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    rgs1 G-protein-signaling regulator Rgs1 [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2541764, updated on 18-Sep-2024

    Summary

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    Official Symbol
    rgs1
    Official Full Name
    G-protein-signaling regulator Rgs1
    Primary source
    PomBase:SPAC22F3.12c
    Locus tag
    SPOM_SPAC22F3.12C
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
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    Genomic context

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    See rgs1 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    1
    Sequence:
    Chromosome: I; NC_003424.3 (679803..681890)

    Chromosome I - NC_003424.3Genomic Context describing neighboring genes Neighboring gene Rheb GAP, hamartin Tsc1 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003424.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A physiologically required G protein-coupled receptor (GPCR)-regulator of G protein signaling (RGS) interaction that compartmentalizes RGS activity. Croft W, et al. J Biol Chem, 2013 Sep 20. PMID 23900842, Free PMC Article
    2. Dual positive and negative regulation of GPCR signaling by GTP hydrolysis. Smith B, et al. Cell Signal, 2009 Jul. PMID 19285552
    3. The RGS domain-containing fission yeast protein, Rgs1p, regulates pheromone signalling and is required for mating. Pereira PS, et al. Genes Cells, 2001 Sep. PMID 11554925
    4. An RGS protein regulates the pheromone response in the fission yeast Schizosaccharomyces pombe. Watson P, et al. Mol Microbiol, 1999 Aug. PMID 10417652
    5. Spatial focalization of pheromone/MAPK signaling triggers commitment to cell-cell fusion. Dudin O, et al. Genes Dev, 2016 Oct 1. PMID 27798845, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. A physiologically required G protein-coupled receptor (GPCR)-regulator of G protein signaling (RGS) interaction that compartmentalizes RGS activity.
      Title: A physiologically required G protein-coupled receptor (GPCR)-regulator of G protein signaling (RGS) interaction that compartmentalizes RGS activity.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables GTPase activator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of pheromone-dependent signal transduction involved in conjugation with cellular fusion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in pheromone response MAPK cascade IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytosol HDA PubMed 
    is_active_in nucleus HDA PubMed 
    is_active_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    G-protein-signaling regulator Rgs1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003424.3 Reference assembly

      Range
      679803..681890
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001018428.3 → NP_593029.1  G-protein-signaling regulator Rgs1 [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_593029.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      Q09777
      Conserved Domains (3) summary
      cd08708
      Location:344 → 480
      RGS_FLBA; Regulator of G protein signaling (RGS) domain found in the FLBA (Fluffy Low BrlA) protein
      smart00049
      Location:59 → 156
      DEP; Domain found in Dishevelled, Egl-10, and Pleckstrin
      cd04450
      Location:224 → 309
      DEP_RGS7-like; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in RGS (regulator of G-protein signaling) proteins of the subfamily R7. This subgroup contains RGS7, RGS6, RGS9 and RGS11. They share a common domain architecture, containing, beside the RGS domain, ...
    Nucleotide Protein
    Heading Accession and Version

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