ZMYND8 zinc finger MYND-type containing 8 [Homo sapiens (human)] - Gene

Summary

Official Symbol: ZMYND8provided by HGNC
Official Full Name: zinc finger MYND-type containing 8provided by HGNC
Primary source: HGNC:HGNC:9397
See related: Ensembl:ENSG00000101040 MIM:615713; AllianceGenome:HGNC:9397
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: RACK7; PRKCBP1; PRO2893
Summary: The protein encoded by this gene is a receptor for activated C-kinase (RACK) protein. The encoded protein has been shown to bind in vitro to activated protein kinase C beta I. In addition, this protein is a cutaneous T-cell lymphoma-associated antigen. Finally, the protein contains a bromodomain and two zinc fingers, and is thought to be a transcriptional regulator. Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Expression: Ubiquitous expression in adrenal (RPKM 6.9), testis (RPKM 4.9) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 20q13.12

Exon count:: 29

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	20	NC_000020.11 (47209214..47356699, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	20	NC_060944.1 (48947314..49094980, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	20	NC_000020.10 (45837859..45985443, complement)

Chromosome 20 - NC_000020.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

ZMYND8 Is a Regulator of Sonic Hedgehog Signaling in ATRA-Mediated Differentiation of Neuroblastoma Cells.
Title: ZMYND8 Is a Regulator of Sonic Hedgehog Signaling in ATRA-Mediated Differentiation of Neuroblastoma Cells.
USP7 deubiquitinates epigenetic reader ZMYND8 to promote breast cancer cell migration and invasion.
Title: USP7 deubiquitinates epigenetic reader ZMYND8 to promote breast cancer cell migration and invasion.
De Novo ZMYND8 variants result in an autosomal dominant neurodevelopmental disorder with cardiac malformations.
Title: De Novo ZMYND8 variants result in an autosomal dominant neurodevelopmental disorder with cardiac malformations.
RACK7 recognizes H3.3G34R mutation to suppress expression of MHC class II complex components and their delivery pathway in pediatric glioblastoma.
Title: RACK7 recognizes H3.3G34R mutation to suppress expression of MHC class II complex components and their delivery pathway in pediatric glioblastoma.
Validation of ZMYND8 as a new treatment target in hepatocellular carcinoma.
Title: Validation of ZMYND8 as a new treatment target in hepatocellular carcinoma.
ZMYND8-regulated IRF8 transcription axis is an acute myeloid leukemia dependency.
Title: ZMYND8-regulated IRF8 transcription axis is an acute myeloid leukemia dependency.
ZMYND8 preferentially binds phosphorylated EZH2 to promote a PRC2-dependent to -independent function switch in hypoxia-inducible factor-activated cancer.
Title: ZMYND8 preferentially binds phosphorylated EZH2 to promote a PRC2-dependent to -independent function switch in hypoxia-inducible factor-activated cancer.
ZMYND8 Expression in Breast Cancer Cells Blocks T-Lymphocyte Surveillance to Promote Tumor Growth.
Title: ZMYND8 Expression in Breast Cancer Cells Blocks T-Lymphocyte Surveillance to Promote Tumor Growth.
Suppression of poised oncogenes by ZMYND8 promotes chemo-sensitization.
Title: Suppression of poised oncogenes by ZMYND8 promotes chemo-sensitization.
ZMYND8 expression combined with pN and pM classification as a novel prognostic prediction model for colorectal cancer: Based on TCGA and GEO database analysis.
Title: ZMYND8 expression combined with pN and pM classification as a novel prognostic prediction model for colorectal cancer: Based on TCGA and GEO database analysis.

Submit: New GeneRIF Correction See all GeneRIFs (25)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide association study to characterize serum bilirubin elevations in patients with HCV treated with GS-9256, an HCV NS3 serine protease inhibitor. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
Envelope surface glycoprotein gp120	env	Genes, including GABRP, ADF, HINT, PRSS2, SDCBP, PTK9, PPP2R5B, ITGA3, PRKCBP1, HMOX2, HAT1, PPP1cB, and ICAM-1, are upregulated after treatment of human astrocytes with HIV-1 gp120	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D20S692 (e-PCR)
- UniSTS:78596

STS-T65756 (e-PCR)
- UniSTS:79367

SGC34777 (e-PCR)
- UniSTS:50733

G18078 (e-PCR)
- UniSTS:25430

WI-17092 (e-PCR)
- UniSTS:6242

RH36015 (e-PCR)
- UniSTS:35946

D20S770 (e-PCR)
- UniSTS:154234

RH66080 (e-PCR)
- UniSTS:41854

RH98976 (e-PCR)
- UniSTS:89984

D20S1104 (e-PCR)
- UniSTS:16261

Z94298 (e-PCR)
- UniSTS:33688

RH16216 (e-PCR)
- UniSTS:78505

STS-R11529 (e-PCR)
- UniSTS:71375

D20S764 (e-PCR)
- UniSTS:57040

RH98433 (e-PCR)
- UniSTS:86998

SHGC-32648 (e-PCR)
- UniSTS:34782

D20S891 (e-PCR), detects polymorphism
- UniSTS:46829

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables DNA-binding transcription factor binding	ISS Inferred from Sequence or Structural Similarity more info
enables lysine-acetylated histone binding	IDA Inferred from Direct Assay more info	PubMed
enables methylated histone binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein domain specific binding	IDA Inferred from Direct Assay more info	PubMed
enables transcription corepressor activity	IBA Inferred from Biological aspect of Ancestor more info
enables transcription corepressor activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables transcription corepressor activity	ISS Inferred from Sequence or Structural Similarity more info
enables zinc ion binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in chromatin organization	IEA Inferred from Electronic Annotation more info
involved_in double-strand break repair via homologous recombination	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in modulation of excitatory postsynaptic potential	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nervous system development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of dendritic spine development	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of dendritic spine maintenance	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of filopodium assembly	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of transcription elongation by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription elongation by RNA polymerase II	IPI Inferred from Physical Interaction more info	PubMed
involved_in protein localization to chromatin	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of postsynaptic density protein 95 clustering	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in chromatin	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IMP Inferred from Mutant Phenotype more info	PubMed
located_in dendritic shaft	IEA Inferred from Electronic Annotation more info
located_in dendritic spine	IEA Inferred from Electronic Annotation more info
located_in nucleolus	IDA Inferred from Direct Assay more info
located_in nucleoplasm	IDA Inferred from Direct Assay more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info
located_in site of DNA damage	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: MYND-type zinc finger-containing chromatin reader ZMYND8

Names: CTCL tumor antigen se14-3; RACK like clone 7; cutaneous T-cell lymphoma-associated antigen se14-3; predicted protein of HQ2893; protein kinase C-binding protein 1; transcription coregulator ZMYND8; zinc finger MYND domain-containing protein 8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001281769.2 → NP_001268698.1 MYND-type zinc finger-containing chromatin reader ZMYND8 isoform d

Status: REVIEWED

Description

Transcript Variant: This variant (4) lacks several exons and its 3'-terminal exon extends past a splice site that is used in variant 1. The encoded isoform (d) has a shorter and distinct C-terminus, compared to isoform a.

Source sequence(s)

BC092432, BX095755

UniProtKB/TrEMBL

Q569J9

Conserved Domains (1) summary

cd15538
Location:110 → 150

PHD_PRKCBP1; PHD finger found in protein kinase C-binding protein 1 (PRKCBP1)
NM_001281771.3 → NP_001268700.1 MYND-type zinc finger-containing chromatin reader ZMYND8 isoform e

Status: REVIEWED

Description

Transcript Variant: This variant (5) has multiple differences in the coding region but maintains the reading frame, compared to variant 1. The encoded isoform (e) is shorter, compared to isoform a.

Source sequence(s)

AI275390, AL022342, BC136608, BC146802, DQ368671, DR422399

Consensus CDS

CCDS63304.1

UniProtKB/TrEMBL

A0A087WYS3

Related

ENSP00000392964.2, ENST00000458360.6

Conserved Domains (7) summary

cd05841
Location:264 → 344

BS69_related; The PWWP domain is part of BS69 protein, a nuclear protein that specifically binds adenoviral E1A and Epstein-Barr viral EBNA2 proteins, suppressing their transactivation functions. BS69 is a multi-domain protein, containing bromo, PHD, PWWP, and MYND ...

cd05508
Location:146 → 244

Bromo_RACK7; Bromodomain, RACK7_like subfamily. RACK7 (also called human protein kinase C-binding protein) was identified as a potential tumor suppressor genes, it shares domain architecture with BS69/ZMYND11; both have been implicated in the regulation of cellular ...

cd15538
Location:85 → 125

PHD_PRKCBP1; PHD finger found in protein kinase C-binding protein 1 (PRKCBP1)

pfam01753
Location:896 → 930

zf-MYND; MYND finger

pfam07798
Location:801 → 892

DUF1640; Protein of unknown function (DUF1640)

pfam10243
Location:599 → 892

MIP-T3; Microtubule-binding protein MIP-T3

pfam12064
Location:421 → 615

DUF3544; Domain of unknown function (DUF3544)
NM_001281772.3 → NP_001268701.1 MYND-type zinc finger-containing chromatin reader ZMYND8 isoform f

Status: REVIEWED

Description

Transcript Variant: This variant (6) differs in the 5' UTR, has multiple coding region differences, and initiates translation from an alternate start codon, compared to variant 1. The encoded isoform (f) is shorter and has a distinct N-terminus, compared to isoform a.

Source sequence(s)

AB032951, AI275390, AK294511, AL022342, BC146802, DQ368674, DR422399

Consensus CDS

CCDS74738.1

UniProtKB/TrEMBL

H7C4X9

Related

ENSP00000379577.4, ENST00000396281.8

Conserved Domains (6) summary

cd05841
Location:269 → 349

BS69_related; The PWWP domain is part of BS69 protein, a nuclear protein that specifically binds adenoviral E1A and Epstein-Barr viral EBNA2 proteins, suppressing their transactivation functions. BS69 is a multi-domain protein, containing bromo, PHD, PWWP, and MYND ...

cd05508
Location:151 → 249

Bromo_RACK7; Bromodomain, RACK7_like subfamily. RACK7 (also called human protein kinase C-binding protein) was identified as a potential tumor suppressor genes, it shares domain architecture with BS69/ZMYND11; both have been implicated in the regulation of cellular ...

cd15538
Location:90 → 130

PHD_PRKCBP1; PHD finger found in protein kinase C-binding protein 1 (PRKCBP1)

pfam01753
Location:1028 → 1062

zf-MYND; MYND finger

pfam07798
Location:933 → 1024

DUF1640; Protein of unknown function (DUF1640)

pfam12064
Location:426 → 620

DUF3544; Domain of unknown function (DUF3544)
NM_001281773.3 → NP_001268702.1 MYND-type zinc finger-containing chromatin reader ZMYND8 isoform g

Status: REVIEWED

Description

Transcript Variant: This variant (7) differs in its 5' UTR, uses an alternate in-frame splice site in the central coding region, and initiates translation from a downstream start codon, compared to variant 1. The encoded isoform (g) is longer, compared to isoform a.

Source sequence(s)

AI275390, AK299899, AL022342, BC146802, DR422399

Consensus CDS

CCDS63300.1

UniProtKB/TrEMBL

H7C4X9

Related

ENSP00000348246.4, ENST00000355972.8

Conserved Domains (6) summary

cd05841
Location:269 → 349

BS69_related; The PWWP domain is part of BS69 protein, a nuclear protein that specifically binds adenoviral E1A and Epstein-Barr viral EBNA2 proteins, suppressing their transactivation functions. BS69 is a multi-domain protein, containing bromo, PHD, PWWP, and MYND ...

cd05508
Location:151 → 249

Bromo_RACK7; Bromodomain, RACK7_like subfamily. RACK7 (also called human protein kinase C-binding protein) was identified as a potential tumor suppressor genes, it shares domain architecture with BS69/ZMYND11; both have been implicated in the regulation of cellular ...

cd15538
Location:90 → 130

PHD_PRKCBP1; PHD finger found in protein kinase C-binding protein 1 (PRKCBP1)

pfam01753
Location:1028 → 1062

zf-MYND; MYND finger

pfam07798
Location:933 → 1024

DUF1640; Protein of unknown function (DUF1640)

pfam12064
Location:426 → 620

DUF3544; Domain of unknown function (DUF3544)
NM_001281774.3 → NP_001268703.1 MYND-type zinc finger-containing chromatin reader ZMYND8 isoform h

Status: REVIEWED

Description

Transcript Variant: This variant (8) differs in its 5' UTR, and initiates translation from a downstream start codon, compared to variant 1. The encoded isoform (h) has a shorter N-terminus, compared to isoform a.

Source sequence(s)

AI275390, AL022342, BC146802, BX641005, DQ368669, DR422399

Consensus CDS

CCDS63301.1

UniProtKB/TrEMBL

H7C4X9

Related

ENSP00000262975.4, ENST00000262975.8

Conserved Domains (6) summary

cd05841
Location:269 → 349

BS69_related; The PWWP domain is part of BS69 protein, a nuclear protein that specifically binds adenoviral E1A and Epstein-Barr viral EBNA2 proteins, suppressing their transactivation functions. BS69 is a multi-domain protein, containing bromo, PHD, PWWP, and MYND ...

cd05508
Location:151 → 249

Bromo_RACK7; Bromodomain, RACK7_like subfamily. RACK7 (also called human protein kinase C-binding protein) was identified as a potential tumor suppressor genes, it shares domain architecture with BS69/ZMYND11; both have been implicated in the regulation of cellular ...

cd15538
Location:90 → 130

PHD_PRKCBP1; PHD finger found in protein kinase C-binding protein 1 (PRKCBP1)

pfam01753
Location:982 → 1016

zf-MYND; MYND finger

pfam07798
Location:887 → 978

DUF1640; Protein of unknown function (DUF1640)

pfam12064
Location:426 → 620

DUF3544; Domain of unknown function (DUF3544)
NM_001281775.3 → NP_001268704.1 MYND-type zinc finger-containing chromatin reader ZMYND8 isoform i

Status: REVIEWED

Description

Transcript Variant: This variant (9) uses an alternate in-frame splice site in the central coding region, compared to variant 1. The encoded isoform (i) is longer, compared to isoform a.

Source sequence(s)

AI275390, AL022342, BC146802, DC362133, DQ368673, DR422399

Consensus CDS

CCDS63306.1

UniProtKB/TrEMBL

H7C4X9

Related

ENSP00000420095.2, ENST00000471951.7

Conserved Domains (6) summary

cd05841
Location:289 → 369

BS69_related; The PWWP domain is part of BS69 protein, a nuclear protein that specifically binds adenoviral E1A and Epstein-Barr viral EBNA2 proteins, suppressing their transactivation functions. BS69 is a multi-domain protein, containing bromo, PHD, PWWP, and MYND ...

cd05508
Location:171 → 269

Bromo_RACK7; Bromodomain, RACK7_like subfamily. RACK7 (also called human protein kinase C-binding protein) was identified as a potential tumor suppressor genes, it shares domain architecture with BS69/ZMYND11; both have been implicated in the regulation of cellular ...

cd15538
Location:110 → 150

PHD_PRKCBP1; PHD finger found in protein kinase C-binding protein 1 (PRKCBP1)

pfam01753
Location:1048 → 1082

zf-MYND; MYND finger

pfam07798
Location:953 → 1044

DUF1640; Protein of unknown function (DUF1640)

pfam12064
Location:446 → 640

DUF3544; Domain of unknown function (DUF3544)
NM_001281776.3 → NP_001268705.1 MYND-type zinc finger-containing chromatin reader ZMYND8 isoform j

Status: REVIEWED

Description

Transcript Variant: This variant (10) lacks an in-frame exon in the central coding region, compared to variant 1. The encoded isoform (j) is shorter, compared to isoform a.

Source sequence(s)

AI275390, AK299899, AL022342, BC146802, DC362133, DQ082999, DR422399

UniProtKB/TrEMBL

A0A087WYS3

Related

ENSP00000482048.1, ENST00000611941.4

Conserved Domains (7) summary

cd05841
Location:289 → 369

BS69_related; The PWWP domain is part of BS69 protein, a nuclear protein that specifically binds adenoviral E1A and Epstein-Barr viral EBNA2 proteins, suppressing their transactivation functions. BS69 is a multi-domain protein, containing bromo, PHD, PWWP, and MYND ...

cd05508
Location:171 → 269

Bromo_RACK7; Bromodomain, RACK7_like subfamily. RACK7 (also called human protein kinase C-binding protein) was identified as a potential tumor suppressor genes, it shares domain architecture with BS69/ZMYND11; both have been implicated in the regulation of cellular ...

cd15538
Location:110 → 150

PHD_PRKCBP1; PHD finger found in protein kinase C-binding protein 1 (PRKCBP1)

pfam01753
Location:921 → 955

zf-MYND; MYND finger

pfam07798
Location:826 → 917

DUF1640; Protein of unknown function (DUF1640)

pfam10243
Location:624 → 917

MIP-T3; Microtubule-binding protein MIP-T3

pfam12064
Location:446 → 640

DUF3544; Domain of unknown function (DUF3544)
NM_001281777.3 → NP_001268706.1 MYND-type zinc finger-containing chromatin reader ZMYND8 isoform k

Status: REVIEWED

Description

Transcript Variant: This variant (11) uses an alternate in-frame splice site in the central coding region, compared to variant 1. The encoded isoform (k) is shorter, compared to isoform a.

Source sequence(s)

AI275390, AL022342, BC146802, DC362133, DQ368672, DR422399

UniProtKB/TrEMBL

H7C4X9

Related

ENSP00000361093.5, ENST00000372023.7

Conserved Domains (6) summary

cd05841
Location:264 → 344

BS69_related; The PWWP domain is part of BS69 protein, a nuclear protein that specifically binds adenoviral E1A and Epstein-Barr viral EBNA2 proteins, suppressing their transactivation functions. BS69 is a multi-domain protein, containing bromo, PHD, PWWP, and MYND ...

cd05508
Location:146 → 244

Bromo_RACK7; Bromodomain, RACK7_like subfamily. RACK7 (also called human protein kinase C-binding protein) was identified as a potential tumor suppressor genes, it shares domain architecture with BS69/ZMYND11; both have been implicated in the regulation of cellular ...

cd15538
Location:85 → 125

PHD_PRKCBP1; PHD finger found in protein kinase C-binding protein 1 (PRKCBP1)

pfam01753
Location:977 → 1011

zf-MYND; MYND finger

pfam07798
Location:882 → 973

DUF1640; Protein of unknown function (DUF1640)

pfam12064
Location:421 → 615

DUF3544; Domain of unknown function (DUF3544)
NM_001281778.3 → NP_001268707.1 MYND-type zinc finger-containing chromatin reader ZMYND8 isoform l

Status: REVIEWED

Description

Transcript Variant: This variant (12) has multiple differences in the coding region but maintains the reading frame, compared to variant 1. The encoded isoform (l) is shorter, compared to isoform a.

Source sequence(s)

AI275390, AL022342, BC146802, DC362133, DQ368674, DR422399

UniProtKB/TrEMBL

H7C4X9

Conserved Domains (6) summary

cd05841
Location:264 → 344

BS69_related; The PWWP domain is part of BS69 protein, a nuclear protein that specifically binds adenoviral E1A and Epstein-Barr viral EBNA2 proteins, suppressing their transactivation functions. BS69 is a multi-domain protein, containing bromo, PHD, PWWP, and MYND ...

cd05508
Location:146 → 244

Bromo_RACK7; Bromodomain, RACK7_like subfamily. RACK7 (also called human protein kinase C-binding protein) was identified as a potential tumor suppressor genes, it shares domain architecture with BS69/ZMYND11; both have been implicated in the regulation of cellular ...

cd15538
Location:85 → 125

PHD_PRKCBP1; PHD finger found in protein kinase C-binding protein 1 (PRKCBP1)

pfam01753
Location:1023 → 1057

zf-MYND; MYND finger

pfam07798
Location:928 → 1019

DUF1640; Protein of unknown function (DUF1640)

pfam12064
Location:421 → 615

DUF3544; Domain of unknown function (DUF3544)
NM_001281779.3 → NP_001268708.1 MYND-type zinc finger-containing chromatin reader ZMYND8 isoform m

Status: REVIEWED

Description

Transcript Variant: This variant (13) differs in its 5' UTR and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (m) has a shorter N-terminus, compared to isoform a.

Source sequence(s)

AI275390, AL022342, BC146802, DC362133, DQ368675, DR422399

UniProtKB/TrEMBL

H7C4X9

Conserved Domains (4) summary

cd05841
Location:21 → 101

BS69_related; The PWWP domain is part of BS69 protein, a nuclear protein that specifically binds adenoviral E1A and Epstein-Barr viral EBNA2 proteins, suppressing their transactivation functions. BS69 is a multi-domain protein, containing bromo, PHD, PWWP, and MYND ...

pfam01753
Location:734 → 768

zf-MYND; MYND finger

pfam07798
Location:639 → 730

DUF1640; Protein of unknown function (DUF1640)

pfam12064
Location:178 → 372

DUF3544; Domain of unknown function (DUF3544)
NM_001281780.3 → NP_001268709.1 MYND-type zinc finger-containing chromatin reader ZMYND8 isoform n

Status: REVIEWED

Description

Transcript Variant: This variant (14) differs in its 5' UTR, lacks an in-frame exon in the 3' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (n) is shorter, compared to isoform a.

Source sequence(s)

AI275390, AL022342, BC146802, DC362133, DQ368676, DR422399

UniProtKB/TrEMBL

H7C4X9

Conserved Domains (4) summary

cd05841
Location:21 → 101

BS69_related; The PWWP domain is part of BS69 protein, a nuclear protein that specifically binds adenoviral E1A and Epstein-Barr viral EBNA2 proteins, suppressing their transactivation functions. BS69 is a multi-domain protein, containing bromo, PHD, PWWP, and MYND ...

pfam01753
Location:734 → 768

zf-MYND; MYND finger

pfam07798
Location:639 → 730

DUF1640; Protein of unknown function (DUF1640)

pfam12064
Location:178 → 372

DUF3544; Domain of unknown function (DUF3544)
NM_001281781.3 → NP_001268710.1 MYND-type zinc finger-containing chromatin reader ZMYND8 isoform o

Status: REVIEWED

Description

Transcript Variant: This variant (15) has multiple differences in the coding region but maintains the reading frame, compared to variant 1. The encoded isoform (o) is shorter, compared to isoform a.

Source sequence(s)

AI275390, AL022342, BC146802, DC362133, DQ368677, DR422399

UniProtKB/TrEMBL

H7C4X9

Conserved Domains (6) summary

cd05841
Location:264 → 344

BS69_related; The PWWP domain is part of BS69 protein, a nuclear protein that specifically binds adenoviral E1A and Epstein-Barr viral EBNA2 proteins, suppressing their transactivation functions. BS69 is a multi-domain protein, containing bromo, PHD, PWWP, and MYND ...

cd05508
Location:146 → 244

Bromo_RACK7; Bromodomain, RACK7_like subfamily. RACK7 (also called human protein kinase C-binding protein) was identified as a potential tumor suppressor genes, it shares domain architecture with BS69/ZMYND11; both have been implicated in the regulation of cellular ...

cd15538
Location:85 → 125

PHD_PRKCBP1; PHD finger found in protein kinase C-binding protein 1 (PRKCBP1)

pfam01753
Location:930 → 964

zf-MYND; MYND finger

pfam07798
Location:835 → 926

DUF1640; Protein of unknown function (DUF1640)

pfam12064
Location:421 → 568

DUF3544; Domain of unknown function (DUF3544)
NM_001281782.3 → NP_001268711.1 MYND-type zinc finger-containing chromatin reader ZMYND8 isoform p

Status: REVIEWED

Description

Transcript Variant: This variant (16) uses an alternate in-frame splice site and lacks an in-frame exon in the central coding region, compared to variant 1. The encoded isoform (p) is shorter, compared to isoform a.

Source sequence(s)

AI275390, AL022342, BC146802, DC362133, DQ368678, DR422399

Consensus CDS

CCDS63305.1

UniProtKB/TrEMBL

A0A087WVZ6, H7C4X9

Related

ENSP00000479806.2, ENST00000617418.4

Conserved Domains (6) summary

cd05841
Location:264 → 344

BS69_related; The PWWP domain is part of BS69 protein, a nuclear protein that specifically binds adenoviral E1A and Epstein-Barr viral EBNA2 proteins, suppressing their transactivation functions. BS69 is a multi-domain protein, containing bromo, PHD, PWWP, and MYND ...

cd05508
Location:146 → 244

Bromo_RACK7; Bromodomain, RACK7_like subfamily. RACK7 (also called human protein kinase C-binding protein) was identified as a potential tumor suppressor genes, it shares domain architecture with BS69/ZMYND11; both have been implicated in the regulation of cellular ...

cd15538
Location:85 → 125

PHD_PRKCBP1; PHD finger found in protein kinase C-binding protein 1 (PRKCBP1)

pfam01753
Location:950 → 984

zf-MYND; MYND finger

pfam11068
Location:875 → 939

YlqD; YlqD protein

pfam12064
Location:421 → 615

DUF3544; Domain of unknown function (DUF3544)
NM_001281783.3 → NP_001268712.1 MYND-type zinc finger-containing chromatin reader ZMYND8 isoform q

Status: REVIEWED

Description

Transcript Variant: This variant (17) uses an alternate in-frame splice site in the central coding region and lacks an in-frame exon in the 3' coding region, compared to variant 1. The encoded isoform (q) is longer, compared to isoform a.

Source sequence(s)

AI275390, AL022342, BC146802, DC362133, DQ368679, DR422399

UniProtKB/TrEMBL

H7C4X9

Conserved Domains (6) summary

cd05841
Location:289 → 369

BS69_related; The PWWP domain is part of BS69 protein, a nuclear protein that specifically binds adenoviral E1A and Epstein-Barr viral EBNA2 proteins, suppressing their transactivation functions. BS69 is a multi-domain protein, containing bromo, PHD, PWWP, and MYND ...

cd05508
Location:171 → 269

Bromo_RACK7; Bromodomain, RACK7_like subfamily. RACK7 (also called human protein kinase C-binding protein) was identified as a potential tumor suppressor genes, it shares domain architecture with BS69/ZMYND11; both have been implicated in the regulation of cellular ...

cd15538
Location:110 → 150

PHD_PRKCBP1; PHD finger found in protein kinase C-binding protein 1 (PRKCBP1)

pfam01753
Location:1048 → 1082

zf-MYND; MYND finger

pfam07798
Location:953 → 1044

DUF1640; Protein of unknown function (DUF1640)

pfam12064
Location:446 → 640

DUF3544; Domain of unknown function (DUF3544)
NM_001281784.3 → NP_001268713.1 MYND-type zinc finger-containing chromatin reader ZMYND8 isoform r

Status: REVIEWED

Description

Transcript Variant: This variant (18) has multiple differences in the coding region but maintains the reading frame, compared to variant 1. The encoded isoform (r) is shorter, compared to isoform a.

Source sequence(s)

AI275390, AL022342, BC146802, DC362133, DQ368680, DR422399

Consensus CDS

CCDS63303.1

UniProtKB/TrEMBL

H7C4X9

Related

ENSP00000443086.3, ENST00000540497.5

Conserved Domains (6) summary

cd05841
Location:264 → 344

BS69_related; The PWWP domain is part of BS69 protein, a nuclear protein that specifically binds adenoviral E1A and Epstein-Barr viral EBNA2 proteins, suppressing their transactivation functions. BS69 is a multi-domain protein, containing bromo, PHD, PWWP, and MYND ...

cd05508
Location:146 → 244

Bromo_RACK7; Bromodomain, RACK7_like subfamily. RACK7 (also called human protein kinase C-binding protein) was identified as a potential tumor suppressor genes, it shares domain architecture with BS69/ZMYND11; both have been implicated in the regulation of cellular ...

cd15538
Location:85 → 125

PHD_PRKCBP1; PHD finger found in protein kinase C-binding protein 1 (PRKCBP1)

pfam01753
Location:976 → 1010

zf-MYND; MYND finger

pfam07798
Location:881 → 972

DUF1640; Protein of unknown function (DUF1640)

pfam12064
Location:421 → 568

DUF3544; Domain of unknown function (DUF3544)
NM_001363714.1 → NP_001350643.1 MYND-type zinc finger-containing chromatin reader ZMYND8 isoform s

Status: REVIEWED

Source sequence(s)

AK295747, AL022342, AL031666

Consensus CDS

CCDS86962.1

UniProtKB/TrEMBL

H7C4X9

Related

ENSP00000439800.1, ENST00000536340.5

Conserved Domains (8) summary

cd05841
Location:296 → 376

BS69_related; The PWWP domain is part of BS69 protein, a nuclear protein that specifically binds adenoviral E1A and Epstein-Barr viral EBNA2 proteins, suppressing their transactivation functions. BS69 is a multi-domain protein, containing bromo, PHD, PWWP, and MYND ...

cd05508
Location:178 → 276

Bromo_RACK7; Bromodomain, RACK7_like subfamily. RACK7 (also called human protein kinase C-binding protein) was identified as a potential tumor suppressor genes, it shares domain architecture with BS69/ZMYND11; both have been implicated in the regulation of cellular ...

cd15538
Location:117 → 157

PHD_PRKCBP1; PHD finger found in protein kinase C-binding protein 1 (PRKCBP1)

pfam01753
Location:1055 → 1089

zf-MYND; MYND finger

pfam07798
Location:960 → 1051

DUF1640; Protein of unknown function (DUF1640)

pfam10243
Location:634 → 795

MIP-T3; Microtubule-binding protein MIP-T3

pfam12064
Location:445 → 647

DUF3544; Domain of unknown function (DUF3544)

cl26267
Location:31 → 160

ING; Inhibitor of growth proteins N-terminal histone-binding
NM_001363741.2 → NP_001350670.1 MYND-type zinc finger-containing chromatin reader ZMYND8 isoform t

Status: REVIEWED

Source sequence(s)

AL022342, AL031666

Consensus CDS

CCDS86961.1

UniProtKB/Swiss-Prot

B3KVL2, B7Z2A8, B7Z3E0, B7Z680, B7ZM62, E1P5U5, F5H0X3, H7C0U2, J3KPU3, Q13517, Q2HXV1, Q2HXV2, Q2HXV3, Q2HXV4, Q2HXV7, Q2HXV8, Q2HXV9, Q2HXW0, Q2HXW1, Q2HXW2, Q4JJ94, Q4JJ95, Q5TH09, Q5TH11, Q6MZM1, Q8WXC5, Q9H1F3, Q9H1F4, Q9H1F5, Q9H1L8, Q9H1L9, Q9H2G5, Q9NYN3, Q9UIX6, Q9ULU4

UniProtKB/TrEMBL

H7C4X9

Related

ENSP00000312237.7, ENST00000311275.11

Conserved Domains (8) summary

cd05841
Location:269 → 349

BS69_related; The PWWP domain is part of BS69 protein, a nuclear protein that specifically binds adenoviral E1A and Epstein-Barr viral EBNA2 proteins, suppressing their transactivation functions. BS69 is a multi-domain protein, containing bromo, PHD, PWWP, and MYND ...

cd05508
Location:151 → 249

Bromo_RACK7; Bromodomain, RACK7_like subfamily. RACK7 (also called human protein kinase C-binding protein) was identified as a potential tumor suppressor genes, it shares domain architecture with BS69/ZMYND11; both have been implicated in the regulation of cellular ...

cd15538
Location:90 → 130

PHD_PRKCBP1; PHD finger found in protein kinase C-binding protein 1 (PRKCBP1)

pfam01753
Location:1028 → 1062

zf-MYND; MYND finger

pfam07798
Location:933 → 1024

DUF1640; Protein of unknown function (DUF1640)

pfam10243
Location:607 → 768

MIP-T3; Microtubule-binding protein MIP-T3

pfam12064
Location:418 → 620

DUF3544; Domain of unknown function (DUF3544)

cl26267
Location:4 → 133

ING; Inhibitor of growth proteins N-terminal histone-binding
NM_012408.6 → NP_036540.3 MYND-type zinc finger-containing chromatin reader ZMYND8 isoform b

Status: REVIEWED

Description

Transcript Variant: This variant (2) lacks an in-frame exon in the 3' coding region, compared to variant 1. The encoded isoform (b) is shorter, compared to isoform a.

Source sequence(s)

AI275390, AL022342, BC146802, DC362133, DQ368670, DR422399

Consensus CDS

CCDS13404.1

UniProtKB/TrEMBL

H7C4X9

Related

ENSP00000335537.3, ENST00000352431.6

Conserved Domains (6) summary

cd05841
Location:289 → 369

BS69_related; The PWWP domain is part of BS69 protein, a nuclear protein that specifically binds adenoviral E1A and Epstein-Barr viral EBNA2 proteins, suppressing their transactivation functions. BS69 is a multi-domain protein, containing bromo, PHD, PWWP, and MYND ...

cd05508
Location:171 → 269

Bromo_RACK7; Bromodomain, RACK7_like subfamily. RACK7 (also called human protein kinase C-binding protein) was identified as a potential tumor suppressor genes, it shares domain architecture with BS69/ZMYND11; both have been implicated in the regulation of cellular ...

cd15538
Location:110 → 150

PHD_PRKCBP1; PHD finger found in protein kinase C-binding protein 1 (PRKCBP1)

pfam01753
Location:1002 → 1036

zf-MYND; MYND finger

pfam07798
Location:907 → 998

DUF1640; Protein of unknown function (DUF1640)

pfam12064
Location:446 → 640

DUF3544; Domain of unknown function (DUF3544)
NM_183047.4 → NP_898868.1 MYND-type zinc finger-containing chromatin reader ZMYND8 isoform a

Status: REVIEWED

Description

Transcript Variant: This variant (1) encodes isoform a.

Source sequence(s)

AI275390, AL022342, BC146802, DC362133, DQ368669, DR422399

Consensus CDS

CCDS13405.1

UniProtKB/TrEMBL

H7C4X9

Related

ENSP00000418210.1, ENST00000461685.5

Conserved Domains (6) summary

cd05841
Location:289 → 369

BS69_related; The PWWP domain is part of BS69 protein, a nuclear protein that specifically binds adenoviral E1A and Epstein-Barr viral EBNA2 proteins, suppressing their transactivation functions. BS69 is a multi-domain protein, containing bromo, PHD, PWWP, and MYND ...

cd05508
Location:171 → 269

Bromo_RACK7; Bromodomain, RACK7_like subfamily. RACK7 (also called human protein kinase C-binding protein) was identified as a potential tumor suppressor genes, it shares domain architecture with BS69/ZMYND11; both have been implicated in the regulation of cellular ...

cd15538
Location:110 → 150

PHD_PRKCBP1; PHD finger found in protein kinase C-binding protein 1 (PRKCBP1)

pfam01753
Location:1002 → 1036

zf-MYND; MYND finger

pfam07798
Location:907 → 998

DUF1640; Protein of unknown function (DUF1640)

pfam12064
Location:446 → 640

DUF3544; Domain of unknown function (DUF3544)
NM_183048.4 → NP_898869.1 MYND-type zinc finger-containing chromatin reader ZMYND8 isoform c

Status: REVIEWED

Description

Transcript Variant: This variant (3) lacks an in-frame exon in the 3' coding region and uses an alternate in-frame splice site in the 5' coding region, compared to variant 1. The encoded isoform (c) is shorter, compared to isoform a.

Source sequence(s)

AI275390, AL022342, BC146802, DC362133, DQ368671, DR422399

Consensus CDS

CCDS46613.1

UniProtKB/TrEMBL

H7C4X9

Related

ENSP00000354166.3, ENST00000360911.7

Conserved Domains (6) summary

cd05841
Location:264 → 344

BS69_related; The PWWP domain is part of BS69 protein, a nuclear protein that specifically binds adenoviral E1A and Epstein-Barr viral EBNA2 proteins, suppressing their transactivation functions. BS69 is a multi-domain protein, containing bromo, PHD, PWWP, and MYND ...

cd05508
Location:146 → 244

Bromo_RACK7; Bromodomain, RACK7_like subfamily. RACK7 (also called human protein kinase C-binding protein) was identified as a potential tumor suppressor genes, it shares domain architecture with BS69/ZMYND11; both have been implicated in the regulation of cellular ...

cd15538
Location:85 → 125

PHD_PRKCBP1; PHD finger found in protein kinase C-binding protein 1 (PRKCBP1)

pfam01753
Location:977 → 1011

zf-MYND; MYND finger

pfam07798
Location:882 → 973

DUF1640; Protein of unknown function (DUF1640)

pfam12064
Location:421 → 615

DUF3544; Domain of unknown function (DUF3544)