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    Pstpip1 proline-serine-threonine phosphatase-interacting protein 1 [ Mus musculus (house mouse) ]

    Gene ID: 19200, updated on 28-Oct-2024

    Summary

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    Official Symbol
    Pstpip1provided by MGI
    Official Full Name
    proline-serine-threonine phosphatase-interacting protein 1provided by MGI
    Primary source
    MGI:MGI:1321396
    See related
    Ensembl:ENSMUSG00000032322 AllianceGenome:MGI:1321396
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    def-2; CD2BP1
    Summary
    Enables actin binding activity and protein phosphatase binding activity. Predicted to be involved in actin filament polymerization. Located in actomyosin contractile ring; cleavage furrow; and stress fiber. Is expressed in several structures, including genitourinary system; liver; musculature; pancreas; and spleen. Human ortholog(s) of this gene implicated in PAPA syndrome. Orthologous to human PSTPIP1 (proline-serine-threonine phosphatase interacting protein 1). [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Biased expression in thymus adult (RPKM 36.1), spleen adult (RPKM 16.1) and 10 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Pstpip1 in Genome Data Viewer
    Location:
    9 B; 9 30.13 cM
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (55985729..56036174)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (56078445..56128890)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_24198 Neighboring gene STARR-positive B cell enhancer mm9_chr9:55889495-55889796 Neighboring gene ring finger protein 19A pseudogene Neighboring gene STARR-positive B cell enhancer mm9_chr9:55923089-55923390 Neighboring gene reticulocalbin 2 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:55937639-55937826 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:55938770-55938923 Neighboring gene STARR-positive B cell enhancer ABC_E10547 Neighboring gene STARR-seq mESC enhancer starr_24202 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:55994441-55994594 Neighboring gene STARR-positive B cell enhancer ABC_E6737 Neighboring gene tetraspanin 3 Neighboring gene pseudopodium-enriched atypical kinase 1 Neighboring gene STARR-positive B cell enhancer mm9_chr9:56112222-56112523 Neighboring gene pseudopodium-enriched atypical kinase 1, opposite strand

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. BAR Proteins PSTPIP1/2 Regulate Podosome Dynamics and the Resorption Activity of Osteoclasts. Sztacho M, et al. PLoS One, 2016. PMID 27760174, Free PMC Article
    2. Inflammation in mice ectopically expressing human Pyogenic Arthritis, Pyoderma Gangrenosum, and Acne (PAPA) Syndrome-associated PSTPIP1 A230T mutant proteins. Wang D, et al. J Biol Chem, 2013 Feb 15. PMID 23293022, Free PMC Article
    3. CD2BP1 modulates CD2-dependent T cell activation via linkage to protein tyrosine phosphatase (PTP)-PEST. Yang H, et al. J Immunol, 2006 May 15. PMID 16670297
    4. The PCH family member proline-serine-threonine phosphatase-interacting protein 1 targets to the leukocyte uropod and regulates directed cell migration. Cooper KM, et al. Mol Biol Cell, 2008 Aug. PMID 18480402, Free PMC Article
    5. Tyrosine phosphorylation regulates the SH3-mediated binding of the Wiskott-Aldrich syndrome protein to PSTPIP, a cytoskeletal-associated protein. Wu Y, et al. J Biol Chem, 1998 Mar 6. PMID 9488710

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. a new PSTPIP1/PTPN6/SHIP1/2-dependent negative feedback mechanism that counterbalances Src and PI(3,4,5)P3 signalling to control osteoclast cell polarity and activity during bone resorption
      Title: BAR Proteins PSTPIP1/2 Regulate Podosome Dynamics and the Resorption Activity of Osteoclasts.
    2. analysis of inflammation in mice ectopically expressing human Pyogenic Arthritis, Pyoderma Gangrenosum, and Acne (PAPA) Syndrome-associated PSTPIP1 A230T mutant proteins
      Title: Inflammation in mice ectopically expressing human Pyogenic Arthritis, Pyoderma Gangrenosum, and Acne (PAPA) Syndrome-associated PSTPIP1 A230T mutant proteins.
    3. PSTPIP1 is a novel component of the leukocyte uropod that regulates endocytosis and cell migration
      Title: The PCH family member proline-serine-threonine phosphatase-interacting protein 1 targets to the leukocyte uropod and regulates directed cell migration.
    4. the intracellular Fas ligand (FasL) domain binding to the adaptor protein PSTPIP results in a cytoplasmic localization of FasL
      Title: Binding of the intracellular Fas ligand (FasL) domain to the adaptor protein PSTPIP results in a cytoplasmic localization of FasL.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (3)  1 citation

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables actin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables actin filament binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein phosphatase binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in actin filament polymerization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell adhesion IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within cytokinesis IC
    Inferred by Curator
    more info
    		 PubMed 
    involved_in endocytosis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in inflammatory response IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in innate immune response IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in actin filament IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in actomyosin contractile ring IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cleavage furrow IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in lamellipodium IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in perinuclear region of cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in stress fiber IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in uropod IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    proline-serine-threonine phosphatase-interacting protein 1
    Names
    PEST phosphatase-interacting protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001409150.1 → NP_001396079.1  proline-serine-threonine phosphatase-interacting protein 1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC158999

    2. NM_001409151.1 → NP_001396080.1  proline-serine-threonine phosphatase-interacting protein 1 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC158999

    3. NM_001409152.1 → NP_001396081.1  proline-serine-threonine phosphatase-interacting protein 1 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC158999

    4. NM_001409153.1 → NP_001396082.1  proline-serine-threonine phosphatase-interacting protein 1 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC158999

    5. NM_001409154.1 → NP_001396083.1  proline-serine-threonine phosphatase-interacting protein 1 isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC158999

    6. NM_001409155.1 → NP_001396084.1  proline-serine-threonine phosphatase-interacting protein 1 isoform 7

      Status: VALIDATED

      Source sequence(s)
      AC158999

    7. NM_001409156.1 → NP_001396085.1  proline-serine-threonine phosphatase-interacting protein 1 isoform 8

      Status: VALIDATED

      Source sequence(s)
      AC158999

    8. NM_001409157.1 → NP_001396086.1  proline-serine-threonine phosphatase-interacting protein 1 isoform 9

      Status: VALIDATED

      Source sequence(s)
      AC158999

    9. NM_001409158.1 → NP_001396087.1  proline-serine-threonine phosphatase-interacting protein 1 isoform 10

      Status: VALIDATED

      Source sequence(s)
      AC158999

    10. NM_001409159.1 → NP_001396088.1  proline-serine-threonine phosphatase-interacting protein 1 isoform 11

      Status: VALIDATED

      Source sequence(s)
      AC158999

    11. NM_001409160.1 → NP_001396089.1  proline-serine-threonine phosphatase-interacting protein 1 isoform 11

      Status: VALIDATED

      Source sequence(s)
      AC158999

    12. NM_001409161.1 → NP_001396090.1  proline-serine-threonine phosphatase-interacting protein 1 isoform 11

      Status: VALIDATED

      Source sequence(s)
      AC158999

    13. NM_011193.3 → NP_035323.2  proline-serine-threonine phosphatase-interacting protein 1 isoform 1

      See identical proteins and their annotated locations for NP_035323.2

      Status: VALIDATED

      Source sequence(s)
      AC158999
      Consensus CDS
      CCDS40645.1
      UniProtKB/Swiss-Prot
      P97814, Q4V9R4
      UniProtKB/TrEMBL
      A0A0R4J0P5
      Related
      ENSMUSP00000055823.8, ENSMUST00000059206.8
      Conserved Domains (2) summary
      cd11824
      Location:362 → 414
      SH3_PSTPIP1; Src homology 3 domain of Proline-Serine-Threonine Phosphatase-Interacting Protein 1
      cl12013
      Location:16 → 257
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      55985729..56036174
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011242677.3 → XP_011240979.1  proline-serine-threonine phosphatase-interacting protein 1 isoform X3

      UniProtKB/Swiss-Prot
      P97814, Q4V9R4
      Conserved Domains (2) summary
      cd11824
      Location:351 → 403
      SH3_PSTPIP1; Src homology 3 domain of Proline-Serine-Threonine Phosphatase-Interacting Protein 1
      cl12013
      Location:5 → 246
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

    2. XM_006510865.3 → XP_006510928.1  proline-serine-threonine phosphatase-interacting protein 1 isoform X1

      UniProtKB/Swiss-Prot
      P97814, Q4V9R4
      Conserved Domains (2) summary
      cd07671
      Location:35 → 276
      F-BAR_PSTPIP1; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Proline-Serine-Threonine Phosphatase-Interacting Protein 1
      cd11824
      Location:381 → 433
      SH3_PSTPIP1; Src homology 3 domain of Proline-Serine-Threonine Phosphatase-Interacting Protein 1

    RNA

    1. XR_004935348.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P97814.1 GenPept UniProtKB/Swiss-Prot:P97814

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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