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These reference sequences exist independently of genome builds. Explain
These reference sequences are curated independently of the genome
annotation cycle, so their versions may not match the RefSeq versions in the current
genome build. Identify version mismatches by comparing the version of the RefSeq in
this section to the one reported in Genomic regions,
transcripts, and products above.
Genomic
-
NG_011608.2 RefSeqGene
- Range
-
5001..28792
- Download
- GenBank, FASTA, Sequence Viewer (Graphics), LRG_44
mRNA and Protein(s)
-
NM_001145873.1 → NP_001139345.1 T-cell surface glycoprotein CD8 alpha chain isoform 1 precursor
See identical proteins and their annotated locations for NP_001139345.1
Status: REVIEWED
- Description
- Transcript Variant: This variant (3) represents use of an alternate promoter and 5' UTR, compared to variant 1. Both variants 1 and 3 encode the longer, membrane associated isoform (1).
- Source sequence(s)
-
AA668685, AK124156, BC025715, DA075688
- Consensus CDS
-
CCDS1992.1
- UniProtKB/Swiss-Prot
- B4DT80, D6W5M8, P01732, Q13970, Q4ZG17
- UniProtKB/TrEMBL
- Q8TAW8, Q96QR6
- Related
- ENSP00000386559.2, ENST00000409511.6
- Conserved Domains (1) summary
-
- cd05720
Location:24 → 133
- IgV_CD8_alpha; Immunoglobulin (Ig)-like variable (V) domain of Cluster of Differentiation (CD) 8 alpha chain
-
NM_001382698.1 → NP_001369627.1 T-cell surface glycoprotein CD8 alpha chain isoform 1 precursor
Status: REVIEWED
- Source sequence(s)
-
AC064848, AC112696
- Consensus CDS
-
CCDS1992.1
- UniProtKB/Swiss-Prot
- B4DT80, D6W5M8, P01732, Q13970, Q4ZG17
- UniProtKB/TrEMBL
- Q8TAW8, Q96QR6
- Conserved Domains (1) summary
-
- cd05720
Location:24 → 133
- IgV_CD8_alpha; Immunoglobulin (Ig)-like variable (V) domain of Cluster of Differentiation (CD) 8 alpha chain
-
NM_001768.7 → NP_001759.3 T-cell surface glycoprotein CD8 alpha chain isoform 1 precursor
See identical proteins and their annotated locations for NP_001759.3
Status: REVIEWED
- Description
- Transcript Variant: This variant (1) encodes the longer, membrane associated isoform (1). Both variants 1 and 3 encode the same isoform (1).
- Source sequence(s)
-
AC064848, AK124156, BC025715
- Consensus CDS
-
CCDS1992.1
- UniProtKB/Swiss-Prot
- B4DT80, D6W5M8, P01732, Q13970, Q4ZG17
- UniProtKB/TrEMBL
- Q8TAW8, Q96QR6
- Related
- ENSP00000283635.3, ENST00000283635.8
- Conserved Domains (1) summary
-
- cd05720
Location:24 → 133
- IgV_CD8_alpha; Immunoglobulin (Ig)-like variable (V) domain of Cluster of Differentiation (CD) 8 alpha chain
-
NM_171827.4 → NP_741969.1 T-cell surface glycoprotein CD8 alpha chain isoform 2 precursor
See identical proteins and their annotated locations for NP_741969.1
Status: REVIEWED
- Description
- Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting protein (isoform 2) lacks an internal segment including the transmembrane domain compared to isoform 1, resulting in a secreted protein.
- Source sequence(s)
-
AC064848
- Consensus CDS
-
CCDS1993.1
- UniProtKB/TrEMBL
- Q8TAW8, Q96QR6
- Related
- ENSP00000321631.3, ENST00000352580.7
- Conserved Domains (2) summary
-
- cd05720
Location:31 → 133
- Ig_CD8_alpha; Immunoglobulin (Ig) like domain of CD8 alpha chain
- smart00410
Location:28 → 128
- IG_like; Immunoglobulin like
RNA
-
NR_027353.2 RNA Sequence
Status: REVIEWED
- Description
- Transcript Variant: This variant (4) uses an alternate 5' splice pattern, compared to variant 1. This variant is represented as non-coding due to the presence of an upstream ORF that is predicted to interfere with translation of the longest ORF; translation of the upstream ORF renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
- Source sequence(s)
-
AC064848, AK300089, BC025715
-
NR_168478.1 RNA Sequence
Status: REVIEWED
- Source sequence(s)
-
AC064848, AC112696
-
NR_168479.1 RNA Sequence
Status: REVIEWED
- Source sequence(s)
-
AC064848, AC112696
-
NR_168480.1 RNA Sequence
Status: REVIEWED
- Source sequence(s)
-
AC064848, AC112696
-
NR_168481.1 RNA Sequence
Status: REVIEWED
- Source sequence(s)
-
AC064848, AC112696
- Related
-
ENST00000699437.1
The following sections contain reference sequences that belong to a
specific genome build. Explain
This section includes genomic Reference
Sequences (RefSeqs) from all assemblies on which this gene is annotated, such as
RefSeqs for chromosomes and scaffolds (contigs) from both reference and alternate
assemblies. Model RNAs and proteins are also reported here.
Reference GRCh38.p14 Primary Assembly
Genomic
-
NC_000002.12 Reference GRCh38.p14 Primary Assembly
- Range
-
86784605..86808396 complement
- Download
- GenBank, FASTA, Sequence Viewer (Graphics)
Alternate T2T-CHM13v2.0
Genomic
-
NC_060926.1 Alternate T2T-CHM13v2.0
- Range
-
86786504..86810303 complement
- Download
- GenBank, FASTA, Sequence Viewer (Graphics)