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    ITPRIP inositol 1,4,5-trisphosphate receptor interacting protein [ Homo sapiens (human) ]

    Gene ID: 85450, updated on 2-Nov-2024

    Summary

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    Official Symbol
    ITPRIPprovided by HGNC
    Official Full Name
    inositol 1,4,5-trisphosphate receptor interacting proteinprovided by HGNC
    Primary source
    HGNC:HGNC:29370
    See related
    Ensembl:ENSG00000148841 MIM:620205; AllianceGenome:HGNC:29370
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    D1A; DANGER; KIAA1754; bA127L20; bA127L20.2
    Summary
    This gene encodes a membrane-associated protein that binds the inositol 1,4,5-trisphosphate receptor (ITPR). The encoded protein enhances the sensitivity of ITPR to intracellular calcium signaling. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2012]
    Expression
    Broad expression in bone marrow (RPKM 60.0), esophagus (RPKM 14.1) and 17 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See ITPRIP in Genome Data Viewer
    Location:
    10q25.1
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (104309700..104338465, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (105197853..105226599, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (106069458..106098223, complement)

    Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124902497 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3981 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3982 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3983 Neighboring gene microRNA 4482 Neighboring gene glutathione S-transferase omega 2 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr10:106058991-106060190 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:106060509-106061008 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:106075123-106075652 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:106075653-106076181 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:106078667-106079168 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:106083478-106084208 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:106084209-106084937 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:106086727-106087372 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:106087373-106088018 Neighboring gene ITPRIP antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2798 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:106089957-106090602 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:106090603-106091248 Neighboring gene Sharpr-MPRA regulatory region 8343 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3984 Neighboring gene Sharpr-MPRA regulatory region 11867 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2799 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr10:106109241-106110165 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3986 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3987 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3988 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3989 Neighboring gene cilia and flagella associated protein 58 Neighboring gene CFAP58 divergent transcript Neighboring gene uncharacterized LOC124902590

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Ancient origin of the new developmental superfamily DANGER. Nikolaidis N, et al. PLoS One, 2007 Feb 14. PMID 17301879, Free PMC Article
    2. ITPRIP promotes glioma progression by linking MYL9 to DAPK1 inhibition. Cao C, et al. Cell Signal, 2021 Sep. PMID 34111521
    3. PHYRN: a robust method for phylogenetic analysis of highly divergent sequences. Bhardwaj G, et al. PLoS One, 2012. PMID 22514627, Free PMC Article
    4. DANGER is involved in high glucose-induced radioresistance through inhibiting DAPK-mediated anoikis in non-small cell lung cancer. Kwon T, et al. Oncotarget, 2016 Feb 9. PMID 26769850, Free PMC Article
    5. DANGER, a novel regulatory protein of inositol 1,4,5-trisphosphate-receptor activity. van Rossum DB, et al. J Biol Chem, 2006 Dec 1. PMID 16990268

    See all (37) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. ITPRIP promotes glioma progression by linking MYL9 to DAPK1 inhibition.
      Title: ITPRIP promotes glioma progression by linking MYL9 to DAPK1 inhibition.
    2. The suggested model of how long noncoding RNAs (lncI) TPRIP-1 orchestrates signal transduction for IFN production illustrates the essential role of lncRNAs in virus elimination.
      Title: Long Noncoding RNA ITPRIP-1 Positively Regulates the Innate Immune Response through Promotion of Oligomerization and Activation of MDA5.
    3. High DANGER expression is involved in high glucose-induced radioresistance through inhibiting DAPK-mediated anoikis in non-small cell lung cancer.
      Title: DANGER is involved in high glucose-induced radioresistance through inhibiting DAPK-mediated anoikis in non-small cell lung cancer.
    4. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
      Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
    5. Observational study of gene-disease association. (HuGE Navigator)
      Title: A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease.
    6. DANGER appears to allosterically modulate the sensitivity of IP(3) RtoCa(2+) inhibition, which likely alters IP(3)R-mediated Ca(2+) dynamics in cells where DANGER and IP(3)R are co-expressed
      Title: DANGER, a novel regulatory protein of inositol 1,4,5-trisphosphate-receptor activity.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    HIV-1 interactions

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    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp160, precursor env HIV-1 gp160 interacts with ITPRIP; predicted interaction to be relevant to viral egress at plasma membrane/extracellular matrix PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • KIAA1754

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein kinase inhibitor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in extrinsic apoptotic signaling pathway via death domain receptors IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of extrinsic apoptotic signaling pathway via death domain receptors IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane HDA PubMed 
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nuclear outer membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    inositol 1,4,5-trisphosphate receptor-interacting protein
    Names
    DANGER family member 1A
    inositol 1,4,5-triphosphate receptor-interacting protein

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001272012.2 → NP_001258941.1  inositol 1,4,5-trisphosphate receptor-interacting protein precursor

      See identical proteins and their annotated locations for NP_001258941.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2, and 3 encode the same protein.
      Source sequence(s)
      AL162742
      Consensus CDS
      CCDS7557.1
      UniProtKB/Swiss-Prot
      D3DRA5, Q5JU17, Q8IWB1, Q96MS8, Q9C0A9
      Related
      ENSP00000350915.2, ENST00000358187.2
      Conserved Domains (3) summary
      pfam03281
      Location:351 → 479
      Mab-21; Mab-21 protein
      pfam06936
      Location:43 → 112
      Selenoprotein_S; Selenoprotein S (SelS)
      cl11433
      Location:12 → 73
      DivIC; Septum formation initiator

    2. NM_001272013.2 → NP_001258942.1  inositol 1,4,5-trisphosphate receptor-interacting protein precursor

      See identical proteins and their annotated locations for NP_001258942.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2, and 3 encode the same protein.
      Source sequence(s)
      AL162742
      Consensus CDS
      CCDS7557.1
      UniProtKB/Swiss-Prot
      D3DRA5, Q5JU17, Q8IWB1, Q96MS8, Q9C0A9
      Related
      ENSP00000337178.1, ENST00000337478.3
      Conserved Domains (3) summary
      pfam03281
      Location:351 → 479
      Mab-21; Mab-21 protein
      pfam06936
      Location:43 → 112
      Selenoprotein_S; Selenoprotein S (SelS)
      cl11433
      Location:12 → 73
      DivIC; Septum formation initiator

    3. NM_033397.4 → NP_203755.1  inositol 1,4,5-trisphosphate receptor-interacting protein precursor

      See identical proteins and their annotated locations for NP_203755.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2, and 3 encode the same protein.
      Source sequence(s)
      AL162742
      Consensus CDS
      CCDS7557.1
      UniProtKB/Swiss-Prot
      D3DRA5, Q5JU17, Q8IWB1, Q96MS8, Q9C0A9
      Related
      ENSP00000278071.2, ENST00000278071.6
      Conserved Domains (3) summary
      pfam03281
      Location:351 → 479
      Mab-21; Mab-21 protein
      pfam06936
      Location:43 → 112
      Selenoprotein_S; Selenoprotein S (SelS)
      cl11433
      Location:12 → 73
      DivIC; Septum formation initiator

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

      Range
      104309700..104338465 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005270257.3 → XP_005270314.1  inositol 1,4,5-trisphosphate receptor-interacting protein isoform X1

      Conserved Domains (3) summary
      pfam03281
      Location:356 → 484
      Mab-21; Mab-21 protein
      pfam06936
      Location:48 → 117
      Selenoprotein_S; Selenoprotein S (SelS)
      cl11433
      Location:17 → 78
      DivIC; Septum formation initiator

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060934.1 Alternate T2T-CHM13v2.0

      Range
      105197853..105226599 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054367055.1 → XP_054223030.1  inositol 1,4,5-trisphosphate receptor-interacting protein isoform X1

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8IWB1.1 GenPept UniProtKB/Swiss-Prot:Q8IWB1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
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