ESRRG estrogen related receptor gamma [Homo sapiens (human)] - Gene

Summary

Official Symbol: ESRRGprovided by HGNC
Official Full Name: estrogen related receptor gammaprovided by HGNC
Primary source: HGNC:HGNC:3474
See related: Ensembl:ENSG00000196482 MIM:602969; AllianceGenome:HGNC:3474
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: ERR3; ERRg; NR3B3; ERRgamma; ERR-gamma
Summary: This gene encodes a member of the estrogen receptor-related receptor (ESRR) family, which belongs to the nuclear hormone receptor superfamily. All members of the ESRR family share an almost identical DNA binding domain, which is composed of two C4-type zinc finger motifs. The ESRR members are orphan nuclear receptors; they bind to the estrogen response element and steroidogenic factor 1 response element, and activate genes controlled by both response elements in the absence of any ligands. The ESRR family is closely related to the estrogen receptor (ER) family. They share target genes, co-regulators and promoters, and by targeting the same set of genes, the ESRRs seem to interfere with the ER-mediated estrogen response in various ways. It has been reported that the family member encoded by this gene functions as a transcriptional activator of DNA cytosine-5-methyltransferases 1 (Dnmt1) expression by direct binding to its response elements in the DNMT1 promoters, modulates cell proliferation and estrogen signaling in breast cancer, and negatively regulates bone morphogenetic protein 2-induced osteoblast differentiation and bone formation. Multiple alternatively spliced transcript variants have been identified, which mainly differ at the 5' end and some of which encode protein isoforms differing in the N-terminal region. [provided by RefSeq, Aug 2011]
Expression: Biased expression in kidney (RPKM 4.4), stomach (RPKM 3.1) and 12 other tissues See more
Orthologs: mouse all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: 1q41

Exon count:: 29

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	1	NC_000001.11 (216503246..217137702, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	1	NC_060925.1 (215743580..216378774, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	1	NC_000001.10 (216676588..217311044, complement)

Chromosome 1 - NC_000001.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

ERRalpha and ERRgamma coordinate expression of genes associated with Alzheimer's disease, inhibiting DKK1 to suppress tau phosphorylation.
Title: ERRα and ERRγ coordinate expression of genes associated with Alzheimer's disease, inhibiting DKK1 to suppress tau phosphorylation.
ERRgamma-inducible FGF23 promotes alcoholic liver injury through enhancing CYP2E1 mediated hepatic oxidative stress.
Title: ERRγ-inducible FGF23 promotes alcoholic liver injury through enhancing CYP2E1 mediated hepatic oxidative stress.
Estrogen receptor-related receptor gamma uppresses hypoxia-induced angiogenesis by regulating VEGFA in endometrial cancer.
Title: Estrogen receptor-related receptor γ uppresses hypoxia-induced angiogenesis by regulating VEGFA in endometrial cancer.
Role of Estrogen-Related Receptor gamma and PGC-1alpha/SIRT3 Pathway in Early Brain Injury After Subarachnoid Hemorrhage.
Title: Role of Estrogen-Related Receptor γ and PGC-1α/SIRT3 Pathway in Early Brain Injury After Subarachnoid Hemorrhage.
Nuclear receptor estrogen-related receptor gamma suppresses colorectal cancer aggressiveness by regulating Wnt/beta-catenin signaling.
Title: Nuclear receptor estrogen-related receptor gamma suppresses colorectal cancer aggressiveness by regulating Wnt/β-catenin signaling.
Sex-specific effects of bisphenol A on the signaling pathway of ESRRG in the human placentadagger.
Title: Sex-specific effects of bisphenol A on the signaling pathway of ESRRG in the human placenta†.
The nuclear receptor ERR cooperates with the cardiogenic factor GATA4 to orchestrate cardiomyocyte maturation.
Title: The nuclear receptor ERR cooperates with the cardiogenic factor GATA4 to orchestrate cardiomyocyte maturation.
Lupus susceptibility gene Esrrg modulates regulatory T cells through mitochondrial metabolism.
Title: Lupus susceptibility gene Esrrg modulates regulatory T cells through mitochondrial metabolism.
Estrogen-related receptor-gamma influences Helicobacter pylori infection by regulating TFF1 in gastric cancer.
Title: Estrogen-related receptor-gamma influences Helicobacter pylori infection by regulating TFF1 in gastric cancer.
Expression of estrogen-related receptors in ovarian cancer and impact on survival.
Title: Expression of estrogen-related receptors in ovarian cancer and impact on survival.

Submit: New GeneRIF Correction See all GeneRIFs (77)

Phenotypes

Go to the top of the page Help

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
A meta-analysis of two genome-wide association studies to identify novel loci for maximum number of alcoholic drinks. EBI GWAS Catalog EBI GWAS CatalogPubMed
Common genetic variation and antidepressant efficacy in major depressive disorder: a meta-analysis of three genome-wide pharmacogenetic studies. EBI GWAS Catalog EBI GWAS CatalogPubMed
Gene-alcohol interactions identify several novel blood pressure loci including a promising locus near SLC16A9. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genome-wide association identifies ATOH7 as a major gene determining human optic disc size. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genome-wide association scan for survival on dialysis in African-Americans with type 2 diabetes. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genome-wide association study of chemotherapeutic agent-induced severe neutropenia/leucopenia for patients in Biobank Japan. EBI GWAS Catalog EBI GWAS CatalogPubMed
Hypertrophy-associated polymorphisms ascertained in a founder cohort applied to heart failure risk and mortality. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

Go to the top of the page Help

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Markers

D1S1838E (e-PCR)
- UniSTS:18179

D1S3320 (e-PCR)
- UniSTS:51205

D1S490 (e-PCR)
- UniSTS:782

D1S227 (e-PCR), detects polymorphism
- UniSTS:58643

D1S2424 (e-PCR)
- UniSTS:36116

RH123324 (e-PCR)
- UniSTS:135701

D10S275 (e-PCR)
- UniSTS:147992

SHGC-86241 (e-PCR)
- UniSTS:104475

D1S227 (e-PCR), detects polymorphism
- UniSTS:14119

D1S2422 (e-PCR)
- UniSTS:48168

ESRRG (e-PCR)
- UniSTS:506422

SHGC-147669 (e-PCR)
- UniSTS:175942

AL010110 (e-PCR)
- UniSTS:16714

AL033895 (e-PCR)
- UniSTS:93771

ESRRG_2260 (e-PCR)
- UniSTS:280660

D1S490 (e-PCR)
- UniSTS:67159

SHGC-79099 (e-PCR)
- UniSTS:170092

D1S229 (e-PCR), detects polymorphism
- UniSTS:5997

G18039 (e-PCR)
- UniSTS:28274

242XF6 (e-PCR)
- UniSTS:36219

SHGC-56916 (e-PCR)
- UniSTS:14716

AL033738 (e-PCR)
- UniSTS:93607

G20464 (e-PCR)
- UniSTS:39854

WI-12511 (e-PCR)
- UniSTS:1717

RH16932 (e-PCR)
- UniSTS:88001

AL033966 (e-PCR)
- UniSTS:93378

SHGC-84976 (e-PCR)
- UniSTS:104902

144XF2 (e-PCR)
- UniSTS:13785

PMC137182P10 (e-PCR)
- UniSTS:270821

PMC137182P11 (e-PCR)
- UniSTS:270822

D5S1597E (e-PCR)
- UniSTS:151019

AL034041 (e-PCR)
- UniSTS:93936

RH120145 (e-PCR)
- UniSTS:132350

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables AF-2 domain binding	ISS Inferred from Sequence or Structural Similarity more info
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	ISA Inferred from Sequence Alignment more info
enables estrogen response element binding	IBA Inferred from Biological aspect of Ancestor more info
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables nuclear receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables nuclear steroid receptor activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables sequence-specific double-stranded DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables steroid binding	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in nuclear receptor-mediated steroid hormone signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of cold-induced thermogenesis	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in retinoic acid receptor signaling pathway	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in chromatin	IBA Inferred from Biological aspect of Ancestor more info
located_in chromatin	ISA Inferred from Sequence Alignment more info
located_in nucleoplasm	TAS Traceable Author Statement more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

Go to the top of the page Help

Preferred Names: estrogen-related receptor gamma

Names: ERR gamma-2; estrogen receptor-related protein 3; nuclear receptor subfamily 3 group B member 3

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_029784.1 RefSeqGene

Range

419327..639505

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001134285.3 → NP_001127757.1 estrogen-related receptor gamma isoform 2

See identical proteins and their annotated locations for NP_001127757.1

Status: REVIEWED

Description

Transcript Variant: This variant (4) lacks the 5' exon but has three alternate 5' exons and uses a downstream AUG start codon, compared to variant 1. The resulting isoform (2) is shorter at the N-terminus, compared to isoform 1. Variants 2-4, 9-15, and 17-21 encode the same isoform.

Source sequence(s)

AB020639, BU752915, BX647076

Consensus CDS

CCDS1517.1

UniProtKB/TrEMBL

C0SQ93, F1D8R6

Related

ENSP00000355907.2, ENST00000366940.6

Conserved Domains (2) summary

cd06946
Location:214 → 433

NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors

cd07170
Location:99 → 195

NR_DBD_ERR; DNA-binding domain of estrogen related receptors (ERR) is composed of two C4-type zinc fingers
NM_001243505.2 → NP_001230434.1 estrogen-related receptor gamma isoform 3

See identical proteins and their annotated locations for NP_001230434.1

Status: REVIEWED

Description

Transcript Variant: This variant (6) lacks three exons from the 5' end but has alternate three 5' exons and uses a downstream AUG start codon, compared to variant 1. The resulting isoform (3) is shorter at the N-terminus, compared to isoform 1.

Source sequence(s)

AB020639, BM723962, BU752915

UniProtKB/Swiss-Prot

P62508

Conserved Domains (1) summary

cd06946
Location:1 → 205

NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors
NM_001243506.2 → NP_001230435.1 estrogen-related receptor gamma isoform 4

See identical proteins and their annotated locations for NP_001230435.1

Status: REVIEWED

Description

Transcript Variant: This variant (7) lacks two exons from the 5' end but has two alternate 5' exons and uses a downstream AUG start codon, compared to variant 1. The resulting isoform (4) is shorter at the N-terminus, compared to isoform 1.

Source sequence(s)

AB020639, AK298851, BP349857, BU752915

UniProtKB/TrEMBL

B7Z5E9

Conserved Domains (2) summary

cd06946
Location:52 → 271

NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors

cl02596
Location:1 → 33

NR_DBD_like; DNA-binding domain of nuclear receptors is composed of two C4-type zinc fingers
NM_001243507.2 → NP_001230436.1 estrogen-related receptor gamma isoform 5

See identical proteins and their annotated locations for NP_001230436.1

Status: REVIEWED

Description

Transcript Variant: This variant (8) lacks a 5' exon and an internal in-frame exon but has three alternate 5' exons and uses a downstream AUG start codon, compared to variant 1. The resulting isoform (5, also known as ERRgamma3) is shorter at the N-terminus and lacks an internal segment corresponding to the second zinc finger motif of the DNA binding domain (PMID:16460929), compared to isoform 1.

Source sequence(s)

AB020639, AB362218, AC096634, AK131193, BU752915, DB220304

Consensus CDS

CCDS58060.1

UniProtKB/TrEMBL

C0SQ93

Related

ENSP00000418629.1, ENST00000463665.5

Conserved Domains (2) summary

cd06946
Location:175 → 394

NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors

cl02596
Location:99 → 156

NR_DBD_like; DNA-binding domain of nuclear receptors is composed of two C4-type zinc fingers
NM_001243509.2 → NP_001230438.1 estrogen-related receptor gamma isoform 2

See identical proteins and their annotated locations for NP_001230438.1

Status: REVIEWED

Description

Transcript Variant: This variant (9) lacks the 5' exon but has three alternate 5' exons and uses a downstream AUG start codon, compared to variant 1. The resulting isoform (2) is shorter at the N-terminus, compared to isoform 1. Variants 2-4, 9-15, and 17-21 encode the same isoform.

Source sequence(s)

AB020639, AB362218, AC096634, BU752915, DB220304

Consensus CDS

CCDS1517.1

UniProtKB/TrEMBL

C0SQ93, F1D8R6

Related

ENSP00000417374.1, ENST00000493748.5

Conserved Domains (2) summary

cd06946
Location:214 → 433

NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors

cd07170
Location:99 → 195

NR_DBD_ERR; DNA-binding domain of estrogen related receptors (ERR) is composed of two C4-type zinc fingers
NM_001243510.3 → NP_001230439.1 estrogen-related receptor gamma isoform 2

See identical proteins and their annotated locations for NP_001230439.1

Status: REVIEWED

Description

Transcript Variant: This variant (10) uses an alternate exon structure in the 5' UTR and 5' coding region, compared to variant 1. This results in a distinct 5' UTR and use of a downstream in-frame start codon. The encoded isoform (2) has a shorter N-terminus compared to isoform 1. Variants 2-4, 9-15, and 17-21 encode the same isoform.

Source sequence(s)

AB020639, AY388457, BU752915, BX647076, DA293919

Consensus CDS

CCDS1517.1

UniProtKB/TrEMBL

C0SQ93, F1D8R6

Related

ENSP00000419594.1, ENST00000493603.5

Conserved Domains (2) summary

cd06946
Location:214 → 433

NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors

cd07170
Location:99 → 195

NR_DBD_ERR; DNA-binding domain of estrogen related receptors (ERR) is composed of two C4-type zinc fingers
NM_001243511.3 → NP_001230440.1 estrogen-related receptor gamma isoform 2

See identical proteins and their annotated locations for NP_001230440.1

Status: REVIEWED

Description

Transcript Variant: This variant (11) uses an alternate exon structure in the 5' UTR and 5' coding region, compared to variant 1. This results in a distinct 5' UTR and use of a downstream in-frame start codon. The encoded isoform (2) has a shorter N-terminus compared to isoform 1. Variants 2-4, 9-15, and 17-21 encode the same isoform.

Source sequence(s)

AB020639, AY388460, BU752915, BX647076, DA293919

Consensus CDS

CCDS1517.1

UniProtKB/TrEMBL

C0SQ93, F1D8R6

Conserved Domains (2) summary

cd06946
Location:214 → 433

NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors

cd07170
Location:99 → 195

NR_DBD_ERR; DNA-binding domain of estrogen related receptors (ERR) is composed of two C4-type zinc fingers
NM_001243512.1 → NP_001230441.1 estrogen-related receptor gamma isoform 2

See identical proteins and their annotated locations for NP_001230441.1

Status: REVIEWED

Description

Transcript Variant: This variant (12) lacks the 5' exon but has more than three alternate 5' exons and uses a downstream AUG start codon, compared to variant 1. The resulting isoform (2) is shorter at the N-terminus, compared to isoform 1. Variants 2-4, 9-15, and 17-21 encode the same isoform.

Source sequence(s)

AB020639, AB362218, AK131193, AY388458, BU752915

Consensus CDS

CCDS1517.1

UniProtKB/TrEMBL

C0SQ93, F1D8R6

Related

ENSP00000419155.1, ENST00000487276.5

Conserved Domains (2) summary

cd06946
Location:214 → 433

NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors

cd07170
Location:99 → 195

NR_DBD_ERR; DNA-binding domain of estrogen related receptors (ERR) is composed of two C4-type zinc fingers
NM_001243513.1 → NP_001230442.1 estrogen-related receptor gamma isoform 2

See identical proteins and their annotated locations for NP_001230442.1

Status: REVIEWED

Description

Transcript Variant: This variant (13) lacks the 5' exon but has more than two alternate 5' exons and uses a downstream AUG start codon, compared to variant 1. The resulting isoform (2) is shorter at the N-terminus, compared to isoform 1. Variants 2-4, 9-15, and 17-21 encode the same isoform.

Source sequence(s)

AB020639, AB362218, AY388459, BU752915

Consensus CDS

CCDS1517.1

UniProtKB/TrEMBL

C0SQ93, F1D8R6

Related

ENSP00000355905.2, ENST00000366938.6

Conserved Domains (2) summary

cd06946
Location:214 → 433

NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors

cd07170
Location:99 → 195

NR_DBD_ERR; DNA-binding domain of estrogen related receptors (ERR) is composed of two C4-type zinc fingers
NM_001243514.2 → NP_001230443.1 estrogen-related receptor gamma isoform 2

See identical proteins and their annotated locations for NP_001230443.1

Status: REVIEWED

Description

Transcript Variant: This variant (14) lacks the 5' exon but has an alternate 5' exon and uses a downstream AUG start codon, compared to variant 1. The resulting isoform (2) is shorter at the N-terminus, compared to isoform 1. Variants 2-4, 9-15, and 17-21 encode the same isoform.

Source sequence(s)

AB020639, AC096635, AY388461, BU752915

Consensus CDS

CCDS1517.1

UniProtKB/TrEMBL

C0SQ93, F1D8R6

Related

ENSP00000353108.3, ENST00000360012.7

Conserved Domains (2) summary

cd06946
Location:214 → 433

NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors

cd07170
Location:99 → 195

NR_DBD_ERR; DNA-binding domain of estrogen related receptors (ERR) is composed of two C4-type zinc fingers
NM_001243515.2 → NP_001230444.1 estrogen-related receptor gamma isoform 2

See identical proteins and their annotated locations for NP_001230444.1

Status: REVIEWED

Description

Transcript Variant: This variant (15) has two additional exons in the 5' region and uses a downstream AUG start codon, compared to variant 1. The resulting isoform (2) is shorter at the N-terminus, compared to isoform 1. Variants 2-4, 9-15, and 17-21 encode the same isoform.

Source sequence(s)

AB020639, AK290945, BU752915, DA720944, DA722064

Consensus CDS

CCDS1517.1

UniProtKB/TrEMBL

C0SQ93, F1D8R6

Conserved Domains (2) summary

cd06946
Location:214 → 433

NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors

cd07170
Location:99 → 195

NR_DBD_ERR; DNA-binding domain of estrogen related receptors (ERR) is composed of two C4-type zinc fingers
NM_001243518.2 → NP_001230447.1 estrogen-related receptor gamma isoform 6

See identical proteins and their annotated locations for NP_001230447.1

Status: REVIEWED

Description

Transcript Variant: This variant (16) has an additional exon in the 5' region, which includes an AUG start codon, and an additional segment in the middle region, compared to variant 1. The resulting isoform (6) has a longer and distinct N-terminus and an additional internal segment, compared to isoform 1.

Source sequence(s)

AB020639, BC064700, BU752915

Consensus CDS

CCDS58061.1

UniProtKB/TrEMBL

C0SQ93

Related

ENSP00000355904.1, ENST00000366937.5

Conserved Domains (2) summary

cd06946
Location:249 → 468

NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors

cd07170
Location:127 → 223

NR_DBD_ERR; DNA-binding domain of estrogen related receptors (ERR) is composed of two C4-type zinc fingers
NM_001243519.2 → NP_001230448.1 estrogen-related receptor gamma isoform 2

See identical proteins and their annotated locations for NP_001230448.1

Status: REVIEWED

Description

Transcript Variant: This variant (17) has an additional segment in the 5' region and uses a downstream AUG start codon, compared to variant 1. The resulting isoform (2) is shorter at the N-terminus, compared to isoform 1. Variants 2-4, 9-15, and 17-21 encode the same isoform.

Source sequence(s)

AB020639, BC008218, BU752915, DA720944

Consensus CDS

CCDS1517.1

UniProtKB/TrEMBL

C0SQ93, F1D8R6

Related

ENSP00000375761.4, ENST00000391890.7

Conserved Domains (2) summary

cd06946
Location:214 → 433

NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors

cd07170
Location:99 → 195

NR_DBD_ERR; DNA-binding domain of estrogen related receptors (ERR) is composed of two C4-type zinc fingers
NM_001350122.2 → NP_001337051.1 estrogen-related receptor gamma isoform 2

Status: REVIEWED

Description

Transcript Variant: This variant (18) lacks the 5' exon but has four alternate 5' exons and uses a downstream AUG start codon, compared to variant 1. The resulting isoform (2) is shorter at the N-terminus, compared to isoform 1. Variants 2-4, 9-15, and 17-21 encode the same isoform.

Source sequence(s)

AB020639, AC096634, AL603752, BU752915, CA397450, DA215341, DA293919, DB220304

Consensus CDS

CCDS1517.1

UniProtKB/TrEMBL

C0SQ93, F1D8R6

Conserved Domains (2) summary

cd06946
Location:214 → 433

NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors

cd07170
Location:99 → 195

NR_DBD_ERR; DNA-binding domain of estrogen related receptors (ERR) is composed of two C4-type zinc fingers
NM_001350123.2 → NP_001337052.1 estrogen-related receptor gamma isoform 2

Status: REVIEWED

Description

Transcript Variant: This variant (19) lacks the 5' exon but has three alternate 5' exons and uses a downstream AUG start codon, compared to variant 1. The resulting isoform (2) is shorter at the N-terminus, compared to isoform 1. Variants 2-4, 9-15, and 17-21 encode the same isoform.

Source sequence(s)

AB020639, BU752915, CA397450, DB220304

Consensus CDS

CCDS1517.1

UniProtKB/TrEMBL

C0SQ93, F1D8R6

Conserved Domains (2) summary

cd06946
Location:214 → 433

NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors

cd07170
Location:99 → 195

NR_DBD_ERR; DNA-binding domain of estrogen related receptors (ERR) is composed of two C4-type zinc fingers
NM_001350124.2 → NP_001337053.1 estrogen-related receptor gamma isoform 2

Status: REVIEWED

Description

Transcript Variant: This variant (20) lacks the 5' exon but has four alternate 5' exons and uses a downstream AUG start codon, compared to variant 1. The resulting isoform (2) is shorter at the N-terminus, compared to isoform 1. Variants 2-4, 9-15, and 17-21 encode the same isoform.

Source sequence(s)

AB020639, AL603752, BU752915, BX647076, CA397450, DA215341

Consensus CDS

CCDS1517.1

UniProtKB/TrEMBL

C0SQ93, F1D8R6

Conserved Domains (2) summary

cd06946
Location:214 → 433

NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors

cd07170
Location:99 → 195

NR_DBD_ERR; DNA-binding domain of estrogen related receptors (ERR) is composed of two C4-type zinc fingers
NM_001350125.2 → NP_001337054.1 estrogen-related receptor gamma isoform 2

Status: REVIEWED

Description

Transcript Variant: This variant (21) lacks the 5' exon but has three alternate 5' exons and uses a downstream AUG start codon, compared to variant 1. The resulting isoform (2) is shorter at the N-terminus, compared to isoform 1. Variants 2-4, 9-15, and 17-21 encode the same isoform.

Source sequence(s)

AB020639, BU752915, CA397450, DA096417, DB220304

Consensus CDS

CCDS1517.1

UniProtKB/TrEMBL

C0SQ93, F1D8R6

Conserved Domains (2) summary

cd06946
Location:214 → 433

NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors

cd07170
Location:99 → 195

NR_DBD_ERR; DNA-binding domain of estrogen related receptors (ERR) is composed of two C4-type zinc fingers
NM_001438.4 → NP_001429.2 estrogen-related receptor gamma isoform 1

See identical proteins and their annotated locations for NP_001429.2

Status: REVIEWED

Description

Transcript Variant: This variant (1) encodes isoform 1.

Source sequence(s)

AB020639, BU752915

Consensus CDS

CCDS41468.1

UniProtKB/Swiss-Prot

A8K4I0, A8K6I2, B3KY84, E9PGB7, F8W8J3, O75454, O96021, P62508, Q68DA0, Q6P274, Q6PK28, Q6TS38, Q9R1F3, Q9UNJ4

UniProtKB/TrEMBL

C0SQ93, F1D8R5

Related

ENSP00000386171.3, ENST00000408911.8

Conserved Domains (2) summary

cd06946
Location:237 → 456

NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors

cd07170
Location:122 → 218

NR_DBD_ERR; DNA-binding domain of estrogen related receptors (ERR) is composed of two C4-type zinc fingers
NM_206594.3 → NP_996317.1 estrogen-related receptor gamma isoform 2

See identical proteins and their annotated locations for NP_996317.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) lacks the 5' exon but has three alternate 5' exons and uses a downstream AUG start codon, compared to variant 1. The resulting isoform (2) is shorter at the N-terminus, compared to isoform 1. Variants 2-4, 9-15, and 17-21 encode the same isoform.

Source sequence(s)

AB020639, BU752915, CA397450

Consensus CDS

CCDS1517.1

UniProtKB/TrEMBL

C0SQ93, F1D8R6

Related

ENSP00000355225.3, ENST00000361525.7

Conserved Domains (2) summary

cd06946
Location:214 → 433

NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors

cd07170
Location:99 → 195

NR_DBD_ERR; DNA-binding domain of estrogen related receptors (ERR) is composed of two C4-type zinc fingers
NM_206595.3 → NP_996318.1 estrogen-related receptor gamma isoform 2

See identical proteins and their annotated locations for NP_996318.1

Status: REVIEWED

Description

Transcript Variant: This variant (3) lacks the 5' exon but has two alternate 5' exons and uses a downstream AUG start codon, compared to variant 1. The resulting isoform (2) is shorter at the N-terminus, compared to isoform 1. Variants 2-4, 9-15, and 17-21 encode the same isoform.

Source sequence(s)

AB020639, AK291028, BU752915

Consensus CDS

CCDS1517.1

UniProtKB/TrEMBL

C0SQ93, F1D8R6

Related

ENSP00000352077.2, ENST00000359162.6

Conserved Domains (2) summary

cd06946
Location:214 → 433

NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors

cd07170
Location:99 → 195

NR_DBD_ERR; DNA-binding domain of estrogen related receptors (ERR) is composed of two C4-type zinc fingers

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000001.11 Reference GRCh38.p14 Primary Assembly

Range

216503246..217137702 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017000625.2 → XP_016856114.1 estrogen-related receptor gamma isoform X1

UniProtKB/TrEMBL

C0SQ93

Conserved Domains (2) summary

cd06946
Location:256 → 475

NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors

cd07170
Location:134 → 230

NR_DBD_ERR; DNA-binding domain of estrogen related receptors (ERR) is composed of two C4-type zinc fingers
XM_047449371.1 → XP_047305327.1 estrogen-related receptor gamma isoform X3
XM_017000622.2 → XP_016856111.1 estrogen-related receptor gamma isoform X1

UniProtKB/TrEMBL

C0SQ93

Conserved Domains (2) summary

cd06946
Location:256 → 475

NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors

cd07170
Location:134 → 230

NR_DBD_ERR; DNA-binding domain of estrogen related receptors (ERR) is composed of two C4-type zinc fingers
XM_047449402.1 → XP_047305358.1 estrogen-related receptor gamma isoform X8

Related

ENSP00000500992.1, ENST00000673908.1
XM_017000637.2 → XP_016856126.1 estrogen-related receptor gamma isoform X8

UniProtKB/TrEMBL

C0SQ93

Conserved Domains (2) summary

cd06946
Location:221 → 440

NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors

cd07170
Location:99 → 195

NR_DBD_ERR; DNA-binding domain of estrogen related receptors (ERR) is composed of two C4-type zinc fingers
XM_017000624.3 → XP_016856113.1 estrogen-related receptor gamma isoform X1

UniProtKB/TrEMBL

C0SQ93

Conserved Domains (2) summary

cd06946
Location:256 → 475

NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors

cd07170
Location:134 → 230

NR_DBD_ERR; DNA-binding domain of estrogen related receptors (ERR) is composed of two C4-type zinc fingers
XM_011509265.4 → XP_011507567.1 estrogen-related receptor gamma isoform X1

UniProtKB/TrEMBL

C0SQ93

Conserved Domains (2) summary

cd06946
Location:256 → 475

NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors

cd07170
Location:134 → 230

NR_DBD_ERR; DNA-binding domain of estrogen related receptors (ERR) is composed of two C4-type zinc fingers
XM_017000621.3 → XP_016856110.1 estrogen-related receptor gamma isoform X1

UniProtKB/TrEMBL

C0SQ93

Conserved Domains (2) summary

cd06946
Location:256 → 475

NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors

cd07170
Location:134 → 230

NR_DBD_ERR; DNA-binding domain of estrogen related receptors (ERR) is composed of two C4-type zinc fingers
XM_047449398.1 → XP_047305354.1 estrogen-related receptor gamma isoform X8
XM_047449392.1 → XP_047305348.1 estrogen-related receptor gamma isoform X7
XM_047449368.1 → XP_047305324.1 estrogen-related receptor gamma isoform X3
XM_047449351.1 → XP_047305307.1 estrogen-related receptor gamma isoform X3
XM_017000634.3 → XP_016856123.1 estrogen-related receptor gamma isoform X8

UniProtKB/TrEMBL

C0SQ93

Conserved Domains (2) summary

cd06946
Location:221 → 440

NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors

cd07170
Location:99 → 195

NR_DBD_ERR; DNA-binding domain of estrogen related receptors (ERR) is composed of two C4-type zinc fingers
XM_017000631.3 → XP_016856120.1 estrogen-related receptor gamma isoform X8

UniProtKB/TrEMBL

C0SQ93

Conserved Domains (2) summary

cd06946
Location:221 → 440

NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors

cd07170
Location:99 → 195

NR_DBD_ERR; DNA-binding domain of estrogen related receptors (ERR) is composed of two C4-type zinc fingers
XM_047449391.1 → XP_047305347.1 estrogen-related receptor gamma isoform X7
XM_047449362.1 → XP_047305318.1 estrogen-related receptor gamma isoform X3
XM_047449396.1 → XP_047305352.1 estrogen-related receptor gamma isoform X8
XM_047449395.1 → XP_047305351.1 estrogen-related receptor gamma isoform X8
XM_047449389.1 → XP_047305345.1 estrogen-related receptor gamma isoform X5
XM_047449344.1 → XP_047305300.1 estrogen-related receptor gamma isoform X3
XM_047449397.1 → XP_047305353.1 estrogen-related receptor gamma isoform X8
XM_017000632.3 → XP_016856121.1 estrogen-related receptor gamma isoform X8

UniProtKB/TrEMBL

C0SQ93

Conserved Domains (2) summary

cd06946
Location:221 → 440

NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors

cd07170
Location:99 → 195

NR_DBD_ERR; DNA-binding domain of estrogen related receptors (ERR) is composed of two C4-type zinc fingers
XM_011509266.4 → XP_011507568.1 estrogen-related receptor gamma isoform X2

UniProtKB/TrEMBL

C0SQ93

Conserved Domains (2) summary

cd06946
Location:249 → 468

NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors

cd07170
Location:134 → 230

NR_DBD_ERR; DNA-binding domain of estrogen related receptors (ERR) is composed of two C4-type zinc fingers
XM_047449307.1 → XP_047305263.1 estrogen-related receptor gamma isoform X1
XM_017000636.3 → XP_016856125.1 estrogen-related receptor gamma isoform X8

UniProtKB/TrEMBL

C0SQ93

Conserved Domains (2) summary

cd06946
Location:221 → 440

NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors

cd07170
Location:99 → 195

NR_DBD_ERR; DNA-binding domain of estrogen related receptors (ERR) is composed of two C4-type zinc fingers
XM_017000623.3 → XP_016856112.1 estrogen-related receptor gamma isoform X1

UniProtKB/TrEMBL

C0SQ93

Conserved Domains (2) summary

cd06946
Location:256 → 475

NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors

cd07170
Location:134 → 230

NR_DBD_ERR; DNA-binding domain of estrogen related receptors (ERR) is composed of two C4-type zinc fingers
XM_047449403.1 → XP_047305359.1 estrogen-related receptor gamma isoform X8
XM_047449385.1 → XP_047305341.1 estrogen-related receptor gamma isoform X4
XM_011509271.3 → XP_011507573.1 estrogen-related receptor gamma isoform X7

See identical proteins and their annotated locations for XP_011507573.1

UniProtKB/TrEMBL

C0SQ93

Conserved Domains (2) summary

cd06946
Location:226 → 445

NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors

cd07170
Location:104 → 200

NR_DBD_ERR; DNA-binding domain of estrogen related receptors (ERR) is composed of two C4-type zinc fingers
XM_047449390.1 → XP_047305346.1 estrogen-related receptor gamma isoform X6
XM_011509269.3 → XP_011507571.1 estrogen-related receptor gamma isoform X3

See identical proteins and their annotated locations for XP_011507571.1

UniProtKB/TrEMBL

C0SQ93

Conserved Domains (2) summary

cd06946
Location:249 → 468

NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors

cd07170
Location:127 → 223

NR_DBD_ERR; DNA-binding domain of estrogen related receptors (ERR) is composed of two C4-type zinc fingers
XM_011509268.3 → XP_011507570.1 estrogen-related receptor gamma isoform X3

See identical proteins and their annotated locations for XP_011507570.1

UniProtKB/TrEMBL

C0SQ93

Conserved Domains (2) summary

cd06946
Location:249 → 468

NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors

cd07170
Location:127 → 223

NR_DBD_ERR; DNA-binding domain of estrogen related receptors (ERR) is composed of two C4-type zinc fingers
XM_011509267.1 → XP_011507569.1 estrogen-related receptor gamma isoform X3

See identical proteins and their annotated locations for XP_011507569.1

UniProtKB/TrEMBL

C0SQ93

Conserved Domains (2) summary

cd06946
Location:249 → 468

NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors

cd07170
Location:127 → 223

NR_DBD_ERR; DNA-binding domain of estrogen related receptors (ERR) is composed of two C4-type zinc fingers
XM_047449394.1 → XP_047305350.1 estrogen-related receptor gamma isoform X7
XM_047449401.1 → XP_047305357.1 estrogen-related receptor gamma isoform X8
XM_047449393.1 → XP_047305349.1 estrogen-related receptor gamma isoform X7