U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    GRB7 growth factor receptor bound protein 7 [ Homo sapiens (human) ]

    Gene ID: 2886, updated on 28-Oct-2024

    Summary

    Official Symbol
    GRB7provided by HGNC
    Official Full Name
    growth factor receptor bound protein 7provided by HGNC
    Primary source
    HGNC:HGNC:4567
    See related
    Ensembl:ENSG00000141738 MIM:601522; AllianceGenome:HGNC:4567
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    The product of this gene belongs to a small family of adapter proteins that are known to interact with a number of receptor tyrosine kinases and signaling molecules. This gene encodes a growth factor receptor-binding protein that interacts with epidermal growth factor receptor (EGFR) and ephrin receptors. The protein plays a role in the integrin signaling pathway and cell migration by binding with focal adhesion kinase (FAK). Several transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jun 2011]
    Expression
    Broad expression in kidney (RPKM 6.4), esophagus (RPKM 5.5) and 16 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See GRB7 in Genome Data Viewer
    Location:
    17q12
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (39737938..39747285)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (40601500..40610848)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (37894191..37903538)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene erb-b2 receptor tyrosine kinase 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:37882556-37883528 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8463 Neighboring gene microRNA 4728 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:37896451-37897048 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:37897647-37898244 Neighboring gene migration and invasion enhancer 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8465 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8464 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8466 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12104 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12105 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12106 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12107 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8467 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12108 Neighboring gene IKAROS family zinc finger 3 Neighboring gene ReSE screen-validated silencer GRCh37_chr17:37934634-37934867 Neighboring gene ReSE screen-validated silencer GRCh37_chr17:37940879-37941109 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12109 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12110 Neighboring gene MPRA-validated peak2840 silencer Neighboring gene MPRA-validated peak2841 silencer Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:37991649-37992148 Neighboring gene keratin 8 pseudogene 34 Neighboring gene ribosomal protein L39 pseudogene 4

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables phosphatidylinositol binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein kinase binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in epidermal growth factor receptor signaling pathway TAS
    Traceable Author Statement
    more info
    PubMed 
    NOT involved_in insulin receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    NOT involved_in negative regulation of insulin receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in negative regulation of translation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of cell migration IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in stress granule assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    located_in cell projection IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoplasmic stress granule ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in focal adhesion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    growth factor receptor-bound protein 7
    Names
    B47
    GRB7 adapter protein
    epidermal growth factor receptor GRB-7

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_029932.2 RefSeqGene

      Range
      5002..14349
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001030002.3NP_001025173.1  growth factor receptor-bound protein 7 isoform a

      See identical proteins and their annotated locations for NP_001025173.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 4. The resulting isoform (a) is shorter at the N-terminus compared to isoform b. Variants 1, 2, and 3 all encode the same isoform (a).
      Source sequence(s)
      AC079199
      Consensus CDS
      CCDS11345.1
      UniProtKB/Swiss-Prot
      B2RAV1, B3KNL0, B3KWP9, B7WP75, J3KQM4, Q14451, Q53YD3, Q92568, Q96DF9, Q9Y220
      UniProtKB/TrEMBL
      A0A0S2Z4F6
      Related
      ENSP00000377761.3, ENST00000394211.7
      Conserved Domains (4) summary
      cd01787
      Location:100184
      GRB7_RA; RA (RAS-associated like) domain of Grb7
      cd10413
      Location:425532
      SH2_Grb7; Src homology 2 (SH2) domain found in the growth factor receptor bound, subclass 7 (Grb7) proteins
      cd01259
      Location:225347
      PH_APBB1IP; Amyloid beta (A4) Precursor protein-Binding, family B, member 1 Interacting Protein pleckstrin homology (PH) domain
      pfam08947
      Location:366410
      BPS; BPS (Between PH and SH2)
    2. NM_001242442.2NP_001229371.2  growth factor receptor-bound protein 7 isoform b

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) encodes the longest isoform (b).
      Source sequence(s)
      AC079199
      Consensus CDS
      CCDS56028.1
      Related
      ENSP00000403459.2, ENST00000445327.6
      Conserved Domains (4) summary
      cd10413
      Location:448555
      SH2_Grb7; Src homology 2 (SH2) domain found in the growth factor receptor bound, subclass 7 (Grb7) proteins
      cd01259
      Location:248370
      PH_APBB1IP; Amyloid beta (A4) Precursor protein-Binding, family B, member 1 Interacting Protein pleckstrin homology (PH) domain
      cd16140
      Location:123210
      RA_GRB7; Ras-associating (RA) domain found in growth factor receptor-bound (Grb) protein 7
      pfam08947
      Location:389433
      BPS; BPS (Between PH and SH2)
    3. NM_001242443.2NP_001229372.1  growth factor receptor-bound protein 7 isoform a

      See identical proteins and their annotated locations for NP_001229372.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence compared to variant 4. The resulting isoform (a) is shorter at the N-terminus compared to isoform b. Variants 1, 2, and 3 all encode the same isoform (a).
      Source sequence(s)
      AC079199
      Consensus CDS
      CCDS11345.1
      UniProtKB/Swiss-Prot
      B2RAV1, B3KNL0, B3KWP9, B7WP75, J3KQM4, Q14451, Q53YD3, Q92568, Q96DF9, Q9Y220
      UniProtKB/TrEMBL
      A0A0S2Z4F6
      Related
      ENSP00000377759.2, ENST00000394209.6
      Conserved Domains (4) summary
      cd01787
      Location:100184
      GRB7_RA; RA (RAS-associated like) domain of Grb7
      cd10413
      Location:425532
      SH2_Grb7; Src homology 2 (SH2) domain found in the growth factor receptor bound, subclass 7 (Grb7) proteins
      cd01259
      Location:225347
      PH_APBB1IP; Amyloid beta (A4) Precursor protein-Binding, family B, member 1 Interacting Protein pleckstrin homology (PH) domain
      pfam08947
      Location:366410
      BPS; BPS (Between PH and SH2)
    4. NM_001330207.2NP_001317136.1  growth factor receptor-bound protein 7 isoform c

      Status: REVIEWED

      Source sequence(s)
      AC079199, BC006535
      Consensus CDS
      CCDS82116.1
      UniProtKB/Swiss-Prot
      Q14451
      Related
      ENSP00000377754.1, ENST00000394204.1
      Conserved Domains (3) summary
      cd01787
      Location:100184
      GRB7_RA; RA (RAS-associated like) domain of Grb7
      cd01259
      Location:225347
      PH_APBB1IP; Amyloid beta (A4) Precursor protein-Binding, family B, member 1 Interacting Protein pleckstrin homology (PH) domain
      pfam08947
      Location:366410
      BPS; BPS (Between PH and SH2)
    5. NM_005310.5NP_005301.2  growth factor receptor-bound protein 7 isoform a

      See identical proteins and their annotated locations for NP_005301.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) differs in the 5' UTR and coding sequence compared to variant 4. The resulting isoform (a) is shorter at the N-terminus compared to isoform b. Variants 1, 2, and 3 all encode the same isoform (a).
      Source sequence(s)
      AC079199
      Consensus CDS
      CCDS11345.1
      UniProtKB/Swiss-Prot
      B2RAV1, B3KNL0, B3KWP9, B7WP75, J3KQM4, Q14451, Q53YD3, Q92568, Q96DF9, Q9Y220
      UniProtKB/TrEMBL
      A0A0S2Z4F6
      Related
      ENSP00000310771.4, ENST00000309156.9
      Conserved Domains (4) summary
      cd01787
      Location:100184
      GRB7_RA; RA (RAS-associated like) domain of Grb7
      cd10413
      Location:425532
      SH2_Grb7; Src homology 2 (SH2) domain found in the growth factor receptor bound, subclass 7 (Grb7) proteins
      cd01259
      Location:225347
      PH_APBB1IP; Amyloid beta (A4) Precursor protein-Binding, family B, member 1 Interacting Protein pleckstrin homology (PH) domain
      pfam08947
      Location:366410
      BPS; BPS (Between PH and SH2)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

      Range
      39737938..39747285
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047435857.1XP_047291813.1  growth factor receptor-bound protein 7 isoform X1

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060941.1 Alternate T2T-CHM13v2.0

      Range
      40601500..40610848
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054315868.1XP_054171843.1  growth factor receptor-bound protein 7 isoform X1