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    MRGPRX2 MAS related GPR family member X2 [ Homo sapiens (human) ]

    Gene ID: 117194, updated on 2-Nov-2024

    Summary

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    Official Symbol
    MRGPRX2provided by HGNC
    Official Full Name
    MAS related GPR family member X2provided by HGNC
    Primary source
    HGNC:HGNC:17983
    See related
    Ensembl:ENSG00000183695 MIM:607228; AllianceGenome:HGNC:17983
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    MGRG3; MRGX2
    Summary
    Enables G protein-coupled receptor activity and neuropeptide binding activity. Involved in mast cell degranulation and positive regulation of cytokinesis. Predicted to be located in membrane. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Low expression observed in reference dataset See more
    Orthologs
    all
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    Genomic context

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    See MRGPRX2 in Genome Data Viewer
    Location:
    11p15.1
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (19054455..19060717, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (19174588..19180847, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (19076002..19082264, complement)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene MAS related GPR family member X10, pseudogene Neighboring gene MAS related GPR family member X9, pseudogene Neighboring gene Sharpr-MPRA regulatory region 14303 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3195 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3196 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3197 Neighboring gene zinc finger DHHC-type palmitoyltransferase 13 Neighboring gene VISTA enhancer hs2144 Neighboring gene CSRP3 and E2F8 antisense RNA 1 Neighboring gene cysteine and glycine rich protein 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Immunoglobulin E cross-linking or MRGPRX2 activation: clinical insights from rocuronium hypersensitivity. Ebo DG, et al. Br J Anaesth, 2021 Jan. PMID 33153719
    2. Expression of MRGPRX2 in skin mast cells of patients with maculopapular cutaneous mastocytosis. Deepak V, et al. J Allergy Clin Immunol Pract, 2021 Oct. PMID 34182161, Free PMC Article
    3. Substance P Serves as a Balanced Agonist for MRGPRX2 and a Single Tyrosine Residue Is Required for β-Arrestin Recruitment and Receptor Internalization. Chompunud Na Ayudhya C, et al. Int J Mol Sci, 2021 May 18. PMID 34070125, Free PMC Article
    4. Multifaceted MRGPRX2: New insight into the role of mast cells in health and disease. Roy S, et al. J Allergy Clin Immunol, 2021 Aug. PMID 33957166, Free PMC Article
    5. Human Mast Cell Line HMC1 Expresses Functional Mas-Related G-Protein Coupled Receptor 2. Hermans MAW, et al. Front Immunol, 2021. PMID 33790895, Free PMC Article

    See all (66) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. CXCL17 induces activation of human mast cells via MRGPRX2.
      Title: CXCL17 induces activation of human mast cells via MRGPRX2.
    2. Beyond Allergies-Updates on The Role of Mas-Related G-Protein-Coupled Receptor X2 in Chronic Urticaria and Atopic Dermatitis.
      Title: Beyond Allergies-Updates on The Role of Mas-Related G-Protein-Coupled Receptor X2 in Chronic Urticaria and Atopic Dermatitis.
    3. Proinflammatory chemokine CXCL14 activates MAS-related G protein-coupled receptor MRGPRX2 and its putative mouse ortholog MRGPRB2.
      Title: Proinflammatory chemokine CXCL14 activates MAS-related G protein-coupled receptor MRGPRX2 and its putative mouse ortholog MRGPRB2.
    4. miR-212/132 attenuates OVA-induced airway inflammation by inhibiting mast cells activation through MRGPRX2 and ASAP1.
      Title: miR-212/132 attenuates OVA-induced airway inflammation by inhibiting mast cells activation through MRGPRX2 and ASAP1.
    5. PACAP activates MRGPRX2 on meningeal mast cells to drive migraine-like pain.
      Title: PACAP activates MRGPRX2 on meningeal mast cells to drive migraine-like pain.
    6. Substance P analogs devoid of key residues fail to activate human mast cells via MRGPRX2.
      Title: Substance P analogs devoid of key residues fail to activate human mast cells via MRGPRX2.
    7. Mas-related G protein-coupled receptor MRGPRX2 in human basophils: Expression and functional studies.
      Title: Mas-related G protein-coupled receptor MRGPRX2 in human basophils: Expression and functional studies.
    8. Unraveling the venom chemistry with evidence for histamine as key regulator in the envenomation by caterpillar Automeris zaruma.
      Title: Unraveling the venom chemistry with evidence for histamine as key regulator in the envenomation by caterpillar Automeris zaruma.
    9. The effect of substance P and its common in vivo-formed metabolites on MRGPRX2 and human mast cell activation.
      Title: The effect of substance P and its common in vivo-formed metabolites on MRGPRX2 and human mast cell activation.
    10. Mast cells, cortistatin, and its receptor, MRGPRX2, are linked to the pathogenesis of chronic prurigo.
      Title: Mast cells, cortistatin, and its receptor, MRGPRX2, are linked to the pathogenesis of chronic prurigo.
    Submit: New GeneRIF Correction See all GeneRIFs (58)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables G protein-coupled receptor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables mast cell secretagogue receptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables neuropeptide binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mast cell activation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in mast cell degranulation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of cytokinesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in sensory perception of pain NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in sleep NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane IC
    Inferred by Curator
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    mas-related G-protein coupled receptor member X2
    Names
    G protein-coupled receptor MRGX2
    MAS-related GPR, member X2
    Mas-related G protein-coupled receptor G3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001303615.2 → NP_001290544.1  mas-related G-protein coupled receptor member X2

      See identical proteins and their annotated locations for NP_001290544.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC027026, BC063450, HY005030
      Consensus CDS
      CCDS7847.1
      UniProtKB/Swiss-Prot
      B5B0C7, Q4QXW4, Q4QXW7, Q4QXX0, Q4QXX2, Q4QXX3, Q4QXX4, Q4QXX6, Q4QXX7, Q96LB1, W8W3L5
      Conserved Domains (1) summary
      cd15106
      Location:31 → 308
      7tmA_MrgprX-like; primate-specific mas-related G protein-coupled receptor subtype X-like, member of the class A family of seven-transmembrane G protein-coupled receptors

    2. NM_054030.4 → NP_473371.1  mas-related G-protein coupled receptor member X2

      See identical proteins and their annotated locations for NP_473371.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC027026, BC063450
      Consensus CDS
      CCDS7847.1
      UniProtKB/Swiss-Prot
      B5B0C7, Q4QXW4, Q4QXW7, Q4QXX0, Q4QXX2, Q4QXX3, Q4QXX4, Q4QXX6, Q4QXX7, Q96LB1, W8W3L5
      Related
      ENSP00000333800.2, ENST00000329773.3
      Conserved Domains (1) summary
      cd15106
      Location:31 → 308
      7tmA_MrgprX-like; primate-specific mas-related G protein-coupled receptor subtype X-like, member of the class A family of seven-transmembrane G protein-coupled receptors

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

      Range
      19054455..19060717 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060935.1 Alternate T2T-CHM13v2.0

      Range
      19174588..19180847 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q96LB1.1 GenPept UniProtKB/Swiss-Prot:Q96LB1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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