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    TCD1 tRNA threonylcarbamoyladenosine dehydratase [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856392, updated on 2-Nov-2024

    Summary

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    Official Symbol
    TCD1
    Official Full Name
    tRNA threonylcarbamoyladenosine dehydratase
    Primary source
    SGD:S000001045
    Locus tag
    YHR003C
    See related
    AllianceGenome:SGD:S000001045; FungiDB:YHR003C; VEuPathDB:YHR003C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables tRNA threonylcarbamoyladenosine dehydratase. Involved in cyclic threonylcarbamoyladenosine biosynthetic process. Located in mitochondrial outer membrane. [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See TCD1 in Genome Data Viewer
    Location:
    chromosome: VIII
    Exon count:
    1
    Sequence:
    Chromosome: VIII; NC_001140.6 (110028..111317, complement)

    Chromosome VIII - NC_001140.6Genomic Context describing neighboring genes Neighboring gene ubiquinol--cytochrome-c reductase subunit 10 Neighboring gene coenzyme A transporter Neighboring gene Nem1-Spo7 phosphatase catalytic subunit NEM1 Neighboring gene guanine nucleotide-binding protein subunit alpha

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001140.6

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A cyclic form of N6-threonylcarbamoyladenosine as a widely distributed tRNA hypermodification. Miyauchi K, et al. Nat Chem Biol, 2013 Feb. PMID 23242255
    2. Misactivation of multiple starvation responses in yeast by loss of tRNA modifications. Bruch A, et al. Nucleic Acids Res, 2020 Jul 27. PMID 32484543, Free PMC Article
    3. tRNA anticodon loop modifications ensure protein homeostasis and cell morphogenesis in yeast. Klassen R, et al. Nucleic Acids Res, 2016 Dec 15. PMID 27496282, Free PMC Article
    4. Decyl Gallate as a Possible Inhibitor of N-Glycosylation Process in Paracoccidioides lutzii. de Paula E Silva ACA, et al. Antimicrob Agents Chemother, 2019 Nov. PMID 31451502, Free PMC Article
    5. Collaboration of tRNA modifications and elongation factor eEF1A in decoding and nonsense suppression. Klassen R, et al. Sci Rep, 2018 Aug 24. PMID 30143741, Free PMC Article

    See all (30) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables tRNA threonylcarbamoyladenosine dehydratase IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables tRNA threonylcarbamoyladenosine dehydratase IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables ubiquitin-like modifier activating enzyme activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cyclic threonylcarbamoyladenosine biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cyclic threonylcarbamoyladenosine biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in macromolecule modification IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrial outer membrane HDA PubMed 
    located_in mitochondrial outer membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    tRNA threonylcarbamoyladenosine dehydratase
    NP_011866.1
    • tRNA threonylcarbamoyladenosine dehydratase; required for the ct6A tRNA base modification, where an adenosine at position 37 is modified to form a cyclized active ester with an oxazolone ring; localized to the mitochondrial outer membrane; TCD1 has a paralog, TCD2, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001140.6 Reference assembly

      Range
      110028..111317 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179133.1 → NP_011866.1  TPA: tRNA threonylcarbamoyladenosine dehydratase [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011866.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D3DKU6, P38756
      UniProtKB/TrEMBL
      A6ZSQ5, B3LSC1, C8ZA69, G2WF69
      Conserved Domains (1) summary
      COG1179
      Location:50 → 309
      TcdA; tRNA A37 threonylcarbamoyladenosine dehydratase [Translation, ribosomal structure and biogenesis]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P38756.1

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