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    tsc1 Rheb GAP, hamartin Tsc1 [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2541869, updated on 18-Sep-2024

    Summary

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    Official Symbol
    tsc1
    Official Full Name
    Rheb GAP, hamartin Tsc1
    Primary source
    PomBase:SPAC22F3.13
    Locus tag
    SPOM_SPAC22F3.13
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
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    Genomic context

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    See tsc1 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    1
    Sequence:
    Chromosome: I; NC_003424.3 (673984..678259, complement)

    Chromosome I - NC_003424.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene THO complex subunit Tho2 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene G-protein-signaling regulator Rgs1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003424.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Crystal structure of the yeast TSC1 core domain and implications for tuberous sclerosis pathological mutations. Sun W, et al. Nat Commun, 2013. PMID 23857276
    2. Using genetic buffering relationships identified in fission yeast to reveal susceptibilities in cells lacking hamartin or tuberin function. Rayhan A, et al. Biol Open, 2018 Jan 17. PMID 29343513, Free PMC Article
    3. The Birt-Hogg-Dube and tuberous sclerosis complex homologs have opposing roles in amino acid homeostasis in Schizosaccharomyces pombe. van Slegtenhorst M, et al. J Biol Chem, 2007 Aug 24. PMID 17556368
    4. Opposite effects of tor1 and tor2 on nitrogen starvation responses in fission yeast. Weisman R, et al. Genetics, 2007 Mar. PMID 17179073, Free PMC Article
    5. Pas1, a G1 cyclin, regulates amino acid uptake and rescues a delay in G1 arrest in Tsc1 and Tsc2 mutants in Schizosaccharomyces pombe. van Slegtenhorst M, et al. Hum Mol Genet, 2005 Oct 1. PMID 16115814

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables GTPase activator activity NAS
    Non-traceable Author Statement
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in negative regulation of G1/S transition of mitotic cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of TOR signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of TORC1 signaling IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of L-arginine import across plasma membrane IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of L-leucine import across plasma membrane IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of L-methionine import across plasma membrane IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of TSC1-TSC2 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of TSC1-TSC2 complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    is_active_in cytoplasm HDA PubMed 

    General protein information

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    Preferred Names
    Rheb GAP, hamartin Tsc1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003424.3 Reference assembly

      Range
      673984..678259 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001018427.3 → NP_593028.1  Rheb GAP, hamartin Tsc1 [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_593028.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      Q09778
      Conserved Domains (1) summary
      pfam10212
      Location:608 → 830
      TTKRSYEDQ; Predicted coiled-coil domain-containing protein
    Nucleotide Protein
    Heading Accession and Version

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