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    Tmem129 transmembrane protein 129 [ Mus musculus (house mouse) ]

    Gene ID: 68366, updated on 28-Oct-2024

    Summary

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    Official Symbol
    Tmem129provided by MGI
    Official Full Name
    transmembrane protein 129provided by MGI
    Primary source
    MGI:MGI:1915616
    See related
    Ensembl:ENSMUSG00000019295 AllianceGenome:MGI:1915616
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    0610039G24Rik; 2410015J15Rik
    Summary
    Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in protein polyubiquitination; retrograde protein transport, ER to cytosol; and ubiquitin-dependent protein catabolic process. Predicted to be located in endoplasmic reticulum membrane. Predicted to be active in endoplasmic reticulum. Is expressed in several structures, including brain; cardiovascular system; genitourinary system; gut; and hemolymphoid system gland. Orthologous to human TMEM129 (transmembrane protein 129, E3 ubiquitin ligase). [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Ubiquitous expression in adrenal adult (RPKM 29.9), ovary adult (RPKM 25.9) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Tmem129 in Genome Data Viewer
    Location:
    5 B2; 5 17.83 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (33810560..33815321, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (33653216..33657977, complement)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E6317 Neighboring gene predicted gene 9903 Neighboring gene STARR-positive B cell enhancer ABC_E6318 Neighboring gene stem-loop binding protein Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:34000710-34000897 Neighboring gene predicted gene 10459 Neighboring gene STARR-seq mESC enhancer starr_12827 Neighboring gene transforming, acidic coiled-coil containing protein 3 Neighboring gene Fgfr3 5' regulatory region Neighboring gene fibroblast growth factor receptor 3 Neighboring gene leucine zipper-EF-hand containing transmembrane protein 1 Neighboring gene STARR-seq mESC enhancer starr_12830 Neighboring gene ribosomal protein S29 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Koscielny G, et al. Nucleic Acids Res, 2014 Jan. PMID 24194600, Free PMC Article
    2. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199
    3. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article
    4. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article
    5. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin protein ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin protein ligase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in ERAD pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein polyubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein polyubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to unfolded protein IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in retrograde protein transport, ER to cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in retrograde protein transport, ER to cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in ubiquitin-dependent protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    E3 ubiquitin-protein ligase TM129
    Names
    RING-type E3 ubiquitin transferase TM129
    NP_001343912.1
    NP_001343914.1
    NP_080974.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001356983.1 → NP_001343912.1  E3 ubiquitin-protein ligase TM129 isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (b) is shorter at the N-terminus compared to isoform a. Variants 2 and 3 both encode the same isoform (b).
      Source sequence(s)
      AC162898
      Conserved Domains (1) summary
      pfam10272
      Location:1 → 288
      Tmpp129; Putative transmembrane protein precursor

    2. NM_001356985.1 → NP_001343914.1  E3 ubiquitin-protein ligase TM129 isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (b) is shorter at the N-terminus compared to isoform a. Variants 2 and 3 both encode the same isoform (b).
      Source sequence(s)
      AC162898
      Related
      ENSMUST00000140931.2
      Conserved Domains (1) summary
      pfam10272
      Location:1 → 288
      Tmpp129; Putative transmembrane protein precursor

    3. NM_026698.3 → NP_080974.2  E3 ubiquitin-protein ligase TM129 isoform a

      See identical proteins and their annotated locations for NP_080974.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (a).
      Source sequence(s)
      AC162898, AK002836, BY275213
      Consensus CDS
      CCDS19206.1
      UniProtKB/Swiss-Prot
      Q3TA74, Q8K304, Q9DCF3
      Related
      ENSMUSP00000019439.8, ENSMUST00000019439.9
      Conserved Domains (1) summary
      pfam10272
      Location:17 → 359
      Tmpp129; Putative transmembrane protein precursor

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      33810560..33815321 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8K304.1 GenPept UniProtKB/Swiss-Prot:Q8K304

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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