LYVE1 lymphatic vessel endothelial hyaluronan receptor 1 [Homo sapiens (human)] - Gene

Summary

Official Symbol: LYVE1provided by HGNC
Official Full Name: lymphatic vessel endothelial hyaluronan receptor 1provided by HGNC
Primary source: HGNC:HGNC:14687
See related: Ensembl:ENSG00000133800 MIM:605702; AllianceGenome:HGNC:14687
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: HAR; XLKD1; LYVE-1; CRSBP-1
Summary: This gene encodes a type I integral membrane glycoprotein. The encoded protein acts as a receptor and binds to both soluble and immobilized hyaluronan. This protein may function in lymphatic hyaluronan transport and have a role in tumor metastasis. [provided by RefSeq, Jul 2008]
Expression: Broad expression in placenta (RPKM 141.7), adrenal (RPKM 68.8) and 14 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 11p15.4

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	11	NC_000011.10 (10556966..10568665, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	11	NC_060935.1 (10641492..10653192, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	11	NC_000011.9 (10578513..10590212, complement)

Chromosome 11 - NC_000011.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

hsa_circ_0129047 Upregulates LYVE1 to Inhibit Hepatocellular Carcinoma Progression by Sponging miR-492.
Title: hsa_circ_0129047 Upregulates LYVE1 to Inhibit Hepatocellular Carcinoma Progression by Sponging miR-492.
Single-Cell RNA-Seq Reveals a Crosstalk between Hyaluronan Receptor LYVE-1-Expressing Macrophages and Vascular Smooth Muscle Cells.
Title: Single-Cell RNA-Seq Reveals a Crosstalk between Hyaluronan Receptor LYVE-1-Expressing Macrophages and Vascular Smooth Muscle Cells.
The prognostic influence of lymphatic endothelium-specific hyaluronan receptor 1 in cancer: A systematic review.
Title: The prognostic influence of lymphatic endothelium-specific hyaluronan receptor 1 in cancer: A systematic review.
An immunohistochemical study of lymphatic elements in the human brain.
Title: An immunohistochemical study of lymphatic elements in the human brain.
Elevated lymphatic vessel density measured by Lyve-1 expression in areas of replacement fibrosis in the ventricular septum of patients with hypertrophic obstructive cardiomyopathy (HOCM).
Title: Elevated lymphatic vessel density measured by Lyve-1 expression in areas of replacement fibrosis in the ventricular septum of patients with hypertrophic obstructive cardiomyopathy (HOCM).
Hyaluronan and LYVE-1 and allograft function in lung transplantation recipients.
Title: Hyaluronan and LYVE-1 and allograft function in lung transplantation recipients.
Serum sLYVE-1 is not associated with coronary disease but with renal dysfunction: a retrospective study.
Title: Serum sLYVE-1 is not associated with coronary disease but with renal dysfunction: a retrospective study.
Studies provide evidence that LYVE-1.hyaluronan axis mediates leucocyte docking and entry to lymphatic vessels advancing the understanding about not just of LYVE-1 itself, but also lymphatic trafficking in general. [review]
Title: Hyaluronan in the lymphatics: The key role of the hyaluronan receptor LYVE-1 in leucocyte trafficking.
Long noncoding RNA ANRIL regulates endothelial cell activities associated with coronary artery disease by up-regulating CLIP1, EZR, and LYVE1 genes
Title: Long noncoding RNA ANRIL regulates endothelial cell activities associated with coronary artery disease by up-regulating CLIP1, EZR, and LYVE1 genes.
The mRNA high expression levels of both podoplanin and LYVE-1 genes had a statistically significantly higher rate of LN metastasis (p<0.01) and histological grade (p<0.01 for podoplanin, p<0.05 for LYVE-1).
Title: Lymphangiogenesis and Lymph Node Metastasis in Oral Squamous Cell Carcinoma.

Submit: New GeneRIF Correction See all GeneRIFs (52)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D11S4637 (e-PCR)
- UniSTS:72712

RH12873 (e-PCR)
- UniSTS:18278

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables cargo receptor activity	IEA Inferred from Electronic Annotation more info
enables hyaluronic acid binding	IBA Inferred from Biological aspect of Ancestor more info
enables hyaluronic acid binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables signaling receptor activity	TAS Traceable Author Statement more info	PubMed
enables transmembrane signaling receptor activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in anatomical structure morphogenesis	TAS Traceable Author Statement more info	PubMed
involved_in cell-matrix adhesion	TAS Traceable Author Statement more info	PubMed
involved_in hyaluronan catabolic process	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cellular extravasation	IDA Inferred from Direct Assay more info	PubMed
involved_in receptor-mediated endocytosis	IEA Inferred from Electronic Annotation more info
involved_in response to wounding	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular exosome	HDA more info	PubMed
located_in membrane	TAS Traceable Author Statement more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	TAS Traceable Author Statement more info

General protein information

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Preferred Names: lymphatic vessel endothelial hyaluronic acid receptor 1

Names: cell surface retention sequence binding protein-1; extracellular link domain-containing 1; extracellular link domain-containing protein 1; hyaluronic acid receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_006691.4 → NP_006682.2 lymphatic vessel endothelial hyaluronic acid receptor 1 precursor

See identical proteins and their annotated locations for NP_006682.2

Status: REVIEWED

Source sequence(s)

AC009532, AY358925, CA449932

Consensus CDS

CCDS7804.1

UniProtKB/Swiss-Prot

Q8TC18, Q9UNF4, Q9Y5Y7

UniProtKB/TrEMBL

B2R672

Related

ENSP00000256178.3, ENST00000256178.8

Conserved Domains (1) summary

cd03516
Location:34 → 174

Link_domain_CD44_like; This domain is a hyaluronan (HA)-binding domain. It is found in CD44 receptor and mediates adhesive interactions during inflammatory leukocyte homing and tumor metastasis. It also plays an important role in arteriogenesis. The functional HA-binding ...