KLK15 kallikrein related peptidase 15 [Homo sapiens (human)] - Gene

Summary

Official Symbol: KLK15provided by HGNC
Official Full Name: kallikrein related peptidase 15provided by HGNC
Primary source: HGNC:HGNC:20453
See related: Ensembl:ENSG00000174562 MIM:610601; AllianceGenome:HGNC:20453
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: ACO; HSRNASPH
Summary: Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. In prostate cancer, this gene has increased expression, which indicates its possible use as a diagnostic or prognostic marker for prostate cancer. The gene contains multiple polyadenylation sites and alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008]
Expression: Biased expression in colon (RPKM 1.2), testis (RPKM 1.0) and 5 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 19q13.33

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	19	NC_000019.10 (50825289..50833574, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	19	NC_060943.1 (53914924..53923210, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	19	NC_000019.9 (51328545..51336830, complement)

Chromosome 19 - NC_000019.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Identification and characterization of novel KLK15 alternative splice variants and their expression patterns in a wide panel of human cancer and normal cell lines
Title: Identification of six novel alternative transcripts of the human kallikrein-related peptidase 15 (KLK15), using 3'RACE and high-throughput sequencing.
KLK15 may be able to cleave many ECM components, similar to several members of the KLK family. Thus the protease could potentially be linked to tumorigenesis by promoting metastasis via this mechanism.
Title: Biochemical characterization of human tissue kallikrein 15 and examination of its potential role in cancer.
Data provide insights into the localization and possible role of KLK15 in human physiology.
Title: Expression profile of human tissue kallikrein 15 provides preliminary insights into its roles in the prostate and testis.
Pronounced correlations between KLK10/KLK11 (rs = 0.647) and between KLK9/KLK15 (rs = 0.716) mRNA, but not between other combinations, indicate coordinate expression of distinct pairs of peptidases
Title: Clinical relevance of kallikrein-related peptidase 9, 10, 11, and 15 mRNA expression in advanced high-grade serous ovarian cancer.
Variations in KLK15, but not KLK11 expression were significantly associated with prognosis in gastric cancer
Title: Prognostic significance of human tissue kallikrein-related peptidases 11 and 15 in gastric cancer.
Advanced pathologic stage was associated with significantly higher expression of KLK15 and PCA3 mRNAs.
Title: Association of transcript levels of 10 established or candidate-biomarker gene targets with cancerous versus non-cancerous prostate tissue from radical prostatectomy specimens.
KLK15 mRNA expression levels are a novel marker for the differential diagnosis of prostate cancer.
Title: Quantified KLK15 gene expression levels discriminate prostate cancer from benign tumors and constitute a novel independent predictor of disease progression.
These findings suggest a role for KLK15 genetic variation in the etiology of prostate cancer among men of European ancestry.
Title: Association between Prostinogen (KLK15) genetic variants and prostate cancer risk and aggressiveness in Australia and a meta-analysis of GWAS data.
association with ovarian cancer survival
Title: A Kallikrein 15 (KLK15) single nucleotide polymorphism located close to a novel exon shows evidence of association with poor ovarian cancer survival.
Multivariate analysis identified dichotomised KLK15 expression, corrected for patient parameters age, preoperative prostate-specific antigen level, pathological tumour stage, Gleason score and surgical margins, as an prognostic factor for poor outcome.
Title: KLK15 is a prognostic marker for progression-free survival in patients with radical prostatectomy.

Submit: New GeneRIF Correction See all GeneRIFs (17)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
A possible mechanism behind autoimmune disorders discovered by genome-wide linkage and association analysis in celiac disease. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genetic variants at 1q32.1, 10q11.2 and 19q13.41 are associated with prostate-specific antigen for prostate cancer screening in two Korean population-based cohort studies. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:486251

NoName (e-PCR)
- UniSTS:482005

NoName (e-PCR)
- UniSTS:480999

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables serine-type endopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables serine-type endopeptidase activity	NAS Non-traceable Author Statement more info	PubMed
enables serine-type peptidase activity	TAS Traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
involved_in protein maturation	IBA Inferred from Biological aspect of Ancestor more info
involved_in proteolysis	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
is_active_in secretory granule	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: kallikrein-15

Names: ACO protease; kallikrein-like serine protease; prostinogen

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_029894.1 RefSeqGene

Range

2950..11235

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001277081.2 → NP_001264010.1 kallikrein-15 isoform 5 preproprotein

See identical proteins and their annotated locations for NP_001264010.1

Status: REVIEWED

Source sequence(s)

AC010325

Consensus CDS

CCDS62766.1

UniProtKB/TrEMBL

Q96RQ0

Related

ENSP00000512319.1, ENST00000695998.1

Conserved Domains (2) summary

smart00020
Location:24 → 248

Tryp_SPc; Trypsin-like serine protease

cd00190
Location:24 → 251

Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
NM_001277082.2 → NP_001264011.1 kallikrein-15 isoform 6 preproprotein

See identical proteins and their annotated locations for NP_001264011.1

Status: REVIEWED

Source sequence(s)

AC010325

Consensus CDS

CCDS12806.2

UniProtKB/TrEMBL

M0R0D7, Q6UBM2

Related

ENSP00000471164.1, ENST00000596931.5

Conserved Domains (2) summary

smart00020
Location:24 → 150

Tryp_SPc; Trypsin-like serine protease

cd00190
Location:24 → 150

Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
NM_017509.4 → NP_059979.2 kallikrein-15 isoform 4 preproprotein

See identical proteins and their annotated locations for NP_059979.2

Status: REVIEWED

Source sequence(s)

AC010325

Consensus CDS

CCDS12805.1

UniProtKB/Swiss-Prot

A0AUY8, Q15358, Q6ISI0, Q9H2R3, Q9H2R4, Q9H2R5, Q9H2R6, Q9HBG9

UniProtKB/TrEMBL

Q96RQ0

Related

ENSP00000469315.1, ENST00000598239.6

Conserved Domains (1) summary

smart00020
Location:25 → 249

Tryp_SPc; Trypsin-like serine protease

RNA

NR_102274.1 RNA Sequence

Status: REVIEWED

Description

Transcript Variant: This variant (7) uses an alternate splice site in two internal exons, compared to variant 4. This variant is represented as non-coding because use of the expected translational start codon, as used in variant 4, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).

Source sequence(s)

AW205420, AY373373, BC069518, BC144045

Related

ENST00000695963.1

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000019.10 Reference GRCh38.p14 Primary Assembly

Range

50825289..50833574 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_047439064.1 → XP_047295020.1 kallikrein-15 isoform X2

UniProtKB/TrEMBL

A0A6B7HEB8

Conserved Domains (1) summary

cd00190
Location:24 → 166

Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
XM_011527087.3 → XP_011525389.1 kallikrein-15 isoform X1

See identical proteins and their annotated locations for XP_011525389.1

UniProtKB/TrEMBL

A0A6B7HBY5

Related

ENSP00000512291.1, ENST00000695965.1

Conserved Domains (1) summary

cd00190
Location:25 → 167

Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
XM_011527088.3 → XP_011525390.1 kallikrein-15 isoform X3

See identical proteins and their annotated locations for XP_011525390.1

UniProtKB/TrEMBL

Q6UBM2

Conserved Domains (2) summary

smart00020
Location:25 → 151

Tryp_SPc; Trypsin-like serine protease

cd00190
Location:25 → 151

Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
XM_017026943.2 → XP_016882432.1 kallikrein-15 isoform X4

UniProtKB/TrEMBL

M0QX22

Related

ENSP00000468856.1, ENST00000602114.1

Conserved Domains (2) summary

smart00020
Location:25 → 120

Tryp_SPc; Trypsin-like serine protease

cd00190
Location:25 → 120

Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

Alternate T2T-CHM13v2.0

Genomic

NC_060943.1 Alternate T2T-CHM13v2.0

Range

53914924..53923210 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054321400.1 → XP_054177375.1 kallikrein-15 isoform X2

UniProtKB/TrEMBL

A0A6B7HEB8
XM_054321399.1 → XP_054177374.1 kallikrein-15 isoform X1

UniProtKB/TrEMBL

A0A6B7HBY5
XM_054321401.1 → XP_054177376.1 kallikrein-15 isoform X3
XM_054321402.1 → XP_054177377.1 kallikrein-15 isoform X4

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_023006.1: Suppressed sequence

Description

NM_023006.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
NM_138563.1: Suppressed sequence

Description

NM_138563.1: This RefSeq was permanently suppressed because currently there is insufficient support for the exon combination represented in this variant.
NM_138564.1: Suppressed sequence

Description

NM_138564.1: This RefSeq was permanently suppressed because currently there is insufficient support for the exon combination represented in this variant.