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    TIR1 GPI-anchored mannoprotein [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856729, updated on 28-Oct-2024

    Summary

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    Official Symbol
    TIR1
    Official Full Name
    GPI-anchored mannoprotein
    Primary source
    SGD:S000000813
    Locus tag
    YER011W
    See related
    AllianceGenome:SGD:S000000813; FungiDB:YER011W; VEuPathDB:YER011W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    SRP1
    Summary
    A structural constituent of cell wall. Involved in fungal-type cell wall organization. Located in cell periphery and fungal-type vacuole. Is active in fungal-type cell wall. [provided by Alliance of Genome Resources, Oct 2024]
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    Genomic context

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    See TIR1 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    1
    Sequence:
    Chromosome: V; NC_001137.3 (175248..176012)

    Chromosome V - NC_001137.3Genomic Context describing neighboring genes Neighboring gene Ran GTPase-binding protein NTF2 Neighboring gene bifunctional 4-hydroxy-4-methyl-2-oxoglutarate aldolase/oxaloacetate decarboxylase Neighboring gene tRNA-Glu Neighboring gene proteasome core particle subunit beta 4

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001137.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The yeast SRP gene: positive modulation by glucose of its transcriptional expression. Marguet D, et al. Biochem Biophys Res Commun, 1986 Jul 16. PMID 3017319
    2. Yeast gene SRP1 (serine-rich protein). Intragenic repeat structure and identification of a family of SRP1-related DNA sequences. Marguet D, et al. J Mol Biol, 1988 Aug 5. PMID 3139887
    3. Regulation by low temperatures and anaerobiosis of a yeast gene specifying a putative GPI-anchored plasma membrane protein [corrected]. Donzeau M, et al. Mol Microbiol, 1996 Apr. PMID 8733242
    4. Identification and analysis of a static culture-specific cell wall protein, Tir1p/Srp1p in Saccharomyces cerevisiae. Kitagaki H, et al. Eur J Biochem, 1997 Oct 1. PMID 9363789
    5. An auxin-based degron system for the rapid depletion of proteins in nonplant cells. Nishimura K, et al. Nat Methods, 2009 Dec. PMID 19915560

    See all (45) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables structural constituent of cell wall IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables structural constituent of cell wall IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables structural constituent of cell wall IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in fungal-type cell wall organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in fungal-type cell wall organization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cell periphery HDA PubMed 
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in fungal-type cell wall IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in fungal-type cell wall IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in fungal-type vacuole HDA PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in side of membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    GPI-anchored mannoprotein
    NP_010927.1
    • Cell wall mannoprotein; expression is downregulated at acidic pH and induced by cold shock and anaerobiosis; abundance is increased in cells cultured without shaking; member of the Srp1p/Tip1p family of serine-alanine-rich proteins

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001137.3 Reference assembly

      Range
      175248..176012
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178902.1 → NP_010927.1  TPA: GPI-anchored mannoprotein [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010927.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D3DLQ8, P10863
      UniProtKB/TrEMBL
      A6ZQV8
      Conserved Domains (1) summary
      pfam00660
      Location:19 → 112
      SRP1_TIP1; Seripauperin and TIP1 family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P10863.1

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