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    Ccser1 coiled-coil serine rich 1 [ Mus musculus (house mouse) ]

    Gene ID: 232035, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Ccser1provided by MGI
    Official Full Name
    coiled-coil serine rich 1provided by MGI
    Primary source
    MGI:MGI:3045354
    See related
    Ensembl:ENSMUSG00000039578 AllianceGenome:MGI:3045354
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Fam190a; 6230405M12Rik; C130092O11Rik
    Summary
    Is expressed in metanephros; nervous system; and trachea. Human ortholog(s) of this gene implicated in cocaine dependence. Orthologous to human CCSER1 (coiled-coil serine rich protein 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in CNS E14 (RPKM 2.1), whole brain E14.5 (RPKM 2.0) and 18 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Ccser1 in Genome Data Viewer
    Location:
    6 B3; 6 29.24 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (61156942..62359847)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (61179960..62382863)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_16065 Neighboring gene STARR-seq mESC enhancer starr_16066 Neighboring gene STARR-seq mESC enhancer starr_16068 Neighboring gene multimerin 1 Neighboring gene STARR-seq mESC enhancer starr_16076 Neighboring gene protein phosphatase 6, catalytic subunit pseudogene Neighboring gene RIKEN cDNA A730020E08 gene Neighboring gene STARR-seq mESC enhancer starr_16079 Neighboring gene STARR-seq mESC enhancer starr_16080 Neighboring gene STARR-seq mESC enhancer starr_16081 Neighboring gene STARR-seq mESC enhancer starr_16082 Neighboring gene STARR-seq mESC enhancer starr_16083 Neighboring gene STARR-seq mESC enhancer starr_16084 Neighboring gene STARR-seq mESC enhancer starr_16085 Neighboring gene STARR-seq mESC enhancer starr_16086 Neighboring gene STARR-seq mESC enhancer starr_16087 Neighboring gene STARR-seq mESC enhancer starr_16088 Neighboring gene STARR-seq mESC enhancer starr_16089 Neighboring gene STARR-seq mESC enhancer starr_16090 Neighboring gene STARR-seq mESC enhancer starr_16091 Neighboring gene STARR-seq mESC enhancer starr_16092 Neighboring gene STARR-seq mESC enhancer starr_16093 Neighboring gene STARR-seq mESC enhancer starr_16094 Neighboring gene STARR-seq mESC enhancer starr_16095 Neighboring gene phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoribosylaminoimidazole, succinocarboxamide synthetase pseudogene Neighboring gene STARR-seq mESC enhancer starr_16096 Neighboring gene sprouty homolog 2 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. CircFam190a: a critical positive regulator of osteoclast differentiation via enhancement of the AKT1/HSP90β complex. Chen K, et al. Exp Mol Med, 2023 Sep. PMID 37653038, Free PMC Article
    2. Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2004 Jun 30. PMID 15368895
    3. EUCOMM--the European conditional mouse mutagenesis program. Friedel RH, et al. Brief Funct Genomic Proteomic, 2007 Sep. PMID 17967808
    4. Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. Bedogni F, et al. Front Mol Neurosci, 2021. PMID 34321999, Free PMC Article
    5. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. CircFam190a: a critical positive regulator of osteoclast differentiation via enhancement of the AKT1/HSP90beta complex.
      Title: CircFam190a: a critical positive regulator of osteoclast differentiation via enhancement of the AKT1/HSP90β complex.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC130404, MGC130405

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    serine-rich coiled-coil domain-containing protein 1
    Names
    coiled-coil serine-rich protein 1
    family with sequence similarity 190, member A
    protein FAM190A

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001164316.1 → NP_001157788.1  serine-rich coiled-coil domain-containing protein 1

      See identical proteins and their annotated locations for NP_001157788.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AK031754, AK173231, BB634602, BB646598
      Consensus CDS
      CCDS51800.1
      UniProtKB/Swiss-Prot
      Q3KN97, Q69ZD5, Q8C0C4, Q8C822
      Related
      ENSMUSP00000040251.7, ENSMUST00000045522.13

    2. NM_183310.2 → NP_899133.2  serine-rich coiled-coil domain-containing protein 1

      See identical proteins and their annotated locations for NP_899133.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AK173231, BB634602, BB646598, BC107398
      Consensus CDS
      CCDS51800.1
      UniProtKB/Swiss-Prot
      Q3KN97, Q69ZD5, Q8C0C4, Q8C822
      Related
      ENSMUSP00000122894.2, ENSMUST00000126214.8

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      61156942..62359847
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036166046.1 → XP_036021939.1  serine-rich coiled-coil domain-containing protein 1 isoform X3

    2. XM_011241297.4 → XP_011239599.1  serine-rich coiled-coil domain-containing protein 1 isoform X4

    3. XM_006505955.3 → XP_006506018.1  serine-rich coiled-coil domain-containing protein 1 isoform X2

    4. XM_006505954.3 → XP_006506017.1  serine-rich coiled-coil domain-containing protein 1 isoform X1

      UniProtKB/Swiss-Prot
      Q8C0C4
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8C0C4.2 GenPept UniProtKB/Swiss-Prot:Q8C0C4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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