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Src Rous sarcoma oncogene [ Mus musculus (house mouse) ]

Gene ID: 20779, updated on 28-Oct-2024

Summary

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Official Symbol: Srcprovided by MGI
Official Full Name: Rous sarcoma oncogeneprovided by MGI
Primary source: MGI:MGI:98397
See related: Ensembl:ENSMUSG00000027646 AllianceGenome:MGI:98397
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: pp60c-src
Summary: Enables several functions, including connexin binding activity; ephrin receptor binding activity; and scaffold protein binding activity. Involved in several processes, including bone resorption; interleukin-6-mediated signaling pathway; and positive regulation of signal transduction. Acts upstream of or within several processes, including cellular response to platelet-derived growth factor stimulus; positive regulation of protein metabolic process; and regulation of signal transduction. Located in several cellular components, including actin cytoskeleton; focal adhesion; and ruffle membrane. Is expressed in several structures, including central nervous system; early conceptus; genitourinary system; gut; and retina. Used to study Williams-Beuren syndrome. Human ortholog(s) of this gene implicated in colorectal cancer (multiple); ductal carcinoma in situ; prostate cancer; thrombocytopenia; and type 2 diabetes mellitus. Orthologous to human SRC (SRC proto-oncogene, non-receptor tyrosine kinase). [provided by Alliance of Genome Resources, Oct 2024]
Expression: Ubiquitous expression in duodenum adult (RPKM 49.0), colon adult (RPKM 48.4) and 23 other tissues See more
Orthologs: human all
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Genomic context

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See Src in Genome Data Viewer

Location:: 2 H1; 2 78.35 cM

Exon count:: 20

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (157265828..157313758)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (157423906..157471838)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Early-stage lung cancer is driven by a transitional cell state dependent on a KRAS-ITGA3-SRC axis.
Title: Early-stage lung cancer is driven by a transitional cell state dependent on a KRAS-ITGA3-SRC axis.
Oxidative Stress Participates in Age-Related Cataract Formation by Disrupting Connection between Lens Epithelial Cells through c-Src/VEGF Pathway.
Title: Oxidative Stress Participates in Age-Related Cataract Formation by Disrupting Connection between Lens Epithelial Cells through c-Src/VEGF Pathway.
SRC and TKS5 mediated podosome formation in fibroblasts promotes extracellular matrix invasion and pulmonary fibrosis.
Title: SRC and TKS5 mediated podosome formation in fibroblasts promotes extracellular matrix invasion and pulmonary fibrosis.
ERbeta promoted invadopodia formation-mediated non-small cell lung cancer metastasis via the ICAM1/p-Src/p-Cortactin signaling pathway.
Title: ERβ promoted invadopodia formation-mediated non-small cell lung cancer metastasis via the ICAM1/p-Src/p-Cortactin signaling pathway.
CircKIF4A combines EIF4A3 to stabilize SDC1 expression to activate c-src/FAK and promotes TNBC progression.
Title: CircKIF4A combines EIF4A3 to stabilize SDC1 expression to activate c-src/FAK and promotes TNBC progression.
Corneal Edema in Inducible Slc4a11 Knockout Is Initiated by Mitochondrial Superoxide Induced Src Kinase Activation.
Title: Corneal Edema in Inducible Slc4a11 Knockout Is Initiated by Mitochondrial Superoxide Induced Src Kinase Activation.
The ubiquitination of CKIP-1 mediated by Src aggravates diabetic renal fibrosis (original article).
Title: The ubiquitination of CKIP-1 mediated by Src aggravates diabetic renal fibrosis (original article).
Src-homology domain 2 containing protein tyrosine phosphatase-1 (SHP-1) directly binds to proto-oncogene tyrosine-protein kinase Src (c-Src) and promotes the transcriptional activation of connexin 43 (Cx43).
Title: Src-homology domain 2 containing protein tyrosine phosphatase-1 (SHP-1) directly binds to proto-oncogene tyrosine-protein kinase Src (c-Src) and promotes the transcriptional activation of connexin 43 (Cx43).
Mesenchymal stem cell-derived small extracellular vesicles mitigate oxidative stress-induced senescence in endothelial cells via regulation of miR-146a/Src.
Title: Mesenchymal stem cell-derived small extracellular vesicles mitigate oxidative stress-induced senescence in endothelial cells via regulation of miR-146a/Src.
Metastasis suppressor 1 controls osteoblast differentiation and bone homeostasis through regulating Src-Wnt/beta-catenin signaling.
Title: Metastasis suppressor 1 controls osteoblast differentiation and bone homeostasis through regulating Src-Wnt/β-catenin signaling.

Submit: New GeneRIF Correction See all GeneRIFs (258)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (7)
Gene trapped (1)
Spontaneous (1) 1 citation
Targeted (7) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AW259666 (e-PCR)
- UniSTS:178756

Src (e-PCR), detects polymorphism
- UniSTS:144506

WI-14593 (e-PCR)
- UniSTS:44757

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables BMP receptor binding	IEA Inferred from Electronic Annotation more info
enables BMP receptor binding	ISO Inferred from Sequence Orthology more info
enables SH2 domain binding	IEA Inferred from Electronic Annotation more info
enables SH2 domain binding	ISO Inferred from Sequence Orthology more info
enables cell adhesion molecule binding	ISO Inferred from Sequence Orthology more info
enables connexin binding	IPI Inferred from Physical Interaction more info	PubMed
enables enzyme binding	ISO Inferred from Sequence Orthology more info
enables ephrin receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables ephrin receptor binding	ISO Inferred from Sequence Orthology more info
enables heme binding	ISO Inferred from Sequence Orthology more info
enables heme binding	ISS Inferred from Sequence or Structural Similarity more info
enables insulin receptor binding	IEA Inferred from Electronic Annotation more info
enables insulin receptor binding	ISO Inferred from Sequence Orthology more info
enables integrin binding	IEA Inferred from Electronic Annotation more info
enables integrin binding	ISO Inferred from Sequence Orthology more info
enables kinase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables non-membrane spanning protein tyrosine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables non-membrane spanning protein tyrosine kinase activity	IEA Inferred from Electronic Annotation more info
enables non-membrane spanning protein tyrosine kinase activity	ISO Inferred from Sequence Orthology more info
enables nuclear estrogen receptor binding	IEA Inferred from Electronic Annotation more info
enables nuclear estrogen receptor binding	ISO Inferred from Sequence Orthology more info
enables phospholipase activator activity	IEA Inferred from Electronic Annotation more info
enables phospholipase activator activity	ISO Inferred from Sequence Orthology more info
enables phospholipase binding	IEA Inferred from Electronic Annotation more info
enables phospholipase binding	ISO Inferred from Sequence Orthology more info
enables phosphoprotein binding	IEA Inferred from Electronic Annotation more info
enables phosphoprotein binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein domain specific binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase C binding	IEA Inferred from Electronic Annotation more info
enables protein kinase C binding	ISO Inferred from Sequence Orthology more info
enables protein kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein kinase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables protein kinase activity	ISO Inferred from Sequence Orthology more info
enables protein kinase binding	ISO Inferred from Sequence Orthology more info
enables protein tyrosine kinase activity	EXP Inferred from Experiment more info	PubMed
enables protein tyrosine kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein tyrosine kinase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables protein tyrosine kinase activity	ISO Inferred from Sequence Orthology more info
enables protein tyrosine kinase activity	TAS Traceable Author Statement more info
enables protein-containing complex binding	ISO Inferred from Sequence Orthology more info
enables scaffold protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables scaffold protein binding	ISO Inferred from Sequence Orthology more info
enables signaling receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables signaling receptor binding	ISO Inferred from Sequence Orthology more info
enables transmembrane transporter binding	IEA Inferred from Electronic Annotation more info
enables transmembrane transporter binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in DNA biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in DNA biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in adherens junction organization	IEA Inferred from Electronic Annotation more info
involved_in angiotensin-activated signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within bone resorption	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in bone resorption	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within branching involved in mammary gland duct morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell adhesion	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell differentiation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell-cell adhesion	IEA Inferred from Electronic Annotation more info
involved_in cellular response to fatty acid	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cellular response to fluid shear stress	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cellular response to hydrogen peroxide	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to hypoxia	IEA Inferred from Electronic Annotation more info
involved_in cellular response to insulin stimulus	IEA Inferred from Electronic Annotation more info
involved_in cellular response to lipopolysaccharide	IEA Inferred from Electronic Annotation more info
involved_in cellular response to peptide hormone stimulus	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within cellular response to platelet-derived growth factor stimulus	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to progesterone stimulus	IEA Inferred from Electronic Annotation more info
involved_in cellular response to progesterone stimulus	ISO Inferred from Sequence Orthology more info
involved_in cellular response to prolactin	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cellular response to reactive oxygen species	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within cellular response to transforming growth factor beta stimulus	IGI Inferred from Genetic Interaction more info	PubMed
involved_in epidermal growth factor receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in epidermal growth factor receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in focal adhesion assembly	IEA Inferred from Electronic Annotation more info
involved_in focal adhesion assembly	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within forebrain development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in immune system process	IEA Inferred from Electronic Annotation more info
involved_in innate immune response	IBA Inferred from Biological aspect of Ancestor more info
involved_in integrin-mediated signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in integrin-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in interleukin-6-mediated signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in interleukin-6-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in intestinal epithelial cell development	IDA Inferred from Direct Assay more info	PubMed
involved_in intestinal epithelial cell development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within intracellular signal transduction	IGI Inferred from Genetic Interaction more info	PubMed
involved_in intracellular signal transduction	ISO Inferred from Sequence Orthology more info
involved_in learning or memory	IEA Inferred from Electronic Annotation more info
involved_in myoblast proliferation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of anoikis	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of anoikis	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cysteine-type endopeptidase activity involved in apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of cysteine-type endopeptidase activity involved in apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of extrinsic apoptotic signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of extrinsic apoptotic signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of extrinsic apoptotic signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of focal adhesion assembly	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of focal adhesion assembly	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of gene expression	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of hippo signaling	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of hippo signaling	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of intrinsic apoptotic signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of intrinsic apoptotic signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of intrinsic apoptotic signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of mitochondrial depolarization	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of mitochondrial depolarization	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of protein-containing complex assembly	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of protein-containing complex assembly	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of telomere maintenance	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of telomere maintenance via telomerase	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
involved_in neurotrophin TRK receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in neurotrophin TRK receptor signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within odontogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within oogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within osteoclast development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in peptidyl-tyrosine autophosphorylation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within peptidyl-tyrosine phosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in peptidyl-tyrosine phosphorylation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within peptidyl-tyrosine phosphorylation	ISO Inferred from Sequence Orthology more info	PubMed
involved_in peptidyl-tyrosine phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in phosphorylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in platelet-derived growth factor receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of ERK1 and ERK2 cascade	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of ERK1 and ERK2 cascade	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of Notch signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of Notch signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of Ras protein signal transduction	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of Ras protein signal transduction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of TORC1 signaling	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of TORC1 signaling	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of bone resorption	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of bone resorption	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of canonical Wnt signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of cell adhesion	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cell adhesion	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cytokine production	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cytokine production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of dephosphorylation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of dephosphorylation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of epithelial cell migration	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of epithelial cell migration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of glucose metabolic process	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of glucose metabolic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of glycolytic process	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of insulin receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of insulin receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of intracellular signal transduction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of lamellipodium morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of lamellipodium morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of male germ cell proliferation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of male germ cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of ovarian follicle development	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of ovarian follicle development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of peptidyl-tyrosine phosphorylation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of peptidyl-tyrosine phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of platelet-derived growth factor receptor-beta signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of podosome assembly	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of podosome assembly	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within positive regulation of protein localization to nucleus	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within positive regulation of protein processing	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of protein serine/threonine kinase activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein transport	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of protein transport	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of small GTPase mediated signal transduction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of smooth muscle cell migration	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of smooth muscle cell migration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of vascular associated smooth muscle cell proliferation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of vascular associated smooth muscle cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in primary ovarian follicle growth	IEA Inferred from Electronic Annotation more info
involved_in primary ovarian follicle growth	ISO Inferred from Sequence Orthology more info
involved_in progesterone receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in progesterone receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in progesterone receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in protein autophosphorylation	ISO Inferred from Sequence Orthology more info
involved_in protein destabilization	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within protein phosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of caveolin-mediated endocytosis	IEA Inferred from Electronic Annotation more info
involved_in regulation of caveolin-mediated endocytosis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of cell projection assembly	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of cell-cell adhesion	IEA Inferred from Electronic Annotation more info
involved_in regulation of cell-cell adhesion	ISO Inferred from Sequence Orthology more info
involved_in regulation of early endosome to late endosome transport	IEA Inferred from Electronic Annotation more info
involved_in regulation of early endosome to late endosome transport	ISO Inferred from Sequence Orthology more info
involved_in regulation of epithelial cell migration	ISO Inferred from Sequence Orthology more info
involved_in regulation of heart rate by cardiac conduction	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within regulation of intracellular estrogen receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of protein binding	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of toll-like receptor 3 signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in regulation of toll-like receptor 3 signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in response to acidic pH	IEA Inferred from Electronic Annotation more info
involved_in response to electrical stimulus	IEA Inferred from Electronic Annotation more info
involved_in response to interleukin-1	IEA Inferred from Electronic Annotation more info
involved_in response to interleukin-1	ISO Inferred from Sequence Orthology more info
involved_in response to mechanical stimulus	IEA Inferred from Electronic Annotation more info
involved_in response to mineralocorticoid	IEA Inferred from Electronic Annotation more info
involved_in response to nutrient levels	IEA Inferred from Electronic Annotation more info
involved_in response to xenobiotic stimulus	IEA Inferred from Electronic Annotation more info
involved_in skeletal muscle cell proliferation	IEA Inferred from Electronic Annotation more info
involved_in spermatogenesis	IEA Inferred from Electronic Annotation more info
involved_in stress fiber assembly	IEA Inferred from Electronic Annotation more info
involved_in stress fiber assembly	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within substrate adhesion-dependent cell spreading	IDA Inferred from Direct Assay more info	PubMed
involved_in transcytosis	IEA Inferred from Electronic Annotation more info
involved_in transcytosis	ISO Inferred from Sequence Orthology more info
involved_in transforming growth factor beta receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in transforming growth factor beta receptor signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within uterus development	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in actin filament	IDA Inferred from Direct Assay more info	PubMed
located_in caveola	IDA Inferred from Direct Assay more info	PubMed
located_in caveola	ISO Inferred from Sequence Orthology more info
located_in cell junction	ISO Inferred from Sequence Orthology more info
located_in cell junction	ISS Inferred from Sequence or Structural Similarity more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoskeleton	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in cytosol	TAS Traceable Author Statement more info
located_in dendritic filopodium	IEA Inferred from Electronic Annotation more info
located_in dendritic filopodium	ISO Inferred from Sequence Orthology more info
located_in dendritic growth cone	IEA Inferred from Electronic Annotation more info
located_in dendritic growth cone	ISO Inferred from Sequence Orthology more info
located_in focal adhesion	IMP Inferred from Mutant Phenotype more info	PubMed
located_in glutamatergic synapse	IEA Inferred from Electronic Annotation more info
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
located_in late endosome	IEA Inferred from Electronic Annotation more info
located_in late endosome	ISO Inferred from Sequence Orthology more info
located_in lysosome	IEA Inferred from Electronic Annotation more info
located_in lysosome	ISO Inferred from Sequence Orthology more info
located_in membrane	IMP Inferred from Mutant Phenotype more info	PubMed
located_in mitochondrial inner membrane	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrial inner membrane	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in neuronal cell body	IEA Inferred from Electronic Annotation more info
located_in neuronal cell body	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	TAS Traceable Author Statement more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in perinuclear region of cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	TAS Traceable Author Statement more info
located_in podosome	IDA Inferred from Direct Assay more info	PubMed
located_in postsynaptic specialization, intracellular component	IEA Inferred from Electronic Annotation more info
is_active_in postsynaptic specialization, intracellular component	ISO Inferred from Sequence Orthology more info
located_in ruffle membrane	IDA Inferred from Direct Assay more info	PubMed
located_in synaptic membrane	IEA Inferred from Electronic Annotation more info
located_in synaptic membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: proto-oncogene tyrosine-protein kinase Src

Names: neuronal proto-oncogene tyrosine-protein kinase Src; p60-Src; proto-oncogene c-Src

NP_001020566.1

EC 2.7.10.2

NP_001399611.1

EC 2.7.10.2

NP_001399612.1

EC 2.7.10.2

NP_001399613.1

EC 2.7.10.2

NP_001399614.1

EC 2.7.10.2

NP_001399615.1

EC 2.7.10.2

NP_001399616.1

EC 2.7.10.2

NP_001399617.1

EC 2.7.10.2

NP_001399618.1

EC 2.7.10.2

NP_001399619.1

EC 2.7.10.2

NP_001399620.1

EC 2.7.10.2

NP_001399622.1

EC 2.7.10.2

NP_001407929.1

EC 2.7.10.2

NP_033297.2

EC 2.7.10.2

XP_006499126.1

EC 2.7.10.2

XP_006499128.1

EC 2.7.10.2

XP_006499129.1

EC 2.7.10.2

XP_011237704.1

EC 2.7.10.2

XP_011237705.1

EC 2.7.10.2

XP_011237706.1

EC 2.7.10.2

XP_030104859.1

EC 2.7.10.2

XP_036015976.1

EC 2.7.10.2

XP_036015977.1

EC 2.7.10.2

XP_036015978.1

EC 2.7.10.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001025395.3 → NP_001020566.1 proto-oncogene tyrosine-protein kinase Src isoform 2

See identical proteins and their annotated locations for NP_001020566.1

Status: VALIDATED

Source sequence(s)

AL672259

Consensus CDS

CCDS16978.1

UniProtKB/Swiss-Prot

F8WI90, P05480, Q2M4I4

UniProtKB/TrEMBL

Q3UKD6

Related

ENSMUSP00000029175.8, ENSMUST00000029175.14

Conserved Domains (3) summary

cd10365
Location:146 → 246

SH2_Src_Src; Src homology 2 (SH2) domain found in tyrosine kinase sarcoma (Src)

cd12008
Location:87 → 142

SH3_Src; Src homology 3 domain of Src Protein Tyrosine Kinase

cd05071
Location:259 → 535

PTKc_Src; Catalytic domain of the Protein Tyrosine Kinase, Src
NM_001412682.1 → NP_001399611.1 proto-oncogene tyrosine-protein kinase Src isoform 1

Status: VALIDATED

Source sequence(s)

AL672259
NM_001412683.1 → NP_001399612.1 proto-oncogene tyrosine-protein kinase Src isoform 1

Status: VALIDATED

Source sequence(s)

AL672259
NM_001412684.1 → NP_001399613.1 proto-oncogene tyrosine-protein kinase Src isoform 1

Status: VALIDATED

Source sequence(s)

AL672259
NM_001412685.1 → NP_001399614.1 proto-oncogene tyrosine-protein kinase Src isoform 1

Status: VALIDATED

Source sequence(s)

AL672259

Related

ENSMUSP00000105155.2, ENSMUST00000109529.2
NM_001412686.1 → NP_001399615.1 proto-oncogene tyrosine-protein kinase Src isoform 1

Status: VALIDATED

Source sequence(s)

AL672259
NM_001412687.1 → NP_001399616.1 proto-oncogene tyrosine-protein kinase Src isoform 2

Status: VALIDATED

Source sequence(s)

AL672259

UniProtKB/Swiss-Prot

F8WI90, P05480, Q2M4I4
NM_001412688.1 → NP_001399617.1 proto-oncogene tyrosine-protein kinase Src isoform 2

Status: VALIDATED

Source sequence(s)

AL672259

UniProtKB/Swiss-Prot

F8WI90, P05480, Q2M4I4
NM_001412689.1 → NP_001399618.1 proto-oncogene tyrosine-protein kinase Src isoform 2

Status: VALIDATED

Source sequence(s)

AL672259

UniProtKB/Swiss-Prot

F8WI90, P05480, Q2M4I4

Related

ENSMUSP00000105157.2, ENSMUST00000109531.8
NM_001412690.1 → NP_001399619.1 proto-oncogene tyrosine-protein kinase Src isoform 2

Status: VALIDATED

Source sequence(s)

AL672259

UniProtKB/Swiss-Prot

F8WI90, P05480, Q2M4I4
NM_001412691.1 → NP_001399620.1 proto-oncogene tyrosine-protein kinase Src isoform 2

Status: VALIDATED

Source sequence(s)

AL672259

UniProtKB/Swiss-Prot

F8WI90, P05480, Q2M4I4
NM_001412693.1 → NP_001399622.1 proto-oncogene tyrosine-protein kinase Src isoform 1

Status: VALIDATED

Source sequence(s)

AL672259
NM_001421000.1 → NP_001407929.1 proto-oncogene tyrosine-protein kinase Src isoform 2

Status: VALIDATED

Source sequence(s)

AL672259

UniProtKB/Swiss-Prot

F8WI90, P05480, Q2M4I4
NM_009271.4 → NP_033297.2 proto-oncogene tyrosine-protein kinase Src isoform 1

See identical proteins and their annotated locations for NP_033297.2

Status: VALIDATED

Source sequence(s)

AL672259

Consensus CDS

CCDS38305.1

UniProtKB/TrEMBL

Q3UKD6

Related

ENSMUSP00000090237.5, ENSMUST00000092576.11

Conserved Domains (3) summary

cd10365
Location:152 → 252

SH2_Src_Src; Src homology 2 (SH2) domain found in tyrosine kinase sarcoma (Src)

cd12008
Location:87 → 148

SH3_Src; Src homology 3 domain of Src Protein Tyrosine Kinase

cd05071
Location:265 → 541

PTKc_Src; Catalytic domain of the Protein Tyrosine Kinase, Src

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000068.8 Reference GRCm39 C57BL/6J

Range

157265828..157313758

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011239404.3 → XP_011237706.1 proto-oncogene tyrosine-protein kinase Src isoform X1

See identical proteins and their annotated locations for XP_011237706.1

UniProtKB/TrEMBL

Q3UKD6

Conserved Domains (3) summary

cd10365
Location:163 → 263

SH2_Src_Src; Src homology 2 (SH2) domain found in tyrosine kinase sarcoma (Src)

cd12008
Location:87 → 159

SH3_Src; Src homology 3 domain of Src Protein Tyrosine Kinase

cd05071
Location:276 → 552

PTKc_Src; Catalytic domain of the Protein Tyrosine Kinase, Src
XM_006499066.4 → XP_006499129.1 proto-oncogene tyrosine-protein kinase Src isoform X1

See identical proteins and their annotated locations for XP_006499129.1

UniProtKB/TrEMBL

Q3UKD6

Conserved Domains (3) summary

cd10365
Location:163 → 263

SH2_Src_Src; Src homology 2 (SH2) domain found in tyrosine kinase sarcoma (Src)

cd12008
Location:87 → 159

SH3_Src; Src homology 3 domain of Src Protein Tyrosine Kinase

cd05071
Location:276 → 552

PTKc_Src; Catalytic domain of the Protein Tyrosine Kinase, Src
XM_036160085.1 → XP_036015978.1 proto-oncogene tyrosine-protein kinase Src isoform X3

UniProtKB/Swiss-Prot

F8WI90, P05480, Q2M4I4

UniProtKB/TrEMBL

Q3UKD6

Conserved Domains (3) summary

cd10365
Location:146 → 246

SH2_Src_Src; Src homology 2 (SH2) domain found in tyrosine kinase sarcoma (Src)

cd12008
Location:87 → 142

SH3_Src; Src homology 3 domain of Src Protein Tyrosine Kinase

cd05071
Location:259 → 535

PTKc_Src; Catalytic domain of the Protein Tyrosine Kinase, Src
XM_030248999.1 → XP_030104859.1 proto-oncogene tyrosine-protein kinase Src isoform X1

UniProtKB/TrEMBL

Q3UKD6

Conserved Domains (3) summary

cd10365
Location:163 → 263

SH2_Src_Src; Src homology 2 (SH2) domain found in tyrosine kinase sarcoma (Src)

cd12008
Location:87 → 159

SH3_Src; Src homology 3 domain of Src Protein Tyrosine Kinase

cd05071
Location:276 → 552

PTKc_Src; Catalytic domain of the Protein Tyrosine Kinase, Src
XM_036160083.1 → XP_036015976.1 proto-oncogene tyrosine-protein kinase Src isoform X3

UniProtKB/Swiss-Prot

F8WI90, P05480, Q2M4I4

UniProtKB/TrEMBL

Q3UKD6

Related

ENSMUSP00000105159.2, ENSMUST00000109533.8

Conserved Domains (3) summary

cd10365
Location:146 → 246

SH2_Src_Src; Src homology 2 (SH2) domain found in tyrosine kinase sarcoma (Src)

cd12008
Location:87 → 142

SH3_Src; Src homology 3 domain of Src Protein Tyrosine Kinase

cd05071
Location:259 → 535

PTKc_Src; Catalytic domain of the Protein Tyrosine Kinase, Src
XM_011239403.3 → XP_011237705.1 proto-oncogene tyrosine-protein kinase Src isoform X1

See identical proteins and their annotated locations for XP_011237705.1

UniProtKB/TrEMBL

Q3UKD6

Conserved Domains (3) summary

cd10365
Location:163 → 263

SH2_Src_Src; Src homology 2 (SH2) domain found in tyrosine kinase sarcoma (Src)

cd12008
Location:87 → 159

SH3_Src; Src homology 3 domain of Src Protein Tyrosine Kinase

cd05071
Location:276 → 552

PTKc_Src; Catalytic domain of the Protein Tyrosine Kinase, Src
XM_036160084.1 → XP_036015977.1 proto-oncogene tyrosine-protein kinase Src isoform X3

UniProtKB/Swiss-Prot

F8WI90, P05480, Q2M4I4

UniProtKB/TrEMBL

Q3UKD6

Conserved Domains (3) summary

cd10365
Location:146 → 246

SH2_Src_Src; Src homology 2 (SH2) domain found in tyrosine kinase sarcoma (Src)

cd12008
Location:87 → 142

SH3_Src; Src homology 3 domain of Src Protein Tyrosine Kinase

cd05071
Location:259 → 535

PTKc_Src; Catalytic domain of the Protein Tyrosine Kinase, Src
XM_006499063.4 → XP_006499126.1 proto-oncogene tyrosine-protein kinase Src isoform X1

See identical proteins and their annotated locations for XP_006499126.1

UniProtKB/TrEMBL

Q3UKD6

Conserved Domains (3) summary

cd10365
Location:163 → 263

SH2_Src_Src; Src homology 2 (SH2) domain found in tyrosine kinase sarcoma (Src)

cd12008
Location:87 → 159

SH3_Src; Src homology 3 domain of Src Protein Tyrosine Kinase

cd05071
Location:276 → 552

PTKc_Src; Catalytic domain of the Protein Tyrosine Kinase, Src
XM_011239402.3 → XP_011237704.1 proto-oncogene tyrosine-protein kinase Src isoform X1

See identical proteins and their annotated locations for XP_011237704.1

UniProtKB/TrEMBL

Q3UKD6

Conserved Domains (3) summary

cd10365
Location:163 → 263

SH2_Src_Src; Src homology 2 (SH2) domain found in tyrosine kinase sarcoma (Src)

cd12008
Location:87 → 159

SH3_Src; Src homology 3 domain of Src Protein Tyrosine Kinase

cd05071
Location:276 → 552

PTKc_Src; Catalytic domain of the Protein Tyrosine Kinase, Src
XM_006499065.3 → XP_006499128.1 proto-oncogene tyrosine-protein kinase Src isoform X1

See identical proteins and their annotated locations for XP_006499128.1

UniProtKB/TrEMBL

Q3UKD6

Conserved Domains (3) summary

cd10365
Location:163 → 263

SH2_Src_Src; Src homology 2 (SH2) domain found in tyrosine kinase sarcoma (Src)

cd12008
Location:87 → 159

SH3_Src; Src homology 3 domain of Src Protein Tyrosine Kinase

cd05071
Location:276 → 552

PTKc_Src; Catalytic domain of the Protein Tyrosine Kinase, Src