U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    ZSCAN4 zinc finger and SCAN domain containing 4 [ Homo sapiens (human) ]

    Gene ID: 201516, updated on 2-Nov-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    ZSCAN4provided by HGNC
    Official Full Name
    zinc finger and SCAN domain containing 4provided by HGNC
    Primary source
    HGNC:HGNC:23709
    See related
    Ensembl:ENSG00000180532 MIM:613419; AllianceGenome:HGNC:23709
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ZNF494
    Summary
    The ZSCAN4 gene encodes a protein involved in telomere maintenance and with a key role in the critical feature of mouse embryonic stem (ES) cells, namely, defying cellular senescence and maintaining normal karyotype for many cell divisions in culture (Zalzman et al., 2010 [PubMed 20336070]).[supplied by OMIM, May 2010]
    Expression
    Low expression observed in reference dataset See more
    Orthologs
    all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See ZSCAN4 in Genome Data Viewer
    Location:
    19q13.43
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (57651476..57679152)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (60748405..60776081)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (58162844..58190520)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15150 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11077 Neighboring gene zinc finger protein 134 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15151 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15152 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11078 Neighboring gene zinc finger protein 211 Neighboring gene MPRA-validated peak3574 silencer Neighboring gene tumor protein p63 regulated 1 like pseudogene 1 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:58193037-58193660 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11079 Neighboring gene zinc finger protein 551 Neighboring gene zinc finger protein 154 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:58220160-58220799

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. ZSCAN4-binding motif-TGCACAC is conserved and enriched in CA/TG microsatellites in both mouse and human genomes. Akiyama T, et al. DNA Res, 2024 Feb 1. PMID 38153767, Free PMC Article
    2. Low expression of ZSCAN4 predicts unfavorable outcome in urothelial carcinoma of upper urinary tract and urinary bladder. He HL, et al. World J Surg Oncol, 2023 Feb 25. PMID 36841776, Free PMC Article
    3. ZSCAN4 facilitates chromatin remodeling and promotes the cancer stem cell phenotype. Portney BA, et al. Oncogene, 2020 Jun. PMID 32507861, Free PMC Article
    4. Zscan4 is expressed specifically during late meiotic prophase in both spermatogenesis and oogenesis. Ishiguro KI, et al. In Vitro Cell Dev Biol Anim, 2017 Feb. PMID 27699653, Free PMC Article
    5. Expression analysis of the endogenous Zscan4 locus and its coding proteins in mouse ES cells and preimplantation embryos. Ishiguro KI, et al. In Vitro Cell Dev Biol Anim, 2017 Feb. PMID 27699651, Free PMC Article

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. ZSCAN4-binding motif-TGCACAC is conserved and enriched in CA/TG microsatellites in both mouse and human genomes.
      Title: ZSCAN4-binding motif-TGCACAC is conserved and enriched in CA/TG microsatellites in both mouse and human genomes.
    2. Low expression of ZSCAN4 predicts unfavorable outcome in urothelial carcinoma of upper urinary tract and urinary bladder.
      Title: Low expression of ZSCAN4 predicts unfavorable outcome in urothelial carcinoma of upper urinary tract and urinary bladder.
    3. The Zscan4-Tet2 Transcription Nexus Regulates Metabolic Rewiring and Enhances Proteostasis to Promote Reprogramming.
      Title: The Zscan4-Tet2 Transcription Nexus Regulates Metabolic Rewiring and Enhances Proteostasis to Promote Reprogramming.
    4. ZSCAN4 facilitates chromatin remodeling and promotes the cancer stem cell phenotype.
      Title: ZSCAN4 facilitates chromatin remodeling and promotes the cancer stem cell phenotype.
    5. The senescence-associated secretory phenotype is potentiated by feedforward regulatory mechanisms involving Zscan4 and TAK1.
      Title: The senescence-associated secretory phenotype is potentiated by feedforward regulatory mechanisms involving Zscan4 and TAK1.
    6. RNF20 depletion stabilizes the ZSCAN4 protein half-life, suggesting that RNF20 negatively regulates ZSCAN4 stability.
      Title: ZSCAN4 is negatively regulated by the ubiquitin-proteasome system and the E3 ubiquitin ligase RNF20.
    7. Zscan4 may play critical roles during late meiotic prophase in both males and females.
      Title: Zscan4 is expressed specifically during late meiotic prophase in both spermatogenesis and oogenesis.
    8. the expression and function of each gene copy of Zscan4 locus in a physiological context, is reported.
      Title: Expression analysis of the endogenous Zscan4 locus and its coding proteins in mouse ES cells and preimplantation embryos.
    9. ZSCAN4 indirectly interacts with TRF1 in cancer cells. We show that ZSCAN4 plays an important role independent of telomere maintenance pathways (telomerase positive and alternative pathway) or cell lineage.
      Title: ZSCAN4 and TRF1: A functionally indirect interaction in cancer cells independent of telomerase activity.
    10. The direct interaction between Zscan4 and Rap1 may explain how Zscan4 rapidly increases telomere length, yielding important information about the role of these proteins in telomere biology.
      Title: Zscan4 interacts directly with human Rap1 in cancer cells regardless of telomerase status.
    Submit: New GeneRIF Correction

    Phenotypes

    Go to the top of the page Help

    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

    Go to the top of the page Help

    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Pathways from PubChem

    Go to the top of the page

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Clone Names

    • FLJ35105, MGC126787, MGC126789

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables sequence-specific double-stranded DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in negative regulation of mitotic recombination ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in telomere maintenance via telomere lengthening ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chromosome, telomeric region ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    zinc finger and SCAN domain-containing protein 4
    Names
    zinc finger protein 494

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001384833.1 → NP_001371762.1  zinc finger and SCAN domain-containing protein 4

      Status: VALIDATED

      Source sequence(s)
      AC003682, AC004017
      Consensus CDS
      CCDS12958.1
      UniProtKB/Swiss-Prot
      Q3MIQ2, Q8NAM6
      Conserved Domains (4) summary
      cd07936
      Location:40 → 124
      SCAN; SCAN oligomerization domain
      sd00017
      Location:342 → 362
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:368 → 390
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:382 → 407
      zf-H2C2_2; Zinc-finger double domain

    2. NM_152677.4 → NP_689890.1  zinc finger and SCAN domain-containing protein 4

      See identical proteins and their annotated locations for NP_689890.1

      Status: VALIDATED

      Source sequence(s)
      AC004017
      Consensus CDS
      CCDS12958.1
      UniProtKB/Swiss-Prot
      Q3MIQ2, Q8NAM6
      Related
      ENSP00000321963.4, ENST00000318203.9
      Conserved Domains (4) summary
      cd07936
      Location:40 → 124
      SCAN; SCAN oligomerization domain
      sd00017
      Location:342 → 362
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:368 → 390
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:382 → 407
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      57651476..57679152
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017026458.1 → XP_016881947.1  zinc finger and SCAN domain-containing protein 4 isoform X1

      UniProtKB/Swiss-Prot
      Q3MIQ2, Q8NAM6
      Conserved Domains (4) summary
      cd07936
      Location:40 → 124
      SCAN; SCAN oligomerization domain
      sd00017
      Location:342 → 362
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:368 → 390
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:382 → 407
      zf-H2C2_2; Zinc-finger double domain

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      60748405..60776081
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054320180.1 → XP_054176155.1  zinc finger and SCAN domain-containing protein 4 isoform X1

      UniProtKB/Swiss-Prot
      Q3MIQ2, Q8NAM6
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8NAM6.1 GenPept UniProtKB/Swiss-Prot:Q8NAM6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous