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    SLC2A3 solute carrier family 2 member 3 [ Homo sapiens (human) ]

    Gene ID: 6515, updated on 28-Oct-2024

    Summary

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    Official Symbol
    SLC2A3provided by HGNC
    Official Full Name
    solute carrier family 2 member 3provided by HGNC
    Primary source
    HGNC:HGNC:11007
    See related
    Ensembl:ENSG00000059804 MIM:138170; AllianceGenome:HGNC:11007
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    GLUT3
    Summary
    Enables D-glucose binding activity; dehydroascorbic acid transmembrane transporter activity; and hexose transmembrane transporter activity. Involved in D-glucose import across plasma membrane; galactose transmembrane transport; and transport across blood-brain barrier. Located in aggresome and plasma membrane. Biomarker of Alzheimer's disease; acanthosis nigricans; diabetes mellitus; and type 2 diabetes mellitus. [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Biased expression in bone marrow (RPKM 183.0), placenta (RPKM 54.5) and 11 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See SLC2A3 in Genome Data Viewer
    Location:
    12p13.31
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (7919230..7936187, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (7933413..7950362, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (8071826..8088783, complement)

    Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene solute carrier family 2 member 14 Neighboring gene myosin light chain 9 pseudogene Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:8025026-8025706 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:8033506-8034091 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:8034092-8034676 Neighboring gene Sharpr-MPRA regulatory region 8483 Neighboring gene Nanog homeobox pseudogene 1 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr12:8057929-8058458 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:8060583-8061114 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:8062177-8062706 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:8065488-8066477 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:8086891-8087844 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4205 Neighboring gene CRISPRi-validated cis-regulatory element chr12.441 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5923 Neighboring gene CRISPRi-validated cis-regulatory element chr12.444 Neighboring gene CRISPRi-validated cis-regulatory element chr12.445 Neighboring gene uncharacterized LOC124902871 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:8120522-8121234 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:8121235-8121947 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:8123373-8124086 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr12:8134452-8135651 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:8145332-8146221 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:8147335-8148256 Neighboring gene ribosomal protein S20 pseudogene 28

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Brain tumor initiating cells adapt to restricted nutrition through preferential glucose uptake. Flavahan WA, et al. Nat Neurosci, 2013 Oct. PMID 23995067, Free PMC Article
    2. SLC2A3 rs12842 polymorphism and risk for Alzheimer's disease. Arseniou S, et al. Neurol Res, 2020 Oct. PMID 32627711
    3. Key Factors in Conformation Transformation of an Important Neuronic Protein Glucose Transport 3 Revealed by Molecular Dynamics Simulation. Sun M, et al. ACS Chem Neurosci, 2019 Nov 20. PMID 31617996
    4. Glucose transporter 3 gene variant is associated with survival outcome of patients with non-small cell lung cancer after surgical resection. Do SK, et al. Gene, 2019 Jun 30. PMID 30954677
    5. Upregulation of SLC2A3 gene and prognosis in colorectal carcinoma: analysis of TCGA data. Kim E, et al. BMC Cancer, 2019 Apr 3. PMID 30943948, Free PMC Article

    See all (152) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. SLC2A3 promotes tumor progression through lactic acid-promoted TGF-beta signaling pathway in oral squamous cell carcinoma.
      Title: SLC2A3 promotes tumor progression through lactic acid-promoted TGF-β signaling pathway in oral squamous cell carcinoma.
    2. Glut-3 Gene Knockdown as a Potential Strategy to Overcome Glioblastoma Radioresistance.
      Title: Glut-3 Gene Knockdown as a Potential Strategy to Overcome Glioblastoma Radioresistance.
    3. GLUT3 promotes macrophage signaling and function via RAS-mediated endocytosis in atopic dermatitis and wound healing.
      Title: GLUT3 promotes macrophage signaling and function via RAS-mediated endocytosis in atopic dermatitis and wound healing.
    4. Concurrent presence of diabetes affects the GLUT3 programming of glucose metabolism in glioblastoma.
      Title: Concurrent presence of diabetes affects the GLUT3 programming of glucose metabolism in glioblastoma.
    5. The YTHDC1/GLUT3/RNF183 axis forms a positive feedback loop that modulates glucose metabolism and bladder cancer progression.
      Title: The YTHDC1/GLUT3/RNF183 axis forms a positive feedback loop that modulates glucose metabolism and bladder cancer progression.
    6. Evolutionary balance between foldability and functionality of a glucose transporter.
      Title: Evolutionary balance between foldability and functionality of a glucose transporter.
    7. SLC2A3 variants in familial and sporadic congenital heart diseases in a Chinese Yunnan population.
      Title: SLC2A3 variants in familial and sporadic congenital heart diseases in a Chinese Yunnan population.
    8. RIP140 inhibits glycolysis-dependent proliferation of breast cancer cells by regulating GLUT3 expression through transcriptional crosstalk between hypoxia induced factor and p53.
      Title: RIP140 inhibits glycolysis-dependent proliferation of breast cancer cells by regulating GLUT3 expression through transcriptional crosstalk between hypoxia induced factor and p53.
    9. The glucose transporter GLUT3 controls T helper 17 cell responses through glycolytic-epigenetic reprogramming.
      Title: The glucose transporter GLUT3 controls T helper 17 cell responses through glycolytic-epigenetic reprogramming.
    10. miR-3189-targeted GLUT3 repression by HDAC2 knockdown inhibits glioblastoma tumorigenesis through regulating glucose metabolism and proliferation.
      Title: miR-3189-targeted GLUT3 repression by HDAC2 knockdown inhibits glioblastoma tumorigenesis through regulating glucose metabolism and proliferation.
    Submit: New GeneRIF Correction See all GeneRIFs (110)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    HIV-1 interactions

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    Replication interactions

    Interaction Pubs
    Knockdown of solute carrier family 2 (facilitated glucose transporter), member 3 (SLC2A3) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ90380

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables D-glucose binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables D-glucose transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables D-glucose transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables dehydroascorbic acid transmembrane transporter activity EXP
    Inferred from Experiment
    more info
    		 PubMed 
    NOT enables fructose transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables galactose transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in D-glucose import IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in D-glucose import across plasma membrane IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in D-glucose transmembrane transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in L-ascorbic acid metabolic process TAS
    Traceable Author Statement
    more info
    		  
    involved_in carbohydrate metabolic process NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in dehydroascorbic acid transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    NOT involved_in fructose transmembrane transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in galactose transmembrane transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in transport across blood-brain barrier IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in aggresome IDA
    Inferred from Direct Assay
    more info
    		  
    located_in cell projection IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in extracellular exosome HDA PubMed 
    located_in ficolin-1-rich granule membrane TAS
    Traceable Author Statement
    more info
    		  
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in perikaryon IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		  
    located_in plasma membrane IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
    		  
    located_in secretory granule membrane TAS
    Traceable Author Statement
    more info
    		  
    located_in specific granule membrane TAS
    Traceable Author Statement
    more info
    		  
    located_in tertiary granule membrane TAS
    Traceable Author Statement
    more info
    		  

    General protein information

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    Preferred Names
    solute carrier family 2, facilitated glucose transporter member 3
    Names
    GLUT-3
    glucose transporter type 3, brain
    solute carrier family 2 (facilitated glucose transporter), member 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_006931.3 → NP_008862.1  solute carrier family 2, facilitated glucose transporter member 3

      See identical proteins and their annotated locations for NP_008862.1

      Status: VALIDATED

      Source sequence(s)
      AC007536
      Consensus CDS
      CCDS8586.1
      UniProtKB/Swiss-Prot
      B2R606, D3DUU6, P11169, Q6I9U2, Q9UG15
      UniProtKB/TrEMBL
      B7Z966
      Related
      ENSP00000075120.7, ENST00000075120.12
      Conserved Domains (1) summary
      cd17431
      Location:12 → 456
      MFS_GLUT_Class1; Class 1 Glucose transporters (GLUTs) of the Major Facilitator Superfamily

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

      Range
      7919230..7936187 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060936.1 Alternate T2T-CHM13v2.0

      Range
      7933413..7950362 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P11169.1 GenPept UniProtKB/Swiss-Prot:P11169

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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