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    DHRS7 dehydrogenase/reductase 7 [ Homo sapiens (human) ]

    Gene ID: 51635, updated on 28-Oct-2024

    Summary

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    Official Symbol
    DHRS7provided by HGNC
    Official Full Name
    dehydrogenase/reductase 7provided by HGNC
    Primary source
    HGNC:HGNC:21524
    See related
    Ensembl:ENSG00000100612 MIM:612833; AllianceGenome:HGNC:21524
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CGI-86; SDR34C1; retDSR4; retSDR4
    Summary
    This gene encodes a member of the short-chain dehydrogenases/reductases (SDR) family, which has over 46,000 members. Members in this family are enzymes that metabolize many different compounds, such as steroid hormones, prostaglandins, retinoids, lipids and xenobiotics. [provided by RefSeq, Apr 2016]
    Expression
    Broad expression in prostate (RPKM 116.8), small intestine (RPKM 40.2) and 22 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See DHRS7 in Genome Data Viewer
    Location:
    14q23.1
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 14 NC_000014.9 (60144119..60169889, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 14 NC_060938.1 (54350401..54376186, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (60610837..60636607, complement)

    Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene H3K27ac hESC enhancer GRCh37_chr14:60124167-60124668 Neighboring gene H3K27ac hESC enhancer GRCh37_chr14:60124669-60125168 Neighboring gene reticulon 1 Neighboring gene microRNA 5586 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5807 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr14:60386022-60387221 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8463 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8462 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8464 Neighboring gene leucine rich repeat containing 9 Neighboring gene ReSE screen-validated silencer GRCh37_chr14:60459076-60459307 Neighboring gene PCNX4 divergent transcript Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8465 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8466 Neighboring gene H3K27ac hESC enhancer GRCh37_chr14:60558835-60559468 Neighboring gene Sharpr-MPRA regulatory region 1153 Neighboring gene pecanex 4 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8467 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8468 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5808 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8469 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8470 Neighboring gene short coiled-coil protein pseudogene 1 Neighboring gene proteasome subunit alpha 3 pseudogene 1 Neighboring gene ribosomal protein L17 pseudogene 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Reduction in Nuclear Size by DHRS7 in Prostate Cancer Cells and by Estradiol Propionate in DHRS7-Depleted Cells. Rizzotto A, et al. Cells, 2023 Dec 27. PMID 38201261, Free PMC Article
    2. Biochemical properties of human dehydrogenase/reductase (SDR family) member 7. Stambergova H, et al. Chem Biol Interact, 2014 Jan 25. PMID 24246760
    3. Purification and reconstitution of human membrane-bound DHRS7 (SDR34C1) from Sf9 cells. Skarka A, et al. Protein Expr Purif, 2014 Mar. PMID 24316191
    4. Human DHRS7, promising enzyme in metabolism of steroids and retinoids? Štambergová H, et al. J Steroid Biochem Mol Biol, 2016 Jan. PMID 26466768
    5. The identification of new substrates of human DHRS7 by molecular modeling and in vitro testing. Zemanová L, et al. Int J Biol Macromol, 2017 Dec. PMID 28687384

    See all (52) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Reduction in Nuclear Size by DHRS7 in Prostate Cancer Cells and by Estradiol Propionate in DHRS7-Depleted Cells.
      Title: Reduction in Nuclear Size by DHRS7 in Prostate Cancer Cells and by Estradiol Propionate in DHRS7-Depleted Cells.
    2. Single nucleotide polymorphism in DHRS7 gene is associated with smoking in African americans.
      Title: An Exome-Wide Association Study Identifies New Susceptibility Loci for Age of Smoking Initiation in African- and European-American Populations.
    3. identification of new substrates of human DHRS7
      Title: The identification of new substrates of human DHRS7 by molecular modeling and in vitro testing.
    4. Data suggest that (1) cortisone is a substrate of DHRS7 and is reduced to 20beta-dihydrocortisone, (2) androstenedione is not a relevant substrate of DHRS7, (3) DHRS7 catalyzes the oxidoreduction of 5alpha-dihydrotestosterone to 3alpha-androstanediol with a suppressive effect on androgen receptor transcriptional activity, and (4) DHRS7 is anchored in endoplasmic reticulum membrane with cytoplasmic orientation.
      Title: DHRS7 (SDR34C1) - A new player in the regulation of androgen receptor function by inactivation of 5α-dihydrotestosterone?
    5. DHRS7 participates in the reductive metabolism of steroids and retinoids.Expression patterns of DHRS7 at the mRNA as well as protein level were determined in a panel of various human tissue samples.
      Title: Human DHRS7, promising enzyme in metabolism of steroids and retinoids?
    6. DHRS7 containing TEV-cleavable His10 and FLAG-tag was cloned and expressed in the Sf9 cell line.
      Title: Purification and reconstitution of human membrane-bound DHRS7 (SDR34C1) from Sf9 cells.
    7. DHRS7 is another enzyme from SDR superfamily that have been proved, at least in vitro, to contribute to the metabolism of xenobiotics with carbonyl group.
      Title: Biochemical properties of human dehydrogenase/reductase (SDR family) member 7.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    A genome-wide meta-analysis of genetic variants associated with allergic rhinitis and grass sensitization and their interaction with birth order.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables all-trans-retinol dehydrogenase (NADP+) activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables carbonyl reductase (NADPH) activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in retinol metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane HDA PubMed 

    General protein information

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    Preferred Names
    dehydrogenase/reductase SDR family member 7
    Names
    dehydrogenase/reductase (SDR family) member 7
    retinal short-chain dehydrogenase/reductase 4
    short chain dehydrogenase/reductase family 34C member 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001322280.2 → NP_001309209.1  dehydrogenase/reductase SDR family member 7 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL163853
      Consensus CDS
      CCDS81810.1
      UniProtKB/Swiss-Prot
      Q9Y394
      Related
      ENSP00000442993.2, ENST00000536410.6
      Conserved Domains (1) summary
      cd05332
      Location:2 → 258
      11beta-HSD1_like_SDR_c; 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1)-like, classical (c) SDRs

    2. NM_001322281.2 → NP_001309210.1  dehydrogenase/reductase SDR family member 7 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AL163853
      Conserved Domains (1) summary
      cl21454
      Location:1 → 168
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

    3. NM_001322282.2 → NP_001309211.1  dehydrogenase/reductase SDR family member 7 isoform 4 precursor

      Status: VALIDATED

      Source sequence(s)
      AL163853
      Conserved Domains (1) summary
      cl21454
      Location:48 → 228
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

    4. NM_016029.4 → NP_057113.1  dehydrogenase/reductase SDR family member 7 isoform 1 precursor

      See identical proteins and their annotated locations for NP_057113.1

      Status: VALIDATED

      Source sequence(s)
      AL163853
      Consensus CDS
      CCDS9743.1
      UniProtKB/Swiss-Prot
      B2R896, Q9UKU2, Q9Y394
      UniProtKB/TrEMBL
      Q659E8
      Related
      ENSP00000451882.1, ENST00000557185.6
      Conserved Domains (1) summary
      cd05332
      Location:48 → 308
      11beta-HSD1_like_SDR_c; 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1)-like, classical (c) SDRs

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000014.9 Reference GRCh38.p14 Primary Assembly

      Range
      60144119..60169889 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060938.1 Alternate T2T-CHM13v2.0

      Range
      54350401..54376186 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9Y394.1 GenPept UniProtKB/Swiss-Prot:Q9Y394

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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