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    SENP5 SUMO specific peptidase 5 [ Homo sapiens (human) ]

    Gene ID: 205564, updated on 28-Oct-2024

    Summary

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    Official Symbol
    SENP5provided by HGNC
    Official Full Name
    SUMO specific peptidase 5provided by HGNC
    Primary source
    HGNC:HGNC:28407
    See related
    Ensembl:ENSG00000119231 MIM:612845; AllianceGenome:HGNC:28407
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    The reversible posttranslational modification of proteins by the addition of small ubiquitin-like SUMO proteins (see SUMO1; MIM 601912) is required for numerous biologic processes. SUMO-specific proteases, such as SENP5, are responsible for the initial processing of SUMO precursors to generate a C-terminal diglycine motif required for the conjugation reaction. They also have isopeptidase activity for the removal of SUMO from high molecular mass SUMO conjugates (Di Bacco et al., 2006 [PubMed 16738315]).[supplied by OMIM, Jun 2009]
    Expression
    Ubiquitous expression in testis (RPKM 8.4), brain (RPKM 6.3) and 25 other tissues See more
    Orthologs
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    Genomic context

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    See SENP5 in Genome Data Viewer
    Location:
    3q29
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (196867920..196934714)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (199593622..199660765)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (196594791..196661585)

    Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene RNA, U4 small nuclear 89, pseudogene Neighboring gene p21 (RAC1) activated kinase 2 Neighboring gene ReSE screen-validated silencer GRCh37_chr3:196499493-196499749 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:196513771-196514477 Neighboring gene RNA, U6 small nuclear 42, pseudogene Neighboring gene ReSE screen-validated silencer GRCh37_chr3:196568870-196569024 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15073 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:196595799-196596300 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr3:196625459-196625966 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:196668731-196669404 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:196669405-196670078 Neighboring gene NCBP2 antisense RNA 1 Neighboring gene NCBP2 antisense 2 (head to head) Neighboring gene nuclear cap binding protein subunit 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Overexpression of SENP5 in oral squamous cell carcinoma and its association with differentiation. Ding X, et al. Oncol Rep, 2008 Nov. PMID 18949399
    2. SENP5 mediates breast cancer invasion via a TGFβRI SUMOylation cascade. Cashman R, et al. Oncotarget, 2014 Feb 28. PMID 24658161, Free PMC Article
    3. Sentrin/small ubiquitin-like modifier-specific protease 5 protects oral cancer cells from oxidative stress-induced apoptosis. Cheng Y, et al. Mol Med Rep, 2015 Aug. PMID 25901414
    4. SENP5 promotes homologous recombination-mediated DNA damage repair in colorectal cancer cells through H2AZ deSUMOylation. Liu T, et al. J Exp Clin Cancer Res, 2023 Sep 8. PMID 37684630, Free PMC Article
    5. The SUMO-specific protease SENP5 is required for cell division. Di Bacco A, et al. Mol Cell Biol, 2006 Jun. PMID 16738315, Free PMC Article

    See all (30) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. SENP5 promotes homologous recombination-mediated DNA damage repair in colorectal cancer cells through H2AZ deSUMOylation.
      Title: SENP5 promotes homologous recombination-mediated DNA damage repair in colorectal cancer cells through H2AZ deSUMOylation.
    2. SUMO proteases SENP3 and SENP5 spatiotemporally regulate the kinase activity of Aurora A.
      Title: SUMO proteases SENP3 and SENP5 spatiotemporally regulate the kinase activity of Aurora A.
    3. Zinc deficiency induces abnormal development of the myocardium by promoting SENP5 overexpression.
      Title: Zinc deficiency induces abnormal development of the myocardium by promoting SENP5 overexpression.
    4. Results from a study on gene expression variability markers in early-stage human embryos shows that SENP5 is a putative expression variability marker for the 3-day, 8-cell embryo stage.
      Title: Variability of Gene Expression Identifies Transcriptional Regulators of Early Human Embryonic Development.
    5. Mild oxidative stress stabilized the SENP5 protein in the oral squamous cell carcinoma cells, and only the combination of SENP5 silencing and H2O2 application led to mitochondria fragmentation and a significant increase in cell apoptosis.
      Title: Sentrin/small ubiquitin-like modifier-specific protease 5 protects oral cancer cells from oxidative stress-induced apoptosis.
    6. Low expression of SENP5 is associated with good prognosis among breast cancer patients.
      Title: SENP5 mediates breast cancer invasion via a TGFβRI SUMOylation cascade.
    7. altered subcellular localization of SENP5 in oral squamous cell carcinoma (OSCC) cells and the correlation between SENP5 expression and the differentiation of OSCC.
      Title: Overexpression of SENP5 in oral squamous cell carcinoma and its association with differentiation.
    8. Nucleolar protein B23/nucleophosmin regulates the vertebrate SUMO pathway through SENP3 and SENP5 proteases.
      Title: Nucleolar protein B23/nucleophosmin regulates the vertebrate SUMO pathway through SENP3 and SENP5 proteases.
    9. Knockdown of SENP5 resulted in increased levels of SUMO-1 and SUMO-2/3, inhibition of cell proliferation, defects in nuclear morphology, and appearance of binucleate cells, revealing an essential role for SENP5 in mitosis and/or cytokinesis.
      Title: The SUMO-specific protease SENP5 is required for cell division.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    HIV-1 interactions

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    Replication interactions

    Interaction Pubs
    Knockdown of SUMO1/sentrin specific peptidase 5 (SENP5) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ42398, MGC27076, DKFZp564O1016

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables SUMO-specific endopeptidase activity EXP
    Inferred from Experiment
    more info
    		 PubMed 
    enables deSUMOylase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein desumoylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein sumoylation TAS
    Traceable Author Statement
    more info
    		  
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in postsynaptic cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in presynaptic cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    sentrin-specific protease 5
    Names
    SUMO1/sentrin specific peptidase 5
    SUMO1/sentrin specific protease 5
    sentrin/SUMO-specific protease SENP5
    NP_001294974.1
    NP_689912.2
    XP_005269367.1
    XP_047303630.1
    XP_047303631.1
    XP_047303632.1
    XP_054201633.1
    XP_054201634.1
    XP_054201635.1
    XP_054201636.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001308045.2 → NP_001294974.1  sentrin-specific protease 5 isoform 2

      See identical proteins and their annotated locations for NP_001294974.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate exon in the 3' coding region but maintains the reading frame, compared to variant 1. The encoded isoform (2) is shorter, compared to isoform 1.
      Source sequence(s)
      AC011322, AK302305, AK313764, AL049229
      Consensus CDS
      CCDS77876.1
      UniProtKB/TrEMBL
      B2R9F5
      Related
      ENSP00000390231.2, ENST00000445299.6
      Conserved Domains (1) summary
      cl23802
      Location:581 → 707
      Peptidase_C48; Ulp1 protease family, C-terminal catalytic domain

    2. NM_152699.5 → NP_689912.2  sentrin-specific protease 5 isoform 1

      See identical proteins and their annotated locations for NP_689912.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC011322, AL049229, BC030705, DC399261
      Consensus CDS
      CCDS3322.1
      UniProtKB/Swiss-Prot
      B4DY82, Q96HI0, Q96SA5
      UniProtKB/TrEMBL
      B2R9F5
      Related
      ENSP00000327197.5, ENST00000323460.10
      Conserved Domains (1) summary
      pfam02902
      Location:581 → 753
      Peptidase_C48; Ulp1 protease family, C-terminal catalytic domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

      Range
      196867920..196934714
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005269310.4 → XP_005269367.1  sentrin-specific protease 5 isoform X1

      UniProtKB/TrEMBL
      B2R9F5
      Conserved Domains (1) summary
      pfam02902
      Location:581 → 725
      Peptidase_C48; Ulp1 protease family, C-terminal catalytic domain

    2. XM_047447675.1 → XP_047303631.1  sentrin-specific protease 5 isoform X3

    3. XM_047447676.1 → XP_047303632.1  sentrin-specific protease 5 isoform X4

    4. XM_047447674.1 → XP_047303630.1  sentrin-specific protease 5 isoform X2

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060927.1 Alternate T2T-CHM13v2.0

      Range
      199593622..199660765
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054345658.1 → XP_054201633.1  sentrin-specific protease 5 isoform X1

    2. XM_054345660.1 → XP_054201635.1  sentrin-specific protease 5 isoform X3

    3. XM_054345661.1 → XP_054201636.1  sentrin-specific protease 5 isoform X4

    4. XM_054345659.1 → XP_054201634.1  sentrin-specific protease 5 isoform X2

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q96HI0.3 GenPept UniProtKB/Swiss-Prot:Q96HI0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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