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    CUL1 cullin 1 [ Homo sapiens (human) ]

    Gene ID: 8454, updated on 3-Nov-2024

    Summary

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    Official Symbol
    CUL1provided by HGNC
    Official Full Name
    cullin 1provided by HGNC
    Primary source
    HGNC:HGNC:2551
    See related
    Ensembl:ENSG00000055130 MIM:603134; AllianceGenome:HGNC:2551
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    Enables ubiquitin ligase complex scaffold activity and ubiquitin protein ligase binding activity. Involved in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; positive regulation of canonical NF-kappaB signal transduction; and protein K48-linked ubiquitination. Located in plasma membrane. Part of Parkin-FBXW7-Cul1 ubiquitin ligase complex and SCF ubiquitin ligase complex. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in testis (RPKM 55.7), lymph node (RPKM 17.7) and 24 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See CUL1 in Genome Data Viewer
    Location:
    7q36.1
    Exon count:
    26
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (148697756..148801110)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (149879652..149982884)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (148394848..148498202)

    Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene huntingtin interacting protein K pseudogene Neighboring gene acyl-CoA thioesterase 13 pseudogene Neighboring gene ReSE screen-validated silencer GRCh37_chr7:148388173-148388399 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18733 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26800 Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:148396297-148397022 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr7:148469244-148470443 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26801 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:148479522-148480224 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr7:148480425-148481624 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr7:148495129-148496328 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:148504832-148505332 Neighboring gene RNA, U7 small nuclear 20 pseudogene Neighboring gene enhancer of zeste 2 polycomb repressive complex 2 subunit Neighboring gene Sharpr-MPRA regulatory region 2848 Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:148580637-148581328 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18737 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18738 Neighboring gene uncharacterized LOC124901767

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Cullin1 is a novel marker of poor prognosis and a potential therapeutic target in human breast cancer. Bai J, et al. Ann Oncol, 2013 Aug. PMID 23592700
    2. Aberrant expression pattern and location of cullin 1 are associated with the development of papillary carcinoma in thyroid and cyclin D1 expression. Do SI, et al. Endocr Pathol, 2014 Sep. PMID 24819753
    3. Cullin1 regulates proliferation, migration and invasion of glioma cells. Fan YC, et al. Med Oncol, 2014 Oct. PMID 25201578
    4. Cul1 expression is increased in early stages of human melanoma. Chen G, et al. Pigment Cell Melanoma Res, 2010 Aug. PMID 20518860
    5. [Effects of Cullin1 on the Biological Characteristics of Lung Adenocarcinoma
A549 and H1395 Cells]. Liu J, et al. Zhongguo Fei Ai Za Zhi, 2021 Feb 20. PMID 33478195, Free PMC Article

    See all (635) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. CircCUL1 inhibits trophoblast cell migration and invasion and promotes cell autophagy by sponging hsa-miR-30e-3p in fetal growth restriction via the ANXA1/PI3K/AKT axis.
      Title: CircCUL1 inhibits trophoblast cell migration and invasion and promotes cell autophagy by sponging hsa-miR-30e-3p in fetal growth restriction via the ANXA1/PI3K/AKT axis.
    2. NNMT/1-MNA Promote Cell-Cycle Progression of Breast Cancer by Targeting UBC12/Cullin-1-Mediated Degradation of P27 Proteins.
      Title: NNMT/1-MNA Promote Cell-Cycle Progression of Breast Cancer by Targeting UBC12/Cullin-1-Mediated Degradation of P27 Proteins.
    3. The membrane-associated ubiquitin ligase MARCHF8 stabilizes the human papillomavirus oncoprotein E7 by degrading CUL1 and UBE2L3 in head and neck cancer.
      Title: The membrane-associated ubiquitin ligase MARCHF8 stabilizes the human papillomavirus oncoprotein E7 by degrading CUL1 and UBE2L3 in head and neck cancer.
    4. Systemwide disassembly and assembly of SCF ubiquitin ligase complexes.
      Title: Systemwide disassembly and assembly of SCF ubiquitin ligase complexes.
    5. A Comprehensive Assessment of Genetic and Epigenetic Alterations Identifies Frequent Variations Impacting Six Prototypic SCF Complex Members.
      Title: A Comprehensive Assessment of Genetic and Epigenetic Alterations Identifies Frequent Variations Impacting Six Prototypic SCF Complex Members.
    6. microRNA-377-3p inhibits osteosarcoma progression by targeting CUL1 and regulating Wnt/beta-catenin signaling pathway.
      Title: microRNA-377-3p inhibits osteosarcoma progression by targeting CUL1 and regulating Wnt/β-catenin signaling pathway.
    7. Reduced SKP1 and CUL1 expression underlies increases in Cyclin E1 and chromosome instability in cellular precursors of high-grade serous ovarian cancer.
      Title: Reduced SKP1 and CUL1 expression underlies increases in Cyclin E1 and chromosome instability in cellular precursors of high-grade serous ovarian cancer.
    8. [Effects of Cullin1 on the Biological Characteristics of Lung AdenocarcinomaA549 and H1395 Cells].
      Title: [Effects of Cullin1 on the Biological Characteristics of Lung Adenocarcinoma
A549 and H1395 Cells].
    9. Cullin 1 (CUL1) Promotes Primary Ciliogenesis through the Induction of Ubiquitin-Proteasome-Dependent Dvl2 Degradation.
      Title: Cullin 1 (CUL1) Promotes Primary Ciliogenesis through the Induction of Ubiquitin-Proteasome-Dependent Dvl2 Degradation.
    10. Abnormal Cullin1 neddylation-mediated p21 accumulation participates in the pathogenesis of recurrent spontaneous abortion by regulating trophoblast cell proliferation and differentiation.
      Title: Abnormal Cullin1 neddylation-mediated p21 accumulation participates in the pathogenesis of recurrent spontaneous abortion by regulating trophoblast cell proliferation and differentiation.
    Submit: New GeneRIF Correction See all GeneRIFs (73)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    HIV-1 interactions

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    Protein interactions

    Protein Gene Interaction Pubs
    Vpu vpu HIV-1 Vpu is identified to have a physical interaction with Cullin 1 (CUL1) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC149834, MGC149835

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein-macromolecule adaptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin ligase complex scaffold activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ubiquitin protein ligase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin protein ligase binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in G1/S transition of mitotic cell cycle TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in animal organ morphogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cell population proliferation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in intrinsic apoptotic signaling pathway TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in positive regulation of canonical NF-kappaB signal transduction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein K48-linked ubiquitination IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein monoubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein ubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein ubiquitination IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of Parkin-FBXW7-Cul1 ubiquitin ligase complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    part_of SCF ubiquitin ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of SCF ubiquitin ligase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of SCF ubiquitin ligase complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of cullin-RING ubiquitin ligase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytoplasm IC
    Inferred by Curator
    more info
    		 PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
    		  
    is_active_in nucleus IC
    Inferred by Curator
    more info
    		 PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    cullin-1
    Names
    CUL-1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_065171.1 RefSeqGene

      Range
      6148..108355
      Download
      GenBank, FASTA, Sequence Viewer (Graphics), LRG_1407

    mRNA and Protein(s)

    1. NM_001370660.1 → NP_001357589.1  cullin-1

      Status: REVIEWED

      Source sequence(s)
      AC005229, AC006323
      Consensus CDS
      CCDS34772.1
      UniProtKB/Swiss-Prot
      D3DWG3, O60719, Q08AL6, Q13616, Q8IYW1
      UniProtKB/TrEMBL
      A0A090N7U0, A0A590UJ21, A0A590UJR3
      Related
      ENSP00000499277.1, ENST00000662716.1
      Conserved Domains (2) summary
      pfam00888
      Location:21 → 660
      Cullin; Cullin family
      pfam10557
      Location:706 → 767
      Cullin_Nedd8; Cullin protein neddylation domain

    2. NM_001370661.1 → NP_001357590.1  cullin-1

      Status: REVIEWED

      Source sequence(s)
      AC005229, AC006323
      Consensus CDS
      CCDS34772.1
      UniProtKB/Swiss-Prot
      D3DWG3, O60719, Q08AL6, Q13616, Q8IYW1
      UniProtKB/TrEMBL
      A0A090N7U0, A0A590UJ21, A0A590UJR3
      Related
      ENSP00000499255.1, ENST00000665936.1
      Conserved Domains (2) summary
      pfam00888
      Location:21 → 660
      Cullin; Cullin family
      pfam10557
      Location:706 → 767
      Cullin_Nedd8; Cullin protein neddylation domain

    3. NM_001370662.1 → NP_001357591.1  cullin-1

      Status: REVIEWED

      Source sequence(s)
      AC005229, AC006323
      Consensus CDS
      CCDS34772.1
      UniProtKB/Swiss-Prot
      D3DWG3, O60719, Q08AL6, Q13616, Q8IYW1
      UniProtKB/TrEMBL
      A0A090N7U0, A0A590UJ21, A0A590UJR3
      Related
      ENSP00000473318.1, ENST00000602748.5
      Conserved Domains (2) summary
      pfam00888
      Location:21 → 660
      Cullin; Cullin family
      pfam10557
      Location:706 → 767
      Cullin_Nedd8; Cullin protein neddylation domain

    4. NM_001370663.1 → NP_001357592.1  cullin-1

      Status: REVIEWED

      Source sequence(s)
      AC005229, AC006323
      Consensus CDS
      CCDS34772.1
      UniProtKB/Swiss-Prot
      D3DWG3, O60719, Q08AL6, Q13616, Q8IYW1
      UniProtKB/TrEMBL
      A0A090N7U0, A0A590UJ21, A0A590UJR3
      Related
      ENSP00000499398.1, ENST00000663044.1
      Conserved Domains (2) summary
      pfam00888
      Location:21 → 660
      Cullin; Cullin family
      pfam10557
      Location:706 → 767
      Cullin_Nedd8; Cullin protein neddylation domain

    5. NM_001370664.1 → NP_001357593.1  cullin-1

      Status: REVIEWED

      Source sequence(s)
      AC005229, AC006323
      Consensus CDS
      CCDS34772.1
      UniProtKB/Swiss-Prot
      D3DWG3, O60719, Q08AL6, Q13616, Q8IYW1
      UniProtKB/TrEMBL
      A0A090N7U0, A0A590UJ21, A0A590UJR3
      Conserved Domains (2) summary
      pfam00888
      Location:21 → 660
      Cullin; Cullin family
      pfam10557
      Location:706 → 767
      Cullin_Nedd8; Cullin protein neddylation domain

    6. NM_003592.3 → NP_003583.2  cullin-1

      See identical proteins and their annotated locations for NP_003583.2

      Status: REVIEWED

      Source sequence(s)
      AF062536, AK096163, CA945052
      Consensus CDS
      CCDS34772.1
      UniProtKB/Swiss-Prot
      D3DWG3, O60719, Q08AL6, Q13616, Q8IYW1
      UniProtKB/TrEMBL
      A0A090N7U0, A0A590UJ21, A0A590UJR3
      Related
      ENSP00000326804.3, ENST00000325222.9
      Conserved Domains (2) summary
      pfam00888
      Location:21 → 660
      Cullin; Cullin family
      pfam10557
      Location:706 → 767
      Cullin_Nedd8; Cullin protein neddylation domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

      Range
      148697756..148801110
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060931.1 Alternate T2T-CHM13v2.0

      Range
      149879652..149982884
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q13616.2 GenPept UniProtKB/Swiss-Prot:Q13616

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
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