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    zfh2 Zn finger homeodomain 2 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 43795, updated on 2-Nov-2024

    Summary

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    Official Symbol
    zfh2provided by FlyBase
    Official Full Name
    Zn finger homeodomain 2provided by FlyBase
    Primary source
    FLYBASE:FBgn0004607
    Locus tag
    Dmel_CG1449
    See related
    AllianceGenome:FB:FBgn0004607
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG1449; Dmel\CG1449; zfh-2; Zfh-2; ZFH-2; Zfh2; ZFH2
    Summary
    Enables RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in imaginal disc-derived wing morphogenesis and nervous system development. Located in nucleus. Is expressed in several structures, including anlage in statu nascendi; imaginal disc; larval neurons; longitudinal glial cell; and somatic precursor cell. Human ortholog(s) of this gene implicated in several diseases, including Marsili syndrome; familial atrial fibrillation; hepatocellular carcinoma; lung non-small cell carcinoma (multiple); and spinocerebellar ataxia type 4. Orthologous to several human genes including ZFHX3 (zinc finger homeobox 3) and ZFHX4 (zinc finger homeobox 4). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
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    Genomic context

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    See zfh2 in Genome Data Viewer
    Location:
    102C3-102C4; 4-0 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 4 NC_004353.4 (501810..540874)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 4 NC_004353.3 (522436..561500)

    Chromosome 4 - NC_004353.4Genomic Context describing neighboring genes Neighboring gene antisense RNA:CR45126 Neighboring gene TBP-associated factor 3 Neighboring gene uncharacterized protein Neighboring gene asator Neighboring gene Thymine DNA glycosylase Neighboring gene long non-coding RNA:CR43958 Neighboring gene Purine-rich binding protein-alpha

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A new visible light DNA fluorochrome for confocal microscopy. Lundell MJ, et al. Biotechniques, 1994 Mar. PMID 8185917
    2. A new family of homeobox genes encoding multiple homeodomain and zinc finger motifs. Hashimoto T, et al. Mech Dev, 1992 Nov. PMID 1362648
    3. Use of ordered deletions in genome sequencing. Ahmed A, et al. Gene, 1997 Sep 15. PMID 9332387
    4. ZFH-2 is required for Drosophila ovarian follicle development and is expressed at the band/interband boundaries of polytene chromosomes. Guntur AR, et al. Dev Biol, 2023 Dec. PMID 37666353
    5. ZFHX3 variants cause childhood partial epilepsy and infantile spasms with favourable outcomes. He MF, et al. J Med Genet, 2024 Jun 20. PMID 38508705, Free PMC Article

    See all (149) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. ZFH-2 is required for Drosophila ovarian follicle development and is expressed at the band/interband boundaries of polytene chromosomes.
      Title: ZFH-2 is required for Drosophila ovarian follicle development and is expressed at the band/interband boundaries of polytene chromosomes.
    2. Zfh-2 facilitates Notch-induced apoptosis in the CNS and appendages of Drosophila melanogaster.
      Title: Zfh-2 facilitates Notch-induced apoptosis in the CNS and appendages of Drosophila melanogaster.
    3. Study identifies the cascade of cellular changes and regulatory steps that control differentiation in the adult fly midgut and identifies zfh2 as a major player in these processes.
      Title: zfh2 controls progenitor cell activation and differentiation in the adult Drosophila intestinal absorptive lineage.
    4. these results identify Zfh2 as the first in vivo mediator of hypercapnic immune suppression.
      Title: Identification of Drosophila Zfh2 as a Mediator of Hypercapnic Immune Regulation by a Genome-Wide RNA Interference Screen.
    5. results demonstrate the key role of zfh-2 in the control of cell death and Notch signaling during leg development
      Title: The zinc finger homeodomain-2 gene of Drosophila controls Notch targets and regulates apoptosis in the tarsal segments.
    6. Zfh2 plays an important role controlling the expression of several wing genes and in the specification of cellular properties that define the differences in cell proliferation between proximal and distal domains of the wing disc.
      Title: Multiple roles of the gene zinc finger homeodomain-2 in the development of the Drosophila wing.
    7. In discs lacking zfh2 the limits of the expression domains of the genes tsh, nub, rn, dve and nab coincide, and expression of wg in the wing hinge, is lost.
      Title: The Drosophila gene zfh2 is required to establish proximal-distal domains in the wing disc.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    mobile_element

    • Loc: 511460-511517 mobile_element_type = transposon:1360{}6091
    • Loc: 511697-511750 mobile_element_type = transposon:INE-1{}5956
    • Loc: 511816-511931 mobile_element_type = transposon:INE-1{}5957
    • Loc: 514139-514480 mobile_element_type = transposon:INE-1{}5959
    • Loc: 518675-518810 mobile_element_type = transposon:INE-1{}5962
    • Loc: 518831-518878 mobile_element_type = transposon:INE-1{}5383
    • Loc: 520400-520647 mobile_element_type = transposon:INE-1{}5384
    • Loc: 527166-527206 mobile_element_type = transposon:1360{}6092

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA binding TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in imaginal disc-derived wing morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in nervous system development IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in wing disc development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Zn finger homeodomain 2
    Names
    CG1449-PA
    CG1449-PB
    CG1449-PC
    zfh2-PA
    zfh2-PB
    zfh2-PC
    zinc finger homeodomain 2
    zinc finger homeodomain-2
    zn finger homeodomain 2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004353.4 Reference assembly

      Range
      501810..540874
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001258496.3 → NP_001245425.1  Zn finger homeodomain 2, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001245425.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      H9XVP0
      Conserved Domains (4) summary
      smart00389
      Location:1795 → 1851
      HOX; Homeodomain
      sd00017
      Location:561 → 581
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00020
      Location:1515 → 1542
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00046
      Location:2762 → 2814
      Homeobox; Homeobox domain

    2. NM_079884.5 → NP_524623.2  Zn finger homeodomain 2, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524623.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P28167, Q95SN9, Q9V4D7
      Related
      FBpp0088139
      Conserved Domains (4) summary
      smart00389
      Location:1797 → 1853
      HOX; Homeodomain
      sd00017
      Location:561 → 581
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00020
      Location:1515 → 1542
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00046
      Location:2764 → 2816
      Homeobox; Homeobox domain

    3. NM_001272130.1 → NP_001259059.1  Zn finger homeodomain 2, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259059.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      L0MLK7
      Conserved Domains (4) summary
      smart00389
      Location:1797 → 1853
      HOX; Homeodomain
      sd00017
      Location:561 → 581
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00020
      Location:1515 → 1542
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00046
      Location:2158 → 2210
      Homeobox; Homeobox domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    H9XVP0 H9XVP0
    L0MLK7 L0MLK7
    P28167.2 P28167

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