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    SSA3 Hsp70 family ATPase SSA3 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852203, updated on 28-Oct-2024

    Summary

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    Official Symbol
    SSA3
    Official Full Name
    Hsp70 family ATPase SSA3
    Primary source
    SGD:S000000171
    Locus tag
    YBL075C
    See related
    AllianceGenome:SGD:S000000171; FungiDB:YBL075C; VEuPathDB:YBL075C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    YG106
    Summary
    Enables ATP hydrolysis activity and unfolded protein binding activity. Involved in SRP-dependent cotranslational protein targeting to membrane, translocation; protein folding; and protein quality control for misfolded or incompletely synthesized proteins. Located in cytosol. Human ortholog(s) of this gene implicated in several diseases, including Kawasaki disease; artery disease (multiple); autoimmune disease of musculoskeletal system (multiple); neurodegenerative disease (multiple); and schizophrenia (multiple). Orthologous to several human genes including HSPA8 (heat shock protein family A (Hsp70) member 8). [provided by Alliance of Genome Resources, Oct 2024]
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    Genomic context

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    See SSA3 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    1
    Sequence:
    Chromosome: II; NC_001134.8 (84499..86448, complement)

    Chromosome II - NC_001134.8Genomic Context describing neighboring genes Neighboring gene ubiquitin-like protein ATG8 Neighboring gene isoleucine--tRNA ligase ILS1 Neighboring gene U5 snRNP complex subunit AAR2 Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001134.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Mutational analysis of Mei5, a subunit of Mei5-Sae3 complex, in Dmc1-mediated recombination during yeast meiosis. Mwaniki S, et al. Genes Cells, 2024 Aug. PMID 38924305
    2. Monitoring dynamics of gene expression in yeast during stationary phase. Paz I, et al. Gene, 1999 Aug 5. PMID 10433964
    3. Saccharomyces cerevisiae HSP70 heat shock elements are functionally distinct. Young MR, et al. Mol Cell Biol, 1993 Sep. PMID 8355706, Free PMC Article
    4. Induction of major heat-shock proteins of Saccharomyces cerevisiae, including plasma membrane Hsp30, by ethanol levels above a critical threshold. Piper PW, et al. Microbiology (Reading), 1994 Nov. PMID 7812443
    5. Cytosolic Hsp70s are involved in the transport of aminopeptidase 1 from the cytoplasm into the vacuole. Satyanarayana C, et al. FEBS Lett, 2000 Mar 31. PMID 10745074

    See all (127) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Hsp70 binding regulates Sti1 conformation.
      Title: Hsp90 regulates the dynamics of its cochaperone Sti1 and the transfer of Hsp70 between modules.
    2. three histone methylation mutants exhibited more severe growth defects and slower activation of GAL1, SSA3 and PHO5 than those of wild type
      Title: [Effects of histone H3 K4L and K36L mutations on the cell growth and the transcription of GAL1, SSA3 and PHO5 in Saccharomyces cerevisiae].
    3. Analysis of a previously uncharacterized region of Pam16 revealed its requirement for formation of an active Pam18:Pam16 complex able to stimulate Hsp70's ATPase activity.
      Title: Reevaluation of the role of the Pam18:Pam16 interaction in translocation of proteins by the mitochondrial Hsp70-based import motor.
    4. The complex formation between the C-terminal motif of Hsp70/Hsp90 and Tom71 could lock Tom71 in the open state where the preprotein-binding pocket of Tom71 is ready to receive preproteins.
      Title: Molecular chaperone Hsp70/Hsp90 prepares the mitochondrial outer membrane translocon receptor Tom71 for preprotein loading.
    5. Functional rescue of mutant human cystathionine beta-synthase by manipulation of Hsp26 and Hsp70 levels in Saccharomyces cerevisiae.
      Title: Functional rescue of mutant human cystathionine beta-synthase by manipulation of Hsp26 and Hsp70 levels in Saccharomyces cerevisiae.
    6. Hsp104, Hsp70 and Hsp40 interplay regulates formation, growth and elimination of Sup35 prions
      Title: Hsp104, Hsp70 and Hsp40 interplay regulates formation, growth and elimination of Sup35 prions.
    7. results indicated that histone acetylation was required for the transcriptional activation of SSA3 and SSA4
      Title: Gcn5- and Elp3-induced histone H3 acetylation regulates hsp70 gene transcription in yeast.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ATP hydrolysis activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    enables ATP-dependent protein folding chaperone IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables heat shock protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein folding chaperone IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables unfolded protein binding IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in SRP-dependent cotranslational protein targeting to membrane, translocation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in chaperone cofactor-dependent protein refolding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein folding IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in protein quality control for misfolded or incompletely synthesized proteins IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein refolding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Hsp70 family ATPase SSA3
    NP_009478.1
    • ATPase involved in protein folding and the response to stress; plays a role in SRP-dependent cotranslational protein-membrane targeting and translocation; member of the heat shock protein 70 (HSP70) family; localized to the cytoplasm; SSA3 has a paralog, SSA4, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001134.8 Reference assembly

      Range
      84499..86448 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178315.1 → NP_009478.1  TPA: Hsp70 family ATPase SSA3 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_009478.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VPS7, P09435, P18862
      UniProtKB/TrEMBL
      A6ZKM6, B3LNK8, C7GK58, C8Z3R8, N1P8N4
      Conserved Domains (1) summary
      PTZ00009
      Location:4 → 649
      PTZ00009; heat shock 70 kDa protein; Provisional
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P09435.3

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