaction more info	PubMed
enables RNA binding	IDA Inferred from Direct Assay more info	PubMed
enables mRNA 3'-UTR binding	IDA Inferred from Direct Assay more info	PubMed
enables mRNA 3'-UTR binding	IPI Inferred from Physical Interaction more info	PubMed
enables mRNA regulatory element binding translation repressor activity	IDA Inferred from Direct Assay more info	PubMed
enables nucleic acid binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein-RNA adaptor activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in dosage compensation complex assembly	IDA Inferred from Direct Assay more info	PubMed
involved_in dosage compensation complex assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of translational initiation	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytosol	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: upstream of N-ras

Names: CG7015-PA; CG7015-PB; CG7015-PC; CG7015-PD; CG7015-PE; Unr-PA; Unr-PB; Unr-PC; Unr-PD; Unr-PE

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_037436.4 Reference assembly

Range

8432322..8442381 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001259740.2 → NP_001246669.1 upstream of N-ras, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001246669.1

Status: REVIEWED

UniProtKB/TrEMBL

Q6NKN1

Conserved Domains (2) summary

smart00357
Location:917 → 981

CSP; Cold shock protein domain

cl09927
Location:347 → 407

S1_like; S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain. ...
NM_001300054.1 → NP_001286983.1 upstream of N-ras, isoform E [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001286983.1

Status: REVIEWED

UniProtKB/TrEMBL

Q6NKN1

Conserved Domains (2) summary

smart00357
Location:942 → 1006

CSP; Cold shock protein domain

cl09927
Location:347 → 395

S1_like; S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain. ...
NM_001144440.2 → NP_001137912.1 upstream of N-ras, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001137912.1

Status: REVIEWED

UniProtKB/TrEMBL

Q6NKN1

Conserved Domains (2) summary

smart00357
Location:942 → 1006

CSP; Cold shock protein domain

cl09927
Location:347 → 395

S1_like; S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain. ...
NM_001274650.1 → NP_001261579.1 upstream of N-ras, isoform D [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001261579.1

Status: REVIEWED

UniProtKB/TrEMBL

Q6NKN1

Conserved Domains (2) summary

smart00357
Location:942 → 1006

CSP; Cold shock protein domain

cl09927
Location:347 → 395

S1_like; S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain. ...
NM_139969.4 → NP_648226.2 upstream of N-ras, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_648226.2

Status: REVIEWED

UniProtKB/Swiss-Prot

B7Z0E2, M9ND61, Q960S8, Q9VSK3

UniProtKB/TrEMBL

Q6NKN1

Related

FBpp0076384

Conserved Domains (2) summary

smart00357
Location:347 → 414

CSP; Cold shock protein domain

cl09927
Location:772 → 816

S1_like; S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain. ...