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    MRPS10 mitochondrial ribosomal protein S10 [ Homo sapiens (human) ]

    Gene ID: 55173, updated on 14-Nov-2024

    Summary

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    Official Symbol
    MRPS10provided by HGNC
    Official Full Name
    mitochondrial ribosomal protein S10provided by HGNC
    Primary source
    HGNC:HGNC:14502
    See related
    Ensembl:ENSG00000048544 MIM:611976; AllianceGenome:HGNC:14502
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    uS10m; MRP-S10; PNAS-122
    Summary
    Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that belongs to the ribosomal protein S10P family. Pseudogenes corresponding to this gene are found on chromosomes 1q, 3p, and 9p. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in esophagus (RPKM 21.1), heart (RPKM 17.6) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See MRPS10 in Genome Data Viewer
    Location:
    6p21.1
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (42206807..42217861, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (42035014..42046095, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (42174545..42185599, complement)

    Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene GUCA1ANB-GUCA1A readthrough Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:42146768-42147472 Neighboring gene CRISPRi-validated cis-regulatory element chr6.2919 Neighboring gene guanylate cyclase activator 1A Neighboring gene CRISPRi-validated cis-regulatory element chr6.2920 Neighboring gene guanylate cyclase activator 1B Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:42183711-42184313 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:42184314-42184915 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24543 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24544 Neighboring gene uncharacterized LOC105375061 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24545 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr6:42209608-42210190 Neighboring gene transcriptional regulating factor 1 Neighboring gene uncharacterized LOC124901316 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr6:42225117-42225844

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. A proteomics approach to the identification of mammalian mitochondrial small subunit ribosomal proteins. Koc EC, et al. J Biol Chem, 2000 Oct 20. PMID 10938081
    2. Gene expression profile of human bone marrow stromal cells: high-throughput expressed sequence tag sequencing analysis. Jia L, et al. Genomics, 2002 Jan. PMID 11827452
    3. p32/gC1qR is indispensable for fetal development and mitochondrial translation: importance of its RNA-binding ability. Yagi M, et al. Nucleic Acids Res, 2012 Oct. PMID 22904065, Free PMC Article
    4. LUBAC assembles a ubiquitin signaling platform at mitochondria for signal amplification and transport of NF-κB to the nucleus. Wu Z, et al. EMBO J, 2022 Dec 15. PMID 36398858, Free PMC Article
    5. Ribosome. The structure of the human mitochondrial ribosome. Amunts A, et al. Science, 2015 Apr 3. PMID 25838379, Free PMC Article

    See all (71) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Observational study of gene-disease association. (HuGE Navigator)
      Title: Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.
    Submit: New GeneRIF Correction

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ10567

    Gene Ontology Provided by GOA

    Process Evidence Code Pubs
    involved_in mitochondrial translation NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in mitochondrial inner membrane NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in mitochondrial inner membrane TAS
    Traceable Author Statement
    more info
    		  
    located_in mitochondrial matrix TAS
    Traceable Author Statement
    more info
    		  
    part_of mitochondrial small ribosomal subunit IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of mitochondrial small ribosomal subunit NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in mitochondrion HTP PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    small ribosomal subunit protein uS10m
    Names
    28S ribosomal protein S10, mitochondrial
    S10mt
    mitochondrial 28S ribosomal protein S10
    mitochondrial small ribosomal subunit protein uS10m
    NP_060611.2
    XP_005249263.1
    XP_011513026.1
    XP_011513027.1
    XP_016866485.1
    XP_054211749.1
    XP_054211750.1
    XP_054211751.1
    XP_054211752.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_018141.4 → NP_060611.2  small ribosomal subunit protein uS10m

      See identical proteins and their annotated locations for NP_060611.2

      Status: REVIEWED

      Source sequence(s)
      AF113220, AI683142, AI754661, AW300686, AW974308, BC012560, BG776014
      Consensus CDS
      CCDS4866.1
      UniProtKB/Swiss-Prot
      B2RE89, P82664, Q9H3E5, Q9NVR3
      Related
      ENSP00000053468.3, ENST00000053468.4
      Conserved Domains (1) summary
      pfam00338
      Location:80 → 173
      Ribosomal_S10; Ribosomal protein S10p/S20e

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

      Range
      42206807..42217861 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005249206.4 → XP_005249263.1  small ribosomal subunit protein uS10m isoform X3

      Conserved Domains (1) summary
      pfam00338
      Location:79 → 171
      Ribosomal_S10; Ribosomal protein S10p/S20e

    2. XM_017010996.2 → XP_016866485.1  small ribosomal subunit protein uS10m isoform X4

      UniProtKB/TrEMBL
      B4DP77
      Conserved Domains (1) summary
      pfam00338
      Location:39 → 131
      Ribosomal_S10; Ribosomal protein S10p/S20e

    3. XM_011514725.4 → XP_011513027.1  small ribosomal subunit protein uS10m isoform X2

      Conserved Domains (1) summary
      pfam00338
      Location:89 → 181
      Ribosomal_S10; Ribosomal protein S10p/S20e

    4. XM_011514724.4 → XP_011513026.1  small ribosomal subunit protein uS10m isoform X1

      Related
      ENSP00000520760.1, ENST00000718325.1
      Conserved Domains (1) summary
      pfam00338
      Location:90 → 182
      Ribosomal_S10; Ribosomal protein S10p/S20e

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060930.1 Alternate T2T-CHM13v2.0

      Range
      42035014..42046095 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054355776.1 → XP_054211751.1  small ribosomal subunit protein uS10m isoform X3

    2. XM_054355777.1 → XP_054211752.1  small ribosomal subunit protein uS10m isoform X4

      UniProtKB/TrEMBL
      B4DP77

    3. XM_054355775.1 → XP_054211750.1  small ribosomal subunit protein uS10m isoform X2

    4. XM_054355774.1 → XP_054211749.1  small ribosomal subunit protein uS10m isoform X1

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P82664.2 GenPept UniProtKB/Swiss-Prot:P82664

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