MOB1A MOB kinase activator 1A [Homo sapiens (human)] - Gene

Summary

Official Symbol: MOB1Aprovided by HGNC
Official Full Name: MOB kinase activator 1Aprovided by HGNC
Primary source: HGNC:HGNC:16015
See related: Ensembl:ENSG00000114978 MIM:609281; AllianceGenome:HGNC:16015
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: MOB1; MATS1; Mob4B; C2orf6; MOBK1B; MABKL1B; MOBKL1B
Summary: The protein encoded by this gene is a component of the Hippo signaling pathway, which controls organ size and tumor growth by enhancing apoptosis. Loss of the encoded protein results in cell proliferation and cancer formation. The encoded protein is also involved in the control of microtubule stability during cytokinesis. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2015]
Expression: Ubiquitous expression in lymph node (RPKM 51.6), appendix (RPKM 43.0) and 24 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 2p13.1

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	2	NC_000002.12 (74152528..74178879, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	2	NC_060926.1 (74160989..74187669, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	2	NC_000002.11 (74379655..74406006, complement)

Chromosome 2 - NC_000002.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

CAF-derived exosomal WEE2-AS1 facilitates colorectal cancer progression via promoting degradation of MOB1A to inhibit the Hippo pathway.
Title: CAF-derived exosomal WEE2-AS1 facilitates colorectal cancer progression via promoting degradation of MOB1A to inhibit the Hippo pathway.
Oxidative stress-CBP axis modulates MOB1 acetylation and activates the Hippo signaling pathway.
Title: Oxidative stress-CBP axis modulates MOB1 acetylation and activates the Hippo signaling pathway.
Circular RNA circCCDC85A inhibits breast cancer progression via acting as a miR-550a-5p sponge to enhance MOB1A expression.
Title: Circular RNA circCCDC85A inhibits breast cancer progression via acting as a miR-550a-5p sponge to enhance MOB1A expression.
RNA-binding protein Musashi2 regulates Hippo signaling via SAV1 and MOB1 in pancreatic cancer.
Title: RNA-binding protein Musashi2 regulates Hippo signaling via SAV1 and MOB1 in pancreatic cancer.
The Legionella kinase LegK7 exploits the Hippo pathway scaffold protein MOB1A for allostery and substrate phosphorylation.
Title: The Legionella kinase LegK7 exploits the Hippo pathway scaffold protein MOB1A for allostery and substrate phosphorylation.
validated the functional importance of an identified interaction network by characterizing a distinct novel interaction between PTPN5 and Mob1a.
Title: A Human Tyrosine Phosphatase Interactome Mapped by Proteomic Profiling.
In this study, we investigated the mechanisms behind the recruitment of MST1 and MST2 kinases to MOB1, which facilitate signal transmission in the Hippo pathway by bringing the MST1 and MST2 kinases in close vicinity to their substrates, the LATS family kinases.
Title: MOB1 Mediated Phospho-recognition in the Core Mammalian Hippo Pathway.
Through a comprehensive set of biochemical, biophysical, mutational and structural studies, we quantitatively assess how phosphorylation of MOB1A regulates its interaction with both MST kinases and LATS/NDR family kinases in vitro.
Title: Regulation of Protein Interactions by Mps One Binder (MOB1) Phosphorylation.
MOB1 binds differently to the NDR2 and LATS1 kinases.MOB1 interaction with Hippo and MST protein is not essential for development and tissue growth control.
Title: Stable MOB1 interaction with Hippo/MST is not essential for development and tissue growth control.
No relationship has been found between the MOBKL1B-NS5A interaction and hepatitis C virus replication.
Title: Seed sequence-matched controls reveal limitations of small interfering RNA knockdown in functional and structural studies of hepatitis C virus NS5A-MOBKL1B interaction.

Submit: New GeneRIF Correction See all GeneRIFs (16)

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH80124 (e-PCR)
- UniSTS:86046

RH93806 (e-PCR)
- UniSTS:87892

G48239 (e-PCR)
- UniSTS:95336

RH66469 (e-PCR)
- UniSTS:51052

RH69565 (e-PCR)
- UniSTS:76172

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase activator activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein serine/threonine kinase activator activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in hippo signaling	IBA Inferred from Biological aspect of Ancestor more info
involved_in hippo signaling	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	TAS Traceable Author Statement more info
located_in extracellular exosome	HDA more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: MOB kinase activator 1A

Names: MOB1 Mps One Binder homolog A; MOB1, Mps One Binder kinase activator-like 1B; mob1 alpha; mob1 homolog 1B; mps one binder kinase activator-like 1B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001317110.2 → NP_001304039.1 MOB kinase activator 1A isoform 2

Status: REVIEWED

Description

Transcript Variant: This variant (2) uses an alternate in-frame splice junction in the 5' end compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is 1 aa shorter compared to isoform 1.

Source sequence(s)

AC073263, AK001650, AL122062, BC003398, BU172616, HY030276

UniProtKB/Swiss-Prot

Q9H8S9

Conserved Domains (1) summary

pfam03637
Location:32 → 203

Mob1_phocein; Mob1/phocein family
NM_001317111.2 → NP_001304040.1 MOB kinase activator 1A isoform 3

Status: REVIEWED

Description

Transcript Variant: This variant (3) contains an alternate exon in place of the first exon compared to variant 1. The resulting isoform (3) has a longer and distinct N-terminus compared to isoform 1.

Source sequence(s)

AC073263, AK001650, AL122062, BC003398, BI825399

UniProtKB/Swiss-Prot

Q9H8S9

Conserved Domains (1) summary

pfam03637
Location:75 → 246

Mob1_phocein; Mob1/phocein family
NM_001317112.2 → NP_001304041.1 MOB kinase activator 1A isoform 4

Status: REVIEWED

Description

Transcript Variant: This variant (4) lacks an alternate coding exon in the 3' end, that causes a frameshift. The resulting isoform (4) has a shorter and distinct C-terminus compared to isoform 1.

Source sequence(s)

AC073263, AK001650, AL122062, BC003398, CN426611, HY030276

UniProtKB/TrEMBL

D6RCK3

Conserved Domains (1) summary

pfam03637
Location:33 → 138

Mob1_phocein; Mob1/phocein family
NM_018221.5 → NP_060691.2 MOB kinase activator 1A isoform 1

See identical proteins and their annotated locations for NP_060691.2

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes isoform 1.

Source sequence(s)

AC073263, AK001650, AL122062, BC003398, HY030276

Consensus CDS

CCDS46340.1

UniProtKB/Swiss-Prot

Q53S34, Q9H3T5, Q9H8S9, Q9HAI0, Q9NVE2

Related

ENSP00000379364.3, ENST00000396049.5

Conserved Domains (1) summary

pfam03637
Location:33 → 204

Mob1_phocein; Mob1/phocein family