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    LRRC4C leucine rich repeat containing 4C [ Homo sapiens (human) ]

    Gene ID: 57689, updated on 28-Oct-2024

    Summary

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    Official Symbol
    LRRC4Cprovided by HGNC
    Official Full Name
    leucine rich repeat containing 4Cprovided by HGNC
    Primary source
    HGNC:HGNC:29317
    See related
    Ensembl:ENSG00000148948 MIM:608817; AllianceGenome:HGNC:29317
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    NGL1; NGL-1
    Summary
    NGL1 is a specific binding partner for netrin G1 (NTNG1; MIM 608818), which is a member of the netrin family of axon guidance molecules (Lin et al., 2003 [PubMed 14595443]).[supplied by OMIM, Mar 2008]
    Expression
    Biased expression in brain (RPKM 5.3), adrenal (RPKM 0.7) and 1 other tissue See more
    Orthologs
    mouse all
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    Genomic context

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    See LRRC4C in Genome Data Viewer
    Location:
    11p12
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (40114199..41459652, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (40260753..41606210, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (40135749..41481202, complement)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105376637 Neighboring gene adaptor related protein complex 5 subunit mu 1 pseudogene Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:39902599-39903100 Neighboring gene ReSE screen-validated silencer GRCh37_chr11:40005787-40006001 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr11:40052323-40052873 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr11:40121095-40121596 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr11:40121597-40122096 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr11:40173418-40174617 Neighboring gene zinc finger CCHC-type containing 9 pseudogene Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr11:40224036-40224631 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr11:40225695-40226477 Neighboring gene NANOG hESC enhancer GRCh37_chr11:40248664-40249165 Neighboring gene zinc finger protein 12 pseudogene Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr11:40669848-40671047 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr11:40700680-40701265 Neighboring gene ReSE screen-validated silencer GRCh37_chr11:40816984-40817169 Neighboring gene Sharpr-MPRA regulatory region 9582 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr11:41138490-41139031 Neighboring gene ReSE screen-validated silencer GRCh37_chr11:41216161-41216333 Neighboring gene RNA, U6 small nuclear 365, pseudogene Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:41266457-41267413 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:41324368-41325026 Neighboring gene NANOG hESC enhancer GRCh37_chr11:41414109-41414610 Neighboring gene NANOG hESC enhancer GRCh37_chr11:41448963-41449564 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr11:41519459-41520022 Neighboring gene ReSE screen-validated silencer GRCh37_chr11:41623188-41623333 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr11:41735352-41736094 Neighboring gene long intergenic non-protein coding RNA 2741 Neighboring gene ribosomal protein L9 pseudogene 23

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Implication of LRRC4C and DPP6 in neurodevelopmental disorders. Maussion G, et al. Am J Med Genet A, 2017 Feb. PMID 27759917, Free PMC Article
    2. Structural basis for cell surface patterning through NetrinG-NGL interactions. Seiradake E, et al. EMBO J, 2011 Sep 23. PMID 21946559, Free PMC Article
    3. The netrin-G1 ligand NGL-1 promotes the outgrowth of thalamocortical axons. Lin JC, et al. Nat Neurosci, 2003 Dec. PMID 14595443
    4. Trans-induced cis interaction in the tripartite NGL-1, netrin-G1 and LAR adhesion complex promotes development of excitatory synapses. Song YS, et al. J Cell Sci, 2013 Nov 1. PMID 23986473
    5. Myosin XVa and whirlin, two deafness gene products required for hair bundle growth, are located at the stereocilia tips and interact directly. Delprat B, et al. Hum Mol Genet, 2005 Feb 1. PMID 15590698

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. These data suggest that the proband's autism may be due to the inheritance of disruptions in both DPP6 and LRRC4C, and may highlight the importance of the netrin G family and potassium channel interacting molecules in neurodevelopmental disorders.
      Title: Implication of LRRC4C and DPP6 in neurodevelopmental disorders.
    2. Interaction between the tripartite NGL-1, netrin-G1 and LAR adhesion complex promotes development of excitatory synapses.
      Title: Trans-induced cis interaction in the tripartite NGL-1, netrin-G1 and LAR adhesion complex promotes development of excitatory synapses.
    3. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
      Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
    4. Observational study of gene-disease association. (HuGE Navigator)
      Title: Association of polymorphisms in the SLIT2 axonal guidance gene with anger in suicide attempters.
    5. netrin-G1 functions as an important component of the NGL-1 receptor to promote TCA outgrowth and that membrane-bound netrins can participate in receiving axonal signaling pathways.
      Title: The netrin-G1 ligand NGL-1 promotes the outgrowth of thalamocortical axons.
    6. NGL-1 is most abundant in the striatum and the cerebral cortex--the intermediate and final targets, of thalamocortical axons; surface-bound NGL-1 stimulates, but soluble NGL-1 disrupts, the growth of embryonic thalamic axons.
      Title: The netrin-G1 ligand NGL-1 promotes the outgrowth of thalamocortical axons.
    Submit: New GeneRIF Correction

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    An integration of genome-wide association study and gene expression profiling to prioritize the discovery of novel susceptibility Loci for osteoporosis-related traits.
    EBI GWAS Catalog
    Genome wide association study (GWAS) of Chagas cardiomyopathy in Trypanosoma cruzi seropositive subjects.
    EBI GWAS Catalog
    Genome-wide association study of temperament in bipolar disorder reveals significant associations with three novel Loci.
    EBI GWAS Catalog
    Genome-wide pharmacogenomic study of neurocognition as an indicator of antipsychotic treatment response in schizophrenia.
    EBI GWAS Catalog
    Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • KIAA1580

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables cell adhesion molecule binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables cell-cell adhesion mediator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cell-cell adhesion mediator activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in modulation of chemical synaptic transmission IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of axonogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of axonogenesis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in synaptic membrane adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in synaptic membrane adhesion IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Schaffer collateral - CA1 synapse IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in extracellular space HDA PubMed 
    is_active_in glutamatergic synapse IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in postsynaptic density membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    leucine-rich repeat-containing protein 4C
    Names
    netrin-G ligand-1
    netrin-G1 ligand

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001258419.2 → NP_001245348.1  leucine-rich repeat-containing protein 4C precursor

      See identical proteins and their annotated locations for NP_001245348.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AB046800, AC090138, BX951676, DQ084201, DQ084202
      Consensus CDS
      CCDS31464.1
      UniProtKB/Swiss-Prot
      A8K0T1, Q7L0N3, Q9HCJ2
      UniProtKB/TrEMBL
      Q4JIW0
      Related
      ENSP00000437132.1, ENST00000528697.6
      Conserved Domains (6) summary
      smart00013
      Location:47 → 80
      LRRNT; Leucine rich repeat N-terminal domain
      smart00082
      Location:301 → 339
      LRRCT; Leucine rich repeat C-terminal domain
      smart00409
      Location:360 → 443
      IG; Immunoglobulin
      sd00033
      Location:78 → 101
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:220 → 279
      LRR_8; Leucine rich repeat
      cd21340
      Location:65 → 235
      PPP1R42; protein phosphatase 1 regulatory subunit 42

    2. NM_020929.3 → NP_065980.1  leucine-rich repeat-containing protein 4C precursor

      See identical proteins and their annotated locations for NP_065980.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the shortest transcript. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AB046800, AC090138, DA387604, DQ084201, DQ084202
      Consensus CDS
      CCDS31464.1
      UniProtKB/Swiss-Prot
      A8K0T1, Q7L0N3, Q9HCJ2
      UniProtKB/TrEMBL
      Q4JIW0
      Related
      ENSP00000434761.1, ENST00000530763.5
      Conserved Domains (6) summary
      smart00013
      Location:47 → 80
      LRRNT; Leucine rich repeat N-terminal domain
      smart00082
      Location:301 → 339
      LRRCT; Leucine rich repeat C-terminal domain
      smart00409
      Location:360 → 443
      IG; Immunoglobulin
      sd00033
      Location:78 → 101
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:220 → 279
      LRR_8; Leucine rich repeat
      cd21340
      Location:65 → 235
      PPP1R42; protein phosphatase 1 regulatory subunit 42

    RNA

    1. NR_047673.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses an alternate 5'-most exon compared to variant 1. This variant is represented as non-coding due to the presence of an upstream ORF that is predicted to interfere with translation of the longest ORF; translation of the upstream ORF renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AB046800, AI806109, AK289646, BC041374

    2. NR_047674.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) uses an alternate 5'-most exon compared to variant 1. This variant is represented as non-coding due to the presence of an upstream ORF that is predicted to interfere with translation of the longest ORF; translation of the upstream ORF renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AB046800, AI806109, AY358293, BC041374

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

      Range
      40114199..41459652 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017018075.3 → XP_016873564.1  leucine-rich repeat-containing protein 4C isoform X1

      UniProtKB/Swiss-Prot
      A8K0T1, Q7L0N3, Q9HCJ2
      UniProtKB/TrEMBL
      Q4JIW0
      Conserved Domains (6) summary
      smart00013
      Location:47 → 80
      LRRNT; Leucine rich repeat N-terminal domain
      smart00082
      Location:301 → 339
      LRRCT; Leucine rich repeat C-terminal domain
      smart00409
      Location:360 → 443
      IG; Immunoglobulin
      sd00033
      Location:78 → 101
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:220 → 279
      LRR_8; Leucine rich repeat
      cd21340
      Location:65 → 235
      PPP1R42; protein phosphatase 1 regulatory subunit 42

    2. XM_017018073.3 → XP_016873562.1  leucine-rich repeat-containing protein 4C isoform X1

      UniProtKB/Swiss-Prot
      A8K0T1, Q7L0N3, Q9HCJ2
      UniProtKB/TrEMBL
      Q4JIW0
      Conserved Domains (6) summary
      smart00013
      Location:47 → 80
      LRRNT; Leucine rich repeat N-terminal domain
      smart00082
      Location:301 → 339
      LRRCT; Leucine rich repeat C-terminal domain
      smart00409
      Location:360 → 443
      IG; Immunoglobulin
      sd00033
      Location:78 → 101
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:220 → 279
      LRR_8; Leucine rich repeat
      cd21340
      Location:65 → 235
      PPP1R42; protein phosphatase 1 regulatory subunit 42

    3. XM_017018077.3 → XP_016873566.1  leucine-rich repeat-containing protein 4C isoform X1

      UniProtKB/Swiss-Prot
      A8K0T1, Q7L0N3, Q9HCJ2
      UniProtKB/TrEMBL
      Q4JIW0
      Conserved Domains (6) summary
      smart00013
      Location:47 → 80
      LRRNT; Leucine rich repeat N-terminal domain
      smart00082
      Location:301 → 339
      LRRCT; Leucine rich repeat C-terminal domain
      smart00409
      Location:360 → 443
      IG; Immunoglobulin
      sd00033
      Location:78 → 101
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:220 → 279
      LRR_8; Leucine rich repeat
      cd21340
      Location:65 → 235
      PPP1R42; protein phosphatase 1 regulatory subunit 42

    4. XM_017018072.3 → XP_016873561.1  leucine-rich repeat-containing protein 4C isoform X1

      UniProtKB/Swiss-Prot
      A8K0T1, Q7L0N3, Q9HCJ2
      UniProtKB/TrEMBL
      Q4JIW0
      Conserved Domains (6) summary
      smart00013
      Location:47 → 80
      LRRNT; Leucine rich repeat N-terminal domain
      smart00082
      Location:301 → 339
      LRRCT; Leucine rich repeat C-terminal domain
      smart00409
      Location:360 → 443
      IG; Immunoglobulin
      sd00033
      Location:78 → 101
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:220 → 279
      LRR_8; Leucine rich repeat
      cd21340
      Location:65 → 235
      PPP1R42; protein phosphatase 1 regulatory subunit 42

    5. XM_017018079.3 → XP_016873568.1  leucine-rich repeat-containing protein 4C isoform X1

      UniProtKB/Swiss-Prot
      A8K0T1, Q7L0N3, Q9HCJ2
      UniProtKB/TrEMBL
      Q4JIW0
      Conserved Domains (6) summary
      smart00013
      Location:47 → 80
      LRRNT; Leucine rich repeat N-terminal domain
      smart00082
      Location:301 → 339
      LRRCT; Leucine rich repeat C-terminal domain
      smart00409
      Location:360 → 443
      IG; Immunoglobulin
      sd00033
      Location:78 → 101
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:220 → 279
      LRR_8; Leucine rich repeat
      cd21340
      Location:65 → 235
      PPP1R42; protein phosphatase 1 regulatory subunit 42

    6. XM_017018070.3 → XP_016873559.1  leucine-rich repeat-containing protein 4C isoform X1

      UniProtKB/Swiss-Prot
      A8K0T1, Q7L0N3, Q9HCJ2
      UniProtKB/TrEMBL
      Q4JIW0
      Conserved Domains (6) summary
      smart00013
      Location:47 → 80
      LRRNT; Leucine rich repeat N-terminal domain
      smart00082
      Location:301 → 339
      LRRCT; Leucine rich repeat C-terminal domain
      smart00409
      Location:360 → 443
      IG; Immunoglobulin
      sd00033
      Location:78 → 101
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:220 → 279
      LRR_8; Leucine rich repeat
      cd21340
      Location:65 → 235
      PPP1R42; protein phosphatase 1 regulatory subunit 42

    7. XM_047427349.1 → XP_047283305.1  leucine-rich repeat-containing protein 4C isoform X1

      UniProtKB/Swiss-Prot
      A8K0T1, Q7L0N3, Q9HCJ2

    8. XM_011520244.4 → XP_011518546.1  leucine-rich repeat-containing protein 4C isoform X1

      See identical proteins and their annotated locations for XP_011518546.1

      UniProtKB/Swiss-Prot
      A8K0T1, Q7L0N3, Q9HCJ2
      UniProtKB/TrEMBL
      Q4JIW0
      Conserved Domains (6) summary
      smart00013
      Location:47 → 80
      LRRNT; Leucine rich repeat N-terminal domain
      smart00082
      Location:301 → 339
      LRRCT; Leucine rich repeat C-terminal domain
      smart00409
      Location:360 → 443
      IG; Immunoglobulin
      sd00033
      Location:78 → 101
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:220 → 279
      LRR_8; Leucine rich repeat
      cd21340
      Location:65 → 235
      PPP1R42; protein phosphatase 1 regulatory subunit 42

    9. XM_011520240.4 → XP_011518542.1  leucine-rich repeat-containing protein 4C isoform X1

      See identical proteins and their annotated locations for XP_011518542.1

      UniProtKB/Swiss-Prot
      A8K0T1, Q7L0N3, Q9HCJ2
      UniProtKB/TrEMBL
      Q4JIW0
      Conserved Domains (6) summary
      smart00013
      Location:47 → 80
      LRRNT; Leucine rich repeat N-terminal domain
      smart00082
      Location:301 → 339
      LRRCT; Leucine rich repeat C-terminal domain
      smart00409
      Location:360 → 443
      IG; Immunoglobulin
      sd00033
      Location:78 → 101
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:220 → 279
      LRR_8; Leucine rich repeat
      cd21340
      Location:65 → 235
      PPP1R42; protein phosphatase 1 regulatory subunit 42

    10. XM_047427352.1 → XP_047283308.1  leucine-rich repeat-containing protein 4C isoform X1

      UniProtKB/Swiss-Prot
      A8K0T1, Q7L0N3, Q9HCJ2

    11. XM_017018071.3 → XP_016873560.1  leucine-rich repeat-containing protein 4C isoform X1

      UniProtKB/Swiss-Prot
      A8K0T1, Q7L0N3, Q9HCJ2
      UniProtKB/TrEMBL
      Q4JIW0
      Conserved Domains (6) summary
      smart00013
      Location:47 → 80
      LRRNT; Leucine rich repeat N-terminal domain
      smart00082
      Location:301 → 339
      LRRCT; Leucine rich repeat C-terminal domain
      smart00409
      Location:360 → 443
      IG; Immunoglobulin
      sd00033
      Location:78 → 101
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:220 → 279
      LRR_8; Leucine rich repeat
      cd21340
      Location:65 → 235
      PPP1R42; protein phosphatase 1 regulatory subunit 42

    12. XM_011520243.4 → XP_011518545.1  leucine-rich repeat-containing protein 4C isoform X1

      See identical proteins and their annotated locations for XP_011518545.1

      UniProtKB/Swiss-Prot
      A8K0T1, Q7L0N3, Q9HCJ2
      UniProtKB/TrEMBL
      Q4JIW0
      Conserved Domains (6) summary
      smart00013
      Location:47 → 80
      LRRNT; Leucine rich repeat N-terminal domain
      smart00082
      Location:301 → 339
      LRRCT; Leucine rich repeat C-terminal domain
      smart00409
      Location:360 → 443
      IG; Immunoglobulin
      sd00033
      Location:78 → 101
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:220 → 279
      LRR_8; Leucine rich repeat
      cd21340
      Location:65 → 235
      PPP1R42; protein phosphatase 1 regulatory subunit 42

    13. XM_011520238.4 → XP_011518540.1  leucine-rich repeat-containing protein 4C isoform X1

      See identical proteins and their annotated locations for XP_011518540.1

      UniProtKB/Swiss-Prot
      A8K0T1, Q7L0N3, Q9HCJ2
      UniProtKB/TrEMBL
      Q4JIW0
      Conserved Domains (6) summary
      smart00013
      Location:47 → 80
      LRRNT; Leucine rich repeat N-terminal domain
      smart00082
      Location:301 → 339
      LRRCT; Leucine rich repeat C-terminal domain
      smart00409
      Location:360 → 443
      IG; Immunoglobulin
      sd00033
      Location:78 → 101
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:220 → 279
      LRR_8; Leucine rich repeat
      cd21340
      Location:65 → 235
      PPP1R42; protein phosphatase 1 regulatory subunit 42

    14. XM_011520239.4 → XP_011518541.1  leucine-rich repeat-containing protein 4C isoform X1

      See identical proteins and their annotated locations for XP_011518541.1

      UniProtKB/Swiss-Prot
      A8K0T1, Q7L0N3, Q9HCJ2
      UniProtKB/TrEMBL
      Q4JIW0
      Conserved Domains (6) summary
      smart00013
      Location:47 → 80
      LRRNT; Leucine rich repeat N-terminal domain
      smart00082
      Location:301 → 339
      LRRCT; Leucine rich repeat C-terminal domain
      smart00409
      Location:360 → 443
      IG; Immunoglobulin
      sd00033
      Location:78 → 101
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:220 → 279
      LRR_8; Leucine rich repeat
      cd21340
      Location:65 → 235
      PPP1R42; protein phosphatase 1 regulatory subunit 42

    15. XM_047427350.1 → XP_047283306.1  leucine-rich repeat-containing protein 4C isoform X1

      UniProtKB/Swiss-Prot
      A8K0T1, Q7L0N3, Q9HCJ2

    16. XM_047427351.1 → XP_047283307.1  leucine-rich repeat-containing protein 4C isoform X1

      UniProtKB/Swiss-Prot
      A8K0T1, Q7L0N3, Q9HCJ2

    17. XM_017018074.3 → XP_016873563.1  leucine-rich repeat-containing protein 4C isoform X1

      UniProtKB/Swiss-Prot
      A8K0T1, Q7L0N3, Q9HCJ2
      UniProtKB/TrEMBL
      Q4JIW0
      Related
      ENSP00000436976.1, ENST00000527150.5
      Conserved Domains (6) summary
      smart00013
      Location:47 → 80
      LRRNT; Leucine rich repeat N-terminal domain
      smart00082
      Location:301 → 339
      LRRCT; Leucine rich repeat C-terminal domain
      smart00409
      Location:360 → 443
      IG; Immunoglobulin
      sd00033
      Location:78 → 101
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:220 → 279
      LRR_8; Leucine rich repeat
      cd21340
      Location:65 → 235
      PPP1R42; protein phosphatase 1 regulatory subunit 42

    18. XM_011520242.4 → XP_011518544.1  leucine-rich repeat-containing protein 4C isoform X1

      See identical proteins and their annotated locations for XP_011518544.1

      UniProtKB/Swiss-Prot
      A8K0T1, Q7L0N3, Q9HCJ2
      UniProtKB/TrEMBL
      Q4JIW0
      Conserved Domains (6) summary
      smart00013
      Location:47 → 80
      LRRNT; Leucine rich repeat N-terminal domain
      smart00082
      Location:301 → 339
      LRRCT; Leucine rich repeat C-terminal domain
      smart00409
      Location:360 → 443
      IG; Immunoglobulin
      sd00033
      Location:78 → 101
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:220 → 279
      LRR_8; Leucine rich repeat
      cd21340
      Location:65 → 235
      PPP1R42; protein phosphatase 1 regulatory subunit 42

    19. XM_017018076.3 → XP_016873565.1  leucine-rich repeat-containing protein 4C isoform X1

      UniProtKB/Swiss-Prot
      A8K0T1, Q7L0N3, Q9HCJ2
      UniProtKB/TrEMBL
      Q4JIW0
      Related
      ENSP00000278198.1, ENST00000278198.2
      Conserved Domains (6) summary
      smart00013
      Location:47 → 80
      LRRNT; Leucine rich repeat N-terminal domain
      smart00082
      Location:301 → 339
      LRRCT; Leucine rich repeat C-terminal domain
      smart00409
      Location:360 → 443
      IG; Immunoglobulin
      sd00033
      Location:78 → 101
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:220 → 279
      LRR_8; Leucine rich repeat
      cd21340
      Location:65 → 235
      PPP1R42; protein phosphatase 1 regulatory subunit 42

    20. XM_011520241.4 → XP_011518543.1  leucine-rich repeat-containing protein 4C isoform X1

      See identical proteins and their annotated locations for XP_011518543.1

      UniProtKB/Swiss-Prot
      A8K0T1, Q7L0N3, Q9HCJ2
      UniProtKB/TrEMBL
      Q4JIW0
      Conserved Domains (6) summary
      smart00013
      Location:47 → 80
      LRRNT; Leucine rich repeat N-terminal domain
      smart00082
      Location:301 → 339
      LRRCT; Leucine rich repeat C-terminal domain
      smart00409
      Location:360 → 443
      IG; Immunoglobulin
      sd00033
      Location:78 → 101
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:220 → 279
      LRR_8; Leucine rich repeat
      cd21340
      Location:65 → 235
      PPP1R42; protein phosphatase 1 regulatory subunit 42

    21. XM_017018078.3 → XP_016873567.1  leucine-rich repeat-containing protein 4C isoform X1

      UniProtKB/Swiss-Prot
      A8K0T1, Q7L0N3, Q9HCJ2
      UniProtKB/TrEMBL
      Q4JIW0
      Conserved Domains (6) summary
      smart00013
      Location:47 → 80
      LRRNT; Leucine rich repeat N-terminal domain
      smart00082
      Location:301 → 339
      LRRCT; Leucine rich repeat C-terminal domain
      smart00409
      Location:360 → 443
      IG; Immunoglobulin
      sd00033
      Location:78 → 101
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:220 → 279
      LRR_8; Leucine rich repeat
      cd21340
      Location:65 → 235
      PPP1R42; protein phosphatase 1 regulatory subunit 42

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060935.1 Alternate T2T-CHM13v2.0

      Range
      40260753..41606210 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054369515.1 → XP_054225490.1  leucine-rich repeat-containing protein 4C isoform X1

      UniProtKB/Swiss-Prot
      A8K0T1, Q7L0N3, Q9HCJ2

    2. XM_054369509.1 → XP_054225484.1  leucine-rich repeat-containing protein 4C isoform X1

      UniProtKB/Swiss-Prot
      A8K0T1, Q7L0N3, Q9HCJ2

    3. XM_054369523.1 → XP_054225498.1  leucine-rich repeat-containing protein 4C isoform X1

      UniProtKB/Swiss-Prot
      A8K0T1, Q7L0N3, Q9HCJ2

    4. XM_054369507.1 → XP_054225482.1  leucine-rich repeat-containing protein 4C isoform X1

      UniProtKB/Swiss-Prot
      A8K0T1, Q7L0N3, Q9HCJ2

    5. XM_054369528.1 → XP_054225503.1  leucine-rich repeat-containing protein 4C isoform X1

      UniProtKB/Swiss-Prot
      A8K0T1, Q7L0N3, Q9HCJ2

    6. XM_054369508.1 → XP_054225483.1  leucine-rich repeat-containing protein 4C isoform X1

      UniProtKB/Swiss-Prot
      A8K0T1, Q7L0N3, Q9HCJ2

    7. XM_054369510.1 → XP_054225485.1  leucine-rich repeat-containing protein 4C isoform X1

      UniProtKB/Swiss-Prot
      A8K0T1, Q7L0N3, Q9HCJ2

    8. XM_054369524.1 → XP_054225499.1  leucine-rich repeat-containing protein 4C isoform X1

      UniProtKB/Swiss-Prot
      A8K0T1, Q7L0N3, Q9HCJ2

    9. XM_054369506.1 → XP_054225481.1  leucine-rich repeat-containing protein 4C isoform X1

      UniProtKB/Swiss-Prot
      A8K0T1, Q7L0N3, Q9HCJ2

    10. XM_054369527.1 → XP_054225502.1  leucine-rich repeat-containing protein 4C isoform X1

      UniProtKB/Swiss-Prot
      A8K0T1, Q7L0N3, Q9HCJ2

    11. XM_054369522.1 → XP_054225497.1  leucine-rich repeat-containing protein 4C isoform X1

      UniProtKB/Swiss-Prot
      A8K0T1, Q7L0N3, Q9HCJ2

    12. XM_054369516.1 → XP_054225491.1  leucine-rich repeat-containing protein 4C isoform X1

      UniProtKB/Swiss-Prot
      A8K0T1, Q7L0N3, Q9HCJ2

    13. XM_054369520.1 → XP_054225495.1  leucine-rich repeat-containing protein 4C isoform X1

      UniProtKB/Swiss-Prot
      A8K0T1, Q7L0N3, Q9HCJ2

    14. XM_054369521.1 → XP_054225496.1  leucine-rich repeat-containing protein 4C isoform X1

      UniProtKB/Swiss-Prot
      A8K0T1, Q7L0N3, Q9HCJ2

    15. XM_054369512.1 → XP_054225487.1  leucine-rich repeat-containing protein 4C isoform X1

      UniProtKB/Swiss-Prot
      A8K0T1, Q7L0N3, Q9HCJ2

    16. XM_054369511.1 → XP_054225486.1  leucine-rich repeat-containing protein 4C isoform X1

      UniProtKB/Swiss-Prot
      A8K0T1, Q7L0N3, Q9HCJ2

    17. XM_054369513.1 → XP_054225488.1  leucine-rich repeat-containing protein 4C isoform X1

      UniProtKB/Swiss-Prot
      A8K0T1, Q7L0N3, Q9HCJ2

    18. XM_054369525.1 → XP_054225500.1  leucine-rich repeat-containing protein 4C isoform X1

      UniProtKB/Swiss-Prot
      A8K0T1, Q7L0N3, Q9HCJ2

    19. XM_054369514.1 → XP_054225489.1  leucine-rich repeat-containing protein 4C isoform X1

      UniProtKB/Swiss-Prot
      A8K0T1, Q7L0N3, Q9HCJ2

    20. XM_054369519.1 → XP_054225494.1  leucine-rich repeat-containing protein 4C isoform X1

      UniProtKB/Swiss-Prot
      A8K0T1, Q7L0N3, Q9HCJ2

    21. XM_054369518.1 → XP_054225493.1  leucine-rich repeat-containing protein 4C isoform X1

      UniProtKB/Swiss-Prot
      A8K0T1, Q7L0N3, Q9HCJ2

    22. XM_054369529.1 → XP_054225504.1  leucine-rich repeat-containing protein 4C isoform X1

      UniProtKB/Swiss-Prot
      A8K0T1, Q7L0N3, Q9HCJ2

    23. XM_054369517.1 → XP_054225492.1  leucine-rich repeat-containing protein 4C isoform X1

      UniProtKB/Swiss-Prot
      A8K0T1, Q7L0N3, Q9HCJ2

    24. XM_054369526.1 → XP_054225501.1  leucine-rich repeat-containing protein 4C isoform X1

      UniProtKB/Swiss-Prot
      A8K0T1, Q7L0N3, Q9HCJ2
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9HCJ2.1 GenPept UniProtKB/Swiss-Prot:Q9HCJ2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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