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    Mfap5 microfibrillar associated protein 5 [ Mus musculus (house mouse) ]

    Gene ID: 50530, updated on 28-Oct-2024

    Summary

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    Official Symbol
    Mfap5provided by MGI
    Official Full Name
    microfibrillar associated protein 5provided by MGI
    Primary source
    MGI:MGI:1354387
    See related
    Ensembl:ENSMUSG00000030116 AllianceGenome:MGI:1354387
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    MAGP-2; MFAP-5
    Summary
    Predicted to enable extracellular matrix constituent conferring elasticity. Involved in definitive hemopoiesis. Acts upstream of or within supramolecular fiber organization. Located in extracellular matrix. Is expressed in aorta; dentate gyrus subgranular zone; esophagus; genitourinary system; and skeletal musculature. Human ortholog(s) of this gene implicated in thoracic aortic aneurysm. Orthologous to human MFAP5 (microfibril associated protein 5). [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Biased expression in subcutaneous fat pad adult (RPKM 54.4), mammary gland adult (RPKM 48.6) and 10 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Mfap5 in Genome Data Viewer
    Location:
    6 F1; 6 57.61 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (122490543..122506249)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (122513584..122529290)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene mitochondrial ribosomal protein S36 pseudogene Neighboring gene STARR-seq mESC enhancer starr_17224 Neighboring gene ribosomal modification protein rimK-like family member B Neighboring gene ribosomal protein S27A, pseudogene 3 Neighboring gene STARR-seq mESC enhancer starr_17225 Neighboring gene STARR-positive B cell enhancer ABC_E10409 Neighboring gene STARR-positive B cell enhancer ABC_E1070 Neighboring gene STARR-positive B cell enhancer ABC_E9100 Neighboring gene STARR-positive B cell enhancer mm9_chr6:122484210-122484511 Neighboring gene STARR-positive B cell enhancer ABC_E11336 Neighboring gene STARR-positive B cell enhancer ABC_E3677 Neighboring gene STARR-positive B cell enhancer ABC_E3678 Neighboring gene activation-induced cytidine deaminase Neighboring gene voltage-dependent anion channel 1 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Microfibril-associated protein 5 and the regulation of skin scar formation. Han C, et al. Sci Rep, 2023 May 30. PMID 37253753, Free PMC Article
    2. MAGP2 promotes osteogenic differentiation during fracture healing through its crosstalk with the β-catenin pathway. Chen Z, et al. J Cell Physiol, 2024 Apr. PMID 38348695
    3. Microfibrillar-associated protein 5 regulates osteogenic differentiation by modulating the Wnt/β-catenin and AMPK signaling pathways. Li H, et al. Mol Med, 2021 Dec 5. PMID 34865619, Free PMC Article
    4. Binding of MAGP2 to microfibrils is regulated by proprotein convertase cleavage. Miyamoto A, et al. Matrix Biol, 2014 Nov. PMID 25153248
    5. Transcriptome analysis of endothelial cell gene expression induced by growth on matrigel matrices: identification and characterization of MAGP-2 and lumican as novel regulators of angiogenesis. Albig AR, et al. Angiogenesis, 2007. PMID 17632767

    See all (42) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. MAGP2 promotes osteogenic differentiation during fracture healing through its crosstalk with the beta-catenin pathway.
      Title: MAGP2 promotes osteogenic differentiation during fracture healing through its crosstalk with the β-catenin pathway.
    2. Tricellulin, alpha-Catenin and Microfibrillar-Associated Protein 5 Exhibit Concomitantly Altered Immunosignals along with Vascular, Extracellular and Cytoskeletal Elements after Experimental Focal Cerebral Ischemia.
      Title: Tricellulin, α-Catenin and Microfibrillar-Associated Protein 5 Exhibit Concomitantly Altered Immunosignals along with Vascular, Extracellular and Cytoskeletal Elements after Experimental Focal Cerebral Ischemia.
    3. Microfibril-Associated Glycoprotein-2 Promoted Fracture Healing via Integrin alphavbeta3/PTK2/AKT Signaling.
      Title: Microfibril-Associated Glycoprotein-2 Promoted Fracture Healing via Integrin αvβ3/PTK2/AKT Signaling.
    4. Microfibril-associated protein 5 and the regulation of skin scar formation.
      Title: Microfibril-associated protein 5 and the regulation of skin scar formation.
    5. MAGP2 induces tumor progression by enhancing uPAR-mediated cell proliferation.
      Title: MAGP2 induces tumor progression by enhancing uPAR-mediated cell proliferation.
    6. Microfibrillar-associated protein 5 regulates osteogenic differentiation by modulating the Wnt/beta-catenin and AMPK signaling pathways.
      Title: Microfibrillar-associated protein 5 regulates osteogenic differentiation by modulating the Wnt/β-catenin and AMPK signaling pathways.
    7. Binding of MAGP2 to microfibrils is regulated by proprotein convertase cleavage.
      Title: Binding of MAGP2 to microfibrils is regulated by proprotein convertase cleavage.
    8. Loss of MAGP2 expression in vivo has pleiotropic effects.
      Title: Microfibril-associated glycoprotein 2 (MAGP2) loss of function has pleiotropic effects in vivo.
    9. MAGP-2 is identified as a novel regulator of angiogenesis.
      Title: Transcriptome analysis of endothelial cell gene expression induced by growth on matrigel matrices: identification and characterization of MAGP-2 and lumican as novel regulators of angiogenesis.
    10. Tight skin fibrillin 1 altered extracellular matrix organization and caused fibrosis by affecting deposition of MAGP-2 or other fibrillin-1-associated proteins.
      Title: Mutant fibrillin 1 from tight skin mice increases extracellular matrix incorporation of microfibril-associated glycoprotein 2 and type I collagen.
    Submit: New GeneRIF Correction See all GeneRIFs (12)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Targeted (1)  1 citation

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables extracellular matrix constituent conferring elasticity RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    enables extracellular matrix constituent conferring elasticity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in definitive hemopoiesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in embryonic eye morphogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within supramolecular fiber organization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in collagen-containing extracellular matrix HDA PubMed 
    located_in extracellular matrix IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in microfibril IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in microfibril ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in microfibril TAS
    Traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    microfibrillar-associated protein 5
    Names
    microfibril-associated glycoprotein 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001347434.1 → NP_001334363.1  microfibrillar-associated protein 5 isoform 2 precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region compared to variant 1. It encodes isoform 2 which is shorter compared to isoform 1.
      Source sequence(s)
      AC155946
      Consensus CDS
      CCDS85155.1
      UniProtKB/TrEMBL
      D3Z4D7, F8WJ99
      Related
      ENSMUSP00000032210.9, ENSMUST00000032210.14

    2. NM_015776.3 → NP_056591.1  microfibrillar-associated protein 5 isoform 1 precursor

      See identical proteins and their annotated locations for NP_056591.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AC155946
      Consensus CDS
      CCDS20496.1
      UniProtKB/Swiss-Prot
      Q9QZJ6
      UniProtKB/TrEMBL
      D3Z4D7
      Related
      ENSMUSP00000122863.2, ENSMUST00000148517.8
      Conserved Domains (1) summary
      pfam05507
      Location:35 → 129
      MAGP; Microfibril-associated glycoprotein (MAGP)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      122490543..122506249
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9QZJ6.1 GenPept UniProtKB/Swiss-Prot:Q9QZJ6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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