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    DPEP1 dipeptidase 1 [ Homo sapiens (human) ]

    Gene ID: 1800, updated on 28-Oct-2024

    Summary

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    Official Symbol
    DPEP1provided by HGNC
    Official Full Name
    dipeptidase 1provided by HGNC
    Primary source
    HGNC:HGNC:3002
    See related
    Ensembl:ENSG00000015413 MIM:179780; AllianceGenome:HGNC:3002
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    MDP; RDP; MBD1
    Summary
    The protein encoded by this gene is a kidney membrane enzyme involved in the metabolism of glutathione and other similar proteins by dipeptide hydrolysis. The encoded protein is known to regulate leukotriene activity by catalyzing the conversion of leukotriene D4 to leukotriene E4. This protein uses zinc as a cofactor and acts as a disulfide-linked homodimer. [provided by RefSeq, Dec 2020]
    Expression
    Biased expression in small intestine (RPKM 104.6), kidney (RPKM 102.2) and 3 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See DPEP1 in Genome Data Viewer
    Location:
    16q24.3
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (89613308..89641540)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (95694848..95725329)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (89679716..89707948)

    Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:89630776-89631518 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:89631519-89632262 Neighboring gene small nucleolar RNA, C/D box 68 Neighboring gene ribosomal protein L13 Neighboring gene ReSE screen-validated silencer GRCh37_chr16:89640372-89640629 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7915 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7916 Neighboring gene copine 7 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:89665942-89666855 Neighboring gene ReSE screen-validated silencer GRCh37_chr16:89679650-89679808 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:89681214-89681918 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:89681919-89682621 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:89689900-89690772 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_46531 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:89698470-89699324 Neighboring gene uncharacterized LOC124903758 Neighboring gene Neanderthal introgressed variant-containing enhancers experimental_46628 and experimental_46635 Neighboring gene charged multivesicular body protein 1A Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7917 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7918 Neighboring gene spermatogenesis associated 33

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Dipeptidase 1: a candidate tumor-specific molecular marker in colorectal carcinoma. McIver CM, et al. Cancer Lett, 2004 Jun 8. PMID 15145522
    2. Distinguishing primary from secondary mucinous ovarian tumors: an algorithm using the novel marker DPEP1. Okamoto T, et al. Mod Pathol, 2011 Feb. PMID 21076463
    3. Importance of Glu-125 in the catalytic activity of human renal dipeptidase. Adachi H, et al. Biochim Biophys Acta, 1993 Apr 21. PMID 8097406
    4. DPEP1 inhibits tumor cell invasiveness, enhances chemosensitivity and predicts clinical outcome in pancreatic ductal adenocarcinoma. Zhang G, et al. PLoS One, 2012. PMID 22363658, Free PMC Article
    5. Gene structural analysis and expression of human renal dipeptidase. Satoh S, et al. Biotechnol Prog, 1994 Mar-Apr. PMID 7764673

    See all (46) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Dipeptidase 1 promotes ferroptosis in renal tubular epithelial cells in diabetic nephropathy via inhibition of the GSH/GPX4 axis.
      Title: Dipeptidase 1 promotes ferroptosis in renal tubular epithelial cells in diabetic nephropathy via inhibition of the GSH/GPX4 axis.
    2. DPEP1 promotes drug resistance in colon cancer cells by forming a positive feedback loop with ASCL2.
      Title: DPEP1 promotes drug resistance in colon cancer cells by forming a positive feedback loop with ASCL2.
    3. The relationship between common variants in the DPEP1 gene and the susceptibility and clinical severity of osteoarthritis.
      Title: The relationship between common variants in the DPEP1 gene and the susceptibility and clinical severity of osteoarthritis.
    4. A single genetic locus controls both expression of DPEP1/CHMP1A and kidney disease development via ferroptosis.
      Title: A single genetic locus controls both expression of DPEP1/CHMP1A and kidney disease development via ferroptosis.
    5. DPEP1 expression promotes proliferation and survival of leukaemia cells and correlates with relapse in adults with common B cell acute lymphoblastic leukaemia.
      Title: DPEP1 expression promotes proliferation and survival of leukaemia cells and correlates with relapse in adults with common B cell acute lymphoblastic leukaemia.
    6. DPEP1 is a direct target of miR-193a-5p and promotes hepatoblastoma progression by PI3K/Akt/mTOR pathway.
      Title: DPEP1 is a direct target of miR-193a-5p and promotes hepatoblastoma progression by PI3K/Akt/mTOR pathway.
    7. The results suggest that DPEP1 promotes cancer metastasis by regulating E-cadherin plasticity and that it might be a potential therapeutic target for preventing the progression of colon cancer.
      Title: Dehydropeptidase 1 promotes metastasis through regulation of E-cadherin expression in colon cancer.
    8. In this study, we present an analysis of Neanderthal introgression at the dipeptidase 1 gene, DPEP1.
      Title: Reintroduction of a Homocysteine Level-Associated Allele into East Asians by Neanderthal Introgression.
    9. Dipeptidase 1 has been identified as an excellent marker of high-grade IEN and CRC, and may thus be applied for screening of early neoplastic lesions and for prognostic stratification.
      Title: Dipeptidase 1 (DPEP1) is a marker for the transition from low-grade to high-grade intraepithelial neoplasia and an adverse prognostic factor in colorectal cancer.
    10. DPEP1 plays a role in pancreatic cancer aggressiveness.
      Title: DPEP1 inhibits tumor cell invasiveness, enhances chemosensitivity and predicts clinical outcome in pancreatic ductal adenocarcinoma.
    Submit: New GeneRIF Correction See all GeneRIFs (16)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Common genetic loci influencing plasma homocysteine concentrations and their effect on risk of coronary artery disease.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables GPI anchor binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables beta-lactamase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables cysteine-type endopeptidase inhibitor activity involved in apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables dipeptidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables metallodipeptidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables metalloexopeptidase activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables modified amino acid binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables zinc ion binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in antibiotic metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in cellular response to calcium ion ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in cellular response to nitric oxide ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in cellular response to xenobiotic stimulus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in glutathione catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in glutathione metabolic process TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in homocysteine metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in inflammatory response IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in lactam catabolic process TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in leukotriene D4 catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of cell migration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of cysteine-type endopeptidase activity involved in apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in neutrophil chemotaxis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in apical part of cell IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in apical plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cell junction IDA
    Inferred from Direct Assay
    more info
    		  
    located_in extracellular exosome HDA PubMed 
    located_in extracellular space ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in microvillus membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
    		 PubMed 
    located_in side of membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    dipeptidase 1
    Names
    beta-lactamase
    dehydropeptidase-I
    dipeptidase 1 (renal)
    hRDP
    microsomal dipeptidase
    renal dipeptidase
    testicular tissue protein Li 57
    NP_001121613.1
    NP_001376395.1
    NP_001376396.1
    NP_001376397.1
    NP_001376398.1
    NP_001376399.1
    NP_001376400.1
    NP_004404.1
    XP_024305941.1
    XP_047289646.1
    XP_047289647.1
    XP_047289649.1
    XP_054235704.1
    XP_054235705.1
    XP_054235706.1

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001128141.3 → NP_001121613.1  dipeptidase 1 isoform a precursor

      See identical proteins and their annotated locations for NP_001121613.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2), as well as variants 1 and 3-6, encodes isoform a.
      Source sequence(s)
      AC010538, BC017023, BM152944
      Consensus CDS
      CCDS10982.1
      UniProtKB/Swiss-Prot
      D3DX80, P16444, Q96AK2
      UniProtKB/TrEMBL
      A0A140VJI3, Q6I9V1
      Related
      ENSP00000397313.1, ENST00000421184.5
      Conserved Domains (1) summary
      pfam01244
      Location:26 → 352
      Peptidase_M19; Membrane dipeptidase (Peptidase family M19)

    2. NM_001389466.1 → NP_001376395.1  dipeptidase 1 isoform a precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3), as well as variants 1, 2, and 4-6, encodes isoform a.
      Source sequence(s)
      AC010538
      Consensus CDS
      CCDS10982.1
      UniProtKB/Swiss-Prot
      D3DX80, P16444, Q96AK2
      UniProtKB/TrEMBL
      A0A140VJI3, Q6I9V1
      Related
      ENSP00000508584.1, ENST00000690203.1
      Conserved Domains (1) summary
      pfam01244
      Location:26 → 352
      Peptidase_M19; Membrane dipeptidase (Peptidase family M19)

    3. NM_001389467.1 → NP_001376396.1  dipeptidase 1 isoform a precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4), as well as variants 1-3, 5, and 6, encodes isoform a.
      Source sequence(s)
      AC010538
      Consensus CDS
      CCDS10982.1
      UniProtKB/Swiss-Prot
      D3DX80, P16444, Q96AK2
      UniProtKB/TrEMBL
      A0A140VJI3, Q6I9V1
      Conserved Domains (1) summary
      pfam01244
      Location:26 → 352
      Peptidase_M19; Membrane dipeptidase (Peptidase family M19)

    4. NM_001389468.1 → NP_001376397.1  dipeptidase 1 isoform a precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5), as well as variants 1-4 and 6, encodes isoform a.
      Source sequence(s)
      AC010538
      Consensus CDS
      CCDS10982.1
      UniProtKB/Swiss-Prot
      D3DX80, P16444, Q96AK2
      UniProtKB/TrEMBL
      A0A140VJI3, Q6I9V1
      Conserved Domains (1) summary
      pfam01244
      Location:26 → 352
      Peptidase_M19; Membrane dipeptidase (Peptidase family M19)

    5. NM_001389469.1 → NP_001376398.1  dipeptidase 1 isoform a precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6), as well as variants 1-5, encodes isoform a.
      Source sequence(s)
      AC010538, BC017023
      Consensus CDS
      CCDS10982.1
      UniProtKB/Swiss-Prot
      D3DX80, P16444, Q96AK2
      UniProtKB/TrEMBL
      A0A140VJI3, Q6I9V1
      Related
      ENSP00000261615.4, ENST00000261615.5
      Conserved Domains (1) summary
      pfam01244
      Location:26 → 352
      Peptidase_M19; Membrane dipeptidase (Peptidase family M19)

    6. NM_001389470.1 → NP_001376399.1  dipeptidase 1 isoform b precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (7), as well as variant 8, encodes isoform b.
      Source sequence(s)
      AC010538
      UniProtKB/TrEMBL
      Q6I9V1
      Conserved Domains (1) summary
      pfam01244
      Location:26 → 352
      Peptidase_M19; Membrane dipeptidase (Peptidase family M19)

    7. NM_001389471.1 → NP_001376400.1  dipeptidase 1 isoform b precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (8), as well as variant 7, encodes isoform b.
      Source sequence(s)
      AC010538
      UniProtKB/TrEMBL
      Q6I9V1
      Conserved Domains (1) summary
      pfam01244
      Location:26 → 352
      Peptidase_M19; Membrane dipeptidase (Peptidase family M19)

    8. NM_004413.4 → NP_004404.1  dipeptidase 1 isoform a precursor

      See identical proteins and their annotated locations for NP_004404.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1), as well as variants 2-6, encodes isoform a.
      Source sequence(s)
      AC010538, BC017023, J05257
      Consensus CDS
      CCDS10982.1
      UniProtKB/Swiss-Prot
      D3DX80, P16444, Q96AK2
      UniProtKB/TrEMBL
      A0A140VJI3, Q6I9V1
      Related
      ENSP00000376807.3, ENST00000393092.7
      Conserved Domains (1) summary
      pfam01244
      Location:26 → 352
      Peptidase_M19; Membrane dipeptidase (Peptidase family M19)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

      Range
      89613308..89641540
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047433691.1 → XP_047289647.1  dipeptidase 1 isoform X2

    2. XM_047433690.1 → XP_047289646.1  dipeptidase 1 isoform X1

      UniProtKB/Swiss-Prot
      D3DX80, P16444, Q96AK2
      UniProtKB/TrEMBL
      A0A140VJI3

    3. XM_047433693.1 → XP_047289649.1  dipeptidase 1 isoform X1

      UniProtKB/Swiss-Prot
      D3DX80, P16444, Q96AK2
      UniProtKB/TrEMBL
      A0A140VJI3

    4. XM_024450173.2 → XP_024305941.1  dipeptidase 1 isoform X3

      UniProtKB/TrEMBL
      Q6I9V1
      Conserved Domains (1) summary
      pfam01244
      Location:5 → 307
      Peptidase_M19; Membrane dipeptidase (Peptidase family M19)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060940.1 Alternate T2T-CHM13v2.0

      Range
      95694848..95725329
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054379729.1 → XP_054235704.1  dipeptidase 1 isoform X1

      UniProtKB/Swiss-Prot
      D3DX80, P16444, Q96AK2
      UniProtKB/TrEMBL
      A0A140VJI3

    2. XM_054379730.1 → XP_054235705.1  dipeptidase 1 isoform X1

      UniProtKB/Swiss-Prot
      D3DX80, P16444, Q96AK2
      UniProtKB/TrEMBL
      A0A140VJI3

    3. XM_054379731.1 → XP_054235706.1  dipeptidase 1 isoform X3

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P16444.3 GenPept UniProtKB/Swiss-Prot:P16444

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