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    Gng3 guanine nucleotide binding protein (G protein), gamma 3 [ Mus musculus (house mouse) ]

    Gene ID: 14704, updated on 2-Nov-2024

    Summary

    Official Symbol
    Gng3provided by MGI
    Official Full Name
    guanine nucleotide binding protein (G protein), gamma 3provided by MGI
    Primary source
    MGI:MGI:102704
    See related
    Ensembl:ENSMUSG00000071658 AllianceGenome:MGI:102704
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Hg3d
    Summary
    Predicted to enable G-protein beta-subunit binding activity and GTPase activity. Predicted to be involved in G protein-coupled receptor signaling pathway and positive regulation of cytosolic calcium ion concentration. Located in cell body; dendrite; and postsynaptic density. Is active in synapse. Is expressed in several structures, including gut; nervous system; oocyte; renal vasculature; and sensory organ. Orthologous to human GNG3 (G protein subunit gamma 3). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in CNS E18 (RPKM 101.4), cortex adult (RPKM 71.8) and 7 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Gng3 in Genome Data Viewer
    Location:
    19 A; 19 5.76 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (8814293..8816610, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (8836929..8839246, complement)

    Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene zinc finger and BTB domain containing 3 Neighboring gene tetratricopeptide repeat domain 9C Neighboring gene STARR-seq mESC enhancer starr_45496 Neighboring gene heterogeneous nuclear ribonucleoprotein U-like 2 Neighboring gene BSCL2 lipid droplet biogenesis associated, seipin Neighboring gene LRRN4 C-terminal like Neighboring gene STARR-seq mESC enhancer starr_45500 Neighboring gene UBX domain protein 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Related articles in PubMed

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables G-protein beta-subunit binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables G-protein beta-subunit binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables GTPase activity ISA
    Inferred from Sequence Alignment
    more info
    PubMed 
    enables GTPase activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cell body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in dendrite IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of heterotrimeric G-protein complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of heterotrimeric G-protein complex ISA
    Inferred from Sequence Alignment
    more info
    PubMed 
    part_of heterotrimeric G-protein complex ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    located_in postsynaptic density IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in synapse EXP
    Inferred from Experiment
    more info
    PubMed 
    is_active_in synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3
    Names
    guanine nucleotide binding protein (G protein), gamma 3 subunit
    heterotrimeric guanine nucleotide-binding protein 3d

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_010316.3NP_034446.1  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3

      See identical proteins and their annotated locations for NP_034446.1

      Status: VALIDATED

      Source sequence(s)
      AK032646, BE949484, BY290040
      Consensus CDS
      CCDS29550.1
      UniProtKB/Swiss-Prot
      P63216
      Related
      ENSMUSP00000093978.5, ENSMUST00000096259.6
      Conserved Domains (1) summary
      smart00224
      Location:1375
      GGL; G protein gamma subunit-like motifs

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000085.7 Reference GRCm39 C57BL/6J

      Range
      8814293..8816610 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)