TRIM10 tripartite motif containing 10 [Homo sapiens (human)] - Gene

Summary

Official Symbol: TRIM10provided by HGNC
Official Full Name: tripartite motif containing 10provided by HGNC
Primary source: HGNC:HGNC:10072
See related: Ensembl:ENSG00000204613 MIM:605701; AllianceGenome:HGNC:10072
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: RNF9; HERF1; RFB30
Summary: The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This protein localizes to cytoplasmic bodies. Studies in mice suggest that this protein plays a role in terminal differentiation of erythroid cells. Alternate splicing of this gene generates two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Expression: Biased expression in bone marrow (RPKM 6.5), kidney (RPKM 1.8) and 6 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 6p22.1

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	6	NC_000006.12 (30151943..30164009, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	6	NC_060930.1 (30016218..30028317, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	6	NC_000006.11 (30119720..30128988, complement)

Chromosome 6 - NC_000006.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

TRIM10 binds to IFN-alpha/beta receptor 1 to negatively regulate type I IFN signal transduction.
Title: TRIM10 binds to IFN-α/β receptor 1 to negatively regulate type I IFN signal transduction.
Oncogenic gene TRIM10 confers resistance to cisplatin in osteosarcoma cells and activates the NF-kappaB signaling pathway.
Title: Oncogenic gene TRIM10 confers resistance to cisplatin in osteosarcoma cells and activates the NF-κB signaling pathway.
Observational study of gene-disease association. (HuGE Navigator)
Title: High-density SNP screening of the major histocompatibility complex in systemic lupus erythematosus demonstrates strong evidence for independent susceptibility regions.

Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Common genetic variation and the control of HIV-1 in humans. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genome-wide association study of proneness to anger. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

TRIM10__3757 (e-PCR)
- UniSTS:462937

NoName (e-PCR)
- UniSTS:483675

RH68466 (e-PCR)
- UniSTS:62046

RH46708 (e-PCR)
- UniSTS:66415

SHGC-79289 (e-PCR)
- UniSTS:102802

RH35894 (e-PCR)
- UniSTS:8888

SGC34813 (e-PCR)
- UniSTS:8889

NoName (e-PCR)
- UniSTS:481212

SHGC-17229 (e-PCR)
- UniSTS:9663

RH46821 (e-PCR)
- UniSTS:9664

G24073 (e-PCR)
- UniSTS:83406

RH36278 (e-PCR)
- UniSTS:54500

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables ubiquitin protein ligase activity	IBA Inferred from Biological aspect of Ancestor more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in erythrocyte differentiation	IEA Inferred from Electronic Annotation more info
involved_in innate immune response	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of viral entry into host cell	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: tripartite motif-containing protein 10

Names: B30-RING finger protein; Zn-finger protein; hematopoietic RING finger 1; ring finger protein 9; tripartite motif protein 10

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_006778.4 → NP_006769.2 tripartite motif-containing protein 10 isoform 1

See identical proteins and their annotated locations for NP_006769.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes isoform 1, which has a distinct C-terminus and is 86 aa longer than isoform 2.

Source sequence(s)

AL360163, AL669914, BC093926

Consensus CDS

CCDS34375.1

UniProtKB/Swiss-Prot

A6NF84, Q5SRJ5, Q5SRK8, Q86Z08, Q96QB6, Q9C023, Q9C024, Q9UDY6

Related

ENSP00000397073.2, ENST00000449742.7

Conserved Domains (4) summary

smart00336
Location:94 → 135

BBOX; B-Box-type zinc finger

cd15827
Location:309 → 480

SPRY_PRY_TRIM10; PRY/SPRY domain of tripartite motif-binding protein 10 (TRIM10) also known as hematopoietic RING finger 1 (HERF1)

cl17238
Location:16 → 60

RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...

cl23765
Location:143 → 217

iSH2_PI3K_IA_R; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunits
NM_052828.3 → NP_439893.2 tripartite motif-containing protein 10 isoform 2

See identical proteins and their annotated locations for NP_439893.2

Status: VALIDATED

Description

Transcript Variant: This variant (2) uses an alternate splice site that results in the introduction of a 539 nt intron between a 3' penultimate and 3' terminal exon, compared to the 3' terminal exon of variant 1. This results in a frameshift and introduction of a novel stop codon. Isoform 2 has a distinct C-terminus and is 86 aa shorter than isoform 1.

Source sequence(s)

AL360163, AL669914, BC093926

Consensus CDS

CCDS4676.1

UniProtKB/TrEMBL

A0A1U9X8M5, A0A1U9X8N7

Related

ENSP00000365894.3, ENST00000376704.3

Conserved Domains (4) summary

smart00336
Location:94 → 135

BBOX; B-Box-type zinc finger

cd16593
Location:13 → 61

RING-HC_TRIM10_C-IV; RING finger, HC subclass, found in tripartite motif-containing protein 10 (TRIM10) and similar proteins

cl02614
Location:309 → 368

SPRY; SPRY domain

cl25407
Location:143 → 217

ClassIIa_HDAC_Gln-rich-N; Glutamine-rich N-terminal helical domain of various Class IIa histone deacetylases (HDAC4, HDAC5 and HDCA9)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000006.12 Reference GRCh38.p14 Primary Assembly

Range

30151943..30164009 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_047418051.1 → XP_047274007.1 tripartite motif-containing protein 10 isoform X1
XM_047418052.1 → XP_047274008.1 tripartite motif-containing protein 10 isoform X1
XM_011514221.2 → XP_011512523.1 tripartite motif-containing protein 10 isoform X1

See identical proteins and their annotated locations for XP_011512523.1

Conserved Domains (4) summary

smart00336
Location:112 → 153

BBOX; B-Box-type zinc finger

cd15827
Location:327 → 498

SPRY_PRY_TRIM10; PRY/SPRY domain of tripartite motif-binding protein 10 (TRIM10) also known as hematopoietic RING finger 1 (HERF1)

cl17238
Location:41 → 78

RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...

cl23765
Location:161 → 235

iSH2_PI3K_IA_R; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunits
XM_011514223.3 → XP_011512525.1 tripartite motif-containing protein 10 isoform X1

See identical proteins and their annotated locations for XP_011512525.1

Conserved Domains (4) summary

smart00336
Location:112 → 153

BBOX; B-Box-type zinc finger

cd15827
Location:327 → 498

SPRY_PRY_TRIM10; PRY/SPRY domain of tripartite motif-binding protein 10 (TRIM10) also known as hematopoietic RING finger 1 (HERF1)

cl17238
Location:41 → 78

RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...

cl23765
Location:161 → 235

iSH2_PI3K_IA_R; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunits
XM_011514222.3 → XP_011512524.1 tripartite motif-containing protein 10 isoform X1

See identical proteins and their annotated locations for XP_011512524.1

Conserved Domains (4) summary

smart00336
Location:112 → 153

BBOX; B-Box-type zinc finger

cd15827
Location:327 → 498

SPRY_PRY_TRIM10; PRY/SPRY domain of tripartite motif-binding protein 10 (TRIM10) also known as hematopoietic RING finger 1 (HERF1)

cl17238
Location:41 → 78

RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...

cl23765
Location:161 → 235

iSH2_PI3K_IA_R; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunits
XM_047418053.1 → XP_047274009.1 tripartite motif-containing protein 10 isoform X2

Reference GRCh38.p14 ALT_REF_LOCI_1

Genomic

NT_167244.2 Reference GRCh38.p14 ALT_REF_LOCI_1

Range

1410039..1421508 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054328439.1 → XP_054184414.1 tripartite motif-containing protein 10 isoform X3

UniProtKB/Swiss-Prot

A6NF84, Q5SRJ5, Q5SRK8, Q86Z08, Q96QB6, Q9C023, Q9C024, Q9UDY6
XM_054328440.1 → XP_054184415.1 tripartite motif-containing protein 10 isoform X3

UniProtKB/Swiss-Prot

A6NF84, Q5SRJ5, Q5SRK8, Q86Z08, Q96QB6, Q9C023, Q9C024, Q9UDY6
XM_054328441.1 → XP_054184416.1 tripartite motif-containing protein 10 isoform X2
XM_054328442.1 → XP_054184417.1 tripartite motif-containing protein 10 isoform X4

UniProtKB/TrEMBL

A0A1U9X8M5
XM_054328438.1 → XP_054184413.1 tripartite motif-containing protein 10 isoform X1
XM_054328437.1 → XP_054184412.1 tripartite motif-containing protein 10 isoform X1

Reference GRCh38.p14 ALT_REF_LOCI_2

Genomic

NT_113891.3 Reference GRCh38.p14 ALT_REF_LOCI_2

Range

1631751..1643791 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054329718.1 → XP_054185693.1 tripartite motif-containing protein 10 isoform X3

UniProtKB/Swiss-Prot

A6NF84, Q5SRJ5, Q5SRK8, Q86Z08, Q96QB6, Q9C023, Q9C024, Q9UDY6
XM_054329716.1 → XP_054185691.1 tripartite motif-containing protein 10 isoform X3

UniProtKB/Swiss-Prot

A6NF84, Q5SRJ5, Q5SRK8, Q86Z08, Q96QB6, Q9C023, Q9C024, Q9UDY6
XM_054329717.1 → XP_054185692.1 tripartite motif-containing protein 10 isoform X3

UniProtKB/Swiss-Prot

A6NF84, Q5SRJ5, Q5SRK8, Q86Z08, Q96QB6, Q9C023, Q9C024, Q9UDY6

Reference GRCh38.p14 ALT_REF_LOCI_3

Genomic

NT_167245.2 Reference GRCh38.p14 ALT_REF_LOCI_3

Range

1407860..1419329 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054330211.1 → XP_054186186.1 tripartite motif-containing protein 10 isoform X3

UniProtKB/Swiss-Prot

A6NF84, Q5SRJ5, Q5SRK8, Q86Z08, Q96QB6, Q9C023, Q9C024, Q9UDY6
XM_054330212.1 → XP_054186187.1 tripartite motif-containing protein 10 isoform X3

UniProtKB/Swiss-Prot

A6NF84, Q5SRJ5, Q5SRK8, Q86Z08, Q96QB6, Q9C023, Q9C024, Q9UDY6
XM_054330213.1 → XP_054186188.1 tripartite motif-containing protein 10 isoform X2
XM_054330214.1 → XP_054186189.1 tripartite motif-containing protein 10 isoform X4

UniProtKB/TrEMBL

A0A1U9X8M5
XM_054330210.1 → XP_054186185.1 tripartite motif-containing protein 10 isoform X1
XM_054330209.1 → XP_054186184.1 tripartite motif-containing protein 10 isoform X1

Reference GRCh38.p14 ALT_REF_LOCI_4

Genomic

NT_167246.2 Reference GRCh38.p14 ALT_REF_LOCI_4

Range

1462665..1474130 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054330506.1 → XP_054186481.1 tripartite motif-containing protein 10 isoform X3

UniProtKB/Swiss-Prot

A6NF84, Q5SRJ5, Q5SRK8, Q86Z08, Q96QB6, Q9C023, Q9C024, Q9UDY6
XM_054330507.1 → XP_054186482.1 tripartite motif-containing protein 10 isoform X3

UniProtKB/Swiss-Prot

A6NF84, Q5SRJ5, Q5SRK8, Q86Z08, Q96QB6, Q9C023, Q9C024, Q9UDY6
XM_054330505.1 → XP_054186480.1 tripartite motif-containing protein 10 isoform X1
XM_054330504.1 → XP_054186479.1 tripartite motif-containing protein 10 isoform X1
XM_054330508.1 → XP_054186483.1 tripartite motif-containing protein 10 isoform X2

Reference GRCh38.p14 ALT_REF_LOCI_5

Genomic

NT_167247.2 Reference GRCh38.p14 ALT_REF_LOCI_5

Range

1496018..1508131 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054330755.1 → XP_054186730.1 tripartite motif-containing protein 10 isoform X1
XM_054330756.1 → XP_054186731.1 tripartite motif-containing protein 10 isoform X3

UniProtKB/Swiss-Prot

A6NF84, Q5SRJ5, Q5SRK8, Q86Z08, Q96QB6, Q9C023, Q9C024, Q9UDY6
XM_054330754.1 → XP_054186729.1 tripartite motif-containing protein 10 isoform X1
XM_054330757.1 → XP_054186732.1 tripartite motif-containing protein 10 isoform X2

Reference GRCh38.p14 ALT_REF_LOCI_6

Genomic

NT_167248.2 Reference GRCh38.p14 ALT_REF_LOCI_6

Range

1407072..1418556 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054330985.1 → XP_054186960.1 tripartite motif-containing protein 10 isoform X3

UniProtKB/Swiss-Prot

A6NF84, Q5SRJ5, Q5SRK8, Q86Z08, Q96QB6, Q9C023, Q9C024, Q9UDY6
XM_054330988.1 → XP_054186963.1 tripartite motif-containing protein 10 isoform X4

UniProtKB/TrEMBL

A0A1U9X8M5
XM_054330986.1 → XP_054186961.1 tripartite motif-containing protein 10 isoform X3

UniProtKB/Swiss-Prot

A6NF84, Q5SRJ5, Q5SRK8, Q86Z08, Q96QB6, Q9C023, Q9C024, Q9UDY6
XM_054330987.1 → XP_054186962.1 tripartite motif-containing protein 10 isoform X2

Reference GRCh38.p14 ALT_REF_LOCI_7

Genomic

NT_167249.2 Reference GRCh38.p14 ALT_REF_LOCI_7

Range

1450868..1462134 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054331268.1 → XP_054187243.1 tripartite motif-containing protein 10 isoform X2

Alternate T2T-CHM13v2.0

Genomic

NC_060930.1 Alternate T2T-CHM13v2.0

Range

30016218..30028317 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054353995.1 → XP_054209970.1 tripartite motif-containing protein 10 isoform X1
XM_054353996.1 → XP_054209971.1 tripartite motif-containing protein 10 isoform X3

UniProtKB/Swiss-Prot

A6NF84, Q5SRJ5, Q5SRK8, Q86Z08, Q96QB6, Q9C023, Q9C024, Q9UDY6
XM_054353997.1 → XP_054209972.1 tripartite motif-containing protein 10 isoform X3

UniProtKB/Swiss-Prot

A6NF84, Q5SRJ5, Q5SRK8, Q86Z08, Q96QB6, Q9C023, Q9C024, Q9UDY6
XM_054353999.1 → XP_054209974.1 tripartite motif-containing protein 10 isoform X4

UniProtKB/TrEMBL

A0A1U9X8M5
XM_054353994.1 → XP_054209969.1 tripartite motif-containing protein 10 isoform X1
XM_054353993.1 → XP_054209968.1 tripartite motif-containing protein 10 isoform X1
XM_054353998.1 → XP_054209973.1 tripartite motif-containing protein 10 isoform X2