CNE1 calnexin [Saccharomyces cerevisiae S288C] - Gene

Summary

Gene symbol: CNE1
Gene description: calnexin
Primary source: FungiDB:YAL058W
Locus tag: YAL058W
See related: SGD:S000000054; AllianceGenome:SGD:S000000054; VEuPathDB:YAL058W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: FUN48
Summary: Enables unfolded protein binding activity. Involved in protein folding and ubiquitin-dependent ERAD pathway. Is integral component of endoplasmic reticulum membrane. Human ortholog(s) of this gene implicated in essential thrombocythemia; myelofibrosis; pancreatic ductal adenocarcinoma; sideroblastic anemia; and thrombocytosis. Orthologous to several human genes including CANX (calnexin). [provided by Alliance of Genome Resources, Apr 2022]
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Chromosome I - NC_001133.9 Genomic Context describing neighboring genes

Go to nucleotide: Graphics FASTA GenBank

Cne1p interacts with misfolded lysozyme proteins
Title: Unstable mutant lysozymes are degraded through the interaction with calnexin homolog Cne1p in Saccharomyces cerevisiae.
Results suggest that under heat stress conditions, the induction of BiP in the ER might recover part of the function of calnexin in calnexin-disrupted yeast, and result in the same growth rate as in wild-type yeast.
Title: The effect of calnexin deletion on the expression level of binding protein (BiP) under heat stress conditions in Saccharomyces cerevisiae.
Calnexin deletion results in higher levels of protein disulfide-isomerase mRNA under heat stress conditions, but this doesn't affect yeast growth rate.
Title: The effect of calnexin deletion on the expression level of PDI in Saccharomyces cerevisiae under heat stress conditions.
Cne1p functions as a molecular chaperone in Saccharomyces cerevisiae
Title: Expression and characterization of Saccharomyces cerevisiae Cne1p, a calnexin homologue.

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables calcium ion binding	IBA Inferred from Biological aspect of Ancestor more info
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables carbohydrate binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables unfolded protein binding	IDA Inferred from Direct Assay more info	PubMed
enables unfolded protein binding	IEA Inferred from Electronic Annotation more info
enables unfolded protein binding	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in ERAD pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in ERAD pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein folding	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein folding	IEA Inferred from Electronic Annotation more info
involved_in protein folding	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in endoplasmic reticulum	HDA more info	PubMed
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
is_active_in endoplasmic reticulum membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum membrane	IDA Inferred from Direct Assay more info	PubMed
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info

NP_009343.1

Calnexin; integral membrane ER chaperone involved in folding and quality control of glycoproteins; chaperone activity is inhibited by Mpd1p, with which Cne1p interacts; 24% identical to mammalian calnexin; Ca+ binding not yet shown in yeast