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    MED15 mediator complex subunit 15 [ Homo sapiens (human) ]

    Gene ID: 51586, updated on 28-Oct-2024

    Summary

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    Official Symbol
    MED15provided by HGNC
    Official Full Name
    mediator complex subunit 15provided by HGNC
    Primary source
    HGNC:HGNC:14248
    See related
    Ensembl:ENSG00000099917 MIM:607372; AllianceGenome:HGNC:14248
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    TIG1; CAG7A; CTG7A; PCQAP; TIG-1; TNRC7; ARC105
    Summary
    The protein encoded by this gene is a subunit of the multiprotein complexes PC2 and ARC/DRIP and may function as a transcriptional coactivator in RNA polymerase II transcription. This gene contains stretches of trinucleotide repeats and is located in the chromosome 22 region which is deleted in DiGeorge syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2014]
    Expression
    Ubiquitous expression in spleen (RPKM 10.5), bone marrow (RPKM 9.5) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See MED15 in Genome Data Viewer
    Location:
    22q11.21
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 22 NC_000022.11 (20507610..20587619)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 22 NC_060946.1 (20916219..20996263)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 22 NC_000022.10 (20861897..20941906)

    Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene kelch like family member 22 Neighboring gene keratin 18 pseudogene 5 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13496 Neighboring gene uncharacterized LOC101928824 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:20850596-20851248 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:20859501-20860000 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18679 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18680 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_62777 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:20884447-20885434 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_62783 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_62800 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:20903520-20904510 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18681 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_62813 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_62823 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18682 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_62834 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_62844 Neighboring gene uncharacterized LOC124905084 Neighboring gene coiled-coil domain containing 74B pseudogene 1 Neighboring gene ReSE screen-validated silencer GRCh37_chr22:20954774-20954964 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:20964690-20965288 Neighboring gene sphingomyelin phosphodiesterase 4 pseudogene 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. A novel glutamine-rich putative transcriptional adaptor protein (TIG-1), preferentially expressed in placental and bone-marrow tissues. Abraham S, et al. Gene, 2000 Sep 19. PMID 11024300
    2. Clinical and molecular implications of MED15 in head and neck squamous cell carcinoma. Adler D, et al. Am J Pathol, 2015 Apr. PMID 25791637
    3. MED15, encoding a subunit of the mediator complex, is overexpressed at high frequency in castration-resistant prostate cancer. Adler D, et al. Int J Cancer, 2014 Jul 1. PMID 24374838
    4. MED15 prion-like domain forms a coiled-coil responsible for its amyloid conversion and propagation. Batlle C, et al. Commun Biol, 2021 Mar 26. PMID 33772081, Free PMC Article
    5. Simple biochemical features underlie transcriptional activation domain diversity and dynamic, fuzzy binding to Mediator. Sanborn AL, et al. Elife, 2021 Apr 27. PMID 33904398, Free PMC Article

    See all (112) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Cystic MED15::TFE3 translocation renal cell carcinoma: histologic mimicker of multilocular cystic renal neoplasm of low malignant potential with review of the literature.
      Title: Cystic MED15::TFE3 translocation renal cell carcinoma: histologic mimicker of multilocular cystic renal neoplasm of low malignant potential with review of the literature.
    2. Simple biochemical features underlie transcriptional activation domain diversity and dynamic, fuzzy binding to Mediator.
      Title: Simple biochemical features underlie transcriptional activation domain diversity and dynamic, fuzzy binding to Mediator.
    3. MED15 prion-like domain forms a coiled-coil responsible for its amyloid conversion and propagation.
      Title: MED15 prion-like domain forms a coiled-coil responsible for its amyloid conversion and propagation.
    4. MED15, transforming growth factor beta 1 (TGF-beta1), FcgammaRIII (CD16), and HNK-1 (CD57) are prognostic biomarkers of oral squamous cell carcinoma.
      Title: MED15, transforming growth factor beta 1 (TGF-β1), FcγRIII (CD16), and HNK-1 (CD57) are prognostic biomarkers of oral squamous cell carcinoma.
    5. In this article, we described MED15-TFE3 renal cell carcinoma (RCC), a rare gene subtype of Xp11 translocation RCCs, that was confirmed by FISH and RNA sequencing. The tumor demonstrated different morphological features and immunophenotypic characteristics with the cases reported in literatures, expanding our understanding on heterogeneity of MED15-TFE3 RCC.
      Title: A Rare Partner of TFE3 in the Xp11 Translocation Renal Cell Carcinoma: Clinicopathological Analyses and Detection of MED15-TFE3 Fusion.
    6. MED15 does seem to play a tumour promoting role in the progression and metastatic spread of renal cell carcinoma
      Title: The Mediator complex subunit MED15, a promoter of tumour progression and metastatic spread in renal cell carcinoma.
    7. MED15 overexpression arises during androgen deprivation therapy via hyper-activation of PI3K/Akt/mTOR signaling pathway in prostate cancer cells.
      Title: MED15 overexpression in prostate cancer arises during androgen deprivation therapy via PI3K/mTOR signaling.
    8. MED15 as a potential biomarker for head and neck squamous cell carcinoma
      Title: MED15: a potential biomarker for head and neck squamous cell carcinoma?
    9. MED15 is differentially expressed in tumor-free testis and testicular germ cell tumors
      Title: Differential expression of Mediator complex subunit MED15 in testicular germ cell tumors.
    10. MED15 overexpression is a clonal event during head and neck squamous cell carcinoma progression.
      Title: Clinical and molecular implications of MED15 in head and neck squamous cell carcinoma.
    Submit: New GeneRIF Correction See all GeneRIFs (20)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    HIV-1 interactions

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    Replication interactions

    Interaction Pubs
    Knockdown of mediator complex subunit 15 (MED15) by siRNA inhibits the early stages of HIV-1 replication in 293T cells infected with VSV-G pseudotyped HIV-1 PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ42282, FLJ42935, DKFZp686A2214, DKFZp762B1216

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables transcription coregulator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in RNA polymerase II preinitiation complex assembly NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in positive regulation of transcription elongation by RNA polymerase II NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in positive regulation of transcription initiation by RNA polymerase II NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in somatic stem cell population maintenance IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of core mediator complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane HDA PubMed 
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		  
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    mediator of RNA polymerase II transcription subunit 15
    Names
    CTG repeat protein 7a
    PC2 (positive cofactor 2, multiprotein complex) glutamine/Q-rich-associated protein
    PC2 glutamine/Q-rich-associated protein
    PC2-glutamine-rich-associated protein
    TPA inducible gene-1
    TPA inducible protein
    TPA-inducible gene 1 protein
    activator-recruited cofactor 105 kDa component
    activator-recruited cofactor, 105-kD
    positive cofactor 2, glutamine/Q-rich-associated protein
    trinucleotide repeat containing 7
    trinucleotide repeat-containing gene 7 protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001003891.3 → NP_001003891.1  mediator of RNA polymerase II transcription subunit 15 isoform a

      See identical proteins and their annotated locations for NP_001003891.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (a).
      Source sequence(s)
      AK090465, BC003078, BC005027
      Consensus CDS
      CCDS33602.1
      UniProtKB/Swiss-Prot
      D3DX31, D3DX32, O15413, Q6IC31, Q8NF16, Q96CT0, Q96IH7, Q96RN5, Q9P1T3
      UniProtKB/TrEMBL
      B7Z2H7
      Related
      ENSP00000263205.7, ENST00000263205.11
      Conserved Domains (1) summary
      pfam09606
      Location:17 → 784
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal

    2. NM_001293234.2 → NP_001280163.1  mediator of RNA polymerase II transcription subunit 15 isoform c

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks an alternate in-frame exon and uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. The encoded protein (isoform c) is shorter than isoform a.
      Source sequence(s)
      AK315540, BC005027
      UniProtKB/TrEMBL
      B7Z2H7
      Conserved Domains (1) summary
      pfam09606
      Location:17 → 727
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal

    3. NM_001293235.2 → NP_001280164.1  mediator of RNA polymerase II transcription subunit 15 isoform d

      See identical proteins and their annotated locations for NP_001280164.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR, lacks a portion of the 5' and 3' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded protein (isoform d) is shorter, compared to isoform a. Variants 4 and 6 encode the same protein (isoform d).
      Source sequence(s)
      BC003078, BC005027, BC013985, DA182752
      Consensus CDS
      CCDS77653.1
      UniProtKB/TrEMBL
      B7Z2H7, G3V1P5
      Related
      ENSP00000384344.1, ENST00000406969.5
      Conserved Domains (1) summary
      pfam09606
      Location:1 → 718
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal

    4. NM_001293236.2 → NP_001280165.1  mediator of RNA polymerase II transcription subunit 15 isoform e

      See identical proteins and their annotated locations for NP_001280165.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) lacks two alternate in-frame exons in the coding region, compared to variant 1. The encoded protein (isoform e) is shorter, compared to isoform a.
      Source sequence(s)
      BC003078, BC005027, CR456537, DA182752
      Consensus CDS
      CCDS74824.1
      UniProtKB/TrEMBL
      B7Z2H7
      Related
      ENSP00000372434.2, ENST00000382974.6
      Conserved Domains (1) summary
      pfam09606
      Location:17 → 78
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal

    5. NM_001293237.2 → NP_001280166.1  mediator of RNA polymerase II transcription subunit 15 isoform d

      See identical proteins and their annotated locations for NP_001280166.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) differs in the 5' UTR, lacks a portion of the 5' and 3' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded protein (isoform d) is shorter, compared to isoform a. Variants 4 and 6 encode the same protein (isoform d).
      Source sequence(s)
      AC007731, AK294734, BC005027, CB156495
      Consensus CDS
      CCDS77653.1
      UniProtKB/TrEMBL
      B7Z2H7, G3V1P5
      Conserved Domains (1) summary
      pfam09606
      Location:1 → 718
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal

    6. NM_015889.5 → NP_056973.2  mediator of RNA polymerase II transcription subunit 15 isoform b

      See identical proteins and their annotated locations for NP_056973.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 3' coding region, compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a.
      Source sequence(s)
      BC005027, BC013985, DA182752
      Consensus CDS
      CCDS13781.1
      UniProtKB/TrEMBL
      B7Z2H7
      Related
      ENSP00000292733.7, ENST00000292733.11
      Conserved Domains (1) summary
      pfam09606
      Location:17 → 744
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000022.11 Reference GRCh38.p14 Primary Assembly

      Range
      20507610..20587619
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047441395.1 → XP_047297351.1  mediator of RNA polymerase II transcription subunit 15 isoform X1

    2. XM_047441398.1 → XP_047297354.1  mediator of RNA polymerase II transcription subunit 15 isoform X3

      UniProtKB/TrEMBL
      G3V1P5

    3. XM_047441401.1 → XP_047297357.1  mediator of RNA polymerase II transcription subunit 15 isoform X6

    4. XM_047441399.1 → XP_047297355.1  mediator of RNA polymerase II transcription subunit 15 isoform X4

    5. XM_011530219.3 → XP_011528521.1  mediator of RNA polymerase II transcription subunit 15 isoform X10

      See identical proteins and their annotated locations for XP_011528521.1

      Conserved Domains (1) summary
      pfam09606
      Location:17 → 149
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal

    6. XM_011530218.4 → XP_011528520.1  mediator of RNA polymerase II transcription subunit 15 isoform X9

      Conserved Domains (1) summary
      pfam09606
      Location:17 → 361
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal

    7. XM_017028821.3 → XP_016884310.1  mediator of RNA polymerase II transcription subunit 15 isoform X8

    8. XM_047441396.1 → XP_047297352.1  mediator of RNA polymerase II transcription subunit 15 isoform X1

    9. XM_047441402.1 → XP_047297358.1  mediator of RNA polymerase II transcription subunit 15 isoform X7

    10. XM_047441397.1 → XP_047297353.1  mediator of RNA polymerase II transcription subunit 15 isoform X2

    11. XM_047441400.1 → XP_047297356.1  mediator of RNA polymerase II transcription subunit 15 isoform X5

    12. XM_047441403.1 → XP_047297359.1  mediator of RNA polymerase II transcription subunit 15 isoform X11

      UniProtKB/TrEMBL
      B3KWF1

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060946.1 Alternate T2T-CHM13v2.0

      Range
      20916219..20996263
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054325677.1 → XP_054181652.1  mediator of RNA polymerase II transcription subunit 15 isoform X1

    2. XM_054325680.1 → XP_054181655.1  mediator of RNA polymerase II transcription subunit 15 isoform X3

      UniProtKB/TrEMBL
      G3V1P5

    3. XM_054325683.1 → XP_054181658.1  mediator of RNA polymerase II transcription subunit 15 isoform X6

    4. XM_054325681.1 → XP_054181656.1  mediator of RNA polymerase II transcription subunit 15 isoform X4

    5. XM_054325687.1 → XP_054181662.1  mediator of RNA polymerase II transcription subunit 15 isoform X10

    6. XM_054325686.1 → XP_054181661.1  mediator of RNA polymerase II transcription subunit 15 isoform X9

    7. XM_054325685.1 → XP_054181660.1  mediator of RNA polymerase II transcription subunit 15 isoform X8

    8. XM_054325678.1 → XP_054181653.1  mediator of RNA polymerase II transcription subunit 15 isoform X1

    9. XM_054325684.1 → XP_054181659.1  mediator of RNA polymerase II transcription subunit 15 isoform X7

    10. XM_054325679.1 → XP_054181654.1  mediator of RNA polymerase II transcription subunit 15 isoform X2

    11. XM_054325682.1 → XP_054181657.1  mediator of RNA polymerase II transcription subunit 15 isoform X5

    12. XM_054325688.1 → XP_054181663.1  mediator of RNA polymerase II transcription subunit 15 isoform X11

      UniProtKB/TrEMBL
      B3KWF1
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q96RN5.2 GenPept UniProtKB/Swiss-Prot:Q96RN5

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