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    AGTRAP angiotensin II receptor associated protein [ Homo sapiens (human) ]

    Gene ID: 57085, updated on 28-Oct-2024

    Summary

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    Official Symbol
    AGTRAPprovided by HGNC
    Official Full Name
    angiotensin II receptor associated proteinprovided by HGNC
    Primary source
    HGNC:HGNC:13539
    See related
    Ensembl:ENSG00000177674 MIM:608729; AllianceGenome:HGNC:13539
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ATRAP
    Summary
    This gene encodes a transmembrane protein localized to the plasma membrane and perinuclear vesicular structures. The gene product interacts with the angiotensin II type I receptor and negatively regulates angiotensin II signaling. Alternative splicing of this gene generates multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in bone marrow (RPKM 38.0), prostate (RPKM 28.1) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See AGTRAP in Genome Data Viewer
    Location:
    1p36.22
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (11736136..11750769)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (11280231..11294863)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (11796193..11810826)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 268 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 269 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 168 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 169 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 170 Neighboring gene F-box protein 6 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 270 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 271 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:11743170-11743751 Neighboring gene mitotic arrest deficient 2 like 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:11744701-11745201 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:11750065-11750574 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:11750575-11751082 Neighboring gene dorsal inhibitory axon guidance protein Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:11764337-11764964 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 171 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:11786269-11787256 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 172 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:11808242-11808918 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:11808919-11809595 Neighboring gene atrophin-1-like Neighboring gene chromosome 1 open reading frame 167 Neighboring gene C1orf167 antisense RNA 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. A role for AT1 receptor-associated proteins in blood pressure regulation. Castrop H. Curr Opin Pharmacol, 2015 Apr. PMID 25562590
    2. Association of angiotensin II type 1 receptor-associated protein gene polymorphism with increased mortality in septic shock. Nakada TA, et al. Crit Care Med, 2011 Jul. PMID 21423001
    3. Association between A1166C Polymorphism of the Angiotensin II Type-1 Receptor Gene and Type-2 Diabetic Nephropathy in an Indonesian Malay Population. Ali Z, et al. Acta Med Indones, 2018 Oct. PMID 30630996
    4. Influence of endogenous angiotensin II on control of sympathetic nerve activity in human dehydration. Rabbitts JA, et al. J Physiol, 2009 Nov 15. PMID 19805740, Free PMC Article
    5. The pathophysiological role of angiotensin receptor-binding protein in hypertension and kidney diseases: Oshima Award Address 2019. Wakui H. Clin Exp Nephrol, 2020 Apr. PMID 32112267, Free PMC Article

    See all (58) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. USF1-ATRAP-PBX3 Axis Promote Breast Cancer Glycolysis and Malignant Phenotype by Activating AKT/mTOR Signaling.
      Title: USF1-ATRAP-PBX3 Axis Promote Breast Cancer Glycolysis and Malignant Phenotype by Activating AKT/mTOR Signaling.
    2. S-adenosylmethionine upregulates the angiotensin receptor-binding protein ATRAP via the methylation of HuR in NAFLD.
      Title: S-adenosylmethionine upregulates the angiotensin receptor-binding protein ATRAP via the methylation of HuR in NAFLD.
    3. The pathophysiological role of angiotensin receptor-binding protein in hypertension and kidney diseases: Oshima Award Address 2019.
      Title: The pathophysiological role of angiotensin receptor-binding protein in hypertension and kidney diseases: Oshima Award Address 2019.
    4. Angiotensin II type 1 receptor-associated protein deficiency attenuates sirtuin1 expression in an immortalised human renal proximal tubule cell line.
      Title: Angiotensin II type 1 receptor-associated protein deficiency attenuates sirtuin1 expression in an immortalised human renal proximal tubule cell line.
    5. Leukocyte ATRAP is an emerging marker capable of reflecting the systemic and leukocyte inflammatory profile, and plays a role as an anti-inflammatory factor in the pathophysiology of non-communicable diseases.
      Title: Angiotensin receptor-binding molecule in leukocytes in association with the systemic and leukocyte inflammatory profile.
    6. There was positive association between A1166C AT1R polymorphism and susceptibility of type-2 diabetics to diabetic nephropathy (DN) in the Malay Indonesian population.
      Title: Association between A1166C Polymorphism of the Angiotensin II Type-1 Receptor Gene and Type-2 Diabetic Nephropathy in an Indonesian Malay Population.
    7. A role for AT1 receptor-associated proteins in blood pressure regulation
      Title: A role for AT1 receptor-associated proteins in blood pressure regulation.
    8. ATRAP, a directly interacting and functionally inhibiting molecule of AT1R, plays a protective role against the development of systemic insulin resistance via regulatory effects on adipose tissue function.
      Title: Angiotensin receptor-binding protein ATRAP/Agtrap inhibits metabolic dysfunction with visceral obesity.
    9. The phosphatidylinositol transfer protein RdgBbeta binds 14-3-3 via its unstructured C-terminus, whereas its lipid-binding domain interacts with the integral membrane protein ATRAP (angiotensin II type I receptor-associated protein).
      Title: The phosphatidylinositol transfer protein RdgBβ binds 14-3-3 via its unstructured C-terminus, whereas its lipid-binding domain interacts with the integral membrane protein ATRAP (angiotensin II type I receptor-associated protein).
    10. the GG genotype of the AGTRAP rs11121816 T/G single nucleotide polymorphism was associated with increased mortality in two cohorts of patients who had septic shock.
      Title: Association of angiotensin II type 1 receptor-associated protein gene polymorphism with increased mortality in septic shock.
    Submit: New GeneRIF Correction See all GeneRIFs (19)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Genome-wide association study identifies eight loci associated with blood pressure.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC29646

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables angiotensin type II receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in angiotensin-activated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of blood pressure IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in response to hypoxia IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    		  
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cell cortex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasmic vesicle membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in intracellular membrane-bounded organelle IDA
    Inferred from Direct Assay
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    type-1 angiotensin II receptor-associated protein
    Names
    AT1 receptor-associated protein
    ATI receptor-associated protein
    angiotensin II, type I receptor-associated protein

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001040194.2 → NP_001035284.1  type-1 angiotensin II receptor-associated protein isoform b

      See identical proteins and their annotated locations for NP_001035284.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1, resulting in a shorter protein (isoform b), compared to isoform a.
      Source sequence(s)
      AI741916, BC017328, BI117521, BQ672962
      Consensus CDS
      CCDS30585.1
      UniProtKB/TrEMBL
      A8K1X7
      Related
      ENSP00000365816.4, ENST00000376629.8
      Conserved Domains (1) summary
      pfam06396
      Location:9 → 145
      AGTRAP; Angiotensin II, type I receptor-associated protein (AGTRAP)

    2. NM_001040195.2 → NP_001035285.1  type-1 angiotensin II receptor-associated protein isoform c

      See identical proteins and their annotated locations for NP_001035285.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks an exon and uses an alternate splice site for a second exon in the 3' coding region, compared to variant 1, resulting in a frameshift. The resulting protein (isoform c) has a distinct C-terminus compared to isoform a.
      Source sequence(s)
      AI741916, BC017328, BQ672962, CA866314
      Consensus CDS
      CCDS30586.1
      UniProtKB/Swiss-Prot
      Q6RW13
      Related
      ENSP00000365824.3, ENST00000376637.7

    3. NM_001040196.2 → NP_001035286.1  type-1 angiotensin II receptor-associated protein isoform d

      See identical proteins and their annotated locations for NP_001035286.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) includes an alternate exon and uses an alternate splice site for a second exon in the 3' coding region, compared to variant 1, resulting in a frameshift. The resulting protein (isoform d) has a distinct C-terminus compared to isoform a.
      Source sequence(s)
      AI741916, BC017328, BE782705, BI117521, BQ672962
      Consensus CDS
      CCDS44056.1
      UniProtKB/TrEMBL
      X6R9H3
      Related
      ENSP00000408505.2, ENST00000452018.6
      Conserved Domains (1) summary
      cl05741
      Location:1 → 20
      AGTRAP; Angiotensin II, type I receptor-associated protein (AGTRAP)

    4. NM_001040197.2 → NP_001035287.1  type-1 angiotensin II receptor-associated protein isoform e

      See identical proteins and their annotated locations for NP_001035287.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) includes an alternate exon in the coding region, compared to variant 1, resulting in a frameshift. The resulting protein (isoform e) has a distinct C-terminus compared to isoform a.
      Source sequence(s)
      AI741916, BC017328, BE782705, BI117521, BQ672962, CD674964
      Consensus CDS
      CCDS41248.1
      UniProtKB/TrEMBL
      X6R9H3
      Related
      ENSP00000383688.2, ENST00000400895.6
      Conserved Domains (1) summary
      cl05741
      Location:1 → 20
      AGTRAP; Angiotensin II, type I receptor-associated protein (AGTRAP)

    5. NM_020350.5 → NP_065083.3  type-1 angiotensin II receptor-associated protein isoform a

      See identical proteins and their annotated locations for NP_065083.3

      Status: REVIEWED

      Description
      Transcript Variant: This variant represents the most common transcript and encodes isoform a.
      Source sequence(s)
      AF312374, AI741916, BC017328, BI117521, BQ672962
      Consensus CDS
      CCDS136.1
      UniProtKB/Swiss-Prot
      A8MVQ5, Q5SNV4, Q5SNV5, Q6RW13, Q96AC0, Q96PL4, Q9NRW9
      UniProtKB/TrEMBL
      A8K1X7
      Related
      ENSP00000319713.5, ENST00000314340.10
      Conserved Domains (1) summary
      pfam06396
      Location:9 → 152
      AGTRAP; Angiotensin II, type I receptor-associated protein (AGTRAP)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      11736136..11750769
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011541802.3 → XP_011540104.1  type-1 angiotensin II receptor-associated protein isoform X2

      UniProtKB/TrEMBL
      X6R9H3
      Related
      ENSP00000365814.1, ENST00000376627.6

    2. XM_011541800.4 → XP_011540102.1  type-1 angiotensin II receptor-associated protein isoform X1

      UniProtKB/TrEMBL
      A8K1X7
      Conserved Domains (1) summary
      pfam06396
      Location:22 → 164
      AGTRAP; Angiotensin II, type I receptor-associated protein (AGTRAP)

    3. XM_011541799.4 → XP_011540101.2  type-1 angiotensin II receptor-associated protein isoform X3

      UniProtKB/TrEMBL
      A8K1X7

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      11280231..11294863
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054337784.1 → XP_054193759.1  type-1 angiotensin II receptor-associated protein isoform X2

    2. XM_054337783.1 → XP_054193758.1  type-1 angiotensin II receptor-associated protein isoform X1

    3. XM_054337785.1 → XP_054193760.1  type-1 angiotensin II receptor-associated protein isoform X3

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6RW13.1 GenPept UniProtKB/Swiss-Prot:Q6RW13

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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