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    Cndp2 CNDP dipeptidase 2 [ Mus musculus (house mouse) ]

    Gene ID: 66054, updated on 14-Nov-2024

    Summary

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    Official Symbol
    Cndp2provided by MGI
    Official Full Name
    CNDP dipeptidase 2provided by MGI
    Primary source
    MGI:MGI:1913304
    See related
    Ensembl:ENSMUSG00000024644 AllianceGenome:MGI:1913304
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Cn2; Pep1; Dip-2; Pep-1; 0610010E05Rik
    Summary
    Enables dipeptidase activity. Acts upstream of or within proteolysis. Predicted to be located in nucleoplasm. Predicted to be active in cytosol. Is expressed in several structures, including 1st branchial arch; ear; limb; nervous system; and urinary system. Orthologous to human CNDP2 (carnosine dipeptidase 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in large intestine adult (RPKM 201.3), placenta adult (RPKM 117.9) and 17 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Cndp2 in Genome Data Viewer
    Location:
    18 E4; 18 57.53 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (84685590..84703827, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (84667465..84685702, complement)

    Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene carnosine dipeptidase 1 Neighboring gene STARR-seq mESC enhancer starr_45251 Neighboring gene STARR-seq mESC enhancer starr_45252 Neighboring gene nucleophosmin 1 pseudogene Neighboring gene STARR-seq mESC enhancer starr_45253 Neighboring gene STARR-positive B cell enhancer ABC_E1964 Neighboring gene STARR-seq mESC enhancer starr_45255 Neighboring gene WD repeat domain 53 pseudogene Neighboring gene divergent protein kinase domain 1C Neighboring gene predicted gene, 25005

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Carnosine dipeptidase II (CNDP2) protects cells under cysteine insufficiency by hydrolyzing glutathione-related peptides. Kobayashi S, et al. Free Radic Biol Med, 2021 Oct. PMID 34324979
    2. Family-wide Annotation of Enzymatic Pathways by Parallel In Vivo Metabolomics. Kim JT, et al. Cell Chem Biol, 2019 Nov 21. PMID 31587987, Free PMC Article
    3. Evidence for an essential role of intradimer interaction in catalytic function of carnosine dipeptidase II using electrospray-ionization mass spectrometry. Okumura N, et al. Protein Sci, 2016 Feb. PMID 26549037, Free PMC Article
    4. Structural basis for substrate recognition and hydrolysis by mouse carnosinase CN2. Unno H, et al. J Biol Chem, 2008 Oct 3. PMID 18550540
    5. An exercise-inducible metabolite that suppresses feeding and obesity. Li VL, et al. Nature, 2022 Jun. PMID 35705806, Free PMC Article

    See all (42) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. this study shows that PEP-1-PEA15 suppresses inflammatory responses by regulation of MAPK in macrophages and animal models
      Title: PEP-1-PEA15 suppresses inflammatory responses by regulation of MAPK in macrophages and animal models.
    2. These results provide evidence showing that intradimer interaction of H228 with the reaction center of the dimer counterpart is essential to the enzymatic activity of Cn2.
      Title: Evidence for an essential role of intradimer interaction in catalytic function of carnosine dipeptidase II using electrospray-ionization mass spectrometry.
    3. These findings suggest that the transduced PEP-1-PRX2 has neuroprotective functions against oxidative stress-induced cell death in vitro and in vivo
      Title: Neuroprotective effect of PEP-1-peroxiredoxin2 on CA1 regions in the hippocampus against ischemic insult.
    4. Structural basis for substrate recognition and hydrolysis by mouse carnosinase CN2.
      Title: Structural basis for substrate recognition and hydrolysis by mouse carnosinase CN2.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4)  1 citation
    • Gene trapped (1) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables carboxypeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables dipeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables dipeptidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables dipeptidase activity ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metallodipeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables peptidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in proteolysis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within proteolysis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within proteolysis ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    cytosolic non-specific dipeptidase
    Names
    CNDP dipeptidase 2 (metallopeptidase M20 family)
    cytosolic nonspecific dipeptidase
    glutamate carboxypeptidase-like protein 1
    peptidase 1
    peptidase A
    threonyl dipeptidase
    NP_001276460.1
    NP_075638.2
    XP_030106430.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001289531.1 → NP_001276460.1  cytosolic non-specific dipeptidase

      See identical proteins and their annotated locations for NP_001276460.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein
      Source sequence(s)
      AK003779, AK152442, CJ306472, CN721222
      Consensus CDS
      CCDS29383.1
      UniProtKB/Swiss-Prot
      Q3TA80, Q3TI32, Q3U7B9, Q99PV1, Q9D1A2
      UniProtKB/TrEMBL
      Q6KAT3
      Related
      ENSMUSP00000128696.2, ENSMUST00000168419.3
      Conserved Domains (1) summary
      cd05676
      Location:7 → 473
      M20_dipept_like_CNDP; M20 cytosolic nonspecific dipeptidases including anserinase and serum carnosinase

    2. NM_023149.3 → NP_075638.2  cytosolic non-specific dipeptidase

      See identical proteins and their annotated locations for NP_075638.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AK003779, CJ078789, CJ306472
      Consensus CDS
      CCDS29383.1
      UniProtKB/Swiss-Prot
      Q3TA80, Q3TI32, Q3U7B9, Q99PV1, Q9D1A2
      UniProtKB/TrEMBL
      Q6KAT3
      Related
      ENSMUSP00000025546.10, ENSMUST00000025546.17
      Conserved Domains (1) summary
      cd05676
      Location:7 → 473
      M20_dipept_like_CNDP; M20 cytosolic nonspecific dipeptidases including anserinase and serum carnosinase

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000084.7 Reference GRCm39 C57BL/6J

      Range
      84685590..84703827 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030250570.2 → XP_030106430.1  cytosolic non-specific dipeptidase isoform X1

      UniProtKB/Swiss-Prot
      Q3TA80, Q3TI32, Q3U7B9, Q99PV1, Q9D1A2
      UniProtKB/TrEMBL
      Q6KAT3
      Conserved Domains (1) summary
      cd05676
      Location:7 → 473
      M20_dipept_like_CNDP; M20 cytosolic nonspecific dipeptidases including anserinase and serum carnosinase
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9D1A2.1 GenPept UniProtKB/Swiss-Prot:Q9D1A2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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