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    MRFAP1L2 Morf4 family associated protein 1 like 2 [ Homo sapiens (human) ]

    Gene ID: 93622, updated on 2-Nov-2024

    Summary

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    Official Symbol
    MRFAP1L2provided by HGNC
    Official Full Name
    Morf4 family associated protein 1 like 2provided by HGNC
    Primary source
    HGNC:HGNC:25109
    See related
    Ensembl:ENSG00000170846 AllianceGenome:HGNC:25109
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    UPP
    Summary
    Involved in regulation of cell cycle. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in brain (RPKM 12.2), ovary (RPKM 8.2) and 24 other tissues See more
    Orthologs
    all
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    Genomic context

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    See MRFAP1L2 in Genome Data Viewer
    Location:
    4p16.1
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (6674075..6676047)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (6648973..6651114)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (6675802..6677774)

    Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124900840 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15234 Neighboring gene long intergenic non-protein coding RNA 2482 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:6674796-6675404 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15235 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:6684859-6685361 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:6685913-6686414 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr4:6690316-6691515 Neighboring gene long intergenic non-protein coding RNA 2481 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:6694289-6694826 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:6695136-6695872 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:6695873-6696608 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:6697811-6698573 Neighboring gene S100 calcium binding protein P

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Interaction between p12CDK2AP1 and a novel unnamed protein product inhibits cell proliferation by regulating the cell cycle. Liu L, et al. Mol Med Rep, 2014 Jan. PMID 24248101
    2. Cross-linking mass spectrometry reveals the structural topology of peripheral NuRD subunits relative to the core complex. Spruijt CG, et al. FEBS J, 2021 May. PMID 33283408, Free PMC Article
    3. Ubiquitin-mediated proteolysis of HuR by heat shock. Abdelmohsen K, et al. EMBO J, 2009 May 6. PMID 19322201, Free PMC Article
    4. RIG-I regulates myeloid differentiation by promoting TRIM25-mediated ISGylation. Wu SF, et al. Proc Natl Acad Sci U S A, 2020 Jun 23. PMID 32513696, Free PMC Article
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • AC093323.3

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in regulation of cell cycle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    MORF4 family associated protein 1 like 2
    Names
    MORF4 family-associated protein 1-like protein UPP
    putative MORF4 family-associated protein 1-like protein UPP

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_138699.3 → NP_619644.1  MORF4 family associated protein 1 like 2

      Status: VALIDATED

      Source sequence(s)
      AC093323
      UniProtKB/Swiss-Prot
      B2RBV5
      Related
      ENSP00000493540.1, ENST00000635031.2
      Conserved Domains (1) summary
      pfam15155
      Location:1 → 119
      MRFAP1; MORF4 family-associated protein1

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

      Range
      6674075..6676047
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047416419.1 → XP_047272375.1  MORF4 family associated protein 1 like 2 isoform X1

      UniProtKB/Swiss-Prot
      B2RBV5
      Related
      ENSP00000495193.1, ENST00000307533.10

    2. XM_047416420.1 → XP_047272376.1  MORF4 family associated protein 1 like 2 isoform X1

      UniProtKB/Swiss-Prot
      B2RBV5
      Related
      ENSP00000493702.1, ENST00000444232.3

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060928.1 Alternate T2T-CHM13v2.0

      Range
      6648973..6651114
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054351268.1 → XP_054207243.1  MORF4 family associated protein 1 like 2 isoform X1

      UniProtKB/Swiss-Prot
      B2RBV5

    2. XM_054351269.1 → XP_054207244.1  MORF4 family associated protein 1 like 2 isoform X1

      UniProtKB/Swiss-Prot
      B2RBV5
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    B2RBV5.1 GenPept UniProtKB/Swiss-Prot:B2RBV5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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    Research Materials