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    PPP4C protein phosphatase 4 catalytic subunit [ Homo sapiens (human) ]

    Gene ID: 5531, updated on 28-Oct-2024

    Summary

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    Official Symbol
    PPP4Cprovided by HGNC
    Official Full Name
    protein phosphatase 4 catalytic subunitprovided by HGNC
    Primary source
    HGNC:HGNC:9319
    See related
    Ensembl:ENSG00000149923 MIM:602035; AllianceGenome:HGNC:9319
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PP4; PPX; PP-X; PP4C; PPH3; PPP4
    Summary
    Enables protein serine/threonine phosphatase activity. Involved in regulation of double-strand break repair via homologous recombination. Located in cytosol; nucleoplasm; and plasma membrane. Part of chromatin and protein phosphatase 4 complex. [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Ubiquitous expression in testis (RPKM 31.5), placenta (RPKM 25.7) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See PPP4C in Genome Data Viewer
    Location:
    16p11.2
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (30075994..30085376)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (30358641..30368019)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (30087315..30096697)

    Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene chromosome 16 open reading frame 92 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:30039801-30040645 Neighboring gene TLC domain containing 3B Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7348 Neighboring gene MPRA-validated peak2562 silencer Neighboring gene uncharaterized LOC112694756 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:30064875-30065853 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:30065854-30066831 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:30076132-30076912 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7349 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7350 Neighboring gene aldolase, fructose-bisphosphate A Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10688 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7351 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10689 Neighboring gene ReSE screen-validated silencer GRCh37_chr16:30096821-30096985 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:30101709-30102582 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7352 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10690 Neighboring gene T-box transcription factor 6 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:30107354-30107960 Neighboring gene yippee like 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. PP4C facilitates lung cancer proliferation and inhibits apoptosis via activating MAPK/ERK pathway. Wang B, et al. Pathol Res Pract, 2020 May. PMID 32139257
    2. Protein phosphatase 4 regulates apoptosis, proliferation and mutation rate of human cells. Mourtada-Maarabouni M, et al. Biochim Biophys Acta, 2008 Aug. PMID 18424272
    3. Protein phosphatase 4 regulates apoptosis in leukemic and primary human T-cells. Mourtada-Maarabouni M, et al. Leuk Res, 2009 Nov. PMID 19539371, Free PMC Article
    4. Overexpression of protein phosphatase 4 correlates with poor prognosis in patients with stage II pancreatic ductal adenocarcinoma. Weng S, et al. Cancer Epidemiol Biomarkers Prev, 2012 Aug. PMID 22665577, Free PMC Article
    5. Suppression of Ser/Thr phosphatase 4 (PP4C/PPP4C) mimics a novel post-mitotic action of fostriecin, producing mitotic slippage followed by tetraploid cell death. Theobald B, et al. Mol Cancer Res, 2013 Aug. PMID 23671329, Free PMC Article

    See all (112) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Comprehensive analysis of PPP4C's impact on prognosis, immune microenvironment, and immunotherapy response in lung adenocarcinoma using single-cell sequencing and multi-omics.
      Title: Comprehensive analysis of PPP4C's impact on prognosis, immune microenvironment, and immunotherapy response in lung adenocarcinoma using single-cell sequencing and multi-omics.
    2. AMBRA1 promotes intestinal inflammation by antagonizing PP4R1/PP4c mediated IKK dephosphorylation in an autophagy-independent manner.
      Title: AMBRA1 promotes intestinal inflammation by antagonizing PP4R1/PP4c mediated IKK dephosphorylation in an autophagy-independent manner.
    3. DOK3 promotes atopic dermatitis by enabling the phosphatase PP4C to inhibit the T cell signaling mediator CARD11.
      Title: DOK3 promotes atopic dermatitis by enabling the phosphatase PP4C to inhibit the T cell signaling mediator CARD11.
    4. Protein Phosphatase 4 Is Required for Centrobin Function in DNA Damage Repair.
      Title: Protein Phosphatase 4 Is Required for Centrobin Function in DNA Damage Repair.
    5. SIRT1 regulates DNA damage signaling through the PP4 phosphatase complex.
      Title: SIRT1 regulates DNA damage signaling through the PP4 phosphatase complex.
    6. Loss of PP4 contributes to diesel exhaust particles-induced epithelial barrier integrity disruption and alarmins release.
      Title: Loss of PP4 contributes to diesel exhaust particles-induced epithelial barrier integrity disruption and alarmins release.
    7. Comprehensive analysis of PPPCs family reveals the clinical significance of PPP1CA and PPP4C in breast cancer.
      Title: Comprehensive analysis of PPPCs family reveals the clinical significance of PPP1CA and PPP4C in breast cancer.
    8. PP4C facilitates lung cancer proliferation and inhibits apoptosis via activating MAPK/ERK pathway.
      Title: PP4C facilitates lung cancer proliferation and inhibits apoptosis via activating MAPK/ERK pathway.
    9. Sciatic nerve but not spinal injury induces calcium-dependent PP4 activity that is required for HDAC3 dephosphorylation.
      Title: PP4-dependent HDAC3 dephosphorylation discriminates between axonal regeneration and regenerative failure.
    10. PP4 regulates breast cancer cell survival and identifies a novel PP4c-PEA15 signalling axis in the control of breast cancer cell survival.
      Title: The protein phosphatase 4 - PEA15 axis regulates the survival of breast cancer cells.
    Submit: New GeneRIF Correction See all GeneRIFs (37)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Biological insights from 108 schizophrenia-associated genetic loci.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables myosin phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein serine/threonine phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine phosphatase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein serine/threonine phosphatase activity NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in double-strand break repair via homologous recombination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of double-strand break repair IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of double-strand break repair via homologous recombination IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in centrosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in chromatin IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		  
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		  
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		  
    part_of protein phosphatase 4 complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    serine/threonine-protein phosphatase 4 catalytic subunit
    Names
    epididymis secretory sperm binding protein
    protein phosphatase 4 (formerly X), catalytic subunit
    protein phosphatase X, catalytic subunit
    NP_001290432.1
    NP_001290433.1
    NP_001290435.1
    NP_001290436.1
    NP_002711.1
    XP_006721124.1
    XP_054169384.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001303503.2 → NP_001290432.1  serine/threonine-protein phosphatase 4 catalytic subunit isoform 1

      See identical proteins and their annotated locations for NP_001290432.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1). Both variants 1 and 2 encode the same isoform (1).
      Source sequence(s)
      AA765831, AF097996, BC001416, BG705710
      Consensus CDS
      CCDS10669.1
      UniProtKB/Swiss-Prot
      P33172, P60510
      UniProtKB/TrEMBL
      A0A024R625, Q5U086
      Conserved Domains (1) summary
      cd07415
      Location:6 → 290
      MPP_PP2A_PP4_PP6; PP2A, PP4, and PP6 phosphoprotein phosphatases, metallophosphatase domain

    2. NM_001303504.2 → NP_001290433.1  serine/threonine-protein phosphatase 4 catalytic subunit isoform 2

      See identical proteins and their annotated locations for NP_001290433.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and lacks an alternate in-frame exon in the central coding region, compared to variant 1. It encodes isoform 2 which is shorter compared to isoform 1.
      Source sequence(s)
      AA765831, AF097996, BG705710, BQ220878
      UniProtKB/TrEMBL
      H3BTA2
      Related
      ENSP00000457089.1, ENST00000562664.5
      Conserved Domains (1) summary
      cd07415
      Location:6 → 256
      MPP_PP2A_PP4_PP6; PP2A, PP4, and PP6 phosphoprotein phosphatases, metallophosphatase domain

    3. NM_001303506.2 → NP_001290435.1  serine/threonine-protein phosphatase 4 catalytic subunit isoform 3

      See identical proteins and their annotated locations for NP_001290435.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR, uses an alternate splice site in an internal exon and uses a downstream start codon compared to variant 1. It encodes isoform 3 which has a shorter N-terminus compared to isoform 1. Both variants 4 and 5 encode the same isoform (3).
      Source sequence(s)
      AA765831, AF097996, BG705710, BG741669
      UniProtKB/TrEMBL
      H3BTA2
      Conserved Domains (1) summary
      cd07415
      Location:1 → 211
      MPP_PP2A_PP4_PP6; PP2A, PP4, and PP6 phosphoprotein phosphatases, metallophosphatase domain

    4. NM_001303507.2 → NP_001290436.1  serine/threonine-protein phosphatase 4 catalytic subunit isoform 3

      See identical proteins and their annotated locations for NP_001290436.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) differs in the 5' UTR, lacks an alternate internal exon and uses a downstream start codon compared to variant 1. It encodes isoform 3 which has a shorter N-terminus compared to isoform 1. Both variants 4 and 5 encode the same isoform (3).
      Source sequence(s)
      AA765831, AF097996, AL519181, BG706310
      UniProtKB/TrEMBL
      H3BTA2
      Conserved Domains (1) summary
      cd07415
      Location:1 → 211
      MPP_PP2A_PP4_PP6; PP2A, PP4, and PP6 phosphoprotein phosphatases, metallophosphatase domain

    5. NM_002720.3 → NP_002711.1  serine/threonine-protein phosphatase 4 catalytic subunit isoform 1

      See identical proteins and their annotated locations for NP_002711.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same isoform (1).
      Source sequence(s)
      AA765831, AF097996, BG705710
      Consensus CDS
      CCDS10669.1
      UniProtKB/Swiss-Prot
      P33172, P60510
      UniProtKB/TrEMBL
      A0A024R625, Q5U086
      Related
      ENSP00000279387.7, ENST00000279387.12
      Conserved Domains (1) summary
      cd07415
      Location:6 → 290
      MPP_PP2A_PP4_PP6; PP2A, PP4, and PP6 phosphoprotein phosphatases, metallophosphatase domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

      Range
      30075994..30085376
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006721061.5 → XP_006721124.1  serine/threonine-protein phosphatase 4 catalytic subunit isoform X1

      See identical proteins and their annotated locations for XP_006721124.1

      UniProtKB/TrEMBL
      H3BTA2
      Conserved Domains (1) summary
      cd07415
      Location:6 → 256
      MPP_PP2A_PP4_PP6; PP2A, PP4, and PP6 phosphoprotein phosphatases, metallophosphatase domain

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060940.1 Alternate T2T-CHM13v2.0

      Range
      30358641..30368019
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054313409.1 → XP_054169384.1  serine/threonine-protein phosphatase 4 catalytic subunit isoform X1

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P60510.1 GenPept UniProtKB/Swiss-Prot:P60510

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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