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    USP31 ubiquitin specific peptidase 31 [ Homo sapiens (human) ]

    Gene ID: 57478, updated on 2-Nov-2024

    Summary

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    Official Symbol
    USP31provided by HGNC
    Official Full Name
    ubiquitin specific peptidase 31provided by HGNC
    Primary source
    HGNC:HGNC:20060
    See related
    Ensembl:ENSG00000103404 MIM:619536; AllianceGenome:HGNC:20060
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    Enables cysteine-type deubiquitinase activity. Predicted to be involved in protein deubiquitination and proteolysis. Located in nucleus. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in testis (RPKM 7.0), urinary bladder (RPKM 3.7) and 24 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See USP31 in Genome Data Viewer
    Location:
    16p12.2
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (23061406..23149452, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (23337392..23425432, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (23072727..23160773, complement)

    Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene collagen alpha-1(XVI) chain Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr16:22871179-22871742 Neighboring gene heparan sulfate-glucosamine 3-sulfotransferase 2 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10575 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr16:22964872-22965382 Neighboring gene ReSE screen-validated silencer GRCh37_chr16:22988092-22988272 Neighboring gene uncharacterized LOC112268176 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:23079291-23079792 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:23104917-23105463 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7271 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7272 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7273 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7274 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10576 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:23183549-23184050 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7275 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:23197073-23197574 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:23197575-23198074 Neighboring gene Sharpr-MPRA regulatory region 8546 Neighboring gene sodium channel epithelial 1 subunit gamma Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr16:23291226-23291748 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10577 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:23312821-23313338 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:23313339-23313855 Neighboring gene sodium channel epithelial 1 subunit beta Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10578 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:23359541-23360042 Neighboring gene Sharpr-MPRA regulatory region 1348 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:23391379-23391880

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. USP31 serves as a potential biomarker for predicting prognosis and immune responses for clear cell renal cell carcinoma via single-cell and bulk RNA-sequencing. Yu Y, et al. J Gene Med, 2024 Jan. PMID 37699648
    2. Plumbagin is a novel GPX4 protein degrader that induces apoptosis in hepatocellular carcinoma cells. Yao L, et al. Free Radic Biol Med, 2023 Jul. PMID 37011699
    3. USP31 acetylation at Lys1264 is essential for its activity and cervical cancer cell growth. Hou Y, et al. Acta Biochim Biophys Sin (Shanghai), 2021 Jul 28. PMID 34184746
    4. Human ubiquitin specific protease 31 is a deubiquitinating enzyme implicated in activation of nuclear factor-kappaB. Tzimas C, et al. Cell Signal, 2006 Jan. PMID 16214042
    5. Cloning and enzymatic analysis of 22 novel human ubiquitin-specific proteases. Quesada V, et al. Biochem Biophys Res Commun, 2004 Jan 30. PMID 14715245

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. USP31 serves as a potential biomarker for predicting prognosis and immune responses for clear cell renal cell carcinoma via single-cell and bulk RNA-sequencing.
      Title: USP31 serves as a potential biomarker for predicting prognosis and immune responses for clear cell renal cell carcinoma via single-cell and bulk RNA-sequencing.
    2. USP31 acetylation at Lys1264 is essential for its activity and cervical cancer cell growth.
      Title: USP31 acetylation at Lys1264 is essential for its activity and cervical cancer cell growth.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • KIAA1203

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables cysteine-type deubiquitinase activity IDA
    Inferred from Direct Assay
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein deubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		  

    General protein information

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    Preferred Names
    ubiquitin carboxyl-terminal hydrolase 31
    Names
    deubiquitinating enzyme 31
    ubiquitin specific proteinase 31
    ubiquitin thioesterase 31
    ubiquitin thiolesterase 31
    ubiquitin-specific-processing protease 31
    NP_001374150.1
    NP_065769.3
    XP_016878986.1
    XP_016878987.1
    XP_016878988.1
    XP_047290345.1
    XP_054169505.1
    XP_054169506.1
    XP_054169507.1
    XP_054169508.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001387221.1 → NP_001374150.1  ubiquitin carboxyl-terminal hydrolase 31 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC099482, AC127459
      Conserved Domains (2) summary
      PHA03307
      Location:961 → 1169
      PHA03307; transcriptional regulator ICP4; Provisional
      COG5560
      Location:126 → 726
      UBP12; Ubiquitin C-terminal hydrolase [Posttranslational modification, protein turnover, chaperones]

    2. NM_020718.4 → NP_065769.3  ubiquitin carboxyl-terminal hydrolase 31 isoform 1

      See identical proteins and their annotated locations for NP_065769.3

      Status: VALIDATED

      Source sequence(s)
      AC099482, AC127459
      Consensus CDS
      CCDS10607.1
      UniProtKB/Swiss-Prot
      Q6AW97, Q6ZTC0, Q6ZTN2, Q70CQ4, Q9ULL7
      Related
      ENSP00000219689.7, ENST00000219689.12
      Conserved Domains (3) summary
      cd02674
      Location:596 → 763
      Peptidase_C19R; A subfamily of peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
      cl02553
      Location:129 → 335
      Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
      pfam10243
      Location:1013 → 1346
      MIP-T3; Microtubule-binding protein MIP-T3

    RNA

    1. NR_170599.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC099482, AC127459

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

      Range
      23061406..23149452 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017023497.3 → XP_016878986.1  ubiquitin carboxyl-terminal hydrolase 31 isoform X1

      Conserved Domains (3) summary
      cd02674
      Location:333 → 500
      Peptidase_C19R; A subfamily of peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
      cl02553
      Location:14 → 72
      Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
      pfam10243
      Location:750 → 1083
      MIP-T3; Microtubule-binding protein MIP-T3

    2. XM_017023498.3 → XP_016878987.1  ubiquitin carboxyl-terminal hydrolase 31 isoform X1

      Conserved Domains (3) summary
      cd02674
      Location:333 → 500
      Peptidase_C19R; A subfamily of peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
      cl02553
      Location:14 → 72
      Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
      pfam10243
      Location:750 → 1083
      MIP-T3; Microtubule-binding protein MIP-T3

    3. XM_017023499.3 → XP_016878988.1  ubiquitin carboxyl-terminal hydrolase 31 isoform X2

    4. XM_047434389.1 → XP_047290345.1  ubiquitin carboxyl-terminal hydrolase 31 isoform X3

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060940.1 Alternate T2T-CHM13v2.0

      Range
      23337392..23425432 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054313530.1 → XP_054169505.1  ubiquitin carboxyl-terminal hydrolase 31 isoform X1

    2. XM_054313531.1 → XP_054169506.1  ubiquitin carboxyl-terminal hydrolase 31 isoform X1

    3. XM_054313532.1 → XP_054169507.1  ubiquitin carboxyl-terminal hydrolase 31 isoform X2

    4. XM_054313533.1 → XP_054169508.1  ubiquitin carboxyl-terminal hydrolase 31 isoform X3

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q70CQ4.2 GenPept UniProtKB/Swiss-Prot:Q70CQ4

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