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    MEGF11 multiple EGF like domains 11 [ Homo sapiens (human) ]

    Gene ID: 84465, updated on 28-Oct-2024

    Summary

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    Official Symbol
    MEGF11provided by HGNC
    Official Full Name
    multiple EGF like domains 11provided by HGNC
    Primary source
    HGNC:HGNC:29635
    See related
    Ensembl:ENSG00000157890 MIM:612454; AllianceGenome:HGNC:29635
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    Predicted to enable scavenger receptor activity. Predicted to be involved in homotypic cell-cell adhesion and retina layer formation. Predicted to be located in basolateral plasma membrane. [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Biased expression in brain (RPKM 3.0), testis (RPKM 0.5) and 2 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See MEGF11 in Genome Data Viewer
    Location:
    15q22.31
    Exon count:
    29
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 15 NC_000015.10 (65895299..66253750, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 15 NC_060939.1 (63704723..64075393, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (66187637..66546088, complement)

    Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9609 Neighboring gene tRNA-Gln (anticodon CTG) 1-4 Neighboring gene ReSE screen-validated silencer GRCh37_chr15:66194834-66194998 Neighboring gene H3K27ac hESC enhancer GRCh37_chr15:66195001-66195792 Neighboring gene RAB11A, member RAS oncogene family Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:66214128-66214697 Neighboring gene Sharpr-MPRA regulatory region 15210 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:66246132-66246645 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:66249933-66250434 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:66249429-66249932 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:66256890-66257866 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:66272648-66273148 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:66273149-66273649 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:66274440-66274940 Neighboring gene uncharacterized LOC105370867 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:66315774-66316274 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:66316275-66316775 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:66340493-66341368 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:66349054-66349554 Neighboring gene ReSE screen-validated silencer GRCh37_chr15:66357857-66358057 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:66358200-66358762 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:66365553-66366053 Neighboring gene microRNA 4311 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:66371850-66372818 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:66372819-66373785 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:66388655-66389435 Neighboring gene ReSE screen-validated silencer GRCh37_chr15:66408056-66408295 Neighboring gene Sharpr-MPRA regulatory region 9514 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:66435333-66436223 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:66460026-66460820 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:66461585-66462085 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr15:66472833-66473489 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6562 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:66591355-66591855 Neighboring gene DIS3L antisense RNA 1 Neighboring gene ReSE screen-validated silencer GRCh37_chr15:66630872-66631107 Neighboring gene DIS3 like exosome 3'-5' exoribonuclease Neighboring gene small Cajal body-specific RNA 14 Neighboring gene TIMELESS interacting protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Overexpression of multiple epidermal growth factor like domains 11 rescues anoikis survival through tumor cells-platelet interaction in triple negative breast Cancer cells. Huang CP, et al. Life Sci, 2022 Jun 15. PMID 35398017
    2. The mammalian Ced-1 ortholog MEGF10/KIAA1780 displays a novel adhesion pattern. Suzuki E, et al. Exp Cell Res, 2007 Jul 1. PMID 17498693
    3. Prenatal phthalate exposure and cord blood DNA methylation. Lee J, et al. Sci Rep, 2023 Apr 29. PMID 37120575, Free PMC Article
    4. Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. Nagase T, et al. DNA Res, 2001 Apr 27. PMID 11347906
    5. Assessment of a polymorphism of SDK1 with hypertension in Japanese Individuals. Oguri M, et al. Am J Hypertens, 2010 Jan. PMID 19851296

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Prenatal phthalate exposure and cord blood DNA methylation.
      Title: Prenatal phthalate exposure and cord blood DNA methylation.
    2. Overexpression of multiple epidermal growth factor like domains 11 rescues anoikis survival through tumor cells-platelet interaction in triple negative breast Cancer cells.
      Title: Overexpression of multiple epidermal growth factor like domains 11 rescues anoikis survival through tumor cells-platelet interaction in triple negative breast Cancer cells.
    3. Observational study of gene-disease association. (HuGE Navigator)
      Title: Association of genetic variants with hemorrhagic stroke in Japanese individuals.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • KIAA1781, DKFZp434L121

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in homotypic cell-cell adhesion ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in retina layer formation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in basolateral plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    multiple epidermal growth factor-like domains protein 11
    Names
    multiple EGF-like domains protein 11

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001385028.1 → NP_001371957.1  multiple epidermal growth factor-like domains protein 11 isoform 1 precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AC011847, AC084854, AC087382
      Consensus CDS
      CCDS92027.1
      UniProtKB/TrEMBL
      A0A0A0MS64
      Related
      ENSP00000378976.2, ENST00000395614.6
      Conserved Domains (2) summary
      pfam07546
      Location:26 → 93
      EMI; EMI domain
      cl21504
      Location:275 → 320
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

    2. NM_001385029.1 → NP_001371958.1  multiple epidermal growth factor-like domains protein 11 isoform 3 precursor

      Status: VALIDATED

      Source sequence(s)
      AC011847, AC084854, AC087382
      UniProtKB/TrEMBL
      A0A0G2JN40
      Conserved Domains (2) summary
      pfam07546
      Location:26 → 93
      EMI; EMI domain
      cl21504
      Location:275 → 320
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

    3. NM_001385030.1 → NP_001371959.1  multiple epidermal growth factor-like domains protein 11 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC011847, AC084854, AC087382
      Consensus CDS
      CCDS92026.1
      UniProtKB/TrEMBL
      A0A0G2JLW8
      Related
      ENSP00000288745.3, ENST00000288745.7

    4. NM_001385031.1 → NP_001371960.1  multiple epidermal growth factor-like domains protein 11 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC011847, AC084854, AC087382
      UniProtKB/TrEMBL
      A0A0G2JLW8

    5. NM_001385032.1 → NP_001371961.1  multiple epidermal growth factor-like domains protein 11 isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC011847, AC084854, AC087382
      UniProtKB/TrEMBL
      A0A0G2JLW8

    6. NM_001385033.1 → NP_001371962.1  multiple epidermal growth factor-like domains protein 11 isoform 7 precursor

      Status: VALIDATED

      Source sequence(s)
      AC011847, AC084854, AC087382
      UniProtKB/TrEMBL
      A0A0G2JN40
      Conserved Domains (1) summary
      pfam07546
      Location:26 → 93
      EMI; EMI domain

    7. NM_001387150.1 → NP_001374079.1  multiple epidermal growth factor-like domains protein 11 isoform 2 precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (13), as well as variant 2, encodes isoform 2.
      Source sequence(s)
      AC011847, AC084854, AC087382
      Consensus CDS
      CCDS10213.2
      UniProtKB/Swiss-Prot
      A6BM72, Q17R86, Q6UXS5, Q8ND91, Q96KG6
      UniProtKB/TrEMBL
      A0A0G2JN40
      Related
      ENSP00000386908.2, ENST00000409699.6
      Conserved Domains (2) summary
      pfam07546
      Location:25 → 94
      EMI; EMI domain
      cl21504
      Location:275 → 320
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

    8. NM_001387151.1 → NP_001374080.1  multiple epidermal growth factor-like domains protein 11 isoform 8 precursor

      Status: VALIDATED

      Source sequence(s)
      AC011847, AC087382
      Conserved Domains (1) summary
      pfam07546
      Location:26 → 93
      EMI; EMI domain

    9. NM_032445.3 → NP_115821.2  multiple epidermal growth factor-like domains protein 11 isoform 2 precursor

      See identical proteins and their annotated locations for NP_115821.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2), as well as variant 13, encodes isoform 2.
      Source sequence(s)
      AC011847, AC084854, AC087382
      Consensus CDS
      CCDS10213.2
      UniProtKB/Swiss-Prot
      A6BM72, Q17R86, Q6UXS5, Q8ND91, Q96KG6
      UniProtKB/TrEMBL
      A0A0G2JN40
      Related
      ENSP00000414475.1, ENST00000422354.6
      Conserved Domains (2) summary
      pfam07546
      Location:25 → 94
      EMI; EMI domain
      cl21504
      Location:275 → 320
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

    RNA

    1. NR_169554.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC011847, AC084854, AC087382

    2. NR_169555.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC011847, AC084854, AC087382

    3. NR_169556.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC011847, AC084854, AC087382

    4. NR_169557.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC011847, AC084854, AC087382

    5. NR_169558.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC011847, AC084854, AC087382

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000015.10 Reference GRCh38.p14 Primary Assembly

      Range
      65895299..66253750 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017022670.3 → XP_016878159.1  multiple epidermal growth factor-like domains protein 11 isoform X1

    2. XM_047433168.1 → XP_047289124.1  multiple epidermal growth factor-like domains protein 11 isoform X6

    3. XM_047433165.1 → XP_047289121.1  multiple epidermal growth factor-like domains protein 11 isoform X4

      UniProtKB/TrEMBL
      A0A0A0MS64

    4. XM_017022671.3 → XP_016878160.1  multiple epidermal growth factor-like domains protein 11 isoform X2

      UniProtKB/TrEMBL
      A0A0G2JN40

    5. XM_017022674.3 → XP_016878163.1  multiple epidermal growth factor-like domains protein 11 isoform X8

    6. XM_017022675.3 → XP_016878164.1  multiple epidermal growth factor-like domains protein 11 isoform X8

    7. XM_047433169.1 → XP_047289125.1  multiple epidermal growth factor-like domains protein 11 isoform X7

    8. XM_047433167.1 → XP_047289123.1  multiple epidermal growth factor-like domains protein 11 isoform X5

    9. XM_017022673.3 → XP_016878162.1  multiple epidermal growth factor-like domains protein 11 isoform X4

      UniProtKB/TrEMBL
      A0A0G2JN40
      Conserved Domains (2) summary
      pfam07546
      Location:26 → 93
      EMI; EMI domain
      cl21504
      Location:275 → 320
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

    10. XM_047433166.1 → XP_047289122.1  multiple epidermal growth factor-like domains protein 11 isoform X3

    11. XM_047433170.1 → XP_047289126.1  multiple epidermal growth factor-like domains protein 11 isoform X9

    Reference GRCh38.p14 ALT_REF_LOCI_1

    Genomic

    1. NW_003315944.2 Reference GRCh38.p14 ALT_REF_LOCI_1

      Range
      850..357705 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060939.1 Alternate T2T-CHM13v2.0

      Range
      63704723..64075393 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054378985.1 → XP_054234960.1  multiple epidermal growth factor-like domains protein 11 isoform X1

    2. XM_054378984.1 → XP_054234959.1  multiple epidermal growth factor-like domains protein 11 isoform X4

    3. XM_054378986.1 → XP_054234961.1  multiple epidermal growth factor-like domains protein 11 isoform X2

    4. XM_054378992.1 → XP_054234967.1  multiple epidermal growth factor-like domains protein 11 isoform X8

    5. XM_054378993.1 → XP_054234968.1  multiple epidermal growth factor-like domains protein 11 isoform X8

    6. XM_054378990.1 → XP_054234965.1  multiple epidermal growth factor-like domains protein 11 isoform X6

    7. XM_054378991.1 → XP_054234966.1  multiple epidermal growth factor-like domains protein 11 isoform X7

    8. XM_054378989.1 → XP_054234964.1  multiple epidermal growth factor-like domains protein 11 isoform X5

    9. XM_054378988.1 → XP_054234963.1  multiple epidermal growth factor-like domains protein 11 isoform X4

    10. XM_054378987.1 → XP_054234962.1  multiple epidermal growth factor-like domains protein 11 isoform X3

    11. XM_054378994.1 → XP_054234969.1  multiple epidermal growth factor-like domains protein 11 isoform X9

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A6BM72.3 GenPept UniProtKB/Swiss-Prot:A6BM72

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