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    LATS1 large tumor suppressor kinase 1 [ Homo sapiens (human) ]

    Gene ID: 9113, updated on 29-Oct-2024

    Summary

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    Official Symbol
    LATS1provided by HGNC
    Official Full Name
    large tumor suppressor kinase 1provided by HGNC
    Primary source
    HGNC:HGNC:6514
    See related
    Ensembl:ENSG00000131023 MIM:603473; AllianceGenome:HGNC:6514
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    wts; WARTS
    Summary
    The protein encoded by this gene is a putative serine/threonine kinase that localizes to the mitotic apparatus and complexes with cell cycle controller CDC2 kinase in early mitosis. The protein is phosphorylated in a cell-cycle dependent manner, with late prophase phosphorylation remaining through metaphase. The N-terminal region of the protein binds CDC2 to form a complex showing reduced H1 histone kinase activity, indicating a role as a negative regulator of CDC2/cyclin A. In addition, the C-terminal kinase domain binds to its own N-terminal region, suggesting potential negative regulation through interference with complex formation via intramolecular binding. Biochemical and genetic data suggest a role as a tumor suppressor. This is supported by studies in knockout mice showing development of soft-tissue sarcomas, ovarian stromal cell tumors and a high sensitivity to carcinogenic treatments. [provided by RefSeq, Apr 2017]
    Expression
    Ubiquitous expression in ovary (RPKM 6.7), endometrium (RPKM 5.8) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See LATS1 in Genome Data Viewer
    Location:
    6q25.1
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (149658153..149718101, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (150857942..150917878, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (149979289..150039237, complement)

    Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA SNORA2/SNORA34 family Neighboring gene katanin catalytic subunit A1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25266 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17664 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr6:150022675-150023256 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17665 Neighboring gene ReSE screen-validated silencer GRCh37_chr6:150045663-150045865 Neighboring gene uncharacterized LOC645967 Neighboring gene nucleoporin 43 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25267 Neighboring gene H3K27ac hESC enhancer GRCh37_chr6:150069877-150070842 Neighboring gene Sharpr-MPRA regulatory region 3985 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:150071808-150072310 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:150072311-150072813 Neighboring gene protein-L-isoaspartate (D-aspartate) O-methyltransferase Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr6:150106480-150106982 Neighboring gene BTB domain containing 10 pseudogene 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Inhibition of cell growth by conditional expression of kpm, a human homologue of Drosophila warts/lats tumor suppressor. Kamikubo Y, et al. J Biol Chem, 2003 May 16. PMID 12624101
    2. lncRNA TINCR attenuates the proliferation and invasion, and enhances the apoptosis of cutaneous malignant melanoma cells by regulating the miR‑424‑5p/LATS1 axis. Han X, et al. Oncol Rep, 2021 Nov. PMID 34542165, Free PMC Article
    3. Molecular Alterations and Expression Dynamics of LATS1 and LATS2 Genes in Non-Small-Cell Lung Carcinoma. Malik SA, et al. Pathol Oncol Res, 2018 Apr. PMID 28434174
    4. Identification of a novel LATS1 variant associated with familial cerebral cavernous malformations in a Chinese family. Geng L, et al. Neurol Sci, 2022 Nov. PMID 35986120
    5. Expression of LATS1 in head and neck squamous cell carcinoma and its effect on tumor cell proliferation and invasion. Wan W, et al. Cell Mol Biol (Noisy-le-grand), 2022 May 31. PMID 36029506

    See all (230) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. HPV18 E7 inhibits LATS1 kinase and activates YAP1 by degrading PTPN14.
      Title: HPV18 E7 inhibits LATS1 kinase and activates YAP1 by degrading PTPN14.
    2. LncRNA HOTAIR promotes the migration and invasion of cervical cancer through DNMT3B/LATS1/ YAP1 pS127 axis.
      Title: LncRNA HOTAIR promotes the migration and invasion of cervical cancer through DNMT3B/LATS1/ YAP1 pS127 axis.
    3. SUMOylation activates large tumour suppressor 1 to maintain the tissue homeostasis during Hippo signalling.
      Title: SUMOylation activates large tumour suppressor 1 to maintain the tissue homeostasis during Hippo signalling.
    4. m[6]A-induced TRIB3 regulates Hippo pathway through interacting with LATS1 to promote the progression of lung adenocarcinoma.
      Title: m(6)A-induced TRIB3 regulates Hippo pathway through interacting with LATS1 to promote the progression of lung adenocarcinoma.
    5. LATS1 Promotes B-ALL Tumorigenesis by Regulating YAP1 Phosphorylation and Subcellular Localization.
      Title: LATS1 Promotes B-ALL Tumorigenesis by Regulating YAP1 Phosphorylation and Subcellular Localization.
    6. S100 Calcium Binding Protein A16 Promotes Cell Proliferation by triggering LATS1 ubiquitin degradation mediated by CUL4A ligase to inhibit Hippo pathway in Glioma development.
      Title: S100 Calcium Binding Protein A16 Promotes Cell Proliferation by triggering LATS1 ubiquitin degradation mediated by CUL4A ligase to inhibit Hippo pathway in Glioma development.
    7. WWP2 drives the progression of gastric cancer by facilitating the ubiquitination and degradation of LATS1 protein.
      Title: WWP2 drives the progression of gastric cancer by facilitating the ubiquitination and degradation of LATS1 protein.
    8. DNMT3B and TET1 mediated DNA methylation of LATS1 regulates BC progression via hippo signaling pathway.
      Title: DNMT3B and TET1 mediated DNA methylation of LATS1 regulates BC progression via hippo signaling pathway.
    9. Inactivation of LATS1/2 drives luminal-basal plasticity to initiate basal-like mammary carcinomas.
      Title: Inactivation of LATS1/2 drives luminal-basal plasticity to initiate basal-like mammary carcinomas.
    10. Identification of a novel LATS1 variant associated with familial cerebral cavernous malformations in a Chinese family.
      Title: Identification of a novel LATS1 variant associated with familial cerebral cavernous malformations in a Chinese family.
    Submit: New GeneRIF Correction See all GeneRIFs (122)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATP binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables histone H2AS1 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables magnesium ion binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables nuclear estrogen receptor binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein kinase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein serine/threonine kinase activity TAS
    Traceable Author Statement
    more info
    		  
    Process Evidence Code Pubs
    involved_in G1/S transition of mitotic cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in G2/M transition of mitotic cell cycle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cytoplasmic sequestering of protein IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in hippo signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in hippo signaling IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in hippo signaling TAS
    Traceable Author Statement
    more info
    		  
    involved_in hormone-mediated signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in inner cell mass cell fate commitment IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in inner cell mass cellular morphogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in keratinocyte differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mammary gland epithelial cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of canonical Wnt signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of cyclin-dependent protein serine/threonine kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of protein localization to nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of apoptotic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of peptidyl-serine phosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of actin filament polymerization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of intracellular estrogen receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of organ growth IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of postsynaptic density assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of protein-containing complex assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of transforming growth factor beta receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of ubiquitin-dependent protein catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in sister chromatid segregation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in centrosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    located_in glutamatergic synapse IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in midbody IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in postsynapse IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in spindle pole IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in spindle pole IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    serine/threonine-protein kinase LATS1
    Names
    LATS (large tumor suppressor, Drosophila) homolog 1
    LATS, large tumor suppressor, homolog 1
    WARTS protein kinase
    h-warts
    large tumor suppressor homolog 1
    NP_001257448.1
    NP_001337268.1
    NP_001337269.1
    NP_001337321.1
    NP_004681.1
    XP_006715666.1
    XP_011534554.1
    XP_016866963.1
    XP_016866966.1
    XP_016866968.1
    XP_024302351.1
    XP_047275473.1
    XP_047275474.1
    XP_047275475.1
    XP_047275477.1
    XP_047275478.1
    XP_054212719.1
    XP_054212720.1
    XP_054212721.1
    XP_054212722.1
    XP_054212723.1
    XP_054212724.1
    XP_054212725.1
    XP_054212726.1
    XP_054212727.1
    XP_054212728.1
    XP_054212729.1

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001270519.2 → NP_001257448.1  serine/threonine-protein kinase LATS1 isoform 2

      See identical proteins and their annotated locations for NP_001257448.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks the last four exons and has a 3' end that extends into an intron compared to variant 1. The resulting isoform (2) has a shorter and distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AF104413, AL358852, AL583963, BC002767
      Consensus CDS
      CCDS59040.1
      UniProtKB/Swiss-Prot
      O95835
      Related
      ENSP00000444678.1, ENST00000392273.7
      Conserved Domains (3) summary
      cd14397
      Location:103 → 143
      UBA_LATS1; UBA domain found in vertebrate serine/threonine-protein kinase LATS1
      cl26247
      Location:473 → 558
      DNA_pol3_delta2; DNA polymerase III, delta subunit
      cl28087
      Location:467 → 673
      FtsK; DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell cycle control, cell division, chromosome partitioning]

    2. NM_001350339.2 → NP_001337268.1  serine/threonine-protein kinase LATS1 isoform 3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) encodes isoform 3.
      Source sequence(s)
      AL358852, AL583963, BX276089
      Conserved Domains (3) summary
      cl21453
      Location:598 → 1012
      PKc_like; Protein Kinases, catalytic domain
      cl21463
      Location:11 → 38
      UBA_like_SF; UBA domain-like superfamily
      cl28087
      Location:343 → 491
      FtsK; DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell cycle control, cell division, chromosome partitioning]

    3. NM_001350340.2 → NP_001337269.1  serine/threonine-protein kinase LATS1 isoform 4

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) encodes isoform 4.
      Source sequence(s)
      AL358852, AL583963, BX276089
      Conserved Domains (3) summary
      cd05625
      Location:598 → 979
      STKc_LATS1; Catalytic domain of the Serine/Threonine Kinase, Large Tumor Suppressor 1
      cl21463
      Location:11 → 38
      UBA_like_SF; UBA domain-like superfamily
      cl28087
      Location:343 → 491
      FtsK; DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell cycle control, cell division, chromosome partitioning]

    4. NM_001350392.2 → NP_001337321.1  serine/threonine-protein kinase LATS1 isoform 5

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) encodes isoform 5.
      Source sequence(s)
      AL358852, AL583963, BX276089
      UniProtKB/TrEMBL
      Q59FN4
      Conserved Domains (2) summary
      cd05625
      Location:423 → 804
      STKc_LATS1; Catalytic domain of the Serine/Threonine Kinase, Large Tumor Suppressor 1
      cl26464
      Location:9 → 312
      Atrophin-1; Atrophin-1 family

    5. NM_004690.4 → NP_004681.1  serine/threonine-protein kinase LATS1 isoform 1

      See identical proteins and their annotated locations for NP_004681.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AF104413, AL358852, AW021064, BX276089
      Consensus CDS
      CCDS34551.1
      UniProtKB/Swiss-Prot
      O95835, Q6PKD0
      Related
      ENSP00000437550.1, ENST00000543571.6
      Conserved Domains (3) summary
      smart00220
      Location:705 → 1010
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14397
      Location:103 → 143
      UBA_LATS1; UBA domain found in vertebrate serine/threonine-protein kinase LATS1
      cd05625
      Location:703 → 1084
      STKc_LATS1; Catalytic domain of the Serine/Threonine Kinase, Large Tumor Suppressor 1

    RNA

    1. NR_073033.2 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) uses an alternate 5' exon and contains an alternate internal exon compared to variant 1. This variant is represented as non-coding due to the presence of an upstream ORF that is predicted to interfere with translation of the longest ORF.
      Source sequence(s)
      AK310422, AW021064, BX276089

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

      Range
      149658153..149718101 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017011474.2 → XP_016866963.1  serine/threonine-protein kinase LATS1 isoform X1

      Conserved Domains (3) summary
      cd14397
      Location:103 → 143
      UBA_LATS1; UBA domain found in vertebrate serine/threonine-protein kinase LATS1
      cl21453
      Location:703 → 1117
      PKc_like; Protein Kinases, catalytic domain
      cl28087
      Location:448 → 596
      FtsK; DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell cycle control, cell division, chromosome partitioning]

    2. XM_024446583.2 → XP_024302351.1  serine/threonine-protein kinase LATS1 isoform X1

      Conserved Domains (3) summary
      cd14397
      Location:103 → 143
      UBA_LATS1; UBA domain found in vertebrate serine/threonine-protein kinase LATS1
      cl21453
      Location:703 → 1117
      PKc_like; Protein Kinases, catalytic domain
      cl28087
      Location:448 → 596
      FtsK; DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell cycle control, cell division, chromosome partitioning]

    3. XM_047419518.1 → XP_047275474.1  serine/threonine-protein kinase LATS1 isoform X2

      UniProtKB/Swiss-Prot
      O95835, Q6PKD0
      Related
      ENSP00000253339.5, ENST00000253339.9

    4. XM_047419517.1 → XP_047275473.1  serine/threonine-protein kinase LATS1 isoform X1

    5. XM_047419521.1 → XP_047275477.1  serine/threonine-protein kinase LATS1 isoform X8

    6. XM_017011479.2 → XP_016866968.1  serine/threonine-protein kinase LATS1 isoform X6

      UniProtKB/TrEMBL
      Q59FN4

    7. XM_011536252.3 → XP_011534554.1  serine/threonine-protein kinase LATS1 isoform X4

      UniProtKB/TrEMBL
      Q59FN4
      Conserved Domains (3) summary
      smart00220
      Location:705 → 961
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14397
      Location:103 → 143
      UBA_LATS1; UBA domain found in vertebrate serine/threonine-protein kinase LATS1
      cl21453
      Location:703 → 961
      PKc_like; Protein Kinases, catalytic domain

    8. XM_017011477.2 → XP_016866966.1  serine/threonine-protein kinase LATS1 isoform X3

    9. XM_047419519.1 → XP_047275475.1  serine/threonine-protein kinase LATS1 isoform X5

    10. XM_006715603.4 → XP_006715666.1  serine/threonine-protein kinase LATS1 isoform X7

      UniProtKB/TrEMBL
      Q59FN4
      Conserved Domains (3) summary
      smart00220
      Location:705 → 862
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14397
      Location:103 → 143
      UBA_LATS1; UBA domain found in vertebrate serine/threonine-protein kinase LATS1
      cl21453
      Location:703 → 863
      PKc_like; Protein Kinases, catalytic domain

    11. XM_047419522.1 → XP_047275478.1  serine/threonine-protein kinase LATS1 isoform X9

    RNA

    1. XR_007059386.1 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060930.1 Alternate T2T-CHM13v2.0

      Range
      150857942..150917878 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054356744.1 → XP_054212719.1  serine/threonine-protein kinase LATS1 isoform X1

    2. XM_054356745.1 → XP_054212720.1  serine/threonine-protein kinase LATS1 isoform X1

    3. XM_054356747.1 → XP_054212722.1  serine/threonine-protein kinase LATS1 isoform X2

      UniProtKB/Swiss-Prot
      O95835, Q6PKD0

    4. XM_054356746.1 → XP_054212721.1  serine/threonine-protein kinase LATS1 isoform X1

    5. XM_054356753.1 → XP_054212728.1  serine/threonine-protein kinase LATS1 isoform X8

    6. XM_054356751.1 → XP_054212726.1  serine/threonine-protein kinase LATS1 isoform X6

    7. XM_054356749.1 → XP_054212724.1  serine/threonine-protein kinase LATS1 isoform X4

    8. XM_054356748.1 → XP_054212723.1  serine/threonine-protein kinase LATS1 isoform X3

    9. XM_054356750.1 → XP_054212725.1  serine/threonine-protein kinase LATS1 isoform X5

    10. XM_054356752.1 → XP_054212727.1  serine/threonine-protein kinase LATS1 isoform X7

    11. XM_054356754.1 → XP_054212729.1  serine/threonine-protein kinase LATS1 isoform X9

    RNA

    1. XR_008487506.1 RNA Sequence

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O95835.1 GenPept UniProtKB/Swiss-Prot:O95835

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