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    ATG42 carboxypeptidase C [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852436, updated on 2-Nov-2024

    Summary

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    Official Symbol
    ATG42
    Official Full Name
    carboxypeptidase C
    Primary source
    SGD:S000000343
    Locus tag
    YBR139W
    See related
    AllianceGenome:SGD:S000000343; FungiDB:YBR139W; VEuPathDB:YBR139W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables serine-type carboxypeptidase activity. Involved in several processes, including cellular response to nitrogen starvation; phytochelatin biosynthetic process; and zymogen activation. Located in fungal-type vacuole lumen. Is active in vacuolar lumen. Human ortholog(s) of this gene implicated in galactosialidosis and lysosomal storage disease. Orthologous to human CTSA (cathepsin A). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See ATG42 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    1
    Sequence:
    Chromosome: II; NC_001134.8 (515664..517190)

    Chromosome II - NC_001134.8Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene GTPase-activating protein IRA1 Neighboring gene 25S rRNA (adenine2142-N1)-methyltransferase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001134.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. An analysis of the sequence of part of the right arm of chromosome II of S. cerevisiae reveals new genes encoding an amino-acid permease and a carboxypeptidase. Nasr F, et al. Curr Genet, 1994 Jul. PMID 7954890
    2. Phytochelatins are synthesized by two vacuolar serine carboxypeptidases in Saccharomyces cerevisiae. Wünschmann J, et al. FEBS Lett, 2007 Apr 17. PMID 17408619
    3. A newly characterized vacuolar serine carboxypeptidase, Atg42/Ybr139w, is required for normal vacuole function and the terminal steps of autophagy in the yeast Saccharomyces cerevisiae. Parzych KR, et al. Mol Biol Cell, 2018 May 1. PMID 29514932, Free PMC Article
    4. Synergistic computational and experimental proteomics approaches for more accurate detection of active serine hydrolases in yeast. Baxter SM, et al. Mol Cell Proteomics, 2004 Mar. PMID 14645503
    5. Identification of direct and indirect targets of the Gln3 and Gat1 activators by transcriptional profiling in response to nitrogen availability in the short and long term. Scherens B, et al. FEMS Yeast Res, 2006 Aug. PMID 16879428

    See all (38) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. This study shows that the vacuolar serine carboxypeptidases CPY and CPC are responsible for phytochelatins synthesis in yeast.
      Title: Phytochelatins are synthesized by two vacuolar serine carboxypeptidases in Saccharomyces cerevisiae.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables carboxypeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables serine hydrolase activity HDA PubMed 
    enables serine-type carboxypeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables serine-type carboxypeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables serine-type carboxypeptidase activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in autophagy IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cellular response to nitrogen starvation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in macroautophagy IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in phytochelatin biosynthetic process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in zymogen activation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in fungal-type vacuole HDA PubMed 
    is_active_in fungal-type vacuole IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in fungal-type vacuole lumen IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in vacuolar lumen IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in vacuolar lumen IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    located_in vacuole IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    carboxypeptidase C
    NP_009697.3
    • Vacuolar serine-type carboxypeptidase; involved, along with functional homolog Prc1p, in vacuolar zymogen activation, breakdown of the autophagic body, and autophagosome-dependent protein synthesis; role in phytochelatin synthesis; localizes to the vacuole lumen; expression induced by nitrogen limitation in a GLN3, GAT1-independent manner; N-glycosylated

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001134.8 Reference assembly

      Range
      515664..517190
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178487.3 → NP_009697.3  TPA: carboxypeptidase C [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_009697.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VQD5, P38109
      UniProtKB/TrEMBL
      A6ZL82, B3LN18, C7GY21, D3UEN3, G2W9E2, N1P6R0
      Conserved Domains (1) summary
      COG2939
      Location:12 → 502
      Kex1; Carboxypeptidase C (cathepsin A) [Amino acid transport and metabolism]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P38109.1

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