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    TGL4 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853964, updated on 22-Aug-2024

    Summary

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    Official Symbol
    TGL4
    Primary source
    FungiDB:YKR089C
    Locus tag
    YKR089C
    See related
    SGD:S000001797; AllianceGenome:SGD:S000001797; VEuPathDB:YKR089C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    STC1
    Summary
    Enables lipase activity and lysophosphatidic acid acyltransferase activity. Involved in cell budding; phospholipid metabolic process; and triglyceride metabolic process. Located in lipid droplet. [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See TGL4 in Genome Data Viewer
    Location:
    chromosome: XI
    Exon count:
    1
    Sequence:
    Chromosome: XI; NC_001143.9 (605633..608365, complement)

    Chromosome XI - NC_001143.9Genomic Context describing neighboring genes Neighboring gene metalloendopeptidase Neighboring gene Tvp38p Neighboring gene Pxl1p Neighboring gene DNA-binding protein SRL3

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001143.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Multiple functions as lipase, steryl ester hydrolase, phospholipase, and acyltransferase of Tgl4p from the yeast Saccharomyces cerevisiae. Rajakumari S, et al. J Biol Chem, 2010 May 21. PMID 20332534, Free PMC Article
    2. Rapid triacylglycerol turnover in Chlamydomonas reinhardtii requires a lipase with broad substrate specificity. Li X, et al. Eukaryot Cell, 2012 Dec. PMID 23042128, Free PMC Article
    3. Lipid droplet-associated proteins are involved in the biosynthesis and hydrolysis of triacylglycerol in Mycobacterium bovis bacillus Calmette-Guerin. Low KL, et al. J Biol Chem, 2010 Jul 9. PMID 20452973, Free PMC Article
    4. Tgl4p and Tgl5p, two triacylglycerol lipases of the yeast Saccharomyces cerevisiae are localized to lipid particles. Athenstaedt K, et al. J Biol Chem, 2005 Nov 11. PMID 16135509
    5. Phosphatidate phosphatase-1 is functionally conserved in lipid synthesis and storage from human to yeast. Fang Z, et al. Acta Biol Hung, 2014 Dec. PMID 25475986

    See all (50) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Multiple functions as lipase, steryl ester hydrolase, phospholipase, and acyltransferase of Tgl4p from the yeast Saccharomyces cerevisiae.
      Title: Multiple functions as lipase, steryl ester hydrolase, phospholipase, and acyltransferase of Tgl4p from the yeast Saccharomyces cerevisiae.
    2. A genetically and functionally related network, consisting of components of the Rim101 pathway and the prefoldin, retromer and SWR1 complexes, and predict its functional relation to PLA(2) activity in a model eukaryotic cell.
      Title: Genetic interactions between a phospholipase A2 and the Rim101 pathway components in S. cerevisiae reveal a role for this pathway in response to changes in membrane composition and shape.
    3. The major yeast TG lipase Tgl4, the functional ortholog of murine adipose TG lipase ATGL, is phosphorylated and activated by cyclin-dependent kinase 1 (Cdk1/Cdc28).
      Title: Cdk1/Cdc28-dependent activation of the major triacylglycerol lipase Tgl4 in yeast links lipolysis to cell-cycle progression.
    4. The identification of Tgl4p and Tgl5p as additional TAG lipases of the yeast is reported.
      Title: Tgl4p and Tgl5p, two triacylglycerol lipases of the yeast Saccharomyces cerevisiae are localized to lipid particles.
    5. yeast Tgl4 is a functional ortholog of mammalian adipose triglyceride lipase
      Title: Obese yeast: triglyceride lipolysis is functionally conserved from mammals to yeast.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables calcium-independent phospholipase A2 activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables calcium-independent phospholipase A2 activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables lysophosphatidic acid acyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables sterol esterase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables sterol esterase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables triglyceride lipase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables triglyceride lipase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables triglyceride lipase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell budding IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in cell budding IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in lipid catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in phospholipid metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in sporulation resulting in formation of a cellular spore IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in triglyceride catabolic process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in triglyceride catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in triglyceride metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in triglyceride mobilization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in triglyceride mobilization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in lipid droplet HDA PubMed 
    located_in lipid droplet IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in lipid droplet IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    triacylglycerol lipase
    NP_013015.1
    • Multifunctional lipase/hydrolase/phospholipase; triacylglycerol lipase, steryl ester hydrolase, and Ca2+-independent phospholipase A2; catalyzes acyl-CoA dependent acylation of LPA to PA; required with Tgl3p for timely bud formation; phosphorylated and activated by Cdc28p; TGL4 has a paralog, TGL5, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001143.9 Reference assembly

      Range
      605633..608365 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179879.1 → NP_013015.1  TPA: triacylglycerol lipase [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013015.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VXE9, P36165
      UniProtKB/TrEMBL
      A7A048, B3LRG3, B5VMN1, C8ZCQ0, N1P105
      Conserved Domains (2) summary
      cd07230
      Location:210 → 632
      Pat_TGL4-5_like; Triacylglycerol lipase 4 and 5
      pfam11815
      Location:139 → 275
      DUF3336; Domain of unknown function (DUF3336)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P36165.1

    Gene LinkOut

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