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    CG8209 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 38888, updated on 18-Sep-2024

    Summary

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    Official Symbol
    CG8209provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0035830
    Locus tag
    Dmel_CG8209
    See related
    AllianceGenome:FB:FBgn0035830
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-WO0172774.138; Dmel\CG8209
    Summary
    Located in cytoplasm and nucleus. Is expressed in several structures, including adult head; embryonic brain; germline cell; gonad; and larval ventral nerve cord. Orthologous to human UBXN1 (UBX domain protein 1). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    See CG8209 in Genome Data Viewer
    Location:
    66A21-66A21; 3-21 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (7976406..7977849)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (7969506..7970949)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Ribonuclease X25 Neighboring gene uncharacterized protein Neighboring gene Heterochromatin protein 4 Neighboring gene POP4 ribonuclease P/MRP subunit Neighboring gene nemo Neighboring gene transfer RNA:Alanine-AGC 2-1 Neighboring gene antisense RNA:CR45867 Neighboring gene bip1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Hip, an HP1-interacting protein, is a haplo- and triplo-suppressor of position effect variegation. Schwendemann A, et al. Proc Natl Acad Sci U S A, 2008 Jan 8. PMID 18162556, Free PMC Article
    2. A conserved unfoldase activity for the p97 AAA-ATPase in proteasomal degradation. Beskow A, et al. J Mol Biol, 2009 Dec 11. PMID 19782090
    3. Genome-wide screen for modifiers of ataxin-3 neurodegeneration in Drosophila. Bilen J, et al. PLoS Genet, 2007 Oct. PMID 17953484, Free PMC Article
    4. Ube3a, the E3 ubiquitin ligase causing Angelman syndrome and linked to autism, regulates protein homeostasis through the proteasomal shuttle Rpn10. Lee SY, et al. Cell Mol Life Sci, 2014 Jul. PMID 24292889, Free PMC Article
    5. A novel strategy to isolate ubiquitin conjugates reveals wide role for ubiquitination during neural development. Franco M, et al. Mol Cell Proteomics, 2011 May. PMID 20861518, Free PMC Article

    See all (37) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables K48-linked polyubiquitin modification-dependent protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of proteasomal ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of protein K48-linked deubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of protein ubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus HDA PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG8209-PA
    UBA/UBX 33.3 kDa protein like

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      7976406..7977849
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_139910.4 → NP_648167.1  uncharacterized protein Dmel_CG8209 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_648167.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8SYN6, Q9VSC5
      Related
      FBpp0076470
      Conserved Domains (2) summary
      cd01772
      Location:250 → 328
      SAKS1_UBX; SAKS1-like UBX domain
      cd14302
      Location:2 → 42
      UBA_UBXN1; UBA domain found in UBX domain-containing protein 1 (UBXN1) and similar proteins
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8SYN6 Q8SYN6
    Q9VSC5 Q9VSC5

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