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    gcs1 glutamate-cysteine ligase Gcs1 [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2541881, updated on 18-Sep-2024

    Summary

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    Official Symbol
    gcs1
    Official Full Name
    glutamate-cysteine ligase Gcs1
    Primary source
    PomBase:SPAC22F3.10c
    Locus tag
    SPOM_SPAC22F3.10C
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
    Also known as
    apd1; gsh1
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    Genomic context

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    See gcs1 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    2
    Sequence:
    Chromosome: I; NC_003424.3 (683834..686347)

    Chromosome I - NC_003424.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene U4/U6 x U5 tri-snRNP complex subunit Snu23 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene MBF transcription factor complex subunit Res2 Neighboring gene ncRNA Neighboring gene ATP-dependent RNA helicase Rok1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003424.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Gcs1, a gene encoding gamma-glutamylcysteine synthetase in the fission yeast Schizosaccharomyces pombe. Coblenz A, et al. Yeast, 1995 Sep 30. PMID 8619315
    2. Molecular cloning and nucleotide sequencing of the gamma-glutamylcysteine synthetase gene of the fission yeast Schizosaccharomyces pombe. Mutoh N, et al. J Biochem, 1995 Feb. PMID 7608113
    3. Accelerated chronological aging of a mutant fission yeast deficient in both glutathione and superoxide dismutase having cu and zn as cofactors and its enhancement by sir2 deficiency. Mutoh N, et al. Biosci Biotechnol Biochem, 2007 Nov. PMID 17986764
    4. Isolation of mutants of Schizosaccharomyces pombe unable to synthesize cadystin, small cadmium-binding peptides. Mutoh N, et al. Biochem Biophys Res Commun, 1988 Feb 29. PMID 2894829
    5. apd1+, a gene required for red pigment formation in ade6 mutants of Schizosaccharomyces pombe, encodes an enzyme required for glutathione biosynthesis: a role for glutathione and a glutathione-conjugate pump. Chaudhuri B, et al. Genetics, 1997 Jan. PMID 9017391, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables glutamate-cysteine ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables glutamate-cysteine ligase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    contributes_to metal chelating activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cellular detoxification of cadmium ion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cellular response to cadmium ion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cysteine metabolic process IC
    Inferred by Curator
    more info
    		  
    involved_in glutathione biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in glutathione biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in phytochelatin biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytosol HDA PubMed 
    part_of glutamate-cysteine ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus HDA PubMed 

    General protein information

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    Preferred Names
    glutamate-cysteine ligase Gcs1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003424.3 Reference assembly

      Range
      683834..686347
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001018430.3 → NP_593031.1  glutamate-cysteine ligase Gcs1 [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_593031.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      Q09768
      Conserved Domains (2) summary
      smart00316
      Location:24 → 70
      S1; Ribosomal protein S1-like RNA-binding domain
      pfam03074
      Location:299 → 655
      GCS; Glutamate-cysteine ligase
    Nucleotide Protein
    Heading Accession and Version

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