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    TMEM45B transmembrane protein 45B [ Homo sapiens (human) ]

    Gene ID: 120224, updated on 28-Oct-2024

    Summary

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    Official Symbol
    TMEM45Bprovided by HGNC
    Official Full Name
    transmembrane protein 45Bprovided by HGNC
    Primary source
    HGNC:HGNC:25194
    See related
    Ensembl:ENSG00000151715 AllianceGenome:HGNC:25194
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    Predicted to be involved in innate immune response. Predicted to be located in Golgi apparatus; endosome membrane; and lysosomal membrane. [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Biased expression in duodenum (RPKM 57.4), small intestine (RPKM 54.1) and 9 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See TMEM45B in Genome Data Viewer
    Location:
    11q24.3
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (129815848..129860003)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (129851489..129895715)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (129685743..129729898)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124902792 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:129619939-129620440 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:129620441-129620940 Neighboring gene uncharacterized LOC124902793 Neighboring gene Sharpr-MPRA regulatory region 8939 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:129673393-129673893 Neighboring gene TMEM45B-NFRKB intergenic CAGE-defined mid-level expression enhancer Neighboring gene ReSE screen-validated silencer GRCh37_chr11:129739277-129739466 Neighboring gene Sharpr-MPRA regulatory region 15352 Neighboring gene nuclear factor related to kappaB binding protein Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4067 Neighboring gene PR/SET domain 10 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4068 Neighboring gene NANOG hESC enhancer GRCh37_chr11:129795831-129796332 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:129806281-129806994 Neighboring gene MPRA-validated peak1509 silencer Neighboring gene Sharpr-MPRA regulatory region 3666 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:129841453-129842000 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4069 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4070 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4071 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4072 Neighboring gene PRDM10 divergent transcript

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. TMEΜ45B Interacts with Sindbis Virus Nsp1 and Nsp4 and Inhibits Viral Replication. Yan F, et al. J Virol, 2022 Sep 14. PMID 35938871, Free PMC Article
    2. Identification of TMEM45B as a protein clearly showing thermal aggregation in SDS-PAGE gels and dissection of its amino acid sequence responsible for this aggregation. Okada N, et al. Protein Expr Purif, 2011 May. PMID 21277373
    3. TMEM45B is a novel predictive biomarker for prostate cancer progression and metastasis. Luo F, et al. Neoplasma, 2018 Sep 19. PMID 30249106
    4. Knockdown of TMEM45B inhibits cell proliferation and invasion in gastric cancer. Shen K, et al. Biomed Pharmacother, 2018 Aug. PMID 29803169
    5. Silencing Transmembrane Protein 45B (TNEM45B) Inhibits Proliferation, Invasion, and Tumorigenesis in Osteosarcoma Cells. Li Y, et al. Oncol Res, 2017 Jul 5. PMID 28244852, Free PMC Article

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. TMEMu45B Interacts with Sindbis Virus Nsp1 and Nsp4 and Inhibits Viral Replication.
      Title: TMEΜ45B Interacts with Sindbis Virus Nsp1 and Nsp4 and Inhibits Viral Replication.
    2. increased expression of TMEM45B appears to be significantly associated with prostate carcinoma progression and metastasis
      Title: TMEM45B is a novel predictive biomarker for prostate cancer progression and metastasis.
    3. TMEM45B may be a new potent therapeutic molecule for the treatment of gastric cancer.
      Title: Knockdown of TMEM45B inhibits cell proliferation and invasion in gastric cancer.
    4. TMEM45B plays an important role in regulating the proliferation, migration, and invasion of osteosarcoma cells.
      Title: Silencing Transmembrane Protein 45B (TNEM45B) Inhibits Proliferation, Invasion, and Tumorigenesis in Osteosarcoma Cells.
    5. TMEM45B expression was significantly upregulated in pancreatic cancer tissues and cell lines. Moreover, TMEM45B was significantly positively correlated with the cell cycle and metastasis up pathways and regulated expression of proteins involved. This indicates an important role of TMEM45B in pancreatic cancer carcinogenesis.
      Title: TMEM45B promotes proliferation, invasion and migration and inhibits apoptosis in pancreatic cancer cells.
    6. Data show that transmembrane protein 45B (TMEM45B) was overexpressed in lung cancer and its expression correlated with overall survival of patients.
      Title: TMEM45B, up-regulated in human lung cancer, enhances tumorigenicity of lung cancer cells.
    7. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
      Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
    8. Observational study of gene-disease association. (HuGE Navigator)
      Title: Association between genetic variants in VEGF, ERCC3 and occupational benzene haematotoxicity.
    Submit: New GeneRIF Correction

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    A genome-wide association search for type 2 diabetes genes in African Americans.
    EBI GWAS Catalog
    Genome-wide association study in east Asians identifies novel susceptibility loci for breast cancer.
    EBI GWAS Catalog
    Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ40787

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in innate immune response IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endosome membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in lysosomal membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    transmembrane protein 45B

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001331210.2 → NP_001318139.1  transmembrane protein 45B

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. All four variants encode the same protein.
      Source sequence(s)
      AP003327, BU607569, HY117153
      Consensus CDS
      CCDS8482.1
      UniProtKB/Swiss-Prot
      A8K2L8, Q96B21
      Conserved Domains (1) summary
      pfam04819
      Location:117 → 234
      DUF716; Family of unknown function (DUF716)

    2. NM_001331211.2 → NP_001318140.1  transmembrane protein 45B

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. All four variants encode the same protein.
      Source sequence(s)
      AK098106, AP003327, BU607569, HY117153
      Consensus CDS
      CCDS8482.1
      UniProtKB/Swiss-Prot
      A8K2L8, Q96B21
      Related
      ENSP00000436293.1, ENST00000524567.1
      Conserved Domains (1) summary
      pfam04819
      Location:117 → 234
      DUF716; Family of unknown function (DUF716)

    3. NM_001331212.2 → NP_001318141.1  transmembrane protein 45B

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. All four variants encode the same protein.
      Source sequence(s)
      AK098106, AP003327, BM762740, BU607569, HY117153
      Consensus CDS
      CCDS8482.1
      UniProtKB/Swiss-Prot
      A8K2L8, Q96B21
      Conserved Domains (1) summary
      pfam04819
      Location:117 → 234
      DUF716; Family of unknown function (DUF716)

    4. NM_138788.5 → NP_620143.1  transmembrane protein 45B

      See identical proteins and their annotated locations for NP_620143.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. All four variants encode the same protein.
      Source sequence(s)
      AK098106, AP003327, BU607569
      Consensus CDS
      CCDS8482.1
      UniProtKB/Swiss-Prot
      A8K2L8, Q96B21
      Related
      ENSP00000281441.3, ENST00000281441.8
      Conserved Domains (1) summary
      pfam04819
      Location:117 → 234
      DUF716; Family of unknown function (DUF716)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

      Range
      129815848..129860003
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047426356.1 → XP_047282312.1  transmembrane protein 45B isoform X1

      UniProtKB/Swiss-Prot
      A8K2L8, Q96B21

    2. XM_047426354.1 → XP_047282310.1  transmembrane protein 45B isoform X1

      UniProtKB/Swiss-Prot
      A8K2L8, Q96B21

    3. XM_047426355.1 → XP_047282311.1  transmembrane protein 45B isoform X1

      UniProtKB/Swiss-Prot
      A8K2L8, Q96B21

    4. XM_017017188.2 → XP_016872677.1  transmembrane protein 45B isoform X1

      UniProtKB/Swiss-Prot
      A8K2L8, Q96B21
      Conserved Domains (1) summary
      pfam04819
      Location:117 → 234
      DUF716; Family of unknown function (DUF716)

    5. XM_047426358.1 → XP_047282314.1  transmembrane protein 45B isoform X1

      UniProtKB/Swiss-Prot
      A8K2L8, Q96B21

    6. XM_047426357.1 → XP_047282313.1  transmembrane protein 45B isoform X1

      UniProtKB/Swiss-Prot
      A8K2L8, Q96B21

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060935.1 Alternate T2T-CHM13v2.0

      Range
      129851489..129895715
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054367646.1 → XP_054223621.1  transmembrane protein 45B isoform X1

      UniProtKB/Swiss-Prot
      A8K2L8, Q96B21

    2. XM_054367648.1 → XP_054223623.1  transmembrane protein 45B isoform X1

      UniProtKB/Swiss-Prot
      A8K2L8, Q96B21

    3. XM_054367647.1 → XP_054223622.1  transmembrane protein 45B isoform X1

      UniProtKB/Swiss-Prot
      A8K2L8, Q96B21

    4. XM_054367651.1 → XP_054223626.1  transmembrane protein 45B isoform X1

      UniProtKB/Swiss-Prot
      A8K2L8, Q96B21

    5. XM_054367649.1 → XP_054223624.1  transmembrane protein 45B isoform X1

      UniProtKB/Swiss-Prot
      A8K2L8, Q96B21

    6. XM_054367650.1 → XP_054223625.1  transmembrane protein 45B isoform X1

      UniProtKB/Swiss-Prot
      A8K2L8, Q96B21
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q96B21.1 GenPept UniProtKB/Swiss-Prot:Q96B21

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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